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Öğe Ayrık Omurilik Malformasyonu(2021) Bolat, ElifAyrık omurilik malformasyonu, orta hat boyunca spinal kordu simetrik veya simetrik olmayan iki kısma ayıran bir yapıyla karakterize,nadir görülen bir konjenital anomalidir. İki tipi mevcuttur. Tip1 ayrık omurilik malformasyonunda her iki hemikord kemik veya kartilajseptumla ayrılmakta ve iki ayrı dural kılıf bulunmaktayken Tip2 ayrık omurilik malformasyonunda her iki hemikord fibröz bir septumlaayrılmıştır ve tek bir dural kılıf mevcuttur. Ayrık omurilik belirti ve bulguları nonspesifiktir ve genellikle eşlik eden diğer anomalilerleilişkilidir. Büyüme ve boy uzamasıyla birlikte ortaya çıkabilecek gergin omurilik sendromundan hastayı korumak için her iki tipindede cerrahi tedavi gereklidir. Özellikle Tip1 ayrık omurilik malformasyonu tedavi edilmezse nörolojik tabloda progresif kötüleşmegörülebilir.Öğe Brain Abscess in Children: A Rare but Serious Infection(Sage Publications Inc, 2018) Bal, Zumrut Sahbudak; Eraslan, Cenk; Bolat, Elif; Avcu, Gulhadiye; Kultursay, Nilgun; Özkınay, Ferda; Kurugol, Zafer; Vardar, FadilBrain abscess is a rare disease in childhood requiring prompt medical and/or surgical treatment. The objective was to review presentation, management, and outcome of brain abscess in children. We reviewed the clinical and radiological features and outcomes of 18 children (10 females, 8 males), with a median age of 48 months (range 1-182), that presented with brain abscesses and admitted to a tertiary pediatric infectious department between December 2010 and January 2017. One (5.5%) patient underwent craniotomy and 14 (77.7%) had burr hole aspirations. The most common localization was the frontal lobe (33.3%). The survival rate was 94.4%, and long-term neurological sequelae affected 27.7% of the patients. Empiric treatment choices require knowledge of common pathogens and local resistance. The most predominant infections were still upper respiratory infections. Clinicians may treat the children with appropriate choice and duration of antibiotic treatment for upper respiratory tract infections.Öğe Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model(Elsevier Sci Ltd, 2020) Mermer, Sinan; Turhan, Tuncer; Bolat, Elif; Aydemir, Sohret; Yamazhan, Tansu; Pullukcu, Husnu; Sipahi, Oguz ResatObjectives: the aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. Methods: the antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24 h and 73 h after the first antibiotic dose. Furthermore, in vitro time-kill data were investigated at 0, 2, 4, 6, 8, 12 and 24 h in sterile human serum. Results: the difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24 h and 73 h after the first antibiotic dose (P < 0.05). At the end of the experiment, there was a significant difference in survival between both the ceftaroline-treated group and the vancomycin-treated group versus the control group, but not between the two treatment groups. Conclusion: These results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model. (C) 2020 the Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.Öğe Çocukluk Çağı Olgularda Spinal Deformitelere Yaklaşım: Erişkin Olgulardan Farklılıklar(2023) Bolat, Elif; Turhan, TuncerPediatrik omurgada, konjenital, gelişimsel veya kazanılmış olmak üzere çeşitli patolojiler görülebilmektedir. Pediatrik omurga patolojileri erişkin patolojilerinden belirgin farklılıklar göstermekle birlikte bunların tedavileri de özellik arz eder. Pediatrik yaş grubunda küçük anatomi ve büyümeye devam eden omurga varlığı, pediatrik yaş grubuna özel enstrümanların yetersizliği, erişkin cerrahi tekniklerin çocuklara uygulanamaması gibi faktörler, pediatrik omurga patolojilerinde cerrahi tedaviyi zorlaştırmaktadır. Gelişimini tamamlamamış omurganın füzyonuna neden olmak, büyüme geriliğinin ötesinde çok daha önemli problemlere yol açmaktadır. Çocuklarda omurga cerrahisinin geleceği, büyümeye izin veren ve hareketi koruyan füzyonsuz tekniklerinin geliştirilmesine bağlıdır. Yeni teknolojilerle geliştirilecek olan spinal enstrümantasyon teknikleri, büyümeye devam eden pediatrik omurga patolojilerinin kusursuz tedavisi için umut verici olacaktır.Öğe Comparison of the Effectiveness of Ceftobiprole and Vancomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus-Induced Meningitis(Karger, 2024) Mermer, Sinan; Turhan, Tuncer; Bolat, Elif; Aydemir, Sohret; Sipahi, Hilal; Sipahi, Oguz ResatIntroduction: Nosocomial meningitis may occur after procedures affecting the central nervous system or following traumatic injury. The causative infectious organism is commonly Staphylococcus aureus, a Gram-positive bacterium. The aim of the present study was to compare the effectiveness of two antibacterial agents, ceftobiprole and vancomycin, in an animal model of methicillin-resistant S. aureus (MRSA) meningitis. Method: The strain of MRSA used was ATCC 43300. The animals were divided into three groups and infected intracisternally with MRSA. Controls received no antibiotherapy while the ceftobiprole group received 25 mg/kg and the vancomycin group received 20 mg/kg intravenously. Blood and cerebrospinal fluid (CSF) samples were collected at three time points. All animals were euthanized at 73 h after start of treatment. Results: There was a significant difference (p < 0.05) between both treatment groups and the control animals at 24 h (drug trough) and 73 h (1 h after third dose) after start of treatment in terms of CSF bacterial levels. At 73 h, there was a significant difference in survival between the control group and the two treatment groups but no difference between the treated animal survival rates. Conclusion: Intravenous treatment with ceftobiprole and vancomycin appears to be equally effective in a rabbit model of MRSA meningitis.Öğe Dysembryoplastic neuroepithelial tumors of childhood: Ege University experience(Springer, 2022) Ataseven, Eda; Ozcan, Muhittin; Olculu, Cemile Busra; Bolat, Elif; Ertan, Yesim; Kitis, Omer; Tekgul, HasanBackground Dysembryoplastic neuroepithelial tumors (DNETs) are rare, low-grade tumors of the central nervous system (CNS) of childhood. It is an important cause of intractable epilepsy, and it is surgically curable. We aimed to review our institutional experience with DNET in children. Methods Medical records of children aged less than 18 years of age diagnosed with DNET between 2009 and 2020 at Ege University Hospital were reviewed. Clinical features of the patients including age, gender, initial symptoms, duration of symptoms, medical treatments, age at the time of surgery, tumor location, degree of surgical resection, and outcome of the patients were documented. Results We reviewed the records of 17 patients with DNETs. Twelve of them were male (70%), 5 of them female (30%). The median age was 11 years (19 months-17 years). The major symptom was a seizure in all of the patients. Thirteen patients presented with complex partial seizures, whereas 2 had a simple partial seizure, and 2 generalized tonic-clonic seizures. Seven patients had drug resistant epilepsy and had received at least two anti-epileptic drugs before surgery. The median duration of symptoms was 6.6 months (0-48 months). In surgery, total surgical resection was performed in 15 patients, and 2 patients underwent partial resection. From these 15 patients, seven patients underwent lesionectomy of the tumor while the other eight patients had extended lesionectomy. The mean follow-up time was 107 months (54-144 months), the seizure control was achieved in 14 patients (82.4%) after surgery, but 3 patients experienced tumor recurrence in the follow-up. Conclusion In DNETs, the complete total resection of the lesion is generally associated with seizure-free outcomes. In the patients with partial resection and lesionectomy, MRI follow-up is recommended for recurrence.Öğe The Effect of Preoperative Three Dimensional Modeling and Simulation on Outcome of Intracranial Aneursym Surgery(Korean Neurosurgical Soc, 2024) Ozgiray, Erkin; Husemoglu, Bugra; Cinar, Celal; Bolat, Elif; Akinturk, Nevhis; Biceroglu, Huseyin; Kizmazoglu, CerenObjective : Three-dimensional (3D) printing in vascular surgery is trending and is useful for the visualisation of intracranial aneurysms for both surgeons and trainees. The 3D models give the surgeon time to practice before hand and plan the surgery accordingly. The aim of this study was to examine the effect of preoperative planning with 3D printing models of aneurysms in terms of surgical time and patient outcomes. Methods : Forty patients were prospectively enrolled in this study and divided into two groups : groups I and II. In group I, only the angiograms were studied before surgery. Solid 3D modelling was performed only for group II before the operation and was studied accordingly. All surgeries were performed by the same senior vascular neurosurgeon. Demographic data, surgical data, both preoperative and postoperative modified Rankin scale (mRS) scores, and Glasgow outcome scores (GOS) were evaluated. Results : The average time of surgery was shorter in group II, and the difference was statistically significant between the two groups (p<0.001). However, no major differences were found for the GOS, hospitalisation time, or mRS. Conclusion : This study is the first prospective study of the utility of 3D aneurysm models. We show that 3D models are useful in surgery preparation. In the near future, these models will be used widely to educate trainees and pre -plan surgical options for senior surgeons.Öğe Evaluation of the Frequency of Multiple Hormone Deficiency and Long-Term Data in Patients with Craniopharyngioma(Karger, 2022) Balki, Hanife Gul; Evin, Ferda; Eraslan, Cenk; Barutcuoglu, Burcu; Bolat, Elif; Ozen, Samim; Goksen, Damla[No Abstract Available]Öğe The identification of risk factors and outcomes of cerebrospinal fluid shunt infections caused by carbapenem-resistant gram-negative bacteria in children: a retrospective cohort(Amer Assoc Neurological Surgeons, 2024) Ozenen, Gizem Guner; Bal, Zumrut Sahbudak; Bolat, Elif; Umit, Zuhal; Bilen, Nimet M.; Arslan, Sema Yildirim; Turhan, TuncerOBJECTIVE Cerebrospinal fluid (CSF) shunt infections caused by gram-negative bacteria are difficult to treat given the limited treatment options and the emergence of carbapenem-resistant (CR) strains. This study aimed to evaluate the demographic and clinical characteristics of children with CSF shunt and external ventricular drain (EVD) infections caused by gram-negative bacteria, to identify the risk factors for acquiring CR CSF shunt infections, and to report on the clinical outcomes of these infections. METHODS A retrospective cohort study was designed to evaluate pediatric patients with CSF shunt and EVD infections caused by gram-negative bacteria between January 2013 and February 2023. RESULTS A total of 64 episodes in 50 patients were evaluated. There were 45 (70.3%) CSF shunt infections and 19 (29.7%) EVD infections. The median (range) ages were 1.4 years (9 months-17.5 years) for CSF shunt infection patients and 4.2 years (1 month-17 years) for EVD infection patients. The most common isolated gram-negative bacteria species in CSF shunt infections were Pseudomonas spp. (12, 26.7%), followed by Escherichia coli (11, 24.4%), Klebsiella pneumoniae (9, 20%), and Enterobacter cloacae (5, 11.1%). In EVD infections, the most common isolated gram-negative bacteria species were Acinetobacter spp. (6, 31.6%), followed by Pseudomonas spp. (4, 21.1%) and E. coli (3, 15.8%). The carbapenem resistance rate was 26.3% (n = 5) in EVD infections and 26.2% (n = 11) in CSF shunt infections. When risk factors for carbapenem resistance were evaluated for CSF shunt infections, prior carbapenem treatment and a prolonged hospital stay > 7 days were risk factors for the CR group (p = 0.032 and p = 0.042, respectively). In definitive treatment, colistin was statistically more commonly used in the CR group (p = 0.049). When outcomes were evaluated, the 30-day mortality rate (18.2% vs 0%) was higher in the CR group, without a significant difference (p = 0.064). CONCLUSIONS A prolonged hospital stay > 7 days and prior carbapenem exposure within 30 days were associated with CR shunt infections caused by gram-negative bacteria.Öğe Medulloblastomada Tedavi Seçenekleri(2017) Bolat, Elif; Turhan, TuncerMedulloblastomalar merkezi sinir sisteminin primer malign embriyonel tümörleridir. Çoğunlukla çocukluk çağında görülürler ve posterior fossaya yerleşme eğilimindedirler. Tedavinin belirlenmesi için hastalar standart ve yüksek risk grubu olarak iki ayrı grupta toplanmaktadırlar. Tedavinin temelini ise cerrahi girişim, kemoterapi ve radyoterapi kombinasyonu oluşturmaktadır. Bu yazıda hastalığın tedavisi için genel olarak kabul görmüş tedavi yöntemleri ve gelecekten beklentiler özetlenmeye çalışılmıştır.Öğe Orbital Cerebrospinal Fluid Leak After Dog Bite: A Case Report(Galenos Publ House, 2024) Akbulut, Bilal Bahadir; Bolat, ElifA 4-year-old boy was referred to our tertiary hospital after a penetrating adnexal injury by a large-breed dog to the left orbital area. There was an increase in lacrimation, which was thought to be due to an inflammatory reaction. However, it was discovered that the lacrimation increased in the reverse-Trendelenburg position and with the Valsalva maneuver. Halo sign and beta transferrin test were positive, which led to the diagnosis of cerebrospinal fluid (CSF) fistula, and the patient was operated using a supraorbital craniotomy. A dural tear was visualized and sutured appropriately, then fibrin glue and an autologous galeal graft were applied to the tear. The CSF oculorrhea stopped postoperatively, and the patient was discharged after 10 days of follow-up. The patient had no recurrent CSF leakage at 4-year follow-up. Although CSF oculorrhea is rare and may be difficult to discern from lacrimation, the presence of pneumocephalus and halo sign should suggest fistula repair.Öğe A rare central nervous system tumor of childhood with spongiform appearance on brain magnetic resonance imaging; primary diffuse leptomeningeal oligodendrogliomatosis(Elsevier Espana Slu, 2022) Tekin, Hande Gazeteci; Karaoglu, Pakize; Bolat, Elifdiffuse leptomeningeal oligodendrogliomatosis is a rare fatal tumor of childhood. Symptoms usually occur when the tumor causes hydrocephalus. Brain magnetic resonance imaging (MRI) may be nearly normal in the early stages of the disease, while hydrocephalus and multiple leptomeningeal cysts with spongiform appearance may appear later on. One may consider the diagnosis when radiologic findings become apparent with multiple leptomeningeal cysts. However, failure to recognize the imaging findings due to the rarity of the disease may delay the diagnosis. Here, we report a 3.5-year-old girl who presented with ataxia and vomiting and had a diagnosis of primary diffuse leptomeningeal glioneuronal tumor with remarkable brain MRI findings as diffuse multiple tiny cystic lesions on the brain and spinal cord. She benefited from radiotherapy and temozolomide treatment with remission of brain MRI findings. Increasing the number of reported cases will enable the elucidation of the disease's pathogenesis and the development of treatment protocols. (C) 2021 Sociedad Espanola de Neurocirug ' ia. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Risk factors for neurological complications and clinical outcomes in patients with left ventricular assist devices(Mre Press, 2021) Kodik, Meltem Songur; Yildiz, Ali Kemal; Uz, Ilhan; Yalcinli, Sercan; Kahraman, Umit; Bolat, Elif; Altunci, Yusuf AliObjectives: Patients with left ventricular assist devices (LVADs) frequently experience cerebrovascular complications. We investigated the complications, including intracranial hemorrhage (ICH) and ischemic stroke (IS), in patients with LVADs. Methods: A historical cohort study was performed at an emergency clinic including patients who underwent LVAD placement between February 16, 2015, and April 1, 2020. of the 295 patients with LVADs, 71 (24.1%) were admitted to the emergency service between the study dates because of IS and ICH. Electronic medical files were reviewed, and patients were categorized as ICH or IS. Results: of the included patients, 245 (83.0%) were male. The most common postoperative complications were pump thrombosis (26.8%, n = 79), blood culture positivity (19.3%, n = 57), and surgical bleeding (5.8%, n = 17). The most frequent LVAD indication was ischemic dilated cardiomyopathy (71.5%, n = 211). The mean age was 49.6 +/- 16.7 and 51.3 +/- 14.8 years for patients with and without neurological complications, respectively (P = 0.415). Neurological complications were seen in 65 (31.3%) patients with and in 6 (6.9%) patients without coronary ischemia (P < 0.001). Neurological complications were found in 39 (30.5%) patients with an implantable cardioverter defibrillator (ICD) and in 32 (19.2%) patients without an ICD (P = 0.024). Neurological complications were found in 19 (61.3%) patients with and in 52 (19.7%) patients without a history of stroke (P < 0.001). Logistic regression analysis revealed that age and Glasgow coma scale (GCS) were the only significant variables independently affecting mortality status. While a younger age was a protective factor, a one-unit increase in the GCS was associated with a 4.1-fold (95% CI: 1.308-13.071) increase in mortality. Conclusions: Coronary ischemia, ICD, cerebrovascular disease, and smoking significantly affected the presence of complications. Moreover, patients with combined IS and ICH had a lower chance of recovering. Interventional procedures should be performed as early as possible, especially in elderly patients with a low GCS.Öğe Unilateral Koronal Sinostoz; Anterior Plagiosefali(2017) Bolat, Elif; Turhan, TuncerFrontal plagiosefali, sinostotik veya deformasyonel olabilir. Deformasyonel tip plagiosefali sinostotik plagiosefaliye göre çok daha sık görülür ve oligohidramniosa, uterin patolojiye, ikiz varlığına, sefalopelvik uyumsuzluğa, doğum travmasına veya postnatal yatış pozisyonuna bağlı olabilir. Anterior sinostotik plagiosefali, skafosefali ve trigonosefalinin ardından üçüncü en sık görülen basit kraniosinostoz şeklidir. Cerrahi girişim olarak başlangıçta basit sütürektomi teknikleri seçilmekteyken günümüzde farklı düzeltme metodları da kullanılmaktadır. Günümüzde en sık kullanılan cerrahi yöntem bilateral frontoorbital ilerletmedir. Bilateral frontoorbital ilerletmede amaç her iki tarafta frontal ve orbital simetriyi ve simetrinin kalıcılığını sağlamaktır. İdeal operasyon zamanlaması 6-12 ay arasıdır. Cerrahi komplikasyonlar arasında peroperatif kan kaybına bağlı hipovolemi, pulmoner emboli, beyin-omurilik sıvısı fistülü, nöral yaralanma, orbital yaralanma, yara yeri ve santral sinir sistemi enfeksiyonu ve yetersiz düzelme yer alır
