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Öğe Effects of Preoperative Gabapentin on Postoperative Pain after Radical Retropubic Prostatectomy(Sage Publications Ltd, 2012) Deniz, M. N.; Sertoz, N.; Erhan, E.; Ugur, G.OBJECTIVE: The impact of preoperative gabapentin on tramadol consumption using patient-controlled analgesia (PCA) and postoperative pain was assessed in patients undergoing radical retropubic prostatectomy (RRP). METHODS: In this prospective, randomized trial, 51 patients undergoing RRP were randomized into two groups: the gabapentin group received 900 mg gabapentin orally 2 h before surgery; the control group did not receive gabapentin. Postoperative analgesia was provided by tramadol PCA. Pain was assessed using a visual analogue scale for, 24 h, postoperatively. RESULTS: Mean cumulative tramadol consumption at 24 h was comparable in the two groups. Pain scores at 45 min, 60 min and 2 h postoperatively, and the number of patients who required rescue analgesia, were significantly lower in the gabapentin group than in the control group. Side-effects were similar in the two groups. CONCLUSIONS: Preoperative administration of 900 mg gabapentin did not decrease tramadol consumption, but was associated with lower pain scores in the early postoperative phase and a reduced need for rescue analgesia, compared with controls, in patients undergoing RRP.Öğe Individualization of enzyme replacement therapy and of therapy for severe skeletal manifestations in a child with Gaucher disease(Elsevier, 2007) Ucar, S. Kalkan; Coker, M.; Argun, M.; Kara, S.; Erhan, E.; Simsek, D. Goksen; Darcan, S.Öğe Intrathecal morphine reduces postoperative tramadol consumption in patients undergoing radical retropubic prostatectomy: a randomized trial(Verduci Publisher, 2013) Deniz, M. Nuri; Erhan, E.; Ugur, G.BACKGROUND: Intrathecal (IT) morphine provides prolonged analgesia after major surgery. AIM: The aim of our study was to assess the impact of intrathecal morphine 200 mu g on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia. MATERIALS AND METHODS: In this prospective trial, 56 men who underwent radical retropubic prostatectomy (RRP) were randomized into 2 groups. Group M received intrathecal morphine (200 mu g) before the induction of general anesthesia. Group C did not receive intrathecal morphine. Postoperative analgesia was provided with tramadol PCA. Pain scores, tramadol consumption, adverse effects, rescue analgesia were recorded. RESULTS: Total tramadol consumption at 24 hours and pain scores during 12 hours postoperatively were significantly lower in Group M compared with Group C (p < 0.05). Rescue analgesia and postoperative nausea were lower in Group M than in Group C (p < 0.05). CONCLUSIONS: Intrathecal morphine 200 mu g provided a significant reduction in tramadol consumption, postoperative pain scores, rescue analgesia, and postoperative nausea after RRP without serious adverse effects.Öğe Intrathecal morphine reduces postoperative tramadol consumption in patients undergoing radical retropubic prostatectomy: a randomized trial(Verduci Publisher, 2013) Deniz, M. Nuri; Erhan, E.; Ugur, G.BACKGROUND: Intrathecal (IT) morphine provides prolonged analgesia after major surgery. AIM: The aim of our study was to assess the impact of intrathecal morphine 200 mu g on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia. MATERIALS AND METHODS: In this prospective trial, 56 men who underwent radical retropubic prostatectomy (RRP) were randomized into 2 groups. Group M received intrathecal morphine (200 mu g) before the induction of general anesthesia. Group C did not receive intrathecal morphine. Postoperative analgesia was provided with tramadol PCA. Pain scores, tramadol consumption, adverse effects, rescue analgesia were recorded. RESULTS: Total tramadol consumption at 24 hours and pain scores during 12 hours postoperatively were significantly lower in Group M compared with Group C (p < 0.05). Rescue analgesia and postoperative nausea were lower in Group M than in Group C (p < 0.05). CONCLUSIONS: Intrathecal morphine 200 mu g provided a significant reduction in tramadol consumption, postoperative pain scores, rescue analgesia, and postoperative nausea after RRP without serious adverse effects.Öğe Ondansetron does not decrease tramadol-induced analgesia in mice(Wiley-Blackwell, 2004) Parlar, A.; Onal, A.; Erhan, E.; Kocabas, S.; Yegul, I.; Kosay, S.
