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    Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
    (Mdpi, 2019) Bellikci-Koyu, Ezgi; Sarer-Yurekli, Banu Pinar; Akyon, Yakut; Aydin-Kose, Fadime; Karagozlu, Cem; Ozgen, Ahmet Gokhan; Buyuktuncer, Zehra
    Several health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. in a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-alpha, IFN-gamma, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p <= 0.05, for each). However, no significant difference was obtained between the kefir and unfermented milk groups (p > 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition.
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    Use of herbal products for weight loss in Turkey
    (Mattioli 1885, 2020) Bellikci-Koyu, Ezgi; Sarer-Yurekli, Banu Pinar; Seckiner, Selda; Ozdemir, Nilufer; Buyuktuncer, Zehra
    Obesity treatment is a long-term challenge that requires a constant change in lifestyle and behaviors. Therefore, patients are usually interested in methods promising rapid weight loss. in this study, we aimed to determine the frequency of herbal product use by overweight and obese individuals for weight management. A cross-sectional study was conducted on 464 individuals admitted to an endocrinology clinic in a hospital in Turkey. Socio-demographic status, medical history, and information about herbal product usage were recorded by researchers using a data collection form. The percentage of participants using herbal products for weight loss, was determined as 24.1% (n:112). Herbal product users were younger and had higher body mass index compared to non-users (p<0.01, for each). Gender and marital status were also related to herbal product use, and it was higher in women and singles (p<0.05, for each). The most preferred products were mixed herbal teas (50.9%), green tea, parsley, and cinnamon. Herbalists (56.3%) and local markets (24.1%) were the most popular places to buy herbal products. A large proportion of patients (88.4%) did not inform health professionals about their herbal usage. Using herbal products for weight management is common among overweight and obese individuals in Turkey. Therefore, it may be suggested that health professionals should monitor the use of these products and patient-physician communication about herbal medicine should be strengthened.