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Öğe A case of erythema annulare centrifigum with Sjögren syndrome [Sjögren sendromu ile birlikteligi olan eritem anüler santrifüj tanili bir olgu](2010) Ertam I.; Erçal H.E.; Kazandi A.; Ünal I.; Alper S.Erythema annulare centrifigum is a dermatose which is frequently seen in adults. It is characterized by erythematous lesions which spread asymmetrically to periphery and have a collarette desquamation. Although infection, tumor, food allergy, drug reaction can play a role in the aetiology, most of the cases are idiopathic. A forty-nine years old, female patient presented to our clinic with erythematous lesions on both of her lower extremities. Six weeks prior to her referral, she treated with quinine for Sjogren syndrome. She had a diagnosis of granuloma annulare in her personal history. There was no significance in her family history. In dermatologic examination; annular erythematous plaques and collarette desquamation were detected on lower extremities. Histopathologic examination of the lesional biopsy specimen revealed focal spongiosis in the epidermis, dermal oedema, vascular proliferation and perivascular infiltration of lymphocytes, eosinophils and histiocytes. In the laboratory examination; blood count, liver and kidney function tests, sedimentation, C-reactive protein was normal. Rheumatoid factor was 30. Antinuclear antibody was 1/640 granular pattern. A case of erythema annulare centrifigum with Sjögren Syndrome is discussed with the other skin findings of the disease.Öğe A case of reversible telogen effluvium caused by a drug [İlaca bagli gelişen bir reversibl effluvium olgusu](2006) Ertam I.; Ünal I.; Alper S.Effluvium, known as diffuse hair loss, is seen as anagen and telogen effluvium. In telogen effluvium, hair follicles pass from anagen phase to telogen phase prematurely. Certain drugs such as anticoagulants, cytostatics, interpherons, retinoids, lithium carbonate, ß- blockers, antimalarials, sexual hormone preparations and angiotensin converting enzyme inhibitors may be cause of effluvium. In this case, we present a 52 years old female patient suffering from diffuse hair loss after using conjugate estrogen plus progesterone preparation for nearly one-month. Etiological investigations revealed no certain pathological results. After cessation of treatment, hair loss diminished and complete hair regrowth was observed during follow up period. In this report, current literatures related to the topic were reviewed and the role of sexual hormone preparations on hair loss was emphasized.Öğe A case of tinea facialis incognito [Bir tinea fasiyalis inkognito olgusu](2009) Karaca N.; Karaarslan I.K.; Ertam I.; Aytimur D.[No abstract available]Öğe A case with systemic sclerosis following exposure to silica and vibration [Silika ve vibrasyon maruziyeti sonrasi{dotless} gelişen bir sistemik skleroz olgusu](2012) Ürkmez A.; Karaarslan I.K.; Ertam I.; Kandiloglu G.; Ceylan C.Systemic sclerosis is an autoimmune disease characterized by inflammatory, vascular and sclerotic changes in the internal organs. Although the etiology is not known with certainty; silica dust, which is one of the environmental risk factors, can lead to scleroderma by some immunological changes. In this case, a mine worker, who worked in a mercury mine during a 15-year period, developed systemic sclerosis due to exposure to chronic silica and vibration, is presented.Öğe Clear cell acanthoma: New observations on dermatoscopy(2008) Akin F.; Ertam I.; Ceylan C.; Kazandi A.; Ozdemir F.[No abstract available]Öğe Dermato-neuro syndrome associated with scleromyxedema(Medknow Publications, 2015) Karaman B.; Guler A.; Ertam I.; Celebisoy N.[No abstract available]Öğe Development of squamous cell carcinoma on an inflammatory linear verrucous epidermal nevus in the genital area(2012) Turk B.G.; Ertam I.; Urkmez A.; Kazandi A.; Kandiloglu G.; Ozdemir F.Inflammatory linear verrucous epidermal nevus is a rare cutaneous disorder characterized by pruritic, erythematous, and verrucous papules and plaques along the lines of Blaschko. Histopathologically, there is a benign verrucous proliferation of keratinocytes together with alternating parakeratosis and orthokeratosis as well as inflammatory changes. We report a patient who developed squamous cell carcinoma (SCC) on an inflammatory linear verrucous epidermal nevus and we discuss the importance of regular follow-up of patients with epidermal nevi.Öğe Discrete papular dermal mucinosis with Hashimoto thyroiditis: a case report.(2011) Ertam I.; Karaca N.; Ceylan C.; Kazandi A.; Alper S.The cutaneous focal mucinoses are a group of connective tissue disorders characterized by deposition of mucin found either focally or diffusely in the dermis. A 47-year-old woman presented with asymptomatic flesh-colored papules on the neck, inguinal area, intergluteal area, vulvar area, and extremities of 5 months' duration. There was no history of preceding trauma or insect bites. The patient had undergone a subtotal thyroidectomy 21 years prior but had not used any thyroid medication before she was referred to our clinic. Thyroid ultrasonography was consistent with Hashimoto thyroiditis. During dermatologic examination, flesh-colored, well-defined, smooth papules that measured approximately 1.5 x 1 cm in size on the genital region, fingers, face, and scalp were seen. Histopathologic examination of a lesional biopsy revealed no abnormalities in the epidermis. Alcian blue staining showed that abundant deposits of dermal mucin had replaced collagen in the dermis.Öğe Effectiveness of Intense Pulsed Light treatment in solar lentigo: A retrospective study [Solar lentigoda yogun atimli işik (Intense Pulse Light) tedavisinin etkinligi: Retrospektif çalişma](Istanbul Assoc. of Dermatology and Venerology, 2014) Ertam I.; Türk B.G.; Karaarslan I.K.; Ünal I.; Alper S.Background and Design: Intense Pulsed Light (IPL) is a light system of 500-1200 nm wavelength which is used for hair removal and nonablative skin resurfacing as well as for the treatment of hyperpigmentation and superficial vascular lesions. The mechanism of action is thought to be the focal epidermal coagulation due to selective photothermolysis in the epidermal keratinocytes and melanocytes. A variety of laser systems can be used in the treatment of solar lentigo. The aim of this study was to investigate the effectiveness of IPL in solar lentigo. Materials and Methods: We retrospectively reviewed the medical records of patients with the diagnosis of solar lentigo in our Cosmetology Unit from March 2007 to November 2010. There were 139 files of patients who received clinical and dermoscopic diagnosis of solar lentigo and treated by IPL (L900 A&M). Informed consent was taken from all patients. Among them, 42 patients, who had attended regular follow-up visits and had pictures taken both before and after treatment, were included in the study. Results: A total of 52 lesions in 42 female and 1 male patients were included in the study. The mean age of the patients was 42±9.6 (33-88) years. Thirty-seven lesions (51.9%) were on the cheek, 7 lesions (13.5%) were on the zygoma, 6 lesions (11.5%) were on the chin, 4 lesions (7.7%) were on the hands, 4 lesions (7.7%) were on the forehead, 2 lesions (3.8%) were on the nose, and 2 lesions (3.8%) were on the forearm. The mean number of sessions was 3.28, ranging between 1 and 7. After treatment, more than 75% improvement was observed in 57.7% of the lesions, 50-75% in 17.3% of the lesions, 25-50% in 17.3% of the lesions, and less than 25% improvement was obtained in 7.7% of the lesions. Conclusion: According to the results of our work, IPL can be considered to be an effective, cheap and safe method in terms of its side effects in the treatment of solar lentigo.Öğe Efficiency of ellagic acid and arbutin in melasma: A randomized, prospective, open-label study(2008) Ertam I.; Mutlu B.; Unal I.; Alper S.; Kivçak B.; Ozer O.The aim of this study was to compare the effectiveness of gel formulations containing arbutin, synthetic ellagic acid and plant extracts that contain ellagic acid, on patients with melasma. Thirty patients who applied to Ege University Medical Faculty, Department of Dermatology, were included in the study. A signed consent was obtained from each patient prior to study. Patients whose type of melasma was determined via Wood's lamp were randomized to groups of arbutin, synthetic ellagic acid and plant extract containing natural ellagic acid. The pigment density of patients was evaluated via Mexameter before and after the treatment. The approval of the Institutional Ethics Committee of Ege University was obtained before the study. Wilcoxon and Kruskal-Wallis tests were used in the statistical analysis. Nine of 10 patients, for whom synthetic ellagic acid was started, completed the study. A decrease in the level of melanin was determined in eight of these nine patients (P = 0.038). A significant decrease in the level of melanin was also determined in all 10 patients who used plant extract containing ellagic acid (P = 0.05). A significant response was obtained from all of 10 patients who used arbutin. The difference between pre- and post-treatment levels of melanin was statistically significant (P = 0.05). Formulations prepared with plant extracts containing ellagic acid was found effective on melasma, similar to the formulations containing synthetic ellagic acid and arbutin. This material that is not yet being used widespread commercially on melasma could be an effective alternative for treatment of melasma. © 2008 Japanese Dermatological Association.Öğe Eosinophilic cellulitis: An 11-year-old male patient [Eozinofilik sellülit: on bir yaşinda erkek olgu](2010) Sezgin A.Ö.; Erçal H.E.; Karaarslan I.K.; Ertam I.; Dereli T.; Kandiloglu G.; Alper F.S.An 11-year-old boy was admitted to our clinic with a three-week of history of infiltrated brownish plaques located on the right cruris anterior, on the medial side of the right popliteal area and on the left cruris anterior. Histopathological examination showed flame figures which were composed of degenerated eosinophils and nuclear debris deposited on collagen fibers and laboratory analysis revealed eosinophilia. According to the clinical and histopathological findings, the case was diagnosed as eosinophilic cellulitis in the granulomatous phase. The case has been reported because of the rare presentation of eosinophilic cellulitis in children and the importance of the histopathology has been emphasized.Öğe Erythema multiforme like lesions in a case of systemic lupus erythematosus [Sistemik lupus eritematozuslu bir olguda eritema multiforme benzeri deri lezyonlari{dotless}](2012) Günaydin A.; Karaarslan I.K.; Ertam I.; Karadadaş H.; Türk B.G.; Kandiloglu G.; Ünal I.Cutaneous involvement may be seen in 70-85% of patients with systemic lupus erythematosus. Erythema multiforme like lesions are considered as non-specific findings in lupus erythematosus and are rarely seen in the systemic form. Seventeen-year-old woman admitted to our clinic with multiple, violet colored, targetoid lesions on the palms and dorsal areas of both hands and dorsal areas of the feet with a 4-month of duration. She was complaining of photosensitivity and hair loss for a few years. Histopathologic examination revealed hyperkeratosis, parakeratosis, single cell necrosis through the epidermis and perivascular mixed cellular infiltration. C3 and C1q were detected at the dermoepidermal junction in immunofluorescence examination. In laboratory, antinuclear antibody was positive. Elevated sedimentation rate, anemia, and hypocomplementemia were detected. Lupus band test was positive. According to these findings, the patient was diagnosed as systemic lupus erythematosus and the lesions on the hand and feet as erythema multiforme like lesions. Methylprednisolone (1mg/kg/day) was started. Notable improvement in her symptoms and in the clinical appearance of the lesion was observed. Erythema multiforme like lesions are the cutaneous findings rarely seen in systemic lupus erythematosus. In the present case, since there was no drug use or herpes virus infection in the history.Öğe Erythromelanosis follicularis faciei et colli: Report of involvement in two female patients(2005) Ertam I.; Unal I.; Alper S.Erythromelanosis follicularis faciei is a rare disease characterized by reddish brown pigmentation and follicular papules localized on certain areas such as the face and neck. Young men are usually affected, but young women or children may be affected. Bilateral distribution is usual, but it may occur unilaterally. Histopathologically, hyperkeratosis, increased melanization and dilatation of the hair follicle are characteristic. Two female patients with typical localizations and clinical findings of the disease are reported here. © 2005 Dermatology Online Journal.Öğe Follicular mucinosis and follicular mycosis fungoides: Clinicopathological evaluation of seven cases [folliküler müsinozis ve folliküler mikozis fungoides: Yedi olgunun klinikopatolojik degerlendirilmesi](2013) Yaman B.; Gereker Türk B.; Öztürk G.; Ertam I.; Kandiloglu G.; Akalin T.Objective: Follicular mucinosis is a disease characterized by follicular degeneration and mucin accumulation. It can be seen in mycosis fungoides, although idiopathic or forms associated with other diseases are also known. Follicular mycosis fungoides is a type of mycosis fungoides with different clinicopathological and prognostic features. Material and Method: Seven cases with follicular centered lesions and multiple biopsies (2-6) were included. Cases were evaluated according to their clinical, histological and immunophenotypical features and follow-up data. Results: All cases were male, and the mean age was 40.3 (range 18-61). Clinical complaints were follicular prominence, erythema and alopecia at head and neck, trunk, and lower limbs. Follicular mucinosis (6/7), and dermal lymphoid infiltration showing minimal-intensive folliculotropism accompanied by eosinophils was seen. Lymphoid infiltration was composed of small-medium sized cells, with scattered hyperchromatic nuclei in six cases. In one case there was only minimal cytological atypia. Intense folliculotropism of atypical lymphocytes and dense dermal infiltration without follicular mucinosis was seen in one case. Local and/or systemic treatments were applied and partial remission was achieved histologically. In three cases new and increasing lesions were seen. Density of infiltration and atypia were increased. Conclusion: The findings supported the opinion that follicular mucinosis is an important finding seen in mycosis fungoides. There can be important differences concerning the amount of infiltration and degree of atypia. In cases where the density of infiltration associated with follicular mucinosis is not diagnostic for MF, there can be progression over time. Long-term follow up is necessary in such cases where the differential diagnosis is difficult.Öğe The frequency of Malassezia as a causative agent in folliculitis [Folikülitte etken olarak Malassezia sikli?i](Turkiye Klinikleri, 2014) Ertam I.; Kocabaş Yenipazar G.; Aytimur D.Objective: It has been known that Malassezia spp. can play role in different dermatologic diseases. The aim of this study is to detect identification of Malassezia spp. species in folliculitis patients. CopyrightMaterial and Methods: One hundred and three patients with folliculitis who attended Ege University Faculty of Medicine Dermatology and Venereology outpatient clinic between January 2010-November 2012 included in the study. The patients were diagnosed as Malassezia folliculitis based on direct microscopic examination and culture of the material taken from the lesion of folliculitis. Samples inoculated in Sabouraud dextrose agar (SDA) with sterile olive oil and modified Dixon agar. Catalase and esculin tests performed to isolated colonies and cultured in Tween-20, 40, 60, and Tween-80 mediums. Species were diagnosed by according to these tests and growth properties.Results: Of 103 patients, 40 (38.8%) female and 63 (61.2%) male. Three of the patients (12.9%), direct microscopic examination was negative but in culture was positive. In eighteen (17.4%) patients not only direct examination but also cultures were found positive. It was determined that in 9 (8.7%) patients, direct examination was positive but no cultural isolation found. 29.1% of the folliculitis patients Malassezia spp. was detected as a causative agent. In all of the cultures, Malassezia globosa was isolated.Conclusion: This is the first study about the frequency of Malassezia species in folliculitis in our region. In this study the only agent isolated is M. globosa. © 2014 by Türkiye Klinikleri.Öğe The frequency of skin diseases among students in a University clinic(Pulse Marketing and Communications LLC, 2010) Ertam I.; Babur Y.; Unal I.; Alper S.This study was conducted to assess the frequency of dermatologic diseases in Turkish university students. University students who visited two dermatology outpatient clinics within the Ege University Health, Culture and Sports Office were included in the study. Each student was examined by two dermatologists. Questions about demographic data and information about the frequency of using the swimming pool were directed to the patients. All dermatological diseases were recorded. Patients were asked to assess and give a score for the state of their mental wellness using the visual analog scale (0-100) during the past month. Chi-square and Student t tests were used for statistical analyses. A total of 1733 individuals, 750 (43.3%) men and 983 (56.7%) women, were included in the study. The most frequently seen diseases were acne vulgaris (40.1%) and fungal diseases (17.08%), whereas the least frequently seen were parasitic skin diseases (0.46%) and vascular diseases (0.51%). The mean mental wellness score was found to be 61.03±21.34 (0-100, median: 65.00). It can be concluded that students visit university dermatology outpatient clinics frequently and the most common complaints are acne vulgaris and fungal diseases. © 2010 Pulse Marketing & Communications, LLC.Öğe Geriatric patients in management of pigmented lesions: Should follow-up be recommended? [Pi·gmente lezyon degerlendi·ri·lmesi·nde geri·atri·k hasta: İzlem öneri·lmeli· mi·?](2009) Kilinç Karaarslan I.; Erçal H.E.; Ertam I.; Türkmen M.; Türk B.G.; Özdemir F.Introduction: Dermatological follow-up is essential in management of pigmented lesions. Elderly people may have poor compliance to follow-up schedules because of immobilization and general health problems. In this study, we aimed to determine the general features of geriatric patients admitted to dermoscopy unit and evaluate their compliance both to follow-up and surgical recommendations. Materials and Method: All patients aged 65 years and over, who admitted to the dermoscopy unit between January 2003 and May 2008, were included in the study. Medical records of the patients were reviewed and age and gender of the patients, pigmented lesions and their localizations, and compliance to the follow-up schedule and surgical recommendations were evaluated retrospectively. Results: A total of 193 geriatric patients constituted 6.4% of 3016 patients admitted to dermoscopy unit in the same period. A total of 242 lesions were detected (158 of them were benign and 84 of them were premalignant/malignant). The most common lesions were seborrheic keratoses (27.3%), melanoma (17.8%), and melanocytic nevi (15.3%). A total of 130 patients (67.7%) were invited for follow-up and 29 of them (22.3%) were able to attend. A surgical procedure was recommended to a total of 99 patients (51.6%) in whom 82 (82.8%) followed the recommendations. Conclusion: Since the compliance may be difficult, it is recommended to consider the elderly as a special group and to avoid inviting them for follow-up if possible.Öğe Graham Little-Piccardi-Lassueur Syndrome: Case report(2012) Karaca N.; Ertam I.; Gerçeker Türk B.; Kazandi A.C.; Dereli T.Graham-Little syndrome, also known as Graham Little-Piccardi-Lassueur Syndrome is characterized by the presence of cicatricial alopecia on the scalp, keratosis pilaris located to trunk and extremities, and non-cicatricial hair loss of pubis and axillae. Graham Little-Piccardi-Lassueur Syndrome is a relatively rare disease. It is four times more common in females in the age group of 30-70 years. Topical or systemic corticosteroids, retinoids or PUVA therapy are the treatments usually proposed and these have partial and temporary benefits. A 31-year-old woman presented with a 18-year history of scarring alopecia of the scalp and pruritic lichenoid papules on the trunk and extremities. On the basis of the clinical features and the histopathological findings, Graham Little-Piccardi-Lassueur syndrome (GLPLS) was diagnosed. Copyright © 2012 by Türkiye Klinikleri.Öğe IgG-anti-IgA antibodies: An autoimmune finding in patients with psoriasis vulgaris(2012) Azarsiz E.; Ertam I.; Karaca N.; Aksu G.; Alper S.; Kutukculer N.Aim. Psoriasis is thought to be an autoimmune disease caused by inappropriate activation of the cellular immune system. In this study, we aimed to search out IgG-anti-IgA antibody levels, serum immunoglobulins and antinuclear antibodies (ANA). Methods. The study entrolled 38 psoriasis vulgaris patients and 40 healthy controls. Results. Mean IgG-anti-IgA levels were significantly higher in psoriasis patients. The frequency of positive ANA testing was 21.1%; however, there was no correlation between IgG-anti-IgA antibody levels and ANA positivity. Only one patient had low IgA levels without high IgG-anti-IgA concentrations. Conclusion. The data about high IgG-anti-IgA antibody levels are noteworthy for a new evidence of autoimmune mechanism.Öğe Imiquimod(2007) Unal I.; Ertam I.Imiquimod is an immune response-modifying agent that demonstrates potent antiviral and antitumour activity. Although it's use has been approved by the FDA (Food and Drug Administration) in the treatment of external genital and perianal warts, actinic keratosis on the face or scalp and superficial basal cell carcinomas, it has recently been tried to treat different types of dermatological diseases including molluscum contagiosum, herpes simplex, melanoma, T-cell lymphoma. Side effects of imiquimod are erythema, itching, burning, crusting, and rarely cytokine-release syndrome, exacerbation of inflammatory skin conditions. In thi review, the structure of imiquimod, mechanism of action and its usage in the treatment of different skin diseases are discussed. © 2007 Bentham Science Publishers Ltd.
