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Öğe Determination of the bioenergy production capacity from biochemical profiles of some aquatic phytoremediation plants. Energy while cleaning(Scibulcom Ltd., 2014) Gunes A.; Cakar H.; Akat O.; Guney M.A.; Ozkul B.; Koru E.; Korkut A.Y.; Suzer C.; Cirik S.; Firat K.; Saka S.This study aims to research the possibilities of converting some hydrophytes into energy by revaluating them after the harvesting process. These hydrophytes used in the phytoremediation studies disperse naturally in aquatic mediums, sometimes even revealing themselves as invasive species. Chosen hydrophytes samples (Eichornia crassipes, Cyperus alternifolius, Lemna minor, Pistia stratiotes, Typha latifolia, Nasturtium officinale, Houttonia cordata) are analysed in terms of oil rate, biochemical profiles which include elaeostearic compositions, COI/T.20/Doc No 17 (capillary column gas chromatography) and in-house methods. The obtained data are analysed in comparison to the elaeostearics rate and compositions of the plants used in biodiesel procurement (canola, soy, palm, sunflower, Botryococcus and Chlorella oils). As a result, it is found that linolenic acid and linoleic acid percentages especially stand forth in the plants Eichornia sp., Cyperus sp., Lemna sp., the stearic and oleic acid percentages are significantly high in Pistia sp., and palmitic elaeostearic percentage is higher in the plants of Houttonia sp. and Nasturtium sp. than the plants currently used in biodiesel procurement, yet the oil rate within their system is lower than these plants. Moreover, it is thought that the plant waste obtained after the harvest carried out in order to ensure the water quality of the systems may in the least meet this deficit.Öğe Investigations for GIS use in legal administrations of protected natural areas -A case study: Villages of Yaka and Çiçeklikoy(Parlar Scientific Publications, 2014) Gunes A.; Kocak G.; Tahta B.T.In this research, the dilemmas between protection and land-usage that are conflicted in legally protected natural sites in Turkey, and the impact of the legal obstacles together with court orders on environmental components and the nature have been examined. The original aspect of the research is integration of the protected natural zones and the legal decisions that were taken on the sites via Geographical Information System (GIS) by taking social structure and legal procedures into the account, and also determining the impact they have through presentation of visual and analytical perspectives. The research areas chosen were the villages of Çiçeldikoy and Yaka, which are classified as first grade natural zones by the protection laws of Turkey in 1999, and became subject to dispute through many individual court appeals. During the legal process, the official complains were examined within the frame of the current law and legislations, and a variety of decisions were taken determining the land-use on existing protection zones. The results obtained were scrutinized within the frame of technical and legal perspective; both during the determination of protection grades and afterwards, during structuring sustainable and well-balanced relation of the protection and the usage, which is also available for development; therefore, suggestions were made accordingly, both for the afore-mentioned problems and for the complaints caused by employment loss. The importance of GIS application during planning and conflict resolution for protected natural sites was emphasized. © by PSP.Öğe Niosomes of Nerium oleander extracts: In vitro assessment of bioactive nanovesicular structures(Editions de Sante, 2017) Gunes A.; Guler E.; Un R.N.; Demir B.; Barlas F.B.; Yavuz M.; Coskunol H.; Timur S.Niosomes are known as non-ionic surfactant-based vesicles and have been used quite a lot for medical applications as a novel drug delivery system in recent years. Herein we describe, the preparation and characterization of niosomes containing oleander (Nerium oleander) (ONs) extract as the herbal compound. In this context, niosomal formulations of two different extracts obtained from oleander roots were prepared by a thin film hydration technique using Tween 60 (non-ionic surfactant) with a cholesterol mixture at 1:1 M ratio. These vesicular structures were characterised by various techniques such as atomic force microscopy, zeta potential and dynamic light scattering size measurements. ONs vesicles are less than 100 nm in size with a good physical stability more than 50 days. Initially, total phenolic and flavonoid contents and antioxidant activities of the extracts were investigated. The methanol extract of oleander roots (MOE) showed higher polyphenolic content and exhibits a better antioxidant activity in compared to the hydro-methanol (20% methanol) extract (MOWE). Total phenolic contents in the MOE and MOWE were calculated as 64.51 ± 0.945 µg/mg and 65.05 ± 0.37 µg/mg gallic acid equivalents, respectively. Encapsulation efficiencies of the vesicles were found as 16.2% for MON (contain MOE) and 13.24% for MWON (contain MOWE). The significant linear correlation was confirmed between the antioxidant activity and total phenolic content of extracts as well as ONs. Cell based cytotoxic activities of methanol extract and MON formulations were also assessed via MTT assay using HeLa and A549 cell lines. © 2016 Elsevier B.V.Öğe Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma(Impact Journals LLC, 2018) Gunes A.; Bagirsakci E.; Iscan E.; Cakan-Akdogan G.; Aykutlu U.; Senturk S.; Ozhan G.; Erdal E.; Nart D.; Barbet F.Y.; Atabey N.Background: Considerable evidence suggests that oxidative stress plays an essential role in the progression of hepatocellular carcinoma (HCC). While acquired resistance to oxidative stress is the main driver of aggressive cell phenotype, the underlying mechanisms remain unknown. Here, we tested the hypothesis that elevated expression of Thioredoxin-interacting protein (TXNIP) is a main regulator of the aggressive phenotype in HCC. Materials and Methods: To test this hypothesis, we measured TXNIP expression levels in 11 HCC cell lines by qPCR and western blotting. In addition, 80 pairs of HCC tissues and matched liver tissues of 73 cases, as well as 11 normal liver tissue samples were examined by immunohistochemistry. Besides, TXNIP expression levels were analyzed by Oncomine Platform in seven independent microarray datasets. Finally, the functional role of TXNIP in HCC was investigated in vitro and in vivo by silencing and overexpression studies. Results: Our results show that TXNIP expression is significantly increased in HCC compared to non-tumor counterparts (p < 0.0001) as well as to normal (p < 0.0001) and cirrhotic (p < 0.0001) liver tissues. Moreover, stable overexpression of TXNIP in HCC cells (i) significantly increases ROS levels, (ii) induces EMT phenotype, (iii) increases motility, invasion and 3D branching tubulogenesis, (iv) decreases apoptosis, and (v) elevates in vivo metastasis in zebrafish embryos. Finally, we identify sinusoidal/stromal and cytoplasmic TXNIP staining patterns as risk factors for intrahepatic vascular invasion (p:0.0400). Conclusion: Our results strongly suggest that overexpression of TXNIP has a pivotal role in HCC progression by inducing cell survival, invasion, and metastasis. Copyright: Gunes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
