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    Anxiety disorder and eating habits in adolescents with gastroesophageal reflux disease
    (Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2018) Ozbeyler, Omer; Eliacik, Kayi; Uzum, Ozlem; Kanik, Ali; Cagan Appak, Yeliz; Karakoyun, Miray; Orbatu, Dilek; Engin Ozyurt, Gonca; Bolat, Nurullah; Baran, Masallah
    Objective: It was aimed to evaluate the relationship between eating habits and reflux by investigating eating habits in adolescent patients with gastroesophageal reflux disease, and also to assess the interplay between gastroesophageal reflux disease and anxiety. Methods: We included patients between the ages of 12 and 18 diagnosed as gastroesophageal reflux disease in the pediatric gastroenterology outpatient clinic but who had not yet been treated. The control group consisted of age matched adolescents who applied for upper respiratory tract infection. The relationship between eating habits and reflux was assessed with Adolescent Nutrition Checklist, and relationship between gastroesophageal reflux disease and anxiety was assessed with Anxiety Disorder Screening Questionnaire. Results: Seventy adolescents with reflux disease and 67 adolescents as the control group were included in the study. There was no significant difference between the groups regarding the eating habits and anxiety scores. However, it was seen that most of the patients in both groups. had poor eating habits and higher general anxiety score. Conclusion: No relation was found between the gastroesophageal reflux disease, anxiety and eating habits in adolescents. These results suggested that reflux disease should be separated from other gastrointestinal complaints such as abdominal pain which may be psychosomatic. However, there was a quantitative increment in poor eating habits in those with gastroesophageal reflux disease. For this reason there is a need for further studies which investigate the eating habits with a larger sample size of this population.
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    The Role of Familial Mediterranean Fever Gene Mutation in Treatment of Infantile Colitis With Resistant Perianal Fistula
    (Turkish League Against Rheumatism, 2018) Baran, Masallah; Cagan Appak, Yeliz; Garipcin, Pinar; Demircelik, Yavuz; Pala, Emel Ebru; Ozyilmaz, Berk; Karakoyun, Miray; Ergun, Orkan
    Symptoms of infantile inflammatory bowel disease (I-IBD) can be life-threatening and associated with poor prognosis. The presence of Mediterranean fever (MEFV) gene mutations play an important role in treatment of I-IBD. In this article, we describe a case of I-IBD with a resistant fistula, in which remission occurred following colchicine therapy. The patient was a six-month-girl with complaints of bloody diarrhea and a perianal abscess of three months duration. Laboratory tests revealed elevated inflammatory parameters, hypoalbuminemia, and anemia. Results of repeated viral, bacterial and parasitic analyses were negative. Endoscopic and histopathological examinations confirmed a diagnosis of I-IBD. Although diarrhea episodes decreased following intensive conventional treatment with immunosuppressive therapy and anti-tumor necrosis factor, the perianal abscess and fistula did not resolve. Molecular genetic analysis to identify causes of infantile disease revealed the MEFV gene mutation. Thus, colchicine was added to the treatment regimen. Following treatment with colchicine, defecation returned to normal, and the fistula resolved. The MEFV gene mutation should be investigated in children with infantile colitis and resistant fistulas, particularly in Mediterranean countries. In patients with infantile colitis who have the MEFV gene mutation, colchicine treatment may be an alternative to intensive immunosuppressive therapy.