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Öğe Critical time point for apoptotic cell death in an experimental ischemia/reperfusion model and the effect of N-acetylcystein [Deneysel iskemi/reperfüzyon modelinde apoptotik hücre ölümü için kritik zamanlama ve N-asetilsistein’in etkisi](Turkish Biochemistry Society, 2017) Ozsarlak-Sozer G.; Emre M.; Demirkol S.; Açıkalın A.; Çetiner S.; Topçu Z.; Demir-Dora D.Objective: Kidney transplantation is an important treatment option in end stage renal failure. Tissue death may be an important problem when a kidney is removed from a cadaver and transported to a donor a long distance away. The purpose of this study is to determine the critical time point for apoptotic cell death in a renal ischemia/reperfusion model and determine the effects of N-acetylcystein on apoptosis induced by ischemia injury. Methods: Apoptotic cell death after induced renal ischemia followed by reperfusion, was estimated in a group of Wistar albino rats by immunoflourescence and ELISA techniques. N-acetylcystein, an antioxidant agent, was given to the rats to study the effect on apoptosis. Tissues were examined immunohistochemically at 0, 1 h, 24 h, 5 days and 10 days for detection of apoptotic cells. Results: Our results showed that an ischemia for 60 min followed by reperfusion for 60 min triggered apoptosis. Moreover, N-acetylcystein significantly diminished both the ischemia/reperfusion damage and apoptosis. Conclusion: We anticipate our results would be important for kidney transplantation in estimating the critical time point for apoptosis and administration of N-acetylcystein prior to removal of the organ may be important in delaying the onset of apoptosis. © 2017, Turkish Biochemistry Society. All rights reserved.Öğe Development of an agent based E-barter system(2011) Demirkol S.; Getir S.; Challenger M.; Kardas G.A barter system is an alternative commerce approach where customers meet at a marketplace in order to exchange their goods or services without currency. In order to cope with challenges of electronic barter systems (e.g. efficient management of trades and determination of best-matching goods and their suppliers), several software systems based on intelligent agents have been proposed. However only a very few of these proposals consider exact development and implementation of multi-agent e-barter systems. Besides, most of the approaches consider matching between exchanged goods in which only price and quantity information are used. Hence, in this paper, we discuss design and implementation of a multi-agent e-barter system which utilizes ontology-based comparison for bid matching. Formal representation and decision-making criteria for agent mediated barter process are given and behavioral model of collaborating agents within the system is described. In addition to the traditional e-barter members, a new type of software agent is introduced in order to infer about semantic closeness between offered and purchased items. Related approach may enhance capabilities of e-barter systems in the way of finding the most appropriate matches between supplies and demands, considering not only price and quantities for goods. © 2011 IEEE.Öğe The GMF-based syntax tool of a DSML for the semantic web enabled multi-agent systems(2011) Getir S.; Demirkol S.; Challenger M.; Kardas G.Internal complexity of agents makes development of agent-based software systems complicated. On the other hand, MAS implementation becomes even more complex when new requirements and interactions for environments such as the Semantic Web is considered. A Domain Specific Modelling Language (DSML) can provide the required abstraction and hence support a more fruitful methodology for the development of MAS especially working on the new challenging environments like the Semantic Web. In this paper, a graphical syntax tool is introduced in which agent developers can model MASs according to a DSML called Semantic web Enabled Agent Modeling Language, SEA-ML. © 2011 ACM.Öğe SEA-L: A Domain-specific Language for Semantic Web enabled Multi-agent Systems(2012) Demirkol S.; Challenger M.; Getir S.; Kosar T.; Kardas G.; Mernik M.Autonomous, reactive and proactive features of software agents make development of agent-based software systems complex. A Domain-specific Language (DSL) can provide the required abstraction and hence support a more fruitful methodology for the development of Multi-agent Systems (MASs) especially working on the new challenging environments such as the Semantic Web. Based on our previously introduced domain-specific metamodel, in this paper we propose a textual concrete syntax of a DSL for MASs working on the Semantic Web and show how the specifications of this DSL can be utilized during the code generation of exact MASs. The new DSL is called Semantic web Enabled Agent Language (SEA-L). The syntax of SEA-L is supported with textual modeling toolkits developed with Xtext. The practical use of SEA-L is illustrated with a case study which considers the modeling of a multi-agent based e-barter system. © 2012 Polish Info Processing Socit.Öğe The semantics of the interaction between agents and web services on the semantic web(2012) Getir S.; Challenger M.; Demirkol S.; Kardas G.Development of agent systems is naturally a complex task due to the fundamental characteristics of agents. In addition, agent internals and inter-agent behavior models inside Multi-agent Systems (MAS) may become even more difficult to implement when interactions of agents with web services on the Semantic Web are taken into account. Our approach consists of the utilization of a Domain-specific Modeling Language (DSML) during MAS development in order to cope with the abovementioned challenge. This paper describes how the formal semantics of this DSML can be defined by especially focusing on its viewpoint on agentsemantic service interactions and discusses the use of this semantics definition on MAS validation. Determined semantic rules are both defined and implemented by using Alloy specification language which has a strong description capability based on both relational and first-order logic. © 2012 IEEE.
