Yazar "Can, C." seçeneğine göre listele

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    Characteristics of food allergy in children: National multicenter study
    (Wiley, 2019) Bingol, A.; Uygun, Kocacik D. F.; Akdemir, M.; Erengin, H.; Bozdogan, G.; Bingol, G.; Orhan, F.; Buyuktiryaki, B.; Sekerel, B.; Kilic, M.; Sackesen, C.; Akarcan, Eren S.; Demir, E.; Kose, S. S.; Asilsoy, S.; Kan, A.; Turktas, I; Arikoglu, T.; Kuyucu, S.; Sipahi, S.; Tamay, Z.; Nacaroglu, T.; Ozdemir, Gokmirza P.; Yazicioglu, M.; Cekic, S.; Sapan, N.; Zeyrek, D.; Dogruel, D.; Aydiner, Karakoc E.; Ozen, A. O.; Can, C.; Ertugrul, A.; Bostanci, I; Akcal, O.; Can, D.; Yilmaz, Arik E.; Anil, H.; Harmanci, K.; Kulhascelik, I; Civelek, E.; Cokugras, H.; Senol, Duman H.; Tuncel, T.; Altintas, Ufuk D.
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    Effects of urotensin receptor antagonist SB-657510 in diabetic erectile dysfunction in vitro
    (Springer, 2011) Olukman, M.; Coskunsever, D.; Celenk, F. G.; Can, C.; Ulker, S.
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    The "extreme" errors in inhaler device use: data from the INTEDA-1 study
    (Wiley-Blackwell, 2011) Caliskaner, Z.; Ozturk, C.; Pekcan, S.; Yilmaz, O.; Ozturk, S.; Ceylan, E.; Can, C.; Sener, O.; Turay, U.; Ersoy, R.
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    Genome wide association study of genes controlling resistance to Didymella rabiei Pathotype IV through genotyping by sequencing in chickpeas (Cicer arietinum)
    (Academic Press Inc., 2023) Şahin, E.S.; Talapov, T.; Ateş, D.; Can, C.; Tanyolaç, M.B.
    Ascochyta blight (AB) is a major disease in chickpeas (Cicer arietinum L.) that can cause a yield loss of up to 100%. Chickpea germplasm collections at the center of origin offer great potential to discover novel sources of resistance to pests and diseases. Herein, 189 Cicer arietinum samples were genotyped via genotyping by sequencing. This chickpea collection was phenotyped for resistance to an aggressive Turkish Didymella rabiei Pathotype IV isolate. Genome-wide association studies based on different models revealed 19 single nucleotide polymorphism (SNP) associations on chromosomes 1, 2, 3, 4, 7, and 8. Although eight of these SNPs have been previously reported, to the best of our knowledge, the remaining ten were associated with AB resistance for the first time. The regions identified in this study can be addressed in future studies to reveal the genetic mechanism underlying AB resistance and can also be utilized in chickpea breeding programs to improve AB resistance in new chickpea varieties. © 2023
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    Physicians' knowledge of and opinions about inhaler treatments in asthma and COPD: the INTEDA-1 study
    (Wiley-Blackwell, 2011) Caliskaner, Z.; Ozturk, C.; Pekcan, S.; Yilmaz, O.; Ozturk, S.; Ceylan, E.; Can, C.; Sener, O.; Turay, U.; Ersoy, R.
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    Posttransplantation Therapeutic Rapamycin Concentration Protects Nitric Oxide-Related Vascular Endothelial Function: Comparative Effects in Rat Thoracic Aorta and Coronary Endothelial Cell Culture
    (Elsevier Science Inc, 2010) Parlar, A.; Can, C.; Erol, A.; Ulker, S.
    Objective. To investigate the potential effects of therapeutic dosages of the immunosuppression agent rapamycin on endothelial function with regard to nitric oxide (NO) synthesis in rat thoracic aorta in vivo and rat coronary endothelial cells in vitro. Materials and Methods. Male Wistar rats were injected with rapamycin, 1.5 mg/kg/d intraperitoneally for 14 days. After the rats were sacrificed, the thoracic aortas were suspended in organ chambers and evaluated for endothelium-dependent and endothelium-independent vascular responses. Results. Rapamycin administration resulted in increased relaxant responses to L-arginine and to greater concentrations of the calcium ionophore (A23187) in the aortas. However, potassium chloride, acetylcholine, sodium nitroprusside, and N-G-nitro-L-arginine methyl ester responses remained unchanged. In addition, phenylephrine-induced contractions were significantly decreased in the aortas regardless of the presence of functional endothelium. In a series of in vitro experiments, isolated rat coronary endothelial cells were incubated with therapeutic concentrations of rapamycin (10 nmol/L). Nitrite accumulation in the supernatants revealed that rapamycin decreased nitrite release induced by interleukin-1 beta but did not affect basal or A23187-stimulated nitrite levels. Western blot analysis demonstrated that rapamycin decreased inducible NO synthase protein expression in coronary endothelial cells. Conclusion. Posttransplantation therapeutic concentrations of rapamycin not only preserve vascular endothelial function mediated by NO synthesis but possibly interact in vivo with adrenergic receptors in favor of vasodilatory mechanisms.
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    Vascular Endothelial Dysfunction in Cyclosporine-Treated Rat Aortas Is Not Associated With Serum Total Homocysteine Levels
    (Elsevier Science Inc, 2008) Can, C.; Erol, A.; Olukrnan, M.; Cinar, M. G.; Ulker, S.
    Objectives. Elevation of serum total homocysteine (tHcy) is considered to contribute to endothelial cell dysfunction, which is considered to be the initial event in posttransplant vascular disease. We sought to investigate whether an association existed between serum tHcy levels and vascular endothelial function during cyclosporine (CsA) treatment. Materials and Methods. Endothelium-dependent and -independent relaxation responses (to acetylcholine [ACh] and sodium nitroprusside [SNP]) were determined on thoracic aortae from CsA-treated rats (5 mg kg/d, subcutaneously, for 14 days). A correlation analysis was performed between ACh responses and tHcy levels. Results. CsA decreased the responses to ACh and the pD(2) values of the concentration-response curves compared with controls (P < .05). Responses to SNP and serum tHcy levels were unchanged among the groups. tHcy negatively correlated with the ACh pD2 values among control (r = -0.69; P < .05) and vehicle (r = -0.73; P < .05) groups, indicating that the increase in tHcy was associated with decreased sensitivity to ACh. In CsA-treated rats, no association was observed between these parameters. Also, no correlation was noted between CsA concentrations and tHcy levels. Conclusion. These data suggested a possible link between serum tHcy and decreased vascular sensitivity to endothelium-dependent vasorelaxation in control aortae, but CsA-induced vascular endothelial dysfunction was not associated with an effect of the drug on homocysteine metabolism.