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Öğe A 5 years follow-up for ischemic cardiac outcomes in patients with carotid artery calcification on panoramic radiographs confirmed by doppler ultrasonography in Turkish population(British Inst Radiology, 2020) Akkemik, Ozlem; Kazaz, Hakki; Tamsel, Sadik; Dundar, Nesrin; Sahinalp, Sahin; Ellidokuz, HulyaObjective: To evaluate the diagnostic accuracy of digital panoramic radiograph (DPR) for detection of carotid artery calcification (CAC) confirmed by Doppler Ultrasonography (DUSG) and to clarify the relationship between between CAC identified by DPR and cardiovascular events through a 5 year follow-up period. Methods: of 3600 consecutive patients examined, 158 patients presented with CAC as detected by DPR. the final study group was composed of 96 patients who had CAC confirmed by DUSG or CT angiogram. the control group was composed of 62 patients who has normal DUSG. the end point of the study was the occurrence of any cardiovascular event. Results: 72 (75%) of the 96 patients with CAC confirmed by DUSG (16 patients had significant stenosis) had bilateral and 24 (25%) had unilateral CAS as detected by DUSG. There was a low agreement between the examination results with a kappa value of 0.488 (p < 0.005) for calcification. Study data revealed that smoking, chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM) and diastolic hypertension were significantly more common in patients with CAC than the control group (p < 0.05). During the follow-up period, 13 subjects had myocardial infarction and 1 subject died; in the control group, 1 patient died after MI and 1 patient died of a non-cardiac event. Conclusion: Patients with CAC detectable by DPR concomitant with COPD, DM, smoking or diastolic hypertension are more likely to suffer from vascular events. Therefore, patients with detectable carotid plaque in DPR require referral to a cardiovascular surgery clinic for further investigations.Öğe The effect of virtual reality on pain, fear, and anxiety during access of a port with huber needle in pediatric hematology-oncology patients: Randomized controlled trial(Elsevier Sci Ltd, 2021) Gerceker, Gulcin Ozalp; Bektas, Murat; Aydinok, Yesim; Oren, Hale; Ellidokuz, Hulya; Olgun, NurPurpose: Port needle insertions are painful and distressing for Pediatric Hematology-Oncology patients. Virtual Reality (VR) can be used during needle-related procedures in these patients. This study aimed to investigate the effect of VR distraction during access to the venous port with a Huber needle in reducing needle-related pain, fear, and anxiety of children and adolescents with cancer. Methods: This randomized controlled study used a parallel trial design guided by the CONSORT checklist. The sample of children (n = 42) was allocated to the VR group (n = 21) and the control group (n = 21). Port needle related pain was assessed using the Wong-Baker Faces Pain Rating Scale after the procedure. Before and after the port needle insertion procedure, anxiety and fear assessed using self-and parent-report using the Children & rsquo;s Anxiety Meter and Child Fear Scale. The primary outcome was the patient-reported pain scores after the procedure and fear and anxiety scores before and after the procedure. Pain, anxiety, and fear scores of the two groups and within groups were analyzed and also Spearman correlation analysis was used. Results: Self-reported pain scores of patients in the VR and control group were 2.4 +/- 1.8 and 5.3 +/- 1.8, respectively. This study found a statistically significant difference between groups in pain scores (p < .001). A statistically significant difference was found between groups according to the self-and parent-reported fear and anxiety scores after the procedure. Self-reported fear scores in the VR and control group were 0.8 +/- 0.9, 2.0 +/- 1.0, self-reported anxiety scores were 2.9 +/- 2.0, 5.4 +/- 2.0, respectively (p < .001). Conclusion: Virtual reality is an effective distraction method in reducing port needle-related pain, fear, and anxiety in Pediatric Hematology-Oncology patients. ClinicalTrials.gov NCT04093154.Öğe Evaluation of children's dental anxiety levels at a kindergarten and at a dental clinic(Sociedade Brasileira De Pesquisa Odontologica, 2016) Kilinc, Gulser; Akay, Aynur; Eden, Ece; Sevinc, Nilgun; Ellidokuz, HulyaThis study evaluated the dental anxiety levels of preschool children at a kindergarten and at a dental clinic. The anxiety levels of ninety 4-6-year-old (4.99 +/- 0.81) preschool children were evaluated according to pulse rates, the facial image scale (FIS), the Venham picture test (VPT), and the Frankl behavior rating scale. The children's mothers were asked to complete the state-trait anxiety inventory (STAI) forms 1 and 2 (STAI 2 and STAI 2). The sample t-test, Mann-Whitney U test, and Pearson's correlation test were used. A statistically significant difference was observed between the children's pulse rates when measured at the dental clinic and those when measured at the kindergarten (p < 0.001). Although the results were not statistically significant, more negative facial expressions were observed in the children at the dental clinic than in those at the kindergarten when assessed using FIS and VPT (p = 0.090 and p = 0.108, respectively). There was a statistically significant correlation between the transient anxiety levels (STAI 1) of mothers and the VPT scores of their children evaluated at the dental clinic (r = 0.506, p < 0.001). The continuous anxiety level of the mothers of males was found to be significantly higher (p = 0.033) than that of the mothers of females (STAI 2). Although the children had been informed about dentistry and were introduced to a dentist at the kindergarten, their anxiety levels seemingly increased as they arrived at the dental clinic. The significant increase observed in the children's pulse rates was a physical indicator that their anxiety levels had increased. It can be concluded that the children felt more anxious at the dental clinic that at the kindergarten.Öğe Long-term Dental Anomalies after Pediatric Cancer Treatment in Children(Galenos Yayincilik, 2019) Kilinc, Gulser; Bulut, Gulcin; Ertugrul, Fahinur; Oren, Hale; Demirag, Bengu; Demiral, Ayse; Aksoylar, Serap; Kernel, Emine Serra; Ellidokuz, Hulya; Olgun, NurObjective: The aim of this study is to determine the frequency of dental anomalies (DAs) (microdontia, hypodontia, hyperdontia, enamel defect, root malformation) in pediatric cancer patients at the ages <5 years and between 5 and 7 years, and understand their relationship with the received therapy. Materials and Methods: Pediatric patients who were diagnosed with cancer and treated before the age of 7 years were investigated in a case-control design. The study included 93 pediatric patients whose ages at diagnosis were between 9 months and 7 years and whose treatments were completed before 5-8 years. Group A consisted of patients in the age range of 9 months to 4 years and Group B consisted of patients in the age range of 5-7 years. Seventy-two siblings with compatible dental age ranges were included in the control group. For both groups, intraoral examinations were performed and panoramic radiographs were taken. Results: Among the 93 pediatric patients, the mean age was 9.54 +/- 1.25 (range: 8-13 years) and 48 (51.6%) patients were male. The most common diagnosis was hematologic malignancy with a rate of 65.5%. At least one DA was detected in 7 (9.7%) individuals of the control group and in 78 (83.9%) of the patient group. While the patients in the study group had all kinds of DAs, those in the control group had only enamel defects. The rates of microdontia (p=0.077) and hypodontia (p=0.058) were detected to be significantly higher in Group A than in Group B. Root malformation was more common in patients receiving chemotherapy and radiotherapy than in those receiving only chemotherapy (p=0.006). Conclusion: In this study it was found that the pediatric patients who received cancer treatment before the age of 7 years constituted a high-risk group for DAs. The frequencies of microdontia and hypodontia were increased even more when the patient was treated for cancer before 5 years of age.Öğe Pauci-immune necrotizing crescentic glomerulonephritis with crescentic and full moon extracapillary proliferation: Clinico-pathologic correlation and follow-up study(Elsevier Gmbh, Urban & Fischer Verlag, 2013) Unlu, Mehtat; Kiremitci, Saba; Ensari, Arzu; Ozluk, Yasemin; Kilicaslan, Isin; Ozdemir, Binnaz Handan; Ates, Deniz; Baydar, Dilek Ertoy; Gonul, Ipek Isik; Memis, Leyla; Sarsik, Banu; Sen, Sait; Akkaya, Bahar; Orhan, Diclehan; Gonlusen, Gulfiliz; Ellidokuz, Hulya; Ada, Sibel; Cavdar, Caner; Akagun, Tulin; Kamali, Sevil; Aksu, Kenan; Yazisiz, Veli; Paydas, Saime; Soylu, Alper; Sarioglu, SulenThe prognostic value of the type and extent of extracapillary proliferation (ECP) in pauci-immune necrotizing crescentic glomerulonephitis (PIGN) was evaluated in this study. In 141 PIGN cases, all glomeruli with ECP were grouped according to type (cellular, fibrocellular and fibrous) and extent of the lesions in Bowman's space; (segmental, semicircumferential and circumferential, which might be termed full moon-FM). Cases with cellular and fibrous lesions involving >= 50% of glomeruli with ECP were classified as cellular and fibrous groups, respectively, while the remaining cases were classified as fibrocellular. Cases with segmental and circumferential (FM glomerulus) lesions involving >= 50% of glomeruli with ECP were classified as ECPI and ECPIII (FM) groups, respectively, while the rest were classified as ECPII. All the cases were classified according to Berden et al. Significant results were only nearly obtained for the FM group, including the need for dialysis. The Cox regression model revealed a 2.6-fold risk for FM cases regarding dialysis requirement. We propose that the percentage of FM glomeruli should be noted in the pathology report, and cases with more than 50% of FM glomeruli (FM group) should be identified in the group with increased risk of dialysis requirement. Our series also suggests that classification according to Berden et al. is of clinical relevance. (C) 2012 Elsevier GmbH. All rights reserved.Öğe Pauci-immune necrotizing crescentic glomerulonephritis with crescentic and full moon extracapillary proliferation: Clinico-pathologic correlation and follow-up study(Elsevier Gmbh, Urban & Fischer Verlag, 2013) Unlu, Mehtat; Kiremitci, Saba; Ensari, Arzu; Ozluk, Yasemin; Kilicaslan, Isin; Ozdemir, Binnaz Handan; Ates, Deniz; Baydar, Dilek Ertoy; Gonul, Ipek Isik; Memis, Leyla; Sarsik, Banu; Sen, Sait; Akkaya, Bahar; Orhan, Diclehan; Gonlusen, Gulfiliz; Ellidokuz, Hulya; Ada, Sibel; Cavdar, Caner; Akagun, Tulin; Kamali, Sevil; Aksu, Kenan; Yazisiz, Veli; Paydas, Saime; Soylu, Alper; Sarioglu, SulenThe prognostic value of the type and extent of extracapillary proliferation (ECP) in pauci-immune necrotizing crescentic glomerulonephitis (PIGN) was evaluated in this study. In 141 PIGN cases, all glomeruli with ECP were grouped according to type (cellular, fibrocellular and fibrous) and extent of the lesions in Bowman's space; (segmental, semicircumferential and circumferential, which might be termed full moon-FM). Cases with cellular and fibrous lesions involving >= 50% of glomeruli with ECP were classified as cellular and fibrous groups, respectively, while the remaining cases were classified as fibrocellular. Cases with segmental and circumferential (FM glomerulus) lesions involving >= 50% of glomeruli with ECP were classified as ECPI and ECPIII (FM) groups, respectively, while the rest were classified as ECPII. All the cases were classified according to Berden et al. Significant results were only nearly obtained for the FM group, including the need for dialysis. The Cox regression model revealed a 2.6-fold risk for FM cases regarding dialysis requirement. We propose that the percentage of FM glomeruli should be noted in the pathology report, and cases with more than 50% of FM glomeruli (FM group) should be identified in the group with increased risk of dialysis requirement. Our series also suggests that classification according to Berden et al. is of clinical relevance. (C) 2012 Elsevier GmbH. All rights reserved.Öğe SALIVARY PRO-INFLAMMATORY CYTOKINES AND SALIVARY BACTERIAL CHALLENGE EFFECT ON DENTAL CARIES: A CLINICO-MOLECULAR CROSS-SECTIONAL STUDY (vol 1, pg 77, 2020)(Dokuz Eylul Univ Inst Health Sciences, 2022) Pakdemirli, Ahu; Kocal, Gizem Calibasi; Kilinc, Gulser; Daskin, Ezgi; Kemaloglu, Hande; Basbinar, Yasemin; Ellidokuz, Hulya[No Abstract Available]Öğe Ubiquitin-Proteasome Axis, Especially Ubiquitin-Specific Protease-17 (USP17) Gene Family, is a Potential Target for Epithelial-Mesenchymal Transition in High-Grade Serous Ovarian Cancer(Sage Publications Inc, 2019) Yildirim, Nuri; Kocal, Gizem Calibasi; Isik, Zerrin; Saatli, Bahadir; Saygili, Ugur; Uysal, Tugba; Ulukus, Cagnur; Koyuncuoglu, Meral; Ellidokuz, Hulya; Basbinar, YaseminObjectives: To investigate gene expression differences and related functions between primary tumor, malignant cells in ascites, and metastatic peritoneal implant in high-grade serous ovarian cancer. Methods: Biopsies from primary tumor, peritoneal implant, and ascites were collected from 10 patients operated primarily for high-grade, advanced-staged serous ovarian cancer. Total RNA isolation was performed from collected tissue biopsy and fluid samples, and RNA expression profile was measured. Messenger RNA expression profiles of 3 different groups were compared. Functional analyses of candidate genes were carried out by gene ontology and pathway analysis. Results: There were significant differences in the expression of 5 genes between primary tumor and peritoneal implant, 979 genes between primary tumor and malignant cells in ascites, and 649 genes between peritoneal implant and malignant cells in ascites. Three commonly enriched gene ontology functions between "primary tumor and malignant cells in the ascites" and "peritoneal implant and malignant cells in the ascites" were protein deubiquitination, ubiquitin-dependent protein catabolism, and apoptotic processes. All genes related to these functions belonged to USP17 gene family. Conclusion: Gene expression difference between primary tumor and the peritoneal implant is not as much as the difference between primary tumor and free cells in the ascites. These results show that malignant cells in the ascites return into its genetic origin after they invade on the peritoneum. Significantly increased expression of DUB-enzyme genes, SNAR gene family, and ribosomal pathway genes in epithelial-mesenchymal transition suggests that this regulation is ubiquitin-proteasome dependent. Especially, this is the first study that offers USP17 as a potential target for epithelial-mesenchymal transition.
