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Öğe Anti-Myelin Oligodendrocyte Glycoprotein-Associated Disease with Recurrent Tumefactive Demyelinating Lesions(Wolters Kluwer Medknow Publications, 2021) Ozdemir, Huseyin; Eraslan, Cenk; Gokcay, Ahmet; Gokcay, Figen[No Abstract Available]Öğe Are COVID-19 vaccines safe for people with epilepsy? A cross-sectional study(Springer-Verlag Italia Srl, 2022) Ozdemir, Huseyin Nezih; Dere, Birgul; Gokcay, Figen; Gokcay, AhmetBackground COVID-19 disease was first seen in December 2019 and was declared a pandemic soon after. To fight the pandemic, there is an immense need for effective vaccines. The purposes of our study were to investigate the effect of coronavirus vaccines on seizures in people with epilepsy (PWE) and assess the adverse events of COVID-19 vaccine in PWE. Methods This was a cross-sectional study. We included epilepsy patients who got vaccinated with two or three doses at least 1 month earlier. We gathered the data using a standardized form. The form contained questions about patients' demographic features, clinical features, and information about the vaccination and its adverse events. The questionnaire included questions about epilepsy-related adverse events. Results We included 178 people with epilepsy in our study. The frequency of adverse events was lower than clinical studies of the vaccines. The mean number of seizures in the month before the vaccination was 1.62, between the doses was 1.61, and after vaccination was 1.64. There was no significant difference in the number of monthly seizures before the vaccination, the month between the doses, or the month after the vaccination (p = 0.46). Conclusions The vaccines under consideration in our study were tolerated well by the epilepsy patients. The vaccines did not affect the monthly number of seizures of the PWE. A small number of patients had more seizures than normal after vaccination. We think that benefits of the vaccines outweigh the slightly increased possibility of having a seizure after vaccination.Öğe Cervical vestibular evoked myogenic potentials in patients with the first episode of posterior canal benign paroxysmal positional vertigo before and after repositioning(Taylor & Francis Ltd, 2020) Saruhan, Gulsum; Gokcay, Ahmet; Gokcay, Figen; Celebisoy, NeseBackground Cervical vestibular evoked myogenic potentials (cVEMPs) are used to assess the sacculo-collic pathways. Benign paroxysmal positional vertigo (BPPV) is mainly a utricular disorder. Objectives To investigate cVEMPs in BPPV patients before and after repositioning maneuvers. Methods Forty patients with posterior canal BPPV with new onset symptoms underwent cVEMP testing at the time of diagnosis and a month after successful repositioning maneuver. p13, n23 latency and amplitude ratio values were compared with the results of 40 healthy controls. Results p13 and n23 latencies of the affected side were significantly longer than the healthy controls more prominent for the p13 latency. Comparison of the affected side with the non-affected side revealed delayed p13 latency on the affected side. Though a significant improvement in p13 latency was observed after repositioning, it was still prolonged when compared with the healthy controls. An abnormality regarding amplitudes was not present. Conclusions and significance cVEMP abnormalities in patients with BPPV indicate saccular dysfunction accompanying utricular dysfunction which seems to be confined to the symptomatic side at least in the early phase of the disease. Partial recovery can be seen after treatment with residual findings following even the first attack.Öğe Childhood-onset optic neuritis as the first manifestation of Behcet's disease(Taylor & Francis As, 2006) Kayim, Ozlem; Gokcay, Ahmet; Celebisoy, Nese; Gokcay, FigenA 15-year-old girl presented with sudden blurring of vision in both eyes, which was recurring for the third time. The fundoscopy demonstrated bilateral optic disc edema with macular star exudates. The diagnosis of Behcet's disease (BD) could be made 5 months after the first visual disturbance, when the other manifestations of the disease occurred. Although ocular involvement is frequent, primer optic neuritis has rarely been reported in BD. Childhood onset of the disorder is very uncommon as well. To our knowledge, this is the first report of optic neuritis as the first manifestation of BD in the pediatric age group.Öğe A cytotoxic lesion of the corpus callosum (CLOCC) in a patient with headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL): a hint for pathophysiology?(Springer Heidelberg, 2022) Ozdemir, Huseyin Nezih; Celebisoy, Nese; Gokcay, Figen; Gokcay, Ahmet[No Abstract Available]Öğe Four novel and two recurrent NHLRC1 (EPM2B) and EPM2A gene mutations leading to Lafora disease in six Turkish families(Elsevier Science Bv, 2012) Salar, Seda; Yeni, Naz; Gunduz, Aysegul; Guler, Ayse; Gokcay, Ahmet; Velioglu, Sibel; Gundogdu, Asli; Caglayan, S. HandeLafora disease (LD) is a type of autosomal recessive, progressive myoclonus epilepsy resulting mostly from mutations in the EPM2A and NHLRC1 genes. Mutational analysis in both genes was initiated with the aim of establishing LD DNA diagnosis in Turkey. Four novel NHLRC1 (p.G131X, p.P69S and p.D82H) and EPM2A (p.V7A) and two recurrent NHLRC1 (p.D146N) and EPM2A (p.R241X) mutations were identified in six families. The delineation of causative mutations in patients provided early disease diagnosis for other family members and contributed to the knowledge of LD pathogenesis. (C) 2011 Elsevier B.V. All rights reserved.Öğe Multimodal Evoked Potentials in Primary Sjogren's Syndrome Without Neurological Manifestations(Journal Neurological Sciences, 2009) Gokcay, Figen; Celebisoy, Nese; Gokcay, Ahmet; Oder, Gonca; Kabasakal, Yasemin; Aksu, Kenan; Kose, TimurWe evaluated multimodal evoked potentials in patients with primary Sjogren's syndrome without clinical neurological manifestations. While brainstem auditory evoked potentials (BAEP) were performed in ninety patients visual (VEP) and somatosensory evoked potentials (SEP) could be evaluated in fifty-eight patients. The control group included 20 healthy adults matched for sex and chronological age. VEP and AEP studies did not reveal any abnormality. In SEP; N9-N13 interpeak latencies were significantly prolonged in the patients group. However, the latency of N9 potentials recorded from Erb's point was normal as well as the N13-N20 interpeak latencies. This result indicates that central branches of the primary sensory neurons are involved in Sjogren's syndrome.Öğe Neurological Symptoms and Signs in Behcet Disease A Western Turkey Experience(Lippincott Williams & Wilkins, 2011) Gokcay, Figen; Celebisoy, Nese; Gokcay, Ahmet; Aksu, Kenan; Keser, GokhanAim: To assess the clinical patterns of neurologic involvement and the frequencies and characteristics of different types of headaches in patients with Behcet disease. Methods: Total 530 patients with Behcet disease were evaluated for the presence of neurologic involvement and/or headache. Results: Of the 54 patients (10.2%) with neurological involvement, 36 (66.7%) had parenchymal and 16 (29%) had vascular involvement. There was a patient with optic neuropathy and another patient with peripheral nerve involvement. There were 46 patients (8.7%) with headache without any evidence of neurological involvement and 25 of them (4.7%) were diagnosed with migraine. Conclusions: The prevalence of neurologic involvement in our group was higher than the studies published previously from the same country. Migraine prevalence on the other hand was low.Öğe Ophthalmoplegia due to Invasive Fungal Sinusitis: A Report of Three Cases(Turkish Neurological Soc, 2017) Colak, Ayse Yagmur; Gokcay, Figen; Celebisoy, Nese; Gokcay, Ahmet; Guler, Ayse; Pullukcu, Husnu; Midilli, Rasit; Gode, SercanInvasive fungal sinusitis is an infection of the paranasal sinuses that should be diagnosed early due to its high mortality and morbidity rates. Mucormycosis and aspergillus are the two most important agents of invasive fungal sinusitis. Although usually seen in patients who are immunocompromised, they are rarely seen in immunocompetent patients. In this article, we present three patients with ophthalmoplegia; one patient with hematologic malignancy, and two patients with uncontrolled diabetes. By presenting these three patients with invasive fungal sinusitis, we aimed to emphasize the possible role of fungal sinusitis in the development of ophthalmoplegia in patients with diabetes or immunosuppression due to any reason, and the importance of early treatment.Öğe Orgasm-induced Seizures: A Case Report and Review of the Literature(Turkish Neurological Soc, 2021) Ozdemir, Huseyin Nezih; Samedli, Kamran; Gokcay, Figen; Gokcay, AhmetCertain types of stimuli can trigger epileptic seizures in patients with epilepsy. This phenomenon is defined as reflex seizure. Stimuli may be in visual, auditory, tactile, or cognitive forms, and orgasm may trigger epileptic seizures. A 42-year-old man was admitted to our department with orgasm-induced generalized seizures that had started 6 months ago. He was examined using electroencephalography and cranial magnetic resonance imaging, and was treated with levetiracetam and clobazam. His seizures were controlled well. In this article, we aim to present our case and review the literature on the subject.Öğe Primary Sjogren's syndrome presenting as neuromyelitis optica(Elsevier Science Inc, 2007) Gokcay, Figen; Celebisoy, Nese; Gokcay, Ahmet; Kabasakal, Yasemin; Oder, GoncaThis report presents a patient with Devic's neuromyelitis optica associated with primary Sjogren's syndrome. Her first attack was right-sided optic neuritis at age 10 years. Attacks involving both optic nerves and medulla spinalis were recorded during the ensuing years. The diagnosis of Sjogren's syndrome could not be made until the second decade because it was not suspected. (c) 2007 by Elsevier Inc. All rights reserved.Öğe Progressive Multifocal Leukoencephalopathy in a Case Without Clear Evidence of Immunodeficiency(Journal Neurological Sciences, 2012) Guler, Ayse; Gokcay, Figen; Haznedaroglu, Damla; Gokcay, Ahmet; Zeytinoglu, Aysin; Sagduyu, Ayse Kocaman; Sirin, HadiyeIntroduction: Progressive Multifocal Leukoencephalopathy(PML) is a rare demyelinating disease of the central nervous system due to reactivation of a latent infection with JC papovavirus. PML predominantly occurs in severely immunosupressed patients, mostly as a late complication of acquired immunodeficiency syndrome and lymphoproliferative disorders. Clinically it is manifested by motor and sensory deficits, ataxia, cognitive impairment and dementia, corresponding to central nervous system (CNS) lesions. It is difficult to distinguish PML clinically from immune-mediated diseases of the CNS, such as multiple sclerosis, neuropsychiatric sistemic lupus erythematosus and CNS vasculitis. Case Report: A 19-year-old woman presented with ataxia and slurred speech rapidly progressing to quadriparesis and confusion. The diagnosis of PML was made by detecting the JC virus in the cerebrospinal fluid by polymerase chain reaction. Discussion: PML predominantly occurs in severely immunosupressed patients. However, it must also be kept in mind in patients without an apparent immunodeficiency when the clinical and radiological features are typical.Öğe Subacute Sclerosing Panencephalitis Cases Diagnosed by Increased CSF/Serum Measles Antibody Indices(Ankara Microbiology Soc, 2012) Samlioglu, Pinar; Unalp, Aycan; Gokcay, Ahmet; Altuglu, Imre; Ozturk, Aysel; Zeytinoglu, AysinSubacute sclerosing panencephalitis (SSPE) caused by persistent defective measles virus strains, is a progressive neurological disorder of children and adolescents. The aim of this letter was to share the data from SSPE-suspected cases who were definitely diagnosed by the detection of increased antibody index in serum and cerebrospinal fluid (CSF) samples. A total of 11 patients (mean age: 14.3 years) with suspected SSPE between February 2006 to August 2008, were included in the study. Simultaneously obtained serum and CSF samples from patients were analyzed in terms of albumin, total IgG and measles-specific IgG levels (Measles Virus IgG ELISA for CSF Diagnostics, Euroimmun, Germany). The value of CSQ(rel) (relative CSF/serum quotient) >= 1.5 was accepted indicative for intrathecal measles antibody synthesis. Seven (63.6%) of the 11 patients' diagnosis were confirmed with the demonstration of elevated CSF/serum indices (CSQ(rel), range: 2.3-36.9; mean: 12.9). Mean age of those seven cases was 12.3 years (age range: 7-21) and four of them were male. The history of patients with high antibody indices indicated that three of four patients who had measles infection had not been vaccinated against measles. These three unvaccinated patients had measles infection at 3rd, 8th and 30th months of age, respectively, and the period of SSPE development were 15, 6 and 4.5 years, respectively. With this letter we would like to emphasize once more that effective measles vaccination is the only way for the prevention of measles and SSPE and the demonstration of increased measles antibody index in simultaneously obtained serum and CSF samples is crucial for the diagnosis of SSPE.Öğe Sydenham Chorea and Hashimoto Thyroiditis: An Unusual Association(Sage Publications Inc, 2010) Yildiz, Ozlem Kayim; Gokcay, Ahmet; Gokcay, Figen; Karasoy, HaticeSydenham chorea is an immune-mediated neuropsychiatric disorder associated with group A beta-hemolytic streptococci infection. The authors present a 12-year-old female patient with Sydenham chorea and Hashimoto thyroiditis. Although Hashimoto thyroiditis has been associated with other autoimmune disorders, the association of Sydenham chorea and Hashimoto thyroiditis has not been previously reported. Immunological processes are suggested to be implicated in the pathogenesis of this association; however, the exact mechanism remains unclear.
