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Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population
(2005) Berdeli A.; Sekuri C.; Sirri Cam F.; Ercan E.; Sagcan A.; Tengiz I.; Eser E.; Akin M.
The renin-angiotensin system (RAS) and endothelial nitric oxide (NO) affect the pathogenesis of atherosclerosis and prognosis of coronary artery disease (CAD). Previous epidemiologic data suggested that genetic factors are more likely to affect young rather than old people. Our objective was to investigate the association between the polymorphisms of eNOS (Glu298Asp) and the RAS genes and premature CAD in a Turkish population. A total of 115 Turkish patients with premature CAD and 83 controls were included in the study. ACE I/D, AT1R A/C, AGT T/M and eNOS Glu298Asp gene polymorphisms were analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). It was found that increased premature CAD risk is associated with higher frequencies of the ACE DD [OR: 2.600 (CI 95% 1.395-4.847, p=0.002)], AGT MM [OR=2.407 (CI 95% 1.267-4.573, p=0.007)] and eNOS 894TT [OR=17.000 (CI 95% 3.952-73.125, p<0.001)] genotypes. Carriers of ACE DD+eNOS 894TT (p=0.002), AGT MM+eNOS 894TT (p=0.001), AT1R AA+eNOS 894TT and AT1R non-AA+eNOS 894TT (p=0.002) genotypes were significantly associated with the risk of premature CAD. This study indicates a synergistic contribution of RAS genes (ACE I/D, AGT T/M, AT1R T/C) and eNOS Glu298Asp polymorphisms to the development of the premature CAD. © 2004 Elsevier B.V. All rights reserved.
Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients
(2006) Şekuri C.; Çam F.S.; Tengiz I.; Ercan E.; Bayturan Ö.; Berdeli A.
Objective: Platelet-activating factor (PAF) is a phospholipid with multiple actions that is involved in inflammatory diseases as well as in atherogenesis. It is inactivated by a plasma enzyme, PAF-acetylhydrolase (PAF-AH). Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (G994T). The aim of this study was to investigate association of this mutation with premature coronary artery disease (CAD). Methods: One hundred and fifteen unrelated Turkish patients with a diagnosis of premature CAD and 128 unrelated healthy subjects were enrolled in this study. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The prevalence of the G994T mutation in the patients was 2.60 % (heterozygote), and 0 % in the controls. There was no significant difference in allele frequency and genotype distribution among the study groups. Conclusion: The G9943T mutation in the plasma PAF acetylhydrola se gene is not associated with premature CAD in Turkish subjects.
Atomoxetine response in the inattentive and combined subtypes of attention deficit hyperactivity disorder: A retrospective chart review
(2013) Ercan E.S.; Akyol Ardic U.; Kabukcu Basay B.; Ercan E.; Basay O.
The DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, 1994, American Psychiatric Association) describes attention deficit hyperactivity disorder (ADHD) as a heterogeneous disorder; providing diagnostic criteria for three subtypes: hyperactive/impulsive (ADHD/HI), inattentive (ADHD/I), and combined type (ADHD/C). Differences among the subtypes are well defined, but there may be also differences in terms of treatment responses. The aim of this study is to assess the responses of ADHD/I and ADHD/C to atomoxetine treatment. The medical records of the January-June 2012 term, first time referrals to outpatient clinic, were reviewed, and 37 ADHD diagnosed primary school age children (18 ADHD/I, 19 ADHD/C) that were treated with atomoxetine were determined. Thirty-five of them who completed 8 weeks of treatment duration were recruited for the study. The children with an ADHD medication use history in 2 months time prior to onset of treatment and/or the children receiving additional psychopharmacologic treatment to atomoxetine were excluded. Baseline and eighth week assessment, records were evaluated. Efficacy assessments included Turgay DSM-IV ADHD Screening and Rating Scale parent and teacher forms (T-DSM-IV) and Clinical Global Impression Scale-Severity and Improvement subscales. Safety assessments included laboratory and body weight assessments, ECG, heart rate, and blood pressure evaluations (baseline and eighth week) along a scale filled by the parents at the eighth week to review side effects. Atomoxetine was found to be effective in both ADHD/I and ADHD/C groups. Atomoxetine also decreased the opposition defiance subscale scores of T-DSM-IV (both parent and teacher forms), whereas it was not found to make statistically significant difference in the conduct disorder subscale scores. Mean difference in 8-week time in T-DSM-IV hyperactivity subscale and total scores of parent and teacher forms; inattention subscale scores of only parent forms and the CGI- severity subscale scores; differed significantly among the ADHD/I and ADHD/C groups; that ADHD/C types responded better to medication. Results of this study revealed that atomoxetine is effective both in ADHD/I and ADHD/C subtypes. ADHD/C types may be responding better to atomoxetine treatment than the ADHD/I subtypes. © 2013 Springer-Verlag Wien.
Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia
(Klinika Kardiologii CMKP, 2004) Ercan E.; Tengiz I.; Altuglu I.; Sekuri C.; Aliyev E.; Ercan H.E.; Akin M.
Background. Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response. Aim. To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the proteinolytic and inflammatory activity. Methods. In this prospective study 44 patients with hypercholesterolemia were randomly assigned into 2 groups; Group 1 (n=22) treated with atorvastatin and diet for 2 months, and Group 2 (n=22) - diet alone. MMP-9 and hs-CRP were measured at baseline and two months later. Results. Groups were matched for age, sex and baseline characteristics. Lipid levels decreased by 32% (LDL from 153.9±26.6 to 94.5±20.8 mg/dl, p<0.005) in the atorvastatin group and by 9% in the diet alone group. Atorvastatin lowered plasma CRP from 5.16±1.9 to 2.88±1.06 mg/L (p<0.001) and MMP-9 activity from 64.3±28.1 to 35.4±20.0 ng/ml (p<0.0001). Atorvastatin-induced reductions in CRP and MMP-9 were greater than in the diet alone group. MMP-9 levels did not show significant changes in Group 2 after two months of diet. Conclusions. Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia.
Cardiac thrombi in a patient with protein-C and S deficiencies: A case report
(2004) Ercan E.; Tengiz I.; Sekuri C.; Sahin F.; Aliyev E.; Akin M.; Ac Kel U.
We report a case of multiple mobile intra-cardiac thrombi accompanying recurrent pulmonary embolism that has been successfully treated by fibrinolytic therapy. Control transesophageal echocardiographic examination showed that prolonged thrombolytic treatment completely removed the thrombi. Surgical removal of emboli has been validated but cannot be proposed to all patients since it is a high-risk intervention. Fibrinolysis is generally efficient but exposes the patient to risk of migration of the intra-cavity thrombus, with occasionally deleterious evolution. Systemic thrombolytic therapy is usually recommended if (a) it is not contraindicated and (b) the thrombi are demonstrated in more than one cardiac chamber, entailing a higher risk of surgical intervention. However, the infusion rate and duration of thrombolytic therapy are important determinants of successful and uncomplicated lysis. Low dose and long infusion time should be chosen to avoid fragmentation of the thrombus and related complications. © 2004 Ercan et al; licensee BioMed Central Ltd.
Cardiovascular involvement in Behçet's disease
(2002) Gürgün C.; Ercan E.; Ceyhan C.; Yavuzgil O.; Zoghi M.; Aksu K.; Cinar C.S.; Türkoglu C.
The incidence and nature of cardiac involvement in Behçet's disease are not yet clearly documented. We first used transesophageal echocardiography in combination with resting and signal averaged electrocardiography to define cardiac involvement in Behçet's patients. Transthoracic and multiplane transesophageal echocardiography, and resting and signal averaged electrocardiography were performed in 35 Behçet's disease patients (9 women and 26 men, mean age: 38±12 years) and 30 normal subjects. Higher incidences of interatrial septum aneurysm (31% to 6%), mitral valve prolapse (25% to 3%), mitral regurgitation (40% to 6%) and aneurysmal dilatations of sinus valsalva and ascendan aorta were observed in the Behçet's disease patients than in the normal subjects. Mean QT dispersion and mean corrected QT dispersion values were significantly greater in the patients with Behçet's disease. Patients with interatrial septum aneurysm (and/or PFO), valvular dysfunction or proximal aorta dilatation had greater QT dispersion values than thase without these pathologies in the Behçet's group (63±11 vs 44±19 ms, 58±23 vs 41±24 and 60±27 vs 42±23 ms respectively, P<0.05). Positive signal averaged electrocardiography parameters were detected in 18 (51%) Behçet's disease patients compared with one (3%) in controls (P<0.001). Dilatation of the proximal aorta, interatrial septal aneurysm, mitral valve prolapse, and mitral regurgitation are the common findings of cardiac involvement in Behçet's disease. Increased dispersion of ventricular repolarisation and positive late potentials are also detected. QT dispersion is significantly higher in patients with these cardiac abnormalities. These findings suggest that cardiac involvement in this disorder is a diffuse process which involves both cardiac structure and vascular elements. Copyright © 2002 by the Japanese Heart Journal.
A case of left atrial myxoma as a cause of platypnea [Platipneye neden olan sol atriyal miksoma olgusu]
(2006) Tengiz I.; Hamza D.; Türk U.; Ercan E.; Nalbantgil S.
[No abstract available]
Children aggression scale-parent version (CAS-P): Turkish validity and reliability study [Çocuklar için saldırganlık ölçeği anne-baba formu: Türkçe geçerlilik ve güvenilirlik çalışması]
(Cukurova University, Faculty of Medicine, 2016) Ercan E.; Ercan E.S.; Akyol Ardiç Ü.; Uçar S.
Objective: The aim of this study was to examine the psychometric properties of the Children Aggression Scale-Parent Version. CAS-P developed to help evaluate severity, frequency and diversity of aggressive behavior. Methods: The scale has 33 items representing five domains. The CAS-P was completed for 473 clinically referred children’s parents. Validity was evaluated by examining the relationship of CAS-P scores to other criteria parent rating scales and for the construct validity confirmatory factor analysis (CFA) was conducted. For the reliability the internal consistency were examined. Results: Consistent with previous research, confirmatory factor analysis of the CAS-P confirmed the good-fit of the original model (?2=842.15; sd=302; ?2/sd)=2.7; RMSEA=0.069; CFI=0.96; NFI=0.95). In order to test the scale for construct validity, the Child Behavior Checklist/4-18 and DSM-IV based Behavior Disorder Screening and rating scale were administered to participants, and the correlations with clinical constructs were in the expected direction. Also the reliability analysis revealed that the CAS-P subscales demonstrated high internal consistency. Conclusion: In the light of the findings, it was concluded that the Turkish version of CAS-P could be used as a reliable and valid tool in research and treatment contexts. © 2016, Cukurova University, Faculty of Medicine. All rights reserved.
Decreased soluble cell adhesion molecules after tirofiban infusion in patients with unstable angina pectoris
(2004) Ercan E.; Bozdemir H.; Tengiz I.; Sekuri C.; Aliyev E.; Akilli A.; Akin M.
Aim: The inflammatory response, initiated by neutrophil and monocyte adhesion to endothelial cells, is important in the pathogenesis of acute coronary syndromes. Platelets play an important role in inflammatory process by interacting with monocytes and neutrophils. In this study, we investigated the effect of tirofiban on the levels of cell adhesion molecules (soluble intercellular adhesion molecule-1, sICAM-1, and vascular cell adhesion molecule-1, sVCAM-1) in patients with unstable angina pectoris (AP). Methods: Thirty-five patients with unstable AP (Group I), ten patients with stable AP (Group II) and ten subjects who had angiographycally normal coronary arteries (Group III) were included the study. Group I was divided into two subgroups for the specific treatment regimens: Group IA (n = 15) received tirofiban and Group IB (n = 20) did not. Blood samples for investigating the cell adhesion molecules were drawn at zero time (baseline; 0 h) in all patients and at 72 h in Group I. Results: The baseline levels of sICAM-1 and sVCAM-1 were higher in Group I than in Groups II and III. They were higher in Group IA than in Group IB. However, the sICAM-1 and sVCAM-1 levels decreased significantly in Group IA after tirofiban infusion. In contrast, these levels remained unchanged or were increased above the baseline value in Group IB at 72 h. Conclusion: The levels of cell adhesion molecules in patients with unstable AP decreased significantly after tirofiban infusion. Inhibition of platelet function by specific glycoprotein IIb/IIIa antagonists may decrease platelet-mediated inflammation and the ischemic end-point. © 2004 Ercan et al; licensee BioMed Central Ltd.
Effect of methylphenidate on neurocognitive test battery: An evaluation according to the diagnostic and statistical manual of mental disorders, fourth edition, subtypes
(Lippincott Williams and Wilkins, 2014) Durak S.; Ercan E.S.; Ardic U.A.; Yuce D.; Ercan E.; Ipci M.
The aims of this study were to evaluate the neuropsychological characteristics of the restrictive (R) subtype according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition and the attention-deficit/hyperactivity disorder (ADHD) combined (CB) type and predominantly inattentive (PI) type subtypes and to evaluate whether methylphenidate (MPH) affects neurocognitive test battery scores according to these subtypes. This study included 360 children and adolescents (277 boys, 83 girls) between 7 and 15 years of age who had been diagnosed with ADHD and compared the neuropsychological characteristics and MPH treatment responses of patients with the R subtype - which has been suggested for inclusion among the ADHD subtypes in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition - with those of patients with the PI and CB subtypes. They did not differ from the control subjects in the complex attention domain, which includes Continuous Performance Test, Stroop test, and Shifting Attention Test, which suggests that the R subtype displayed a lower level of deterioration in these domains compared with the PI and CB subtypes. The patients with the CB and PI subtypes did not differ from the control subjects in the Continuous Performance Test correct response domain, whereas those with the R subtype presented a poorer performance than the control subjects. The R subtype requires a more detailed evaluation because it presented similar results in the remaining neuropsychological evaluations and MPH responses. Copyright © 2014 by Lippincott Williams & Wilkins.
The effects of attention deficit hyperactivity disorder on clothing selection and habits among Turkish University students
(Springer-Verlag Wien, 2015) Ercan E.; İpci M.; İnci S.B.; Ercan E.; Ercan E.S.
The purpose of this study was to identify the factors that influence the shopping attitudes of college students with and without ADHD. This study also examined the effects of ADHD on the academic and social lives of college students. The sample consisted of 219 university students. These students were interviewed by a psychiatrist with regard to ADHD symptoms according to the DSM-IV. The Adult ADHD Self Report Scale (ASRS), the Teen Interpersonal Influence Scale, and a demographic information form were used as measurement devices. The ADHD and control groups were classified in three different ways: (1) met the ADHD criteria for both Clinical Diagnosis and the ASRS; (2) met only the criteria for Clinical Diagnosis; or (3) met only the criteria of the ASRS. Our research shows that individuals with ADHD experience more problems with money management and are more affected by the media, friends, and brands compared with individuals without ADHD. Smoking and alcohol use disorders, accidents, being held back, and disciplinary actions often accompany ADHD in college students. To the best of our knowledge, the shopping attitudes of young adults with ADHD and the influence of the media, peers, family, and brands have not been studied until now. © 2014, Springer-Verlag Wien.
The effects of cholesterol lowering therapy with atorvastatin on flow-mediated vasodilation in patients with hypercholesterolemic coronary artery disease
(Klinika Kardiologii CMKP, 2001) Ercan E.; Ceyhan C.; Gürgün C.; Tekten T.; Onbasi A.; Zoghi M.; Türkoglu C.
Background. Hypercholesterolemia impairs the endothelial function. Lipid-lowering therapy has been reported to improve endothelial function. Aim. To assess the effects of atorvastatin on endothelial function by the measurement of flow-mediated vasodilatation (FMD) in patients with hypercholesterolemia and coronary artery disease (CAD). Methods. In twenty-six patients (mean age 55±5 years) with angiographically proven CAD a high-resolution vascular ultrasound was used at baseline and after two months of atorvastatin therapy (10 mg/day) in order to measure brachial artery responses to reactive hyperaemia and sublingual nitrate (endothelium-independent mechanism). The baseline FMD values obtained in patients were compared with those measured in healthy controls. Results. The FMD values in the control group were significantly higher than in the CAD group (12.5±6% versus 3.8±3%, p<0.001). The FMD improved significantly in CAD patients after the effective lowering of total cholesterol and LDL-cholesterol by atorvastatin therapy (3.8±3% versus 7.2±3.5%, p<0.001) whereas no significant change in the endothelium-independent vasodilation was noted. Conclusions. Endothelium-dependent vasodilatation of the brachial artery is impaired in CAD patients. Significant lowering of cholesterol levels in CAD patients with atorvastatin markedly improves endothelium-dependent arterial vasodilatation.
Effects of fiber reinforced plaster on the earthquake behavior of masonry buildings
(Shiraz University, 2015) Başaran H.; Demir A.; Bagci M.; Ercan E.
In this paper the traditional covering plaster of masonry buildings is supplied with Polypropylene and steel fiber to enhance their seismic behavior. The plaster mix proportion is determined by some initial mortar tests. Also, one story, single span masonry building specimen plastered with different mortars is tested on a shaking table 8 times under a seismic input and the performance of the specimens with the above types of mortar is evaluated. The specimen plastered with a traditional plaster was regarded as control and its earthquake behavior was compared to that reinforced by fiber plaster. Steel fiber or polypropylene addition significantly increased stiffness, displacement ability and energy consumption ability of specimens as compared to control. The suggested reinforcement method was proven to strengthen masonry buildings in a fast, reliable and economical way. Moreover, it can easily be adapted to any masonry building without causing any negative impact. The suggested method is fire and corrosion resistant. © Shiraz University.
Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study
(2004) Tengiz I.; Ercan E.; Aliyev E.; Sekuri C.; Duman C.; Altuglu I.
Background: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degrading enzyme activity in the arterial wall may act as a susceptibility factor for the development of coronary aneurysms. The aim of this study was to investigate the association between MMPs and presence of coronary aneurysms. Methods: Thirty patients with aneurysmal coronary artery disease and stable angina were enrolled into study (Group 1). Fourteen coronary artery disease patients with stable angina were selected as control group (Group 2). MMP-1, MMP-3 and C-reactive protein (CRP) were measured in peripheral venous blood and matched between the groups. Results: Serum MMP-3 level was higher in patients with aneurismal coronary artery disease compared to the control group (20.23 ± 14.68 vs 11.45 ± 6.55 ng/ml, p = 0.039). Serum MMP-1 (13.63 ± 7.73 vs 12.15 ± 6.27 ng/ml, p = 0.52) and CRP levels (4.78 ± 1.47 vs 4.05 ± 1.53 mg/l, p = 0.13) were not significantly different between the groups. Conclusion: MMPs can cause arterial wall destruction. MMP-3 may play role in the pathogenesis of coronary aneurysm development through increased proteolysis of extracellular matrix proteins. © 2004 Tengiz et al; licensee BioMed Central Ltd.
Erratum: Aripiprazole in Children and Adolescents with Conduct Disorder: A Single-Center, Open-Label Study (Pharmacopsychiatry (2012) 45 (13-19) DOI: 10.1055/s-0031-1286348)
(Georg Thieme Verlag, 2015) Ercan E.S.; Uysal T.; Ercan E.; Akyol Ardic U.
[No abstract available]
Experimental assessment of RC beam-column connections with internal and external strengthening techniques
(Hindawi Limited, 2019) Ercan E.; Arisoy B.; Ertem O.B.
This paper presents the performance of reinforced concrete beam-column connections strengthened with carbon fiber-reinforced plastic (CFRP) sheets externally and steel bars internally. The work emphasized joint behavior under reverse cyclic loading to assess deformation capacity and strength. The study aims the existing buildings designed inadequately in joint sections. For experimental analysis, an exterior joint application was used. In strengthening, four different strengthening configurations were used. Each configuration was designed to illustrate the effect of strengthening at joint sections of the samples. Cyclic performance of the retrofitted samples compared to the control sample satisfies the current building code requirements. Test results indicated that bearing capacity and ductility of the connections were closely related to the original condition of the element and strengthening application. © 2019 Emre Ercan et al.
Femoral signal intensity: A new method for prediction of embolic risk
(2003) Ercan E.; Baris N.; Tengiz I.; Ercan H.E.; Onbasili O.A.; Duman C.; Cinar C.S.
Mitral stenotic patients with left atrial spontaneous echo contrast (LA SEC) are associated with high risk of thromboembolism. The aim of this study was to predict thromboembolic risk in mitral stenotic patients. Femoral artery signal intensity alteration (%) was compared among the groups. Group 1 had severe mitral stenosis with LA SEC and group 2 slight mitral stenosis without LA SEC. Group 3 patients had normal transthoracic echocardiography. Femoral artery longitudinal view was studied with a linear USG probe (7.5 MHz, HP 2500). The femoral cuff was inflated to 300 mmHg, 7-12 cm below the inguinal ligament. Cuff inflation resulted in femoral arterial blood stasis. Intraluminal signal intensity increased in seconds. The femoral signal intensity alteration (%) at 180 seconds was compared to baseline. After femoral cuff inflation, femoral signal intensity alteration (%) was significantly higher in group 1 than groups 2 and 3 (P < 0.001). Group 1 patients had higher thromboembolic risk on the basis of their echocardiographic, clinical, and laboratory parameters. Increased signal intensity alteration (%) can be detected in the femoral artery in mitral stenotic patients with LA SEC. Copyright © 2004 by the Japanese Heart Journal.
Finite element model updating of a historical minaret via operational modal analysis
(International Operational Modal Analysis Conference (IOMAC), 2017) Ercan E.; Hökelekli E.; Demir A.; Nohutçu H.
Finite element method is commonly used for analysis of historical structures. However, since material properties of historical structures are evaluated from destructive tests using empirical formulas, this approach makes the results of finite element analysis questionable. In recent years Operational Modal Analysis of historical masonry structures have found great interest because by the help of Operational Modal Analysis, the material parameters and the boundary conditions can be verified and the finite element model can be updated. The updated model is a more realistic model of the historical structures and gives more accurate results. This study describes the results of a model updating study conducted on a historical minaret. For the purposes of developing a 3-D solid model of the minaret; the dimensions, defects and material degradations in the minaret were determined in detail by making a measurement survey. For evaluation of the material properties of the minaret, nondestructive and destructive testing methods were applied. The modal analysis of the structure was done by FEM. Then, Operational Modal Analysis was carried out and dynamic properties were extracted. The results obtained from ambient vibration measurements of the minaret were used to update the finite element model of the minaret. The natural frequencies and corresponding mode shapes were determined from both theoretical and experimental modal analyses and compared with each other. A good harmony was attained between mode shapes, but differences between natural frequencies were observed. Model updating was realized via changing material parameters and boundary conditions. Finally, the more realistic finite element model of the minaret was put forward and the results were discussed.
Fracture mechanism of CFRP-strengthened RC beam identified by AE-SIGMA
(CRC Press/Balkema, 2016) Alver N.; Tanarslan H.M.; Sülün Ö.Y.; Ercan E.
Externally bonded Carbon Fiber-Reinforced Polymer (CFRP) has been used widely to repair and/or strengthen structures that are deficient in strength. Even though strengthening with CFRP has many advantages, previous studies have shown that sudden failure due to debonding is the major problem for FRP-strengthened RC beams. Thus, it is important to clarify failure mechanisms of a strengthened RC beam with CFRP to hinder this problem. In this study, AE-SiGMA method is applied for determination of cracking development mechanism of RC beams strengthened with CFRP in different widths. In the experimental work, specimens strengthened with CFRP strips were tested under cyclic loading along with AE tests. It was found out that increasing the strip width does not enhance the behaviour. © 2016 Taylor & Francis Group, London.
G protein ß3 subunit gene polymorphism in Turkish hypertensives
(2008) Alioglu E.; Ercan E.; Tengiz I.; Yildiz A.; Saygi U.ö.T.S.; Çam F.S.; Berdeli A.
Objective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein ß3 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein ß3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein ß3 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein ß3 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (?2=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein ß3 subunit C825T gene polymorphism is associated with systolic a diastolic blood pressure. Furthermore, the study indicates that the G protein ß3 subunit may be a susceptible gene to essential hypertension.

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