Yazar "Cinar, Cahide Soydas" seçeneğine göre listele

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    3D-speckle tracking echocardiography for assessment of coronary artery disease severity in stable angina pectoris
    (Wiley, 2019) Dogdus, Mustafa; Simsek, Evrim; Cinar, Cahide Soydas
    Background and Aim: Stable angina pectoris is a common disease that may cause disability. Some noninvasive new methods can be useful for the detection of early stage coronary artery disease. The relationship between coronary artery disease (CAD) severity and resting 3-dimensional-speckle tracking echocardiography (3D-STE) in stable angina pectoris patients was evaluated in this study. Methods: One hundred and twenty consecutive patients between 18-80 years of age and without a history of CAD to whom elective coronary angiography was planned after positive stress test or myocardial perfusion scintigraphy were enrolled in the study. 3D-STE was performed and global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were measured before coronary angiography. A Gensini score of >= 20 was accepted as critical CAD. Correlation between Gensini scores and 3D-STE results were evaluated. Results: Mean age was 60.7 +/- 10.01 years, and 55% of the patient population were male. There were not any significant differences between critical CAD and noncritical CAD groups for age, gender, history of hypertension, diabetes mellitus, hyperlipidemia, and Left Ventricular Ejection Fraction. Mean GLS was-12, GCS was-18.8, GRS was 33.4, GAS was-28.9, and mean Gensini score was 18.8. GLS and all other strain parameters were significantly worse in patients with critical CAD group compared with noncritical CAD group and also positive linear correlation was observed between Gensini score and all measured strain parameters (r = 0.568, P < 0.001 for Gensini score and GLS; r = 0.617, P < 0.001 for Gensini score and GAS). A GLS value of >-10 has 88.9% sensitivity and 92.9% specificity; A GAS value of >-21 has 97.2% sensitivity and 88.1% specificity to detect critical CAD. Conclusions: 3D-STE is a noninvasive and handy parameter to detect subclinical left ventricular dysfunction and global strain values were significantly correlated with CAD severity. GAS has the sensitivity of 97.2% and specificity of 88.1% to detect critical CAD. Adding 3D strain echocardiography to exercise test or myocardial perfusion scintigraphy might increase sensitivity to detect critical CAD in clinical practice.
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    Cardiovascular System Effects of Anti-personnel Agents
    (Elsevier Science Inc, 2013) Kocabas, Umut; Kaya, Esra; Gurgun, Cemil; Cinar, Cahide Soydas
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    Chronic Papillary Muscle Rupture: 14-Year Survival without Surgical Treatment
    (Taiwan Soc Cardiology, 2015) Tuluce, Selcen Yakar; Tuluce, Kamil; Yuksel, Alper; Yayuzgil, Oguz; Cinar, Cahide Soydas
    Papillary muscle rupture is a life-threatening complication of myocardial infarction which is usually refractory to medical treatment. We present a very rare case of a 65-year-old woman who had a myocardial infarction and posteromedial papillary muscle rupture which was only treated with medical therapy, including her corresponding 14-year follow-up. However, surgical intervention is still strongly recommended because the prognosis of acute papillary muscle rupture associated with myocardial infarction remains poor.
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    Chronic Papillary Muscle Rupture: 14-Year Survival without Surgical Treatment
    (Taiwan Soc Cardiology, 2015) Tuluce, Selcen Yakar; Tuluce, Kamil; Yuksel, Alper; Yayuzgil, Oguz; Cinar, Cahide Soydas
    Papillary muscle rupture is a life-threatening complication of myocardial infarction which is usually refractory to medical treatment. We present a very rare case of a 65-year-old woman who had a myocardial infarction and posteromedial papillary muscle rupture which was only treated with medical therapy, including her corresponding 14-year follow-up. However, surgical intervention is still strongly recommended because the prognosis of acute papillary muscle rupture associated with myocardial infarction remains poor.
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    Chronic Papillary Muscle Rupture: 14-Year Survival without Surgical Treatment
    (Taiwan Soc Cardiology, 2015) Tuluce, Selcen Yakar; Tuluce, Kamil; Yuksel, Alper; Yayuzgil, Oguz; Cinar, Cahide Soydas
    Papillary muscle rupture is a life-threatening complication of myocardial infarction which is usually refractory to medical treatment. We present a very rare case of a 65-year-old woman who had a myocardial infarction and posteromedial papillary muscle rupture which was only treated with medical therapy, including her corresponding 14-year follow-up. However, surgical intervention is still strongly recommended because the prognosis of acute papillary muscle rupture associated with myocardial infarction remains poor.
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    Comparison of Warfarin use in terms of efficacy and safety in two different polyclinics
    (Turkish Soc Cardiology, 2017) Kilic, Salih; Kemal, Hatice Soner; Yuce, Elif Ilkay; Simsek, Evrim; Yagmur, Burcu; Akgul, Nuray Memisoglu; Cinar, Cahide Soydas; Zoghi, Mehdi; Gurgun, Cemil
    Objective: This study compared the efficacy and safety of warfarin in specialized international normalized ratio (INR) outpatient clinic (INR-C) and in general cardiology outpatient clinic (General-C). Methods: Herein, 381 consecutive patients with a regular follow-up at INR-C (n=233) or General-C (n=148) for at least 1 year were retrospectively included. While INR-C patients were followed by a single experienced trained nurse, General-C patients were followed by a different cardiologist who worked in a rotational principle every month. During controls, demographic characteristics, INR levels, bleeding events, ischemic stroke, and transient ischemic attacks in the last 1 year were recorded. Primary endpoint was defined as the evaluation of the combined major bleeding and ischemic event, and secondary endpoint was defined as the evaluation of them separately. Results: The mean age of the patients was 62 +/- 12.86 and 43.8% were male. Mean time in therapeutic range (TTR) level was statistically higher in INR-C than that in General-C (68.8%+/- 15.88 and 51.6%+/- 23.04, respectively; p<0.001). Primary outcomes were significantly higher in General-C than that in INR-C [13.5% (20) and 6.4% (15); respectively, p=0.020]. Overall, major bleeding was observed in 25 patients (6.5%) and (2.6%) ischemic event was observed in 10 patients. In General-C patients, both major bleeding (8.8% vs. 5.2%; p=0.163) and the ischemic event (4.7% vs. 1.3%; p=0.051) were more, and no statistically significant differences were detected between the two clinics. Conclusion: The findings of our study demonstrate that patients followed in INR-C had higher TTR levels and lower bleeding and ischemic events rates that those followed in General-C.
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    A complicated trilogy: persistent left superior vena cava with hypertrophic cardiomyopathy and atrial septal defect
    (Bioscientifica Ltd, 2016) Kocabas, Umut; Kaya, Esra; Cinar, Cahide Soydas
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    Coronary tortuosity affects left ventricular myocardial functions: a 3D-speckle tracking echocardiography study
    (Springer, 2020) Dogdus, Mustafa; Demir, Emre; Cinar, Cahide Soydas; Gurgun, Cemil
    Coronary artery tortuosity (CAT) is a common finding in coronary angiography, and is defined as three fixed bends during both systole and diastole in at least one epicardial coronary artery, with each bend showing a 45 degrees change in vessel direction. the impact of CAT on the myocardial deformation has not been completely evaluated using 3D-STE. As a result of this, we aimed to assess the effects of CAT on LV functions using 3D-STE in the present study. Eighty-two patients with CAT and 80 age- and gender-matched controls who proved to have normal coronary angiograms were enrolled into the study. 3D-STE was performed and LV-GLS, LV-GCS, LV-GAS, and LV-GRS were obtained for every patient after coronary angiography. the LV-GLS was significantly depressed in the CAT ( +) group than in the control group (p = 0.001). ROC analysis was performed to find out ideal LV-GLS cut off value to predict the presence of CAT. A LV-GLS value of > - 17 has 81.3% sensitivity, 56.7% specificity to detect the presence of CAT. the present study is the first to focus on the assessing LV myocardial functions in patients with CAT by 3D-STE. CAT has a considerable negative effect on LV myocardial longitudinal deformation as evaluated by 3D strain parameters. Our results support that patients with CAT may have subclinical LV longitudinal deformation abnormalities even though they are apparently healthy.
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    Determination of right ventricular changes in elite athletes along with left ventricular remodelling
    (Lippincott Williams & Wilkins, 2007) Ozdogan, Oner; Yilmaz, Meral; Gurgun, Cemil; Cinar, Cahide Soydas
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    Early Reverse Cardiac Remodeling Effect of Laparoscopic Sleeve Gastrectomy
    (Springer, 2017) Tuluce, Kamil; Kara, Cemal; Tuluce, Selcen Yakar; Cetin, Nurullah; Topaloglu, Caner; Bozkaya, Yasemin Turhan; Saklamaz, Ali; Cinar, Cahide Soydas; Ergene, Oktay
    This study evaluated the early postoperative benefits of laparoscopic sleeve gastrectomy (LSG) on the left ventricular (LV) function and left atrial (LA) structural, mechanical, and electrical functions in severely obese patients. Thirty-two patients with severe obesity who were consecutively scheduled for LSG and 30 healthy controls were included in the study. LV global longitudinal strain (LGS), peak atrial longitudinal strain (PALS), and strain rates (S-Sr, E-Sr, and A-Sr) of the lateral and septal LA walls, and intra- and interatrial dyssynchrony periods for all subjects were evaluated using strain echocardiography. The measurements were repeated in patients 1 month after surgery. LGS of the LV was significantly depressed in the patient group compared with the control group (p < 0.001). LA peak septal and lateral wall strain values were significantly lower in patients than in controls (both p values < 0.001). LA intra- and interatrial dyssynchrony periods were longer in patients than in controls (p = 0.012 and p = 0.004, respectively). LGS significantly improved after LSG (p < 0.001). Significant reductions were noted in the LA antero-posterior diameter (p < 0.001), LA volume index (LAVI, p = 0.001), and in the mitral velocity to the early diastolic velocity of the mitral annulus ratio (E/e' ratio, p = 0.046). The PALS of the septal and lateral LA walls significantly increased (p = 0.001 and p < 0.001, respectively). S-Sr, E-Sr, and A-Sr values of the septal LA wall (p = 0.049, p < 0.001, and p = 0.001, respectively) and the lateral LA wall (p = 0.009, p = 0.007, and p = 0.002, respectively) significantly improved postoperatively. Intra- and interatrial dyssynchrony significantly decreased (p = 0.001 and p < 0.001, respectively). Weight loss positively correlated with changes in LGS (R = 0.39, p = 0.039), LAVI (R = 0.39, p = 0.034), intra-atrial dyssynchrony (R = 0.45, p = 0.021), interatrial dyssynchrony (R = 0.42, p = 0.038), septal LA wall peak strain (R = 0.44, p = 0.027), lateral LA wall peak strain (R = 0.46, p = 0.017), septal LA wall A-Sr (R = 0.43, p = 0.028), and lateral LA wall A-Sr (R = 0.46, p = 0.019). The comparison of postoperative findings of the patients with controls revealed that the LA diameter, both LA volume and volume index (LAVI), E/e' ratio, S-Sr and E-Sr of both lateral and septal LA walls, intra- and interatrial LA dyssynchrony of the patient group became similar to the control group (all p value > 0.05). Postoperative A-Sr values of both LA walls (both p value < 0.001) were higher in patients than controls. The benefits of LSG on LV and LA function may be observed even in the early postoperative phase. The resulting weight loss correlates with LV and LA reverse remodeling in severely obese patients.
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    Evaluating Left Ventricular Functions in Primary Mitral Regurgitation by Two Dimensional Strain Echocardiography
    (Elsevier Science Inc, 2013) Zihni, Burcu; Alkan, Mustafa Beyazit; Bilgin, Murat; Sayin, Ahmet; Kemal, Hatice Soner; Cinar, Cahide Soydas
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    Evaluation of the Severity of Mitral Regurgitation by the Use of Signal Void in Magnetic Resonance Imaging
    (Wiley-Blackwell Publishing, Inc, 2009) Ozdogan, Oner; Yuksel, Alper; Gurgun, Cemil; Kayikcioglu, Meral; Yavuzgil, Oguz; Cinar, Cahide Soydas
    Background: The study was designed to evaluate the severity of mitral regurgitation by cardiac magnetic resonance imaging (MRI). We proposed a new measurement of signal void by MRI and tried to define threshold values for the severity of regurgitation with different sequences. Methods: Twenty-one patients with mitral regurgitation were evaluated by echocardiography and MRI. We measured the length, width, and the area of jet flow void from long-axis and four-chamber views. The regurgitant area was measured with TrueFISP, FLASH sequences, and phase images by tracing the signal-void area in left atrium parallel to mitral annulus. This new parameter for grading of the severity of mitral regurgitation by cine MRI was called regurgitant area from short axis (RAFSA). Results: All methods (EROA, vena contracta) were correlated for determining the regurgitation severity (P < 0.01). There was a correlation between EROA by echocardiography and RAFSA by MRI with the TrueFISP, FLASH sequences, and phase images (P < 0.01). Stepwise regression analysis revealed that EROA was significantly correlated with RAFSA by phase images (P < 0.001). After regression analysis, threshold values of RAFSA by phase imaging were calculated and found to be 0.27 cm(2) and 0.92 cm(2) between mild, moderate, and severe mitral regurgitations (100% sensitivity, 67% specificity, and 100% sensitivity, 78% specificity, respectively) (P < 0.01, P < 0.05). Conclusions: MRI is an alternative method for evaluating mitral regurgitation. Our study suggests a new parameter, RAFSA by cine MRI, to grade the severity of mitral regurgitation and provides threshold values in order to define mild, moderate, and severe regurgitations. (ECHOCARDIOGRAPHY, Volume 26, November 2009)
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    Evaluation of the Severity of Mitral Regurgitation by the Use of Signal Void in Magnetic Resonance Imaging
    (Wiley-Blackwell Publishing, Inc, 2009) Ozdogan, Oner; Yuksel, Alper; Gurgun, Cemil; Kayikcioglu, Meral; Yavuzgil, Oguz; Cinar, Cahide Soydas
    Background: The study was designed to evaluate the severity of mitral regurgitation by cardiac magnetic resonance imaging (MRI). We proposed a new measurement of signal void by MRI and tried to define threshold values for the severity of regurgitation with different sequences. Methods: Twenty-one patients with mitral regurgitation were evaluated by echocardiography and MRI. We measured the length, width, and the area of jet flow void from long-axis and four-chamber views. The regurgitant area was measured with TrueFISP, FLASH sequences, and phase images by tracing the signal-void area in left atrium parallel to mitral annulus. This new parameter for grading of the severity of mitral regurgitation by cine MRI was called regurgitant area from short axis (RAFSA). Results: All methods (EROA, vena contracta) were correlated for determining the regurgitation severity (P < 0.01). There was a correlation between EROA by echocardiography and RAFSA by MRI with the TrueFISP, FLASH sequences, and phase images (P < 0.01). Stepwise regression analysis revealed that EROA was significantly correlated with RAFSA by phase images (P < 0.001). After regression analysis, threshold values of RAFSA by phase imaging were calculated and found to be 0.27 cm(2) and 0.92 cm(2) between mild, moderate, and severe mitral regurgitations (100% sensitivity, 67% specificity, and 100% sensitivity, 78% specificity, respectively) (P < 0.01, P < 0.05). Conclusions: MRI is an alternative method for evaluating mitral regurgitation. Our study suggests a new parameter, RAFSA by cine MRI, to grade the severity of mitral regurgitation and provides threshold values in order to define mild, moderate, and severe regurgitations. (ECHOCARDIOGRAPHY, Volume 26, November 2009)
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    Hypereosinophilic Syndrome Presenting with Large Left Ventricular Apical Thrombus and Pulmonary Embolism
    (Wiley-Blackwell, 2011) Gurgun, Alev; Tuluce, Kamil; Tuluce, Selcen Yakar; Gurgun, Cemil; Bayraktaroglu, Selen; Tombuloglu, Murat; Cinar, Cahide Soydas
    A 45-year-old man presented with dyspnea on exertion, fatigue, and cough. Transthoracic echocardiography showed a large apical thrombus in the left ventricle. The laboratory results showed prominent eosinophilia on blood smear, elevated acute phase reactants and D-dimer serum levels. Bone marrow examination showed a Fip1-like platelet-derived growth factor receptor alfa fusion gene mutation. The case was diagnosed as myeloproliferative variant hypereosinophilic syndrome. Contrast-enhanced computed tomography demonstrated thrombi not only in left ventricle but also in multiple segmental pulmonary arteries. Cardiac magnetic resonance imaging showed left ventricular apical thrombus without subendocardial fibrosis. Cardiopulmonary manifestations of hypereosinophilic syndrome completely resolved after treatment. (Echocardiography 2011;28:E180-E182)
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    Non-ischemic cardiomyopathy patient's characteristics, achievement of optimal medical treatment doses, and prognosis in age tertiles. Ege University cardiomyopathy observational research age substudy
    (Kare Publ, 2022) Demir, Emre; Jabiyev, Fuad; Candemir, Aytac; Candemir, Yesim; Zoghi, Mehdi; Gurgun, Cemil; Cinar, Cahide Soydas
    [No abstract available]
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    Perioperative assessment of elderly patient with cardiovascular disease
    (Turkish Soc Cardiology, 2017) Simsek, Evrim; Cinar, Cahide Soydas
    Elderly people who require surgery is increasing as a resul of increased life expectancy. Surgery is a major stress factor for all patients however older patients have limited reserve to handle this stress. In this review preoperative assessment of cardiovascular reserve in elderly population and major subjects to take attention in perioperative period were evaluated according to recent guidelines and literature.
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    Relationships between P wave dispersion, atrial electromechanical delay, left atrial remodeling, and NT-proBNP levels, in patients with hypertrophic cardiomyopathy
    (Via Medica, 2015) Tuluce, Kamil; Ozerkan, Filiz; Tuluce, Selcen Yakar; Yavuzgil, Oguz; Gurgun, Cemil; Bilgin, Murat; Eren, Nihan Kahya; Kocabas, Ugur; Nalbantgil, Sanem; Cinar, Cahide Soydas
    Background: We evaluated the associations among the well-known atrial fibrillation (AF) predictors including P-wave dispersion (PWD), intra- and inter-atrial electromechanical dyssynchrony (EMD), left atrial (LA) phasic functions, and plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels, in patients with hypertrophic cardiomyopathy (HCM). Methods: Seventy patients with HCM and age and sex matched 70 subjects were enrolled. PWD, LA total emptying fraction (LATEFr), active emptying fraction (LAAEFr), passive emptying fraction (LAPEFr), expansion index (LAEI) intra-and inter-atrial EMD were calculated. Levels of NT-proBNP of all subjects were determined. Results: Higher PWD (p = 0.006), significantly decreased LAEI (p < 0.001), LATEFr, and LAPEFr (both p values < 0.001) values and significantly increased inter-atrial (p < 0.001), LA (p = 0.001), and right atrial dyssynchrony (p < 0.001) were observed in the HCM group compared to controls. PWD was negatively correlated with LAEI (r = -0.236, p = 0.005) and LATEFr (r = -0.242, p = 0.04), however not with LAPEFr (p = 0.7), or LAAEFr (p = 0.3). Except for the LA lateral wall PA' (r = 0.283, p = 0.02), PWD was not correlated with any atrial EMD parameter. Inter-atrial dyssynchrony was related to LAEI (r = -0.272, p = 0.001), LATEFr (r = -0.256, p = 0.03), and LAPEFr (r = -0.332, p = 0.006), but not, however, to LAAEFr (p = 0.4). The plasma NT-proBNP levels of patients were not correlated with either PWD (p = 0.927) or inter-atrial dyssynchrony (p = 0.102). Conclusions: PWD and inter-atrial dysynchrony seem to independently promote AF, although both are associated with LA reservoir function in HCM populations. The NT-proBNP level is not associated with these two AF predictors in patients with HCM. NT-proBNP seems to be a poor marker of atrial electrical remodeling in HCM patients.
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    Right Ventricular Adaptations Along with Left Ventricular Remodeling in Older Athletes
    (Wiley, 2009) Ozdogan, Oner; Yilmaz, Gulsum Meral; Gurgun, Cemil; Kayikcioglu, Meral; Cinar, Cahide Soydas
    Background: Afterload changes and anatomic interaction between the ventricles cause right ventricle (RV) adaptation along with left ventricle (LV) remodeling. This study was designed to evaluate RV adaptations along with LV remodeling and to determine the effect of aging on both ventricles in a population of older athletes. Methods: Echocardiographic characteristics of 48 endurance trained older athletes were examined by tissue Doppler imaging (TDI) and integrated backscatter (IBS). Results: Mean LV mass index was calculated as 107.8 +/- 17.0 g/m(2). Twenty-two athletes were > 55 years old. Age was found to be a risk factor for diastolic dysfunction regarding lateral TDI velocities (E-m < A(m)) (r = 0.385, P < 0.001). RV long-axis (LAX) diameters were associated with LA volumes and LV masses (r = 0.380, P < 0.01 and r = 0.307, P < 0.05). RV LAX diameters were correlated with RV TDI E-wave (r = -0.285, P < 0.05), RV LAX average, and peak IBS values (r = 0.36, P < 0.05 and r = 0.348, P < 0.05). Conclusions: TDI and IBS are applicable methods to evaluate the relationship between the two ventricles in athletes' heart. Increased RV LAX IBS values indicate increased LV mass and LA volume as a result of RV changes along with LV remodeling. Our data suggest that RV TDI E-wave and average RV IBS values reflect cardiac adaptations of both RV and LV in older athletes. (ECHOCARDIOGRAPHY, Volume 26, March 2009)
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