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    The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome
    (2018) Dilek, Gamze; Öztürk, Cihat; Hepgüler, Asiye Simin; Özkınay, Ferda; Dilek, Mustafa
    Aim: Down syndrome (DS) is a predisposing factor for osteoporosis. the aim of this study is to investigate the effect of resistance and jumping exercises on the bone mineral density (BMD) and bone mineral content (BMC) of patients with DS. Materials and Methods: DS and normal individuals aged between 10 and 30 years old were randomized into an exercise group and a control group: a DS without-exercise group (n=15), DS exercise group (n=17), control without-exercise group (n=18), and control exercise group (n=20) were designated. A supervised 45-minute period of exercise was given to the DS exercise group and control exercise group three times per week for six months. the lumbar total and femoral neck BMD and BMC were measured both before and after six months of exercise using dual-energy X-ray absorptiometry. Results: the change in BMD and BMC over six months did not differ significantly between the exercise and control groups. the BMD and BMC of the DS exercise group decreased in the vertebral and femur areas over six months. the study on resistance and jumping exercises over six months did not lead to a significant change in the total BMD and BMC in the vertebral and femoral neck areas of the patients with DS. Conclusion: the decrease in BMD and BMC over six months in the DS exercise group is not a predictable result.
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    The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome
    (Galenos Yayincilik, 2018) Dilek, Gamze; Ozturk, Cihat; Hepguler, Simin; Özkınay, Ferda; Dilek, Mustafa
    Aim: Down syndrome (DS) is a predisposing factor for osteoporosis. The aim of this study is to investigate the effect of resistance and jumping exercises on the bone mineral density (BMD) and bone mineral content (BMC) of patients with DS. Materials and Methods: DS and normal individuals aged between 10 and 30 years old were randomized into an exercise group and a control group: a DS without-exercise group (n=15), DS exercise group (n=17), control without-exercise group (n=18), and control exercise group (n=20) were designated. A supervised 45-minute period of exercise was given to the DS exercise group and control exercise group three times per week for six months. The lumbar total and femoral neck BMD and BMC were measured both before and after six months of exercise using dual-energy X-ray absorptiometry. Results: The change in BMD and BMC over six months did not differ significantly between the exercise and control groups. The BMD and BMC of the DS exercise group decreased in the vertebral and femur areas over six months. The study on resistance and jumping exercises over six months did not lead to a significant change in the total BMD and BMC in the vertebral and femoral neck areas of the patients with DS. Conclusion: The decrease in BMD and BMC over six months in the DS exercise group is not a predictable result.
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    Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
    (Springer, 2022) Akin, Ilke Mungan; Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Imdadoglu, Timucin; Dilek, Mustafa; Yaman, Akan
    The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17-21.71), tachypnea (OR: 26.5, 95% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.