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    Fluctuation of “sperm DNA integrity” in accordance with semen parameters, and it’s relationship with infertility
    (Springer New York LLC, 2014) Durmaz A.; Dikmen N.; Gündüz C.; Göker E.N.T.; Tavmergen E.
    Methods: In this study, DNA damage evaluation was planned in infertile males with the COMET assay, a method which is simple, cheap, sensitive and reliable. For this purpose, the sperm DNA damage of normospermic, oligospermic, asthenospermic and teratospermic cases were investigated and the relationship between sperm parameters (sperm count, motility, morphology) and DNA damage was assessed.Results and conclusion: According to our results we suggest that the factors to blame for sperm DNA damage and semen quality are the same. Also it was found that the infertile males possess substantially more sperm DNA damage than fertile men do. Improving and using the DNA damage evaluation tests seem to improve the results in ART clinics.Purpose: Nowadays sperm analysis is used routinely to assess infertile men, but it’s predictive value is still restricted. For this reason, new markers are needed for diagnosis and guide treatment. A DNA damage evaluation method, which is easily applicable for routine analysis is described in this paper to provide an important support in clinical evaluation. © 2014, Springer Science+Business Media New York.
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    In-vitro fertilization outcome predictors in women with high baseline follicle-stimulating hormone levels: Analysis of over 1000 cycles from a tertiary center
    (Sociedade Brasileira de Reproducao Assistida, 2021) Sahin G.; Akdogan A.; Aydın M.H.; Tekindal M.A.; Göker E.N.T.; Tavmergen E.
    Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors of clinical pregnancy and live birth in women with elevated baseline follicle-stimulating hormone (FSH) levels, who have undergone intracytoplasmic sperm injection (ICSI) treatment. Methods: This retrospective study included 1011 ICSI cycles of women with high baseline FSH levels (> 10 IU/L), from a tertiary university IVF center between 2010 and 2015. Logistic regression analysis was performed to evaluate the prognostic factors of clinical pregnancy and live birth. Results: Among the 1011 ICSI cycles, the clinical pregnancy and live birth rates per oocyte retrieval were 19.5% and 14.3%, respectively. The live birth rates were 21.1% and 1.7% in women aged ?30 years and those aged ?40 years, respectively. In addition, the live birth rate was 1.47-fold higher in women from whom >3 oocytes were retrieved, compared to those from whom ?3 oocytes were retrieved (p=0.047). Logistic regression analysis indicated that the age categories ?30y, 36-39y and ?40y, level of baseline FSH (?20 IU/L) and the ovarian response (?3 or >3 oocytes retrieved) were significantly associated with live birth. Conclusions: Our study indicated that age, baseline FSH level, and ovarian response are independent predictive factors for clinical pregnancy and live birth among women with baseline FSH levels >10 IU/L. © 2021, Sociedade Brasileira de Reproducao Assistida. All rights reserved.
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    Premature luteinization defined as progesterone estradiol ratio >1 on hCG administration day seems to adversely affect clinical outcome in long gonadotropin-releasing hormone agonist cycles
    (2004) Özçakir H.T.; Levi R.; Tavmergen E.; Göker E.N.T.
    Aim: To examine the effect of premature luteinization on the outcomes in long gonadotropin-releasing hormone agonist cycles. Methods: Two-hundred and forty-eight patients who had undergone assisted reproductive technology for infertility treatment between 2001 and 2002 were enrolled into the study. The patients were separated into two groups according to P/E2 ratios on human chorionic gonadotropin administration day. Group A consisted of the patients whose P/E2 ratio was 1 (n = 116) and Group B consisted of the patients with premature luteinization of which P/E2 ratio was > 1 (n = 132). The P/E2 ratio calculation was performed as follows: P (in ng/mL) × †1,000/E2 (in pg/mL). The primary outcome measures included oocyte quality, fertilization rates and clinical pregnancy rates. Results: The mean number of mature oocytes retrieved in the groups were 9.5 ± 4.8 and 6.4 ± 3.6, respectively, and the difference was statistically significant (P < 0.05). Although the difference between the fertilization rates in Group A and Group B was not statistically significant (P > 0.05), the clinical pregnancy rates seemed to be affected adversely in the Group B patients with premature luteinization (41.4% versus 28%, respectively; P < 0.05). Conclusion: Premature luteinization, defined as P/E2 > 1 on human chorionic gonadotropin administration day, in long gonadotropin-releasing hormone agonist cycles seems to adversely affect clinical outcome.