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Öğe COMPARISON OF MOLECULAR SUBTYPES OF BREAST CANCER IN WOMEN <= 35 YEARS AND > 35 YEARS: DOES AGE MATTER?(Oxford Univ Press, 2014) Erdogan, A.; Karaca, B. S.; Yasdik, H.; Surmeli, Z.; Sanli, U. A.; Karabulut, B.; Uslu, R.Öğe Hybridization breeding program for resistance to monilinia (Monilinia laxa) on apricot(International Society for Horticultural Science, 2020) Bilgin, N.A.; Misirli, A.; Evrenosoğlu, Y.; Yolageldi, L.; Erdogan, A.Turkey is the leading country in production and export of apricots in the world, besides, there are fluctuations in yield, depending on years. In this situation, many factors are effective, pests and diseases also play an important role. Monilinia, which is one of the fungal diseases that appeared especially in the years when climatic conditions suitable leads to serious product loss in apricot production areas. Due to the importance of human and environmental health, intensive breeding programs are carried out in order to obtain genotypes resistant to diseases and having favorable fruit characteristics. In this context, a long-term hybridization breeding project is carried out in order to gain resistance 'Hacihaliloglu' cultivar, which is one of the most important export products of our country and world famous, having superior drying properties but sensitive to monilinia. In this circumstance, genotypes obtained from different hybridization combinations between 'Hacihaliloglu' and resistant cultivars were tested artificial inoculation against disease and transferred to the land. The phonological observations, plant and fruit characteristics in the bearing genotypes were examined. As a result of the evaluations, promising genotypes have been determined and studies are going on. © 2020 International Society for Horticultural Science. All rights reserved.Öğe The Potential Effect of Anticonvulsant Drugs on Neuropeptides in Pentylenetetrazol Kindling Model Of Epilepsy(Wiley, 2018) Tekgul, H.; Simsek, E.; Erdogan, A.; Yigitturk, G.; Taskiran, D.; Erbas, O.Öğe Production of secondary metabolites using tissue culture-based biotechnological applications(Frontiers Media SA, 2023) Ozyigit, I.I.; Dogan, I.; Hocaoglu-Ozyigit, A.; Yalcin, B.; Erdogan, A.; Yalcin, I.E.; Cabi, E.Plants are the sources of many bioactive secondary metabolites which are present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to the plants in many cases, they are not necessary for metabolisms related to growth, development, and reproduction. They are specific to plant species and are precursor substances, which can be modified for generations of various compounds in different plant species. Secondary metabolites are used in many industries, including dye, food processing and cosmetic industries, and in agricultural control as well as being used as pharmaceutical raw materials by humans. For this reason, the demand is high; therefore, they are needed to be obtained in large volumes and the large productions can be achieved using biotechnological methods in addition to production, being done with classical methods. For this, plant biotechnology can be put in action through using different methods. The most important of these methods include tissue culture and gene transfer. The genetically modified plants are agriculturally more productive and are commercially more effective and are valuable tools for industrial and medical purposes as well as being the sources of many secondary metabolites of therapeutic importance. With plant tissue culture applications, which are also the first step in obtaining transgenic plants with having desirable characteristics, it is possible to produce specific secondary metabolites in large-scale through using whole plants or using specific tissues of these plants in laboratory conditions. Currently, many studies are going on this subject, and some of them receiving attention are found to be taken place in plant biotechnology and having promising applications. In this work, particularly benefits of secondary metabolites, and their productions through tissue culture-based biotechnological applications are discussed using literature with presence of current studies. Copyright © 2023 Ozyigit, Dogan, Hocaoglu-Ozyigit, Yalcin, Erdogan, Yalcin, Cabi and Kaya.
