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Öğe The effect of pralidoxime on blood catecholamine levels in experimental Organophosphate Intoxication [Deneysel organik fosfor zehirlenmesinde pralidoksimin kan katekolamin düzeyine etkisi](2009) Çankayali I.; Demirag K.; Eriş O.; Solak I.; Ersöz B.; Moral A.R.Aim: Although the clinical symptoms of organophosphate intoxication show up as cholinergic hyperactivity due to muscarinic receptor activation, the symptoms of sympathetic hyperactivity through nicotinic receptors and its central effects can also be seen clinically. Activation of the sympathoadrenal system leads to the emergence of some immunologic reactions, hemodynamic instability and additional undesirable problems and prolongation of the therapy. In our study investigation of the effects of acetylcholinesterase enzyme reactivator pralidoxime (PAM) on sympathetic hyperactivity was aimed. Material and Method: Seventeen Wistar rats were randomly divided into two groups. After induction of anesthesia, tracheotomy and catheterization of the internal carotid artery were performed. Drugs were injected into the rats as follows: Group I (n=9; 70 mg kg -1 IP DDVP+10 mg kg -1 IP Atropine) Group II (n=8; 70 mg kg -1 IP DDVP+10 mg kg -1 IP Atropine+ 40 mg kg -1 PAM). Plasma levels of epinephrine, norepinephrine and dopamine were measured. Biochemical and hemodynamic data were analyzed statistically, and p<0.05 was accepted as statistically significant. Results: Blood catecholamine levels and hemodynamic findings were not statistically different between groups. Conclusion: We conclude that in organophosphate intoxications PAM has no effect on the development of sympathomimetic hyperactivity mediated via blood nicotinic receptors.Öğe In vivo interaction between cadmium and essential trace elements copper and zinc in rats(2001) Hakan Aydin H.; Çoker C.; Ersöz B.The complex in vivo interaction between Cd, a toxic metal and essential trace elements, mainly Zn and Cu, has not been elucidated yet. The objective being the elucidation of this interrelationship, Cd was subcutaneously administered as CdCl2 (1 mg/kg/day) for 5 consecutive days to Swiss albino male rats (n=10). After 5 days, the rats were decapitated. Cd, Zn and Cu levels were estimated in hepatic, renal, cardiac and skeletal muscle specimens. Cd was found to be significantly elevated in all tissues (p< 0.001). Zn was increased in hepatic and renal tissues (p< 0.001 and p< 0.05) compared to the controls. Cu was also significantly increased in these tissues. Myocardial and skeletal muscle tissues also manifested a significant increase in Cu and Zn in this group. It is concluded that Cd administration alters the Zn and Cu status in vivo. However, the mechanism underlying the interactions between toxic and essential elements should be further investigated.Öğe Interaction of the prefrontal cortex biogenic amines and mao inhibitors during the physiological aging process [Fizyolojik yaşlanma sürecinde prefrontal korteks biyojen aminler ve mao inhibitörlerinin etkileşimi](1999) Gülter C.; Girgin F.; Alper G.; Özgönül M.; Menteş G.; Ersöz B.The process of aging is becoming increasingly important as the avarage longevity of the population increases and the number of people with both age-associated impairment and neurodegenerative diseases of old age rises sharply. The disturbed integrity of dopaminergic, noradrenergic and serotonergic neurons is considered to be the key in the impairments seen during aging and certain diseases. Underlying of the mental and motor changes observed in the elderly population, biogenic amines seem to play an important role. Monoamine oxidase(MAO) is an enzyme responsible for the inactivation of these biologically important active amines. It is one of the most investigated enzyme presumably because of its importance in biological psychiatry. The activity of MAO displays great variances in different organs during the process of aging and in the physiopathology of certain neurodegenerative diseases. Thus in the recent years, MAO inhibition is a widely used therapeutic strategy in the treatment of Alzheimer's disease, Parkinson's disease and depression seen in the elderly. The aim of our study was to determine the changes in biogenic amines, adrenalin (A), noradrenalin (NA), serotonin (5-HT), dopamine (DA), as well as in their metabolites, normetanephrine (NMN), homovanillic acid (HVA), dihydroxy phenyl acetic acid (DOPAC), 5-hydroxyindol acetic acid (5-HIAA) occuring concurrently with the changes in MAO activity of the prefrontal cortex of aging rats. We aimed to observe the effects of MAO inhibitors on altered levels of biogenic amines and their metabolites, in the first part of this study MAO activity and the levels of biogenic amines and their metabolites were measured in the prefrontal collides of young (2-3 months old, n = 15) and aging (16-18 months old, n = 15) rats. In the second step, after chronic administration of deprenyl, MAO-B inhibitor, (0.25 mg/kg/day, 14days, I.P) the above mentioned parameters were measured in the prefrontal corticies of young (2-3 months old. n=10) and aging (16-18 months, n=10) rats. The'results showed that MAO activities in prefrontal cortex were significantly higher in the aging groups (p=0.05). As for the biogenic amines elevated levels of noradrenaline and dopamine (respectively p=0.03,p=0.009); for the metabolites elevated levels of normetanephrine homovanillic acid and dihydroxyphenyl acetic acid were found in the aging groups (respectively p=0,006, p=0.001, p=0.05). Administration of MAO inhibitor resulted in no difference in the levels of biogenic amines between placebo and deprenyl groups in neither young nor aging groups. However MAO activities were significantly decreased (respectively %65, %76).Öğe Standardized method comparison for ACS:180 plus and immulite sensitive PSA (sPSA) measurement methods(Springer New York, 2001) Kurtulmus Y.; Tanyalçin T.; Bozkaya G.; Gündüz O.; Çerçi Ö.; Kutay F.Z.; Ersöz B.The aim of this study was to compare two immunoassay measurement methods, the ACS: 180 Plus (Chiron Diagnostics) kit and the Immulite sPSA (DPC) kit. Method comparison analysis was performed according to EP9-A; approved guideline of NCCLS 51. Serum samples having a wide range of total prostate-specific antigen (PSA) concentrations were evaluated in split-sample analysis. F-test, t-est analysis and regression statistics were performed. In Deming regression analysis the coefficients were as follows; the slope=0.967; y-intercept=-0.148, r=0.989. An acceptable bias was seen since the systematical error was calculated to have a value less than the total allowable error calculated from biological variations. Nonparametric evaluation of the area under ROC curves for ACS: 180 Plus and Immulite sPSA were 0.997 and 0.987, respectively. Diagnostic accuracy was at the level of p= 0.000 and no statistical difference was found between the two assay methods.
