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Öğe Assessment of cases with intracranial hydatid cyst: A 23-year experience [İntrakranial hidatik kist olgulari{dotless}ni{dotless}n degerlendirilmesi: 23 yi{dotless}lli{dotless}k deneyim](Ege University Press, 2014) Turan Y.; Yilmaz T.; Göçmez C.; Kamaşak K.; Kemaloglu S.; Tekin R.; Hattapoglu S.; Bozkaya H.; Çalişkan A.; Ceviz A.Objective: Brain is involved in 1-2% of hydatid cyst infections. A cranial location is rare. In this study, we aimed to assess clinical findings, radiological investigations, and treatment modalities of cases with intracranial hydatid cyst. Materials and Method: The present study included 26 patients operated for cerebral hydatid cyst disease between January 1990 and October 2012. Results: Seventeen patients were male and 9 were female. The mean age of the study population was 20.3 years (range 7-50 years). Headache and nausea were the most common clinical symptoms. The lesions were demonstrated by computed tomography (CT) and magnetic resonance imaging (MRI) as large, smooth, thin walled, spherical-shaped, cystic homogenous lesions with the same density as cerebro spinal fluid, which showed no edema or contrast uptake. Two patients were complicated or infected cysts with perifocal edema and contrast uptake. In 20 patients, the cysts were removed completely with Dowlings technique, by rectifying cysts without rupturing. Eleven patients with ruptured cysts during operation, recurrent or systemic hydatid cyst were treated medically. Conclusion: Medical therapy appears effective in hydatid cyst disease. Cerebral hydatid cysts should be excised totally without rupturing them. Preoperative imaging techniques are central to surgical planning. Intracranial hydatid cyst should be remembered when CT or MRI shows a cystic lesion, especially in countries where hydatid cyst is endemic.Öğe Brain infarction in a young patient with Buerger’s disease -- A case of cerebral thromboangiitis obliterans(ASEAN Neurological Association, 2016) Aydın E.; Çınar C.; Bozkaya H.; Oran İ.[No abstract available]Öğe Does endovascular repair affect aortic remodeling in acute complicated type B aortic dissection?(Baycinar Medical Publishing, 2015) Ertugay S.; Bozkaya H.; Çinar C.; Parildar M.; Posacioğlu H.Background: This study aims to analyze the volume changes of true and false lumens at a late stage in patients undergoing thoracic endovascular aortic repair (TEVAR) due to acute complicated type B aortic dissection. Methods: B etween M arch 2 006 a nd N ovember 2 012, 1 8 consecutive patients (14 males, 4 females; mean age was 61.9±11 years; range 39 to 77 years) who underwent TEVAR for acute complicated type B aortic dissection in our clinic were included in this study. Computed tomography scans obtained at the final visit were used for the volume analysis of true and false lumens. The median follow-up was 35.3 (range, 12 to 84) months. Indications for intervention were rupture or malperfusion in 17 patients (both in some patients) and persistent chest pain in one patient. The stent-graft part of the descending thoracic aorta (DTA) was defined as Segment 1, DTA without stent-graft (supraceliac) as Segment 2, and the abdominal aorta as Segment 3. Results: In segment 1, the mean volume of true lumen increased from 74.4±49 mL to 110±50 mL (p=0.0145), while the mean volume of false lumen decreased from 124.2±81 mL to 59.5±59 mL (p<0.00001). In segment 2, the mean volume of true lumen increased from 23.1±28 mL to 40.5±33 mL (p=0.0015), while the mean volume of false lumen decreased from 32.8±29 mL to 29±1 mL (p=0.624). In segment 3, the mean volume of true lumen increased from 46.5±63 mL to 57.3±74 mL (p=0.0388), the mean volume of false lumen decreased from 41.8±30 mL to 37.6±32 mL (p=0.5195). True and false lumens volume changes were statistically significant except volume decrease in segment 3. Conclusion: Endovascular repair of type B aortic dissection may positively affect aortic remodeling in chronic settings and may prevent possible aorta-related complications during longterm follow-up.Öğe Endovascular management of vascular injury during transsphenoidal surgery(Edizioni del Centauro, 2013) Çinar C.; Bozkaya H.; Parildar M.; Oran I.Vascular injury is an unusual and serious complication of transsphenoidal surgery. We aimed to define the role of angiography and endovascular treatment in patients with vascular injuries occurring during transsphenoidal surgery. During the last ten-year period, we retrospectively evaluated nine patients with vascular injury after transsphenoidal surgery. Eight patients were symptomatic due to vascular injury, while one had only suspicion of vascular injury during surgery. Four patients presented with epistaxis, two with subarachnoid hemorrhage, one with exophthalmos, and one with hemiparesia. Emergency angiography revealed a pseudoaneurysm in four patients, contrast extravasation in two, vessel dissection in one, vessel wall irregularity in one, and arteriovenous fistula in one. All patients but one were treated successfully with parent artery occlusion, with one covered stent implantation, one stent-assisted coiling method, while one patient was managed conservatively. One patient died due to complications related to the primary insult without rebleeding. Vascular injuries suspected intra or postoperatively must be investigated rapidly after transsphenoidal surgery. Endovascular treatment with parent artery occlusion is feasible with acceptable morbidity and mortality rates in the treatment of vascular injuries occurring in transsphenoidal surgery.Öğe Endovascular repair and adjunctive immunosuppressive therapy of aortic involvement in behçet's disease(W.B. Saunders Ltd, 2015) Balcioglu O.; Ertugay S.; Bozkaya H.; Parildar M.; Posacioglu H.Objectives Aortic aneurysm is a serious problem in Behçet's disease, but open surgical therapy carries the risk of recurrent pseudoaneurysm. Here the outcomes of endovascular repair and adjunctive immunosuppressive therapy for aortic disease in Behçet's disease are presented. Materials This was a retrospective study. Between 2002 and 2012, nine patients with Behçet's disease (8 male, median age 41 years, range 33-60 years) were treated by endovascular stent grafting for abdominal or thoraco-abdominal aortic pseudoaneurysm. Methods Computed tomography angiography revealed infrarenal pseudoaneurysm in six (66.6%) patients and suprarenal pseudoaneurysm in three (33.3%). Patients received immunosuppressive therapy with oral prednisolone (60 mg/day) and cyclophosphamide (200 mg/day) for 2 weeks or more before the procedure, and intravenous hydrocortisone (200 mg/day) combined with cyclophosphamide (200 mg/day) for 3 days after the procedure. Thereafter, oral immunosuppressive therapy was continued for 2 years. Results A straight tube graft was implanted in seven patients and a bifurcated graft in two patients. Two stage procedures (debranching before endovascular therapy) were performed in three patients for thoraco-abdominal aortic pseudoaneurysms. Stent grafting was successful in all patients, without any peri-operative complications. However, two patients needed abdominal exploration later: one for seroma around the graft and the other for a fistula between the duodenum and the graft. No recurrence of aneurysm was observed during a mean follow up of 40 ± 16 months. One patient died in the 15th month from a non-vascular cause. Conclusions Endovascular stent graft implantation and adjunctive immunosuppressive therapy seems to be safe and effective in the treatment of aortic involvement in Behçet's disease, but this approach needs further evaluation. © 2015 European Society for Vascular Surgery.Öğe Endovascular treatment of acute type B dissection complicating graft-bypass repair for aortic coarctation(Elsevier Ltd, 2015) Ertugay S.; Posacioglu H.; Parildar M.; Bozkaya H.Objectives The early dissection of the descending aorta after the repair of aortic coarctation is very rare. Herein, we present a special endovascular technique used for acute type B dissection complicating graft bypass for aortic coarctation. Methods The 48 year-old male patient with the diagnosis of adult type aortic coarctation had bypass procedure between the aortic arch and the descending aorta. Six weeks after the first operation, the patient was readmitted with severe back pain and had the diagnosis of acute type B dissection which involved the descending aorta at the distal part of the graft anastomosis. Results Two separate stent-grafts were deployed respectively 31 × 150 mm and 34 × 200 mm (C-TAG™ WL Gore&Asc., Flagstaff, AZ, USA). The previous Dacron bypass graft was used as a proximal landing zone for the first stent-graft. The distal landing zone for the second stent was the area between the celiac trunk and superior mesenteric artery. Therefore, the covered stent-graft was implanted to the celiac trunk (Viabahn™ 7 × 50 mm WL Gore&Asc, AZ, USA) to maintain its patency before the deployment of the second graft. The segment of coarctation was closed with a vascular plug (Amplatzer™ vascular plug II) to prevent persistent perfusion of aneurysmal false lumen. Conclusion The endovascular approach offers multiple less invasive options based on a patient-specific problem. © 2015 The Authors. Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.Öğe Evaluation of treatment response of chemoembolization in hepatocellular carcinoma with diffusion-weighted imaging on 3.0-T MR imaging(2012) Sahin H.; Harman M.; Cinar C.; Bozkaya H.; Parildar M.; Elmas N.Purpose: To assess the treatment response of hepatocellular carcinoma (HCC) after transarterial chemoembolization with diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance (MR) imaging with a 3-T system. Materials and Methods: Between February 2010 and November 2010, 74 patients were treated with chemoembolization in our interventional radiology unit. Twenty-two patients (29%) who had liver MR imaging including diffusion and dynamic contrast-enhanced MR imaging on a 3-T system before and after transarterial chemoembolization were evaluated retrospectively. Tumor size, arterial enhancement, venous washout, and apparent diffusion coefficient (ADC) values of lesions, peritumoral parenchyma, normal liver parenchyma, and spleen were recorded before and after treatment. The significance of differences between ADC values of responding and nonresponding lesions was calculated. Results: The study included 77 HCC lesions (mean diameter, 31.4 mm) in 20 patients. There was no significant reduction in mean tumor diameter after treatment. Reduction in tumor enhancement in the arterial phase was statistically significant (P =.01). Tumor ADC value increased from 1.10 × 10 -3 mm 2/s to 1.27 × 10 -3 mm 2/s after treatment (P <.01), whereas the ADC values for liver and spleen remained unchanged. ADC values from cellular parts of the tumor and necrotic areas also increased after treatment. However, pretreatment ADC values were not reliable to identify responding lesions according to the results of receiver operating characteristic analysis. Conclusions: After transarterial chemoembolization, responding HCC lesions exhibited decreases in arterial enhancement and increases in ADC values in cellular and necrotic areas. Pretreatment ADC values were not predictive of response to chemoembolization. © 2012 SIR.Öğe Imaging findings and endovascular management of iatrogenic hepatic arterial injuries(AVES Ibrahim Kara, 2015) Güneyli S.; Gök M.; Çınar C.; Bozkaya H.; Korkmaz M.; Parıldar M.; Oran İ.Iatrogenic hepatic arterial injuries (IHAIs) include pseudoaneurysm, extravasation, arteriovenous fistula, arteriobiliary fistula, and dissection. IHAIs are usually demonstrated following percutaneous transhepatic biliary drainage, percutaneous liver biopsy, liver surgery, chemoembolization, radioembolization, and endoscopic retrograde cholangiopancreatography. The latency period between the intervention and diagnosis varies. The most common symptom is hemorrhage, and the most common lesion is pseudoaneurysm. Computed tomography angiography (CTA) is mostly performed prior to angiography, and IHAIs are demonstrated on CTA in most of the patients. Patients with IHAI are mostly treated by coils, but some patients may be treated by liquid embolic materials or stent-grafts. CTA can also be used in the follow-up period. Endovascular treatment is a safe and minimally invasive treatment option with high success rates. © Turkish Society of Radiology 2015.Öğe Interferon-?2b induction treatment with or without ribavirin in chronic hepatitis C: A multicenter, randomized, controlled trial(2003) Senturk H.; Ersoz G.; Ozaras R.; Kaymakoglu S.; Bozkaya H.; Akdogan M.; Mert A.; Bozdayi M.; Tabak F.; Yenice N.; Ozbay G.We aimed to compare the efficacy of interferon-?2b (IFN) induction treatment in combination with ribavirin to IFN induction alone in chronic hepatitis C. In total, 125 patients (66 male, 59 female, mean age: 48 ± 9, range: 21-70) were enrolled and randomized into two arms: In the first, patients received 5 MU/day of IFN for 4 weeks followed by 3 MU/day for the next 4 weeks. Treatment was continued with 3 MU three times a week IFN for an additional 40 weeks. Ribavirin was administered 1000-1200 mg/day according to the body weight for the entire 48-week period. In the second arm, patients received placebo in addition to IFN. Fifty-nine patients were placed in the ribavirin arm and 66 in placebo arm. All patients were genotype 1. At week 48, 24/66 (36%) from the placebo and 31/59 (52%) from the ribavirin group responded (P > 0.05). However, during the 24-week untreated follow-up period, 13/24 (54%) from the placebo, and 8/31 (26%) from the ribavirin group relapsed (P = 0.002.), resulting in a sustained virologic response (SVR) rate of 17% in the placebo and 39% in the ribavirin group (P = 0.005.) In conclusion, IFN induction treatment in combination with ribavirin is superior to IFN induction treatment alone in genotype 1 patients, and the SVR rate of 39% is encouraging.Öğe Is postrenal acute renal failure possible in the absence of hydronephrosis?(Turkish Society of Nephrology, 2014) Yaprak M.; Turan M.N.; Tamer A.F.; Tatar E.; Garip A.; Ismayilov F.; Bozkaya H.; Özyurt C.; Seziş Demirci M.Acute renal failure (ARF) is a clinical situation that renal functions deteriorate suddenly within hours to days. Postrenal causes are responsible for a small part of ARF. In this article, we presented a case gone to left nephrectomy priorly, with a right ureter stone led to complete obstruction, ARF, and treated by ureterorenoscopy (URS). A seventy year old male patient was sent to Emergency Department because of anuria for 48 hours. In ultrasonographic exam; there wasn't hydronephrosis of right kidney. A right lower ureter stone was seen in the non-contrast spiral abdominal computed tomography. The lower ureter stone was removed by URS and JJ catheter was replaced. He was discharged with normal renal function tests. In conclusion, postrenal ARF must be ruled out in patients with acute anuria, especially zero urine, even if hydronephrosis delinea. If postrenal ARF is diagnosed and treated quickly, the outcomes will be excellent.Öğe Liver abscess following radioembolization with yttrium-90 microspheres [Leberabszess nach Radioembolisation mit Yttrium-90 Mikrosphären](Springer-Verlag Wien, 2014) Korkmaz M.; Bozkaya H.; Çinar C.; Sanal B.; Güneyli S.; Parildar M.; Oran I.Radioembolization with yttrium-90 microspheres is an accepted and useful intervention model with minimal invasion in both primary and secondary liver malignancies. Radioembolization may lead to some complications. Liver abscess is a rare complication that can occur several weeks after radioembolization treatment of liver tumor with yttrium-90 microspheres. There are only a few case reports on hepatic liver abscess observed in early term of radioembolization treatment, and our case also constitutes a rare report that may contribute to the possible future improvements in radioembolization field to get more insight into the current understanding of the formation of some deleterious insults such as hepatic abscess. © Springer-Verlag Wien 2014.Öğe Minimally invasive treatment of giant haemangiomas of the liver: Embolisation with bleomycin(2014) Bozkaya H.; Cinar C.; Besir F.H.; Parildar M.; Oran I.Purpose: The management of patients with giant haemangioma of the liver remains controversial. Although the usual treatment method for symptomatic giant haemangioma is surgery, the classical paradigm of operative resection remains. In this study, we evaluated the symptomatic improvement and size-reduction effect of embolisation with bleomycin mixed with lipiodol for the treatment of symptomatic giant hepatic haemangioma. Methods: This study included 26 patients [21 female, five male; age 41-65 years (mean 49.83 ± 1.53)] with symptomatic giant haemangioma unfit for surgery and treated with selective embolisation by bleomycin mixed with lipiodol. The patients were followed-up (mean 7.4 ± 0.81 months) clinically and using imaging methods. Statistical analysis was performed using SPSS version 16.0, and p < 0.05 was considered to indicate statistical significance. Results: Embolisation of 32 lesions in 26 patients was performed. The mean volume of the haemangiomas was 446.28 ± 88 cm3 (range 3.39-1559 cm3) before intervention and 244.43 ± 54.38 cm3 (range 94-967 cm 3) after intervention. No mortality or morbidity related to the treatment was identified. Symptomatic improvement was observed in all patients, and significant volume reduction was achieved (p = 0.001). Conclusion: The morbidity of surgical treatment in patients with giant liver hemangioma were similar to those obtained in patients followed-up without treatment. Therefore, follow-up without treatment is preferred in most patients. Thus, minimally invasive embolisation is an alternative and effective treatment for giant symptomatic haemangioma of the liver. © 2013 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).Öğe The rapid pull-back technique for navigation across a wide-necked aneurysm: A report of four cases(Edizioni del Centauro, 2013) Oran I.; Çinar C.; Bozkaya H.; Beşir F.H.Embolization of wide-necked and/or giant aneurysms may fail due to the inability to pass across the aneurysm neck. We describe the rapid bull-back technique used in four patients in which a small diameter microcatheter with the aid of a hydrophilic microguidewire was navigated along the inner surface of the aneurysm, making a loop in the dome, exiting the neck to reach distal intracranial vessels. After withdrawal of microguidewire, the microcatheter is pulled back rapidly up to a predetermined length. This maneuver results in elimination of the loop, straightening the microcatheter to allow an exchange procedure for another device to cross the neck distally and continue the embolization procedure. The rapid pull-back technique is useful during the endovascular treatment of wide-necked and/or giant aneurysms as it helps to achieve reliable access to the distal parent vessel with the microcatheter. This is of increasing importance since an increasing number of aneurysms will be treated in the future with refinements in various intracranial stents.Öğe A rare cause of obstructive jaundice: Superior mesenteric artery pseudoaneurysm(2012) Cinar C.; Bozkaya H.; Parildar M.; Oran I.Visceral arterial aneurysm and pseudoaneurysm are uncommon forms of vascular disease that have a significant potential for rupture or erosion into an adjacent viscera, resulting in life-threatening hemorrhage. Pseudoaneurysms related to the superior mesenteric artery are a recognized complication of trauma to the vessel, and successful treatment with stenting has been previously described. Percutaneous techniques offer an alternative form of therapy, and the number of reported cases treated with embolization has been rising steadily. We present the case of a 26-year-old patient with a large pseudoaneurysm of the superior mesenteric artery complicated with obstructive jaundice. © The Author(s) 2013.Öğe Successful transcatheter closure of a congenital high-flow portosystemic venous shunt with the amplatzer vascular plug II(2012) Guneyli S.; Cinar C.; Bozkaya H.; Parildar M.; Oran I.; Akin Y.Congenital portosystemic venous shunt is extremely rare and should be treated. Advances in treatment techniques allow for patients to be treated safely. We present a 9-year-old boy with a large congenital portosystemic venous shunt. The shunt was occluded interventionally with the Amplatzer vascular plug II. Our case was unique with its clinical manifestation, the use of a 22-mm Amplatzer vascular plug II, and the presence of the patient's 1-year follow-up. © The Author(s) 2013.Öğe Symptomatic Spinal Migration of Subarachnoid Hemorrhage due to Ruptured Intradural Vertebral Artery Aneurysm(Blackwell Publishing Inc., 2015) Ovali G.Y.; Adam G.; Çinar C.; Bozkaya H.; Çalli C.; Kitiş Ö.; Oran I.A 55-year-old patient was admitted to the hospital with severe acute back pain. Thoracolumbar magnetic resonance (MR) imaging showed hemorrhage in subarachnoidal-subdural space. On cranial MR imaging and MR angiography, an aneurysm was suspected in the V4 segment of the right vertebral artery. Angiography showed a fusiform dissecting aneurysm in the V4 segment of right vertebral artery. The final diagnosis was ruptured V4 segment aneurysm with subsequent symptomatic migration of hemorrhage into the spinal subarachnoidal-subdural space. The patient was treated endovascularly by coil occlusion of both the aneurysm and vertebral artery. This rare cause and possible mechanisms for spinal migration of intracranial hemorrhage after aneurysmal rupture is discussed. © 2014 by the American Society of Neuroimaging.Öğe Two different treatment options for intramuscular plantar hemangioma: Surgery versus percutaneous sclerotherapy(Academic Press Inc., 2014) Uslu M.; Beşir H.; Turan H.; Bozkaya H.; Erdem H.Intramuscular hemangiomas are benign neoplasms usually seen in children and adolescents. They tend to occur in the deep fascia and muscle and more often in the lower extremity, although they are rarely encountered in the plantar musculature. Surgical excision, ultrasound- or fluoroscopic-guided percutaneous sclerotherapy, and angiographic embolization are all treatment options. Surgical excision is the most prevalent form of therapy, although this can be difficult in the hands and feet. For this reason, ultrasound- and fluoroscopic-guided percutaneous sclerotherapy is a useful treatment option for pedal intramuscular hemangioma. In the present report, we describe 2 cases of intramuscular hemangioma in children, 1 treated by excision and 1 by percutaneous sclerosis. © 2014 American College of Foot and Ankle Surgeons.Öğe Unusual treatment of Kasabach–Merritt syndrome secondary to hepatic hemangioma: embolization with bleomycin [Ungewöhnliche Behandlung eines Kasabach-Meritt Syndroms als Folge eines Hämangioms der Leber: Embolisation mit Bleomycin](Springer-Verlag Wien, 2015) Bozkaya H.; Cinar C.; Ünalp Ö.V.; Parildar M.; Oran I.Kasabach–Merritt syndrome (KMS) is a rare complication of cavernous hemangiomas characterized with anemia, thrombocytopenia, and consumption coagulopathy. This syndrome usually develops due to superficial soft tissue hemangiomas in infancy and childhood. KMS developing secondarily to hepatic hemangioma is very rare. In this report, we aimed to present the treatment of KMS developing secondarily to giant cavernous hemangioma of the liver with transarterial chemoembolization using bleomycin © 2014, Springer-Verlag Wien.