Yazar "Guler, A." seçeneğine göre listele
Listeleniyor 1 - 20 / 24
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A case with hyperammonemic encephalopathy triggered by single dose valproate(Springer-Verlag Italia Srl, 2016) Ciftci, S.; Guler, A.; Deveci, E.; Celebisoy, N.; Yuceyar, N.Öğe CEREBRAL VENOUS THROMBOSIS AND TURNER SYNDROME: A RARE REPORTED ASSOCIATION(Medecine Et Hygiene, 2015) Guler, A.; Alpaydin, S.; Bademkiran, F.; Sirin, H.; Celebisoy, N.Cerebral venous thrombosis and Turner Syndrome: a rare reported association: Turner Syndrome is the only known viable chromosomal monosomy, characterised by the complete or partial absence of an X chromosome. It's the most common chromosomal abnormality in females. Apart from the well known dysmorphic features of the syndrome, it has been associated with a number of vascular pathologies; mainly involving the cardiovascular, renovascular, peripheral vascular and cerebrovascular system. It seems striking that thromboembolism is not considered as a feature of the syndrome. Most of the thromboembolism cases are related to the arterial vascular system; except for some rare reported portal venous thrombosis cases, peripheral venous thrombosis cases and to the best of our knowledge a single case of cerebral venous thrombosis with Dandy Walker malformation and polymicrogyria. We herein report a cerebral venous thrombosis case with Turner Syndrome. With no other found underlying etiology, we want to highlight that Turner Syndrome, itself, may have a relationship not only with the cerebral arterial vascular system pathologies but also with the cerebral venous thrombosis.Öğe Circulating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndrome(Springer, 2019) Bicer, M.; Alan, M.; Alarslan, P.; Guler, A.; Kocabas, G. U.; Imamoglu, C.; Aksit, M.; Bozkaya, G.; Isil, A. M.; Baloglu, A.; Aslanipoiur, B.; Calan, MehmetPurposeInsulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT).MethodsA total of 164 subjects were recruited in this cross-sectional study (82 women with PCOS and 82 age- and BMI-matched controls). Circulating INSL5 levels were assessed via ELISA method. High-resolution B-mode ultrasound was used to measure cIMT. The hormonal and metabolic parameters of the recruited subjects were determined.ResultsCirculating INSL5 levels were significantly elevated in women with PCOS compared to controls (27.637.74 vs. 19.90 +/- 5.85ng/ml, P<0.001). The mean values of INSL5 were significantly higher in overweight subjects compared to lean weight subjects in both groups. The women with PCOS having insulin resistance have increased INSL5 compared to those of PCOS subjects without insulin resistance. INSL5 is associated with insulin resistance, BMI, luteinizing hormone and free androgen index. Multivariate logistic regression analyses revealed that the odds ratio for having PCOS in the highest tertile of INSL5 was higher than in the lowest tertile.Conclusions PCOS subjects exhibited an elevation in circulating INSL5 levels along with a link between INSL5 level induction and metabolic-hormonal parameters.Öğe Co-existence of Gastrointestinal Stromal Tumors with Malign Epithelial Tumors : a Report of Two Cases(Acta Medical Belgica, 2009) Firat, O.; Yazici, P.; Makay, O.; Aydin, A.; Tuncyurek, M.; Ersin, S.; Guler, A.Aim : To emphasize the importance of a detailed observation for incidental simultaneous tumoral masses during surgery for gastrointestinal stromal tumors (GISTs) at any location in the gastrointestinal system. Case presentations : Case 1 : a 39 years old female patient with an esophageal squamous cell carcinoma and a synchronous small intestinal GIST discovered incidentally during esophagectomy. Case 2 : a 73 years old female patient with a gastric GIST and a synchronous colorectal cancer detected incidentally during gastrectomy. In both cases, immunohistochemical examinations of the resected specimens confirmed the coexistences of GISTs and epithelial malignancies. Conclusion : The coexistences of GISTs with epithelial tumors have been increasing in recent years. In any case of a GIST or gastrointestinal adenocarcinoma, the surgeon should be alert to recognize a possible coexistent tumor with different histological origin.Öğe Co-existence of Gastrointestinal Stromal Tumors with Malign Epithelial Tumors : a Report of Two Cases(Acta Medical Belgica, 2009) Firat, O.; Yazici, P.; Makay, O.; Aydin, A.; Tuncyurek, M.; Ersin, S.; Guler, A.Aim : To emphasize the importance of a detailed observation for incidental simultaneous tumoral masses during surgery for gastrointestinal stromal tumors (GISTs) at any location in the gastrointestinal system. Case presentations : Case 1 : a 39 years old female patient with an esophageal squamous cell carcinoma and a synchronous small intestinal GIST discovered incidentally during esophagectomy. Case 2 : a 73 years old female patient with a gastric GIST and a synchronous colorectal cancer detected incidentally during gastrectomy. In both cases, immunohistochemical examinations of the resected specimens confirmed the coexistences of GISTs and epithelial malignancies. Conclusion : The coexistences of GISTs with epithelial tumors have been increasing in recent years. In any case of a GIST or gastrointestinal adenocarcinoma, the surgeon should be alert to recognize a possible coexistent tumor with different histological origin.Öğe Effect of decompressive craniectomy for malignant middle cerebral artery infarction especially in elderly patients: a Single center experience for 113 patients(Wiley, 2015) Guler, A.; Ciftci, S.; Sirin, H.; Celebisoy, N.; Kumral, E.; Turhan, T.; Ozgiray, E.Öğe Effect of decompressive craniectomy for malignant middle cerebral artery infarction especially in elderly patients: a Single center experience for 113 patients(Wiley, 2015) Guler, A.; Ciftci, S.; Sirin, H.; Celebisoy, N.; Kumral, E.; Turhan, T.; Ozgiray, E.Öğe Effect of decompressive craniectomy for malignant middle cerebral artery infarction especially in elderly patients: a Single center experience for 113 patients(Wiley, 2015) Guler, A.; Ciftci, S.; Sirin, H.; Celebisoy, N.; Kumral, E.; Turhan, T.; Ozgiray, E.Öğe Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome(Springer, 2020) Bicer, M.; Alarslan, P.; Guler, A.; Demir, I; Aslanipour, B.; Calan, M.Purpose Secreted frizzled-related protein 4 (SFRP4) is an adipokine involving in apoptotic process during ovulation and energy metabolism. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with insulin resistance and impaired oocyte maturation as well as apoptotic dysfunctions through oocyte development. Our aim was to determine whether there was an alteration in levels of SFRP4 and if there was an association between metabolic or hormonal parameters and SFRP4 in women with PCOS. Methods We enrolled 80 subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle into current case-control study. Metabolic and hormonal parameters of enrolled subjects were determined. Circulating SFRP4 levels were measured with ELISA method. Results We found that circulating SFRP4 levels were elevated in women with PCOS with respect to controls (5.87 +/- 1.91 vs. 3.72 +/- 1.29 ng/ml, P < 0.001). We also found a positive association between SFRP4 and insulin resistance, androgens, ovarian follicular number or ovarian volume in women with PCOS. Binary logistic regression analysis revealed that subjects with the highest tertile of SFPR4 levels displayed increased possibility of having PCOS risk compared to those subjects with the lowest tertile of SFRP4 levels. Conclusions Increased SFRP4 levels were not only associated with higher possibility of having PCOS but also related to insulin resistance, hyperandrogenism, ovarian follicular number and ovarian volume, suggesting that SFPR4 could be a player in different pathophysiologic pathways of PCOS.Öğe Endovascular stenting for treatment of carotid artery stenosis: A series of 40 patients(Wiley-Blackwell, 2014) Ciftci, S.; Guler, A.; Sirin, H.; Gokcay, F.; Kumral, E.; Cinar, C.; Oran, I.Öğe EVALUATION OF 11 CASES WITH EPILEPTIC NYSTAGMUS(Wiley, 2016) Aydogdu, I; Ekinci, A.; Gulluoglu, H.; Tabakoglu, A.; Ciftci, S.; Guler, A.; Bademkiran, F.; Arac, N.Öğe FRONTAL INTERMITTANT RHYTHMIC DELTA ACTIVITY (FIRDA): CLINICAL AND LABORATORY CORRELATES IN 20 PATIENTS(Wiley-Blackwell, 2015) Ciftci, S.; Ekinci, A.; Tabakoglu, A.; Guler, A.; Aydogdu, I.; Bademkiran, F.; Uludag, B.; Arac, N.Öğe Ileal obstruction after duodenal metallic stent placement(Georg Thieme Verlag Kg, 2007) Ozutemiz, O.; Tekin, F.; Oruc, N.; Ersoz, G.; Guler, A.Öğe The impact of malnutrition on stroke management in tertiary hospitals in Turkey(Springer Heidelberg, 2014) Arsava, E. M.; Ozcagli, T. G.; Guler, A.; Yaka, E.; Uluc, K.; Gungor, L.; Topcuoglu, M. A.; Yesilot, N.; Ozdemir, O.; Giray, S.; Berktas, M.Öğe The impact of malnutrition on stroke management in tertiary hospitals in Turkey(Wiley-Blackwell, 2014) Arsava, E. M.; Ozcagli, T. G.; Guler, A.; Yaka, E.; Uluc, K.; Gungor, L.; Topcuoglu, M. A.; Yesilot, N.; Ozdemir, O.; Giray, S.; Berktas, M.Öğe Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?(Springer, 2019) Demirpence, M.; Guler, A.; Yilmaz, H.; Sayin, A.; Pekcevik, Y.; Turkon, H.; Colak, A.; Ari, E. M.; Aslanipour, B.; Kocabas, G. U.; Calan, M.PurposeAcromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role in atherosclerosis and glucose metabolism. The aim of this study was to ascertain whether circulating UII levels are altered in subjects with acromegaly, and to describe the relationship between UII and hormonal or cardiometabolic parameters. MethodsThis cross-sectional study included 41 subjects with active acromegaly, 28 subjects with controlled acromegaly, and 37 age- and BMI-matched controls without acromegaly. Hormonal and metabolic features of the subjects as well as carotid intima media thickness (cIMT) and epicardial fat thickness (EFT) were defined. Circulation of UII levels was determined via ELISA.ResultsBoth active and controlled acromegalic subjects showed a significant elevation of circulating levels of UII with respect to controls. There was no remarkable difference in circulating levels of UII between active and controlled acromegalic groups. Both cIMT and EFT were remarkably increased in acromegaly subjects comparing to controls. UII positively correlated with cIMT, EFT, BMI, and HOMA-IR. There was no correlation between UII and GH, insulin-like growth factor-1. According to the results obtained from regression models, UII levels independently predicted cIMT and EFT.ConclusionElevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects.Öğe MANAGEMENT OF CEREBROVASCULAR EVENTS IN TERTIARY HOSPITALS IN TURKEY AND EFFECTS OF MALNUTRITION ON THE MANAGEMENT: A COST OF ILLNESS ANALYSIS(Elsevier Science Inc, 2014) Arsava, M.; Ozcagi, T. G.; Guler, A.; Yaka, E.; Uluc, K.; Gungor, L.; Topcuoglu, M. A.; Yesilot, N.; Ozdemir, O.; Giray, S.; Berktas, M.Öğe ONE-DIMENSIONAL CUTTING STOCK PROBLEM WITH DIVISIBLE ITEMS: A CASE STUDY IN STEEL INDUSTRY(Turkic World Mathematical Soc, 2019) Tanir, D.; Ugurlu, O.; Guler, A.; Nuriyev, U.This paper considers the one-dimensional cutting stock problem (1D-CSP) with divisible items, which arises in the steel industries. While planning the steel cutting operations, each item can be divided into smaller pieces, then they can be recombined by welding. The objective is to minimize both the trim loss and the number of the welds. The problem can be seen as a natural generalization of the cutting stock problem (CSP) with skiving option [1] where recombining operation has a cost. In this paper, a mathematical model for the problem is given and a dynamic programming based heuristic algorithm is proposed in accordance with the company needs. Furthermore, a software, which is based on the proposed heuristic algorithm, is developed to use in MKA Company, and its performance is analyzed by solving real-life problems in the steel industry. The computational experiments show the efficiency of the proposed algorithm.Öğe Posterior reversible encephalopathy Syndrome (PRES): a series of 22 patients(Springer Heidelberg, 2014) Ciftci, S.; Guler, A.; Eraslan, C.; Sirin, H.; Celebisoy, N.; Calli, C.Öğe Posterior reversible encephalopathy syndrome (PRES): a series of 22 patients(Wiley-Blackwell, 2014) Ciftci, S.; Guler, A.; Eraslan, C.; Sirin, H.; Celebisoy, N.; Calli, C.
