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    Association between resistin level and renal function in patients undergoing coronary artery bypass graft surgery
    (BMJ Publishing Group, 2012) Gungor H.; Kirilmaz B.; Zorlu A.; Oguz E.; Fatih Ayik M.; Kumak F.; Zoghi M.
    Aim: The purpose of this study was to evaluate the association between resistin levels and renal function in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: Thirty-seven consecutive patients (mean T SD, age 60 T 10 years, 29 (78%) male) undergoing CABG surgery at our department were enrolled into our study. Blood samples were taken to examine quantities of resistin level and other blood parameters the day before surgery. The patients were categorized into 2 groups: lower resistin level (group 1) or higher resistin level (group 2) according to the median value of 9 ng/mL. Results: Mean T SD resistin level, glomerular filtration rate (GFR), and urea and creatinine levels were 9.5 T 4.2 ng/mL, 78 T 25 mL/min per 1.73 m2, 42 T 14 mg/dL, and 1.08 T 0.2 mg/dL, respectively. Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r =j0.398; P = 0.015), statin usage (r =j0.393; P = 0.016), and A-blocker usage (r = j0.365; P = 0.026). In the multivariate logistic regression model, only GFR (odds ratio, 0.960; 95 confidence interval, 0.928-0.993; P = 0.018) remained independently associated with higher resistin levels after adjustment of other potential confounders in patients undergoing CABG surgery. According to the receiver operating characteristics curve analysis, the optimal cutoff value of GFR to predict higher resistin levels was found as 91 mL/min or less per 1.73 m2, with 100% sensitivity and 61.1% specificity. Conclusion: The present study demonstrated that a lower glomerular filtration rate was associated with higher circulating resistin levels, independent of coronary heart disease risk factors in patients undergoing CABG surgery. Copyright © 2012 by The American Federation for Medical Research.
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    Transthoracic echocardiographic and cardiopulmonary exercise testing parameters in Eisenmenger's syndrome. Association with six-minute walk test distance
    (Urban und Vogel GmbH, 2014) Gungor H.; Fatih Ayik M.; Engin C.; Yagdi T.; Atay Y.; Ozbaran M.; Nalbantgil S.
    Objective. The six-minute walk test (6MWT) evaluates the functional exercise capacity in patients with cardiopulmonary disease. We aimed to investigate the association between 6MWT distance and transthoracic echocardiographic (TTE) findings as well as cardiopulmonary exercise testing (CPET) parameters in Eisenmenger's syndrome (ES) patients waiting for heart-lung transplantation on their initial admission to our center. Patients and methods. A total of 23 patients with ES (12 women, 11 men; mean age, 28.2±8.1 years) were included in the study. The correlation between 6MWT distance and CPET and TTE findings was retrospectively analyzed. Results. The most frequent underlying heart diseases were ventricular septal defect (VSD) with complex congenital heart disease (n=10, 43%) and isolated VSD (n=7, 30%). The 6MWT distance was 349.7±77.4 m in the study group. An inverse correlation was found between 6MWT distance and systolic pulmonary arterial pressure (SPAP) measured with TTE (r=-0.445; p=0.03). All patients underwent CPET at the first visit. Mean VO2max was 14.9±3.3 ml/kg/min and the VE/VCO 2 rate was 50.4±9.2%. No significant correlation was observed between 6MWT and CPET findings. SPAP, which did not display any correlation with CPET findings, was the only independent predictor of 6MWT distance. Conclusion. We suggest that 6MWT distance may be more suitable than CPET in the follow-up of ES patients. Further prospective, randomized, controlled trials are necessary to make more robust interpretations of this issue. © 2013 Urban & Vogel.