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Öğe Chemical composition of the essential oil and n-hexane extract of Stachys tmolea subsp. Tmolea Boiss., an endemic species of Turkey, and their mosquitocidal activity against dengue vector Aesdes aegypti(Elsevier, 2019) Demiray, Hatice; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Demirci, BetulStachys tmolea subsp. tmolea Boiss. is endemic to Turkey and is a species of the genus Stachys L. which is one of the largest genera of the family Lamiaceae with about 300 species. The aims of this study were to examine the chemical composition of the essential oil and n-hexane extract of S. tmolea subsp. tmolea as natural sources of insecticidal activity against the dengue vector, Aedes aegypti. Analysis of the essential oil by GC-FID and gas chromatography-mass +spectrometry (GC-MS) systems identified hexahydrofarnesyl acetone (15%), viridiflorol (10%), hexadecanoic acid (7%) and 9-geranyl-p-cymene (6%) as major components. The volatile components of the n-hexane extract were extracted using headspace solid-phase microextraction (HS-SPME) and were analyzed using GC-MS. The principal constituents were 3,4-dimethyl decane (16%), 3-methyl-3-pentanol (15%), 2-methyl-2-pentanol (12%), 1,4-bis (1,1-dimethylethyl) benzene (12%), heptanal (10%), acetic acid (6%) and decane (4%). Bioassay of the n-hexane extract, at 5 mu g/mosquito, produced 90% mortality against adult Ae. aegypti while the S. tmolea essential oil demonstrated 13% mortality. No larvicidal activity was observed both in essential oil and n-hexane extract. Further studies are needed to assess the adulticidal activity of the responsible compounds in the crude extract. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.Öğe Chemical Constituents from Rheum ribes Shoots and its Insecticidal Activity Against Aedes aegypti(Springernature, 2022) Demiray, Hatice; Estep, Alden S.; Tabanca, Nurhayat; Becnel, James J.; Demirci, BetulA phytochemical investigation of hexane extract of Rheum ribes L., Polygonaceae, shoots was analyzed by gas chromatography with flame ionization dection and mass specrometry and revealed seven components including methyl hexadecanoate (methyl palmitate) (2.4%), (Z)-9-methyl octadecenoate (methyl oleate) (2.9%), (Z,Z,Z)-9,12,15-methyl octadecatrienoate (methyl linolenate) (3.5%), 1-octadecanol (4.3%), (Z,Z)-9,12-methyl octadecadienoate (methyl linoleate) (5.7%), heptacosane (13.5%), and hexadecanoic acid (palmitic acid) (67.7%). The hexane extract was bioassayed for larvicidal and adult topical activity against an insecticide susceptible strain of Aedes aegypti, the yellow fever mosquito. Results demonstrated a 90% mortality against adults at 5 mu g/mosquito and first instar larvae at 1 mu g/mu l. The major compound hexadecanoic acid showed 20% mortality at 6.25 ppm against adults whereas the compound provided 100% mortality at the highest screening dose of 1000 ppm against 1st instar larvae. The mosquitocidal activity of the analyzed plant material may be related to a specific combination of compounds present in the hexane extract.Öğe Toxicity of Cephalaria Species and their Individual Constituents against Aedes aegypti(Natural Products Inc, 2015) Sarikahya, Nazli Boke; Kayce, Peyker; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Khan, Ikhlas A.; Kirmizigul, SuheylaCrude acetone and ethanol extracts of the aerial parts of 21 Cephalaria species collected from Turkey were investigated for larvicidal and adult topical activity against Aedes aegypti. The ethanol extracts from C. elazigensis var. purpurea, C. anatolica, and C. elmaliensis possessed the highest mortality against first instar Ae. aegypti larvae. Luteolin-7-O-beta-D-glycoside (1), isolated from C. elmaliensis ethanol extract, demonstrated 33% and 53% mortality at 0.1 mu g/mL concentration against first instar ORL (susceptible) and PR (pyrethroid resistant) strains, respectively. C. scoparia acetone extract showed 100% mortality against adult Ae. aegypti. From this extract compounds 2-8 were isolated. Compound 2 (isoorientin) possessed the highest toxicity with 31.7% and 65% mortality at a 10 mu g/mL concentration against adult ORL and PR strains, respectively. This is the first screening report of potential insecticides from Cephalaria species against the yellow fever mosquito, Ae. aegypti, and the active compounds (1 and 2) could lead to the development of a new class of insecticide.Öğe Toxicity of Cephalaria Species and their Individual Constituents against Aedes aegypti(Natural Products Inc, 2015) Sarikahya, Nazli Boke; Kayce, Peyker; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Khan, Ikhlas A.; Kirmizigul, SuheylaCrude acetone and ethanol extracts of the aerial parts of 21 Cephalaria species collected from Turkey were investigated for larvicidal and adult topical activity against Aedes aegypti. The ethanol extracts from C. elazigensis var. purpurea, C. anatolica, and C. elmaliensis possessed the highest mortality against first instar Ae. aegypti larvae. Luteolin-7-O-beta-D-glycoside (1), isolated from C. elmaliensis ethanol extract, demonstrated 33% and 53% mortality at 0.1 mu g/mL concentration against first instar ORL (susceptible) and PR (pyrethroid resistant) strains, respectively. C. scoparia acetone extract showed 100% mortality against adult Ae. aegypti. From this extract compounds 2-8 were isolated. Compound 2 (isoorientin) possessed the highest toxicity with 31.7% and 65% mortality at a 10 mu g/mL concentration against adult ORL and PR strains, respectively. This is the first screening report of potential insecticides from Cephalaria species against the yellow fever mosquito, Ae. aegypti, and the active compounds (1 and 2) could lead to the development of a new class of insecticide.Öğe Toxicity of Cephalaria Species and their Individual Constituents against Aedes aegypti(Natural Products Inc, 2015) Sarikahya, Nazli Boke; Kayce, Peyker; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Khan, Ikhlas A.; Kirmizigul, SuheylaCrude acetone and ethanol extracts of the aerial parts of 21 Cephalaria species collected from Turkey were investigated for larvicidal and adult topical activity against Aedes aegypti. The ethanol extracts from C. elazigensis var. purpurea, C. anatolica, and C. elmaliensis possessed the highest mortality against first instar Ae. aegypti larvae. Luteolin-7-O-beta-D-glycoside (1), isolated from C. elmaliensis ethanol extract, demonstrated 33% and 53% mortality at 0.1 mu g/mL concentration against first instar ORL (susceptible) and PR (pyrethroid resistant) strains, respectively. C. scoparia acetone extract showed 100% mortality against adult Ae. aegypti. From this extract compounds 2-8 were isolated. Compound 2 (isoorientin) possessed the highest toxicity with 31.7% and 65% mortality at a 10 mu g/mL concentration against adult ORL and PR strains, respectively. This is the first screening report of potential insecticides from Cephalaria species against the yellow fever mosquito, Ae. aegypti, and the active compounds (1 and 2) could lead to the development of a new class of insecticide.