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  • Küçük Resim Yok
    Öğe
    Ischemia-Modified Albumin Levels in Essential Thrombocytosis
    (2018) Ersoy, Ercan; Soyaltın, Utku Erdem; Peker, Ahmet; Çolak, Ayfer; Ceylan, Cengiz; Akar, Harun
    Objective: the aim of this study was to investigate the levels of ischemia-modified albumin (IMA) in people with essential thrombocytosis (ET). Methods: A total of 30 patients with ET patient group and 30 volunteers with no known disease control group (C group) were included in this study after the approval of ethics committee and written informed consent was obtained. Patients with a history of major thrombosis were excluded. IMA levels and independent variables were investigated and effects on thrombosis susceptibility were also studied. in addition to that; comorbid disease state, drug use and used drugs group were questioned in patient group and effects of them on IMA levels were studied. Results: in our study, when ET patient group and C group were compared, the mean serum IMA levels in ET patient group and C group was detected as 0,6726 (0,527- 0,776) Absorbans Unite (ABSU) and 0,4342 (0,346-0,612) ABSU respectively and in ET patient group was significantly higher than C group (p<0,001). the glucose, total cholesterol and triglyceride values were significantly higher in ET patient group (p= 0,026, p= 0,058, p= 0,004, respectively). There is a correlation between IMA concentration and age (p= 0,042). Conclusions: in our study IMA levels were found significantly high in ET patient group, this supports increased risk of thrombosis in ET. the difference of metabolic parameters between the ET patient group and C group can be explained by insulin resistance and atherosclerosis background caused by chronic inflammation.
  • Küçük Resim Yok
    Öğe
    Ischemia-Modified Albumin Levels in Essential Thrombocytosis
    (Duzce Univ, 2018) Ersoy, Ercan; Soyaltin, Utku Erdem; Peker, Ahmet; Colak, Ayfer; Ceylan, Cengiz; Akar, Harun
    Objective: The aim of this study was to investigate the levels of ischemia-modified albumin (IMA) in people with essential thrombocytosis (ET). Methods: A total of 30 patients with ET patient group and 30 volunteers with no known disease control group (C group) were included in this study after the approval of ethics committee and written informed consent was obtained. Patients with a history of major thrombosis were excluded. IMA levels and independent variables were investigated and effects on thrombosis susceptibility were also studied. In addition to that; comorbid disease state, drug use and used drugs group were questioned in patient group and effects of them on IMA levels were studied. Results: In our study, when ET patient group and C group were compared, the mean serum IMA levels in ET patient group and C group was detected as 0,6726 (0,527-0,776) Absorbans Unite (ABSU) and 0,4342 (0,346-0,612) ABSU respectively and in ET patient group was significantly higher than C group (p<0,001). The glucose, total cholesterol and triglyceride values were significantly higher in ET patient group (p= 0,026, p= 0,058, p= 0,004, respectively). There is a correlation between IMA concentration and age (p= 0,042). Conclusions: In our study IMA levels were found significantly high in ET patient group, this supports increased risk of thrombosis in ET. The difference of metabolic parameters between the ET patient group and C group can be explained by insulin resistance and atherosclerosis background caused by chronic inflammation.
  • Küçük Resim Yok
    Öğe
    Özefagus varis kanamaları dışındaki üst gastrointestinal sistem kanamalı 141 olgunun analizi
    (2018) Ekinci, Ferhat; Soyaltın, Utku Erdem; Ersoy, Ercan; Biniçier, Ömer Burçak; Yıldız, Coşkun; Ertem, İhsan Sedat; Akar, Harun
    Amaç: Varis dışı üst gastrointestinal sistem (VDÜGİS) kanama tanısı ile takip edilen olgularımızın özelliklerinin değerlendirilmesi amaçlanmıştır. Yöntem: Tepecik Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniğine 01.08.2013 ile 01.08.2014 tarihleri arasında başvuran ve İç Hastalıkları ile Gastroenteroloji Kliniğinde yatarak izlenen VDÜGİSK 141 hasta demografik özellikleri, nedensellik ilişkileri, risk faktörleri açısından ele alınmıştır. Bulgular: Doksan yedisi (%68,8) erkek, 44’ü (%31,2) kadın olan 141 olgunun yaş ortalaması 63,2+17,3 yıl (20-103) idi. Olguların 36’sında (%25,5) sigara kullanımı, 21’inde (%14.9) alkol alımı, 39’unda (%27,7) aspirin, 51’inde (%36,2) nonsteroid anti-inflamatuvar ilaç (NSAİİ), 13’ü (%9,2) klopidogrel, 13’ü (%9,2) warfarin, 3’ü (%2,1) yeni nesil oral antikoagulan ve 8’inde (%5,7) proton pompa inhibitörü (PPİ) alımı mevcut idi. Eşlik eden komorbidite sıralamasında hipertansiyon (HT) ilk sırayı 55 (%39,0) olgu ile alırken, koroner arter hastalığı (KAH) 33 (%23,4) olguda, diyabetes mellitus (DM) 27 (%19,1) olguda, serebrovasküler hastalık (SVH) hikayesi 16 (%11,3) olguda, kronik böbrek yetersizliği (KBY) 13 (%9,2) olguda, maliğnite 13 (%9,2) olguda belirlendi. Yapılan üst gis endoskopi sonucunda görülen kanama nedenlerinde duodenum ülseri (%45) ilk sırayı alırken, sırası ile diğerleri mide ülseri (%25) ve antral gastrit (%19) olarak raporlandı. Sonuç: Ülkemizde endoskopi ile raporlanan, VDÜGİSK’nin ilk sıra görülme nedeninin duodenal ülser olduğu belirlenmiştir. Kanayan olgularda yaşın ileri olması, komorbidite ve kullanılan ilaçlar (NSAİİ vs) ölüm oranlarınds artış olarak yansımaktadır.