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    Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to X-radiation
    (John Wiley & Sons Ltd, 2007) Enginar, Hueseyin; Cemek, Mustafa; Karaca, Turan; Unak, Perihan
    The present studies were designed to evaluate supplemental grape seed extract (GSE) and vitamin E supplements on lipid peroxidation, on antioxidant systems and peripheral blood lymphocytes in rats exposed to x-rays. Three groups of rats were investigated: a control group (CG) received intraperitoneal (i.p.)physiological serum I mL/day (n = 10), i.p.; a vitamin E group (VG) received 50 mg/kg/day (n = 10); an i.p. grape seed extract group received 50 mg/kg/day (n = 10). Four weeks later, a 6 Gy radiation dose was given to the rats. Blood samples were taken 24h later after irradiation and lymphocyte, malondialdehyde (MDA), reduced glutathione (GSH), nitrate, nitrite, reduced ascorbic acid, retinol, beta-carotene and ceruloplasmin concentrations were analysed. The levels of GSH (p < 0.05), retinol (p < 0.001), fi-carotene (p < 0.05) and ceruloplasmin concentration (p < 0.001) in the GSE group were found to be higher than in the control group but the level of MDA (p < 0.001) and nitrite concentration (p < 0.05) in rats supplemented with GSE were found to be lower than in the control group. The results indicate that GSE enhanced the antioxidant status and decreased the incidence of free radical-induced lipid peroxidation in blood samples of rats exposed to x-radiation. The antioxidant effect of GSE given to animals was more effective than vitamin E administered before whole-body irradiation in rats. Copyright (c) 2007 John Wiley & Sons, Ltd.
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    Evaluation of the efficacy of Tc-99m-labeled ascorbic acid on common cold-cough drugs in rats
    (Springer Birkhauser, 2007) Lambrecht, Fatma Yurt; Kayaalp, Erhan; Unak, Perihan; Enginar, Hueseyin; Muftuler, F. Zuemruet Biber; Medine, E. Ilker; Cetinkaya, Berkan
    Multiple-drug therapy is common in current clinical practice. Because of this, people have been ready to embrace simplistic approaches to cold treatment, such as vitamin C and zinc. Ascorbic acid (vitamin C) is mostly administrated together with cough-cold drugs. The aim of this study was to investigate the effect of cough-cold drugs on the uptake of ascorbic acid using Tc-99m-ascorbic acid (Tc-99m-AA) in male albino Wistar rats. Ascorbic acid was labeled with Tc-99m and the distribution of Tc-99m-AA was investigated. The uptake of Tc-99m-AA was evaluated when administrated alone (group I), with chlorpheniramine maleate (CPR) (group II), with phenylpropanolamine hydrochloride (PPA) (group III), and with acetaminophen (APAP) (group IV). In some organs (apart from kidneys, intestinal system, and stomach) the uptake of Tc-99m-AA was not significantly affected by the administration of Tc-99m with CPR or Tc-99m with APAP at 120 min. On the other hand, there was significant difference in the uptake of Tc-99m-AA between groups I and III. The administration of Tc-99m-AA with PPA in rats caused an increase of the uptake of Tc-99m-AA at 120 min in the investigated organs compared to the administration of Tc-99m-AA alone. The present data show that vitamin C might be more effective for the treatment of common cold when coad-ministered with PPA compared to with CPR, with APAP, or alone.
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    Radiolabeling of Morphine with I-131 and Its Biodistribution in Rats
    (Mary Ann Liebert Inc, 2010) Enginar, Hueseyin; Unak, Perihan; Yurt-Lambrecht, Fatma; Biber-Mueftueler, Fazilet Z.; Seyitoglu, Beyza; Yurt, Ayfer; Yolcular, Seniha; Medine, Ilker; Bulduk, Ibrahim
    This study was conducted to determine the possible radiopharmaceutical potential of morphin labeled with I-131. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.), purified by high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified compound was labeled with I-131. Male Albino Wistar rats (18) were used for receptor blockage and unblockage biodistribution studies. Tissue distribution studies showed that radiolabeled morphine had higher uptake in lung, liver, small intestines, large intestines, and stomach than the other tissues. The highest uptake of radiolabeled compounds in rats' brain was found to be in the midbrain and hypothalamus. After receptor blockage with morphine, uptake of I-131-morphine decreased in the lungs, liver, kidney, testis, prostate, spinal cord, cerebellum, hippocampus, striatum, and temporal cortex with respect to receptor unblockage studies of rats. This study concludes that the labeling yield of I-131-morphine was high, high amount of I-131-morphine was found in the hypothalamus, and I-131-morphine has enough stability for diagnostic scanning.