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Öğe Demographic, clinical, laboratory, ultrasonographic, and cytological features of patients with Hashimoto's thyroiditis: results of a university hospital of 769 patients in Turkey(Humana Press Inc, 2009) Erdogan, Mehmet; Erdem, Nihat; Cetinkalp, Sevki; Ozgen, Ahmet Gokhan; Saygili, Fusun; Yilmaz, Candeger; Tuzun, Mehmet; Kabalak, TaylanWe investigated the demographic and clinical features of patients with Hashimoto's thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey. Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Patients with Hashimoto's thyroiditis were selected among those patients. Seven hundred and sixty-nine patients fulfilled diagnostic criteria for Hashimoto's thyroiditis (725 females, 44 males; mean age 41.76 +/- A 12.49 years). 62.7% of patients were between 30 and 50 years of age. 53.3% of females and 63.6% of males had diffuse enlargement of the thyroid gland. TSH level was above 4.0 IU/l in 25.6% of females and 27.4% of males. Anti-tyroglobulin antibody was positive in 92% of females and 93.2 % of males. Anti-thyroid peroxidase antibody was positive in 98.4 % of females (713 patients) and 100% of males. Thyroid ultrasonography demonstrated single nodule in 52.2% and multiple nodules in 11.3% of female patients; and single nodule 32% and multiple nodules in 20% of male patients. Fine-needle aspirations of the nodules were performed in 207 patients, and none of those biopsies was diagnosed as malignant. Women with suspicious biopsis were operated. After surgery, we found that, 2% (n = 4) of patients with FNAC diagnosis of suspicious biopsies were papillary carcinoma and the other patients (3% (n = 6)) were lymphocytic thyroiditis. Age and sex distribution and laboratory findings of our patients were comparable to the previous reports. Nodule formation was the most common ultrasonographic finding in our patients, probably due to pseudonodularity. We found four women patients with thyroid cancer in our population.Öğe Demographic, clinical, laboratory, ultrasonographic, and cytological features of patients with Hashimoto's thyroiditis: results of a university hospital of 769 patients in Turkey(Humana Press Inc, 2009) Erdogan, Mehmet; Erdem, Nihat; Cetinkalp, Sevki; Ozgen, Ahmet Gokhan; Saygili, Fusun; Yilmaz, Candeger; Tuzun, Mehmet; Kabalak, TaylanWe investigated the demographic and clinical features of patients with Hashimoto's thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey. Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Patients with Hashimoto's thyroiditis were selected among those patients. Seven hundred and sixty-nine patients fulfilled diagnostic criteria for Hashimoto's thyroiditis (725 females, 44 males; mean age 41.76 +/- A 12.49 years). 62.7% of patients were between 30 and 50 years of age. 53.3% of females and 63.6% of males had diffuse enlargement of the thyroid gland. TSH level was above 4.0 IU/l in 25.6% of females and 27.4% of males. Anti-tyroglobulin antibody was positive in 92% of females and 93.2 % of males. Anti-thyroid peroxidase antibody was positive in 98.4 % of females (713 patients) and 100% of males. Thyroid ultrasonography demonstrated single nodule in 52.2% and multiple nodules in 11.3% of female patients; and single nodule 32% and multiple nodules in 20% of male patients. Fine-needle aspirations of the nodules were performed in 207 patients, and none of those biopsies was diagnosed as malignant. Women with suspicious biopsis were operated. After surgery, we found that, 2% (n = 4) of patients with FNAC diagnosis of suspicious biopsies were papillary carcinoma and the other patients (3% (n = 6)) were lymphocytic thyroiditis. Age and sex distribution and laboratory findings of our patients were comparable to the previous reports. Nodule formation was the most common ultrasonographic finding in our patients, probably due to pseudonodularity. We found four women patients with thyroid cancer in our population.Öğe Determination of potential allergenic fungal flora and its clinical reflection in suburban elementary schools in Izmir(Springer, 2010) Haliki-Uztan, Alev; Ates, Mustafa; Abaci, Ozlem; Gulbahar, Okan; Erdem, Nihat; Ciftci, Oezlem; Boyacioglu, HayalIn this research, in order to determine mean fungus counts, indoor and outdoor air samples were taken in five elementary school buildings located in the city center of Seferihisar, Izmir (45 km from Izmir) within a 1-year period between March and April 2004, and between January and February 2005 representing similar climatic characteristics. Five samples, three from three classes where 5-8, 10-12, and 12-15 age group students attended, one from the corridors, and one from outside the buildings in all the schools, were taken for each period. Within the period of the study, in indoor and outdoor air samples, 7,122 microfungus colonies were counted. Sixty-four species were identified that belong to 17 genera as a result of the identification of isolates obtained. Skin prick tests were applied to 55 out of a total of 117 teachers by the clinicians. According to these test results, 24 teachers were sensitive to at least one agent. Results revealed that, in terms of mold counts, the difference between the schools and the difference between the times (periods) were statistically significant (p < 0.05).Öğe Ege Üniversitesi Tıp Fakültesi Endokrinoloji Bilim Dalı polikliniğine başvuran hastalardan Hashimoto Tiroiditli ve Subakut Tiroiditli hastaların demografik olarak incelenmesi(Ege Üniversitesi, 2002) Erdem, Nihat; Kabalak, TaylanÖZET Tiroiditler tiroid bezinin otoimmün, infeksiyöz, fizik ve kimyasal sebeplerle oluşan iltihabi hastalıklarıdır. Tiroiditier tiroid nodüllerinden sonra en sık karşılaşılan tiroid patolojisidir. Hashimoto Tiroiditi ve Subakut Granülamatöz tiroidit klinik pratikte en sık karşılaşdığımız tiroid itlerdir. Hashimoto Tiroidıti ve Subakut Granülamatöz tiroidit ile ilgili olarak literatürde çok sayıda çalışma olmasına rağmen, her iki tiroidit içinde ayrıntılı demografik çalışmalar saptayamadık. Bizde toplum taraması şeklinde olmasa da, bölge hastahanesi niteliğindeki hasta hanemizde Endokrinoloji Polikliniğine Ocak 1987 ile Aralık 2001 tarihleri arasında başvuran toplam 19570 hastadan, 769 Hashimoto tiroiditli ve 169 Subakut Granülamatöz tiroiditli hastanın retrospektif olarak demografik dökümünü yaptık. Her iki hastalığında ayrıntılı olarak yaptığımız demografik dökümlerinde; başvuru yılı, yaş, yaş ortalaması, cinsiyet, ağrı, ateş, ödem, çarpıntı yakınmaları, sedimantasyon değerleri, Anti-Tiroglobulin ve Anti-Tiroid Peroksidaz antikor titreleri, Tiroid fonksiyon testleri, palpasyon ve ultrasonografı bulguları ile ince iğne aspirasyon biopsiteri, aldıkları tedavi ve tedavi ile nüks oranlan irdelendi. Hashimoto tiroiditi ve Subakut Granülamatöz tiroiditli hastaların demografik bulguları kadın-erkek, yaş-nüks, cinsiyet-nüks, tedavi-nüks, laboratuvar (sedimantasyon, antikor titreleri)-nüks, ultrasonografi bulgulan- nüks açısından istatiksel olarak değerlendirildi. Elde edilen verilerin istatiksel olarak incelenmesinde anlamlı bir fark bulunmadı. Hastaların demografik özellikleri literatürdeki çalışmalarla karşılaştırıldığında da; elde edilen verilerin literatürdeki verilerle benzer olduğu saptandı. 80Öğe Ot poleni alerjisi olan alerjik rinokonjonktivitli hastalarda mevsim öncesi immunoterapi ile klasik immunoterapinin karşılaştırmalı sonuçları(Ege Üniversitesi, 2005) Erdem, Nihat; Sin, AytülÖZET: Grass polenine bağlı mevsimsel alerjik rinokonjonktivitli hastalarda hem konvansiyonel immunoterapi hem de presezonal immunoterapi oldukça etkili tedavi metodudur. Her iki immunoterapi programıda gereken hastalarda güvenle kullanılabilir. 53
