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    Clinical value of metabolic PET parameters of primary vulvar carcinoma
    (Elsevier Espana Slu, 2021) Yanarates, A.; Budak, E.; Budak, A.; Inan, A. Hamdi; Kanmaz, A. Goksel; Oral, A.; Yazici, B.
    Purpose: We aim to establish the prognostic value of metabolic parameters of the primary tumor in patients diagnosed with vulvar squamous cell carcinoma (VSCC) who underwent a pretreatment F-18 FDG PET/CT scan. Materials and methods: This retrospective study included 47 patients with a his topathologically confirmed diagnosis of VSCC, and who underwent a F-18 FDG PET/CT scan prior to treatment. The disease stage and age at diagnosis, the maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (WV) and total lesion glycolysis (TLG) values of the primary tumor, based on a baseline PET scan, were recorded. The relationship between these factors, and progression-free survival (PFS) and overall survival (OS) was evaluated. Results: The mean age of the 47 study patients was 69.6 +/- 1.9 years. Among the patients, 18 were in early stage of the disease and 29 were in the advanced stage. The age, and SUVmax, SUVmean, MTV and TLG values were statistically significantly associated with OS and PFS. Furthermore, it was noted that OS and PFS were significantly longer in the early stage patients than in the advanced stage patients, in patients with a tumor size >= 4 cm than those with a tumor size 4 cm, and in patients with a negative lymph node metastasis than those with a positive lymph node metastasis. Conclusion: Our findings suggest that PET parameters are prognostic factors for VSCC. To the best of our knowledge, this study is the first to investigate the prognostic value of the PET parameters of primary tumors in patients with VSCC, and as such, we believe it contributes to literature. (C) 2020 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved.
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    The prognostic role of PET/CT in small-cell lung cancer
    (Elsevier Espana Slu, 2020) Budak, E.; Yanarates, A.; Akgun, A.
    Objective: the aim in the present study is to determine the prognostic value of metabolic parameters related to the primary tumors detected in pretreatment Fluorine-18 2-fluoro-2-Deoxy-D-glucose (F-18 FDG) positron emission tomography/computerized tomography (PET/CT) scans of patients diagnosed with small-cell lung cancer (SCLC). Material and Methods: Enrolled in this retrospective study were 63 patients with a histopathologically confirmed diagnosis of SCLC who underwent an( 15)F FDG PET/CT scan at baseline. Disease stage, age at diagnosis, gender, albumin level and maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values related to the primary tumor at the baseline PET scan were recorded, and the relationship of these factors with progression-free survival (PFS) and overall survival (OS) was evaluated. Results: the study included a total of 63 patients (10 female, 53 male, mean age of 64.8 and age range of 43-82 years), 22 of which had limited disease ( ID) and 41 had extensive disease (ED). the OS and PFS were significantly higher in patients with LD than in patients with ED (15 +/- 2.9 vs. 10 +/- 0.9 months, p = 0.002 for OS; 10 +/- 0.7 vs 6 +/- 0.6 months, p = 0.014 for PFS). However, no statistically significant relationship was identified between gender, albumin level, age and SUVmax, SUVmean, MTV, TLG values related to the primary tumor and PFS or OS. Conclusion: the present study found that pretreatment PET parameters were of not predictive value for PFS and OS in patients with SCLC. (C) 2019 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved.