Yazar "Biber, F. Z." seçeneğine göre listele

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    Investigation of new bifunctional agents: D-Penicillamine
    (Springer, 2007) Acar, C.; Teksoez, S.; Uenak, P.; Biber, F. Z.
    Somatostatin inhibits the release of growth hormone (somatotropin) from the Anterior Pituitary. The main use of derivatives of somatostatin is to diagnose growth hormone problems and to use against some forms of cancer which involve growth hormone. Also somatostatin suppresses gastric acid secretion, gallbladder contractions, and pancreatic enzyme secretion. The aim of the current study is to investigate new bifunctional agents for labeling with Tc-99m. Therefore D-Penicillamine was used as a bifunctional agent and compared to DTPA in the labeling with(99m)Tc. Quality controls were established using thin layer radio chromatography (TLRC) and electrophoresis techniques. In addition, high performance liquid radio chromatography (HPLRC) was also performed for elimination of possible uncertainties. The radiolabeled complexes maintained their stabilities throughout the study. The results obtained showed that Tc-99m-D-Penicillamine-somatostatin is a promising potential radiopharm aceutical and an alternative of Tc-99m-DTPA-somatostatin for in vivo and in vitro applications.
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    Iodine measurements by isotope dilution analysis in drinking water in Western Turkey
    (Springer, 2007) Uenak, P.; Lambrecht, F. Yurt; Biber, F. Z.; Darcan, S.
    This study was designed to evaluate iodine concentrations in drinking water samples using isotope dilution analysis (IDA) in the Aegean region of Turkey A total of 76 drinking water samples from rural and urban areas in regional cities were analyzed. The mean iodine concentration was 78 +/- 27 mu g/l and iodine concentration ranges were within 69 +/- 26 mu g/l and 103 +/- 6 mu g/l.
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    Radioiodinated magnetic targeted carriers (I-131-MTC)
    (Springer, 2007) Dagdeviren, K.; Uenak, P.; Bekis, R.; Biber, F. Z.; Akdurak, S.; Ulker, O.; Ergur, B.; Ertay, T.; Durak, H.
    Magnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized disease sites, such as tumors. Thus, high concentrations of carrier molecules such as therapeutic radiopharmaceuticals can be achieved near the target site without any toxic effects to normal surrounding tissue. In this study, magnetic targeting carriers (MTC) were radioiodinated with I-131 using three different methods (1) I-131 was directly bound onto MTC, (2) an iron complex of 8-hydroxyquinoline (8-OHQ) has been absorbed onto magnetic microspheres. The iodogen method was performed for the iodination of the complexes. (3) 8-OHQ was radioiodinated before chelating with Fe. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The best labeling yield and the best stability were obtained when 8-OHQ was chelated before the radioiodination. Binding efficiency was found to be 99.58%. The labeling of the MTC with I-131 was undertaken to allow for therapy with I-131-labeled MTC with simultaneous imaging.
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    Scintigraphic imaging with a peptide glucuronide in rabbits: Tc-99m-exorphin C glucuronide
    (Pergamon-Elsevier Science Ltd, 2007) Ertay, T.; Unak, P.; Biber, F. Z.; Tasci, C.; Zihnioglu, F.; Durak, H.
    A peptide glucuronide (Exorphin C glucuronide) was labeled with Tc-99m using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with Tc-99m using glucoheptonate as a bifunctional chelate. Results demonstrated that Tc-99m-GEG may be a useful new type of glucuronide derivative of peptides for diagnosis of some cancer diseases. (c) 2006 Elsevier Ltd. All rights reserved.
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    Tc-99m-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats
    (Springer, 2006) Ertay, T.; Unak, P.; Ozdogan, O.; Biber, F. Z.; Zihnioglu, F.; Medine, E. I.; Durak, H.
    A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7 +/- 0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with Tc-99m-GH-exorphin C glucuronide (Tc-99m-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that Tc-99m-GEG can be used as a vehicle to target tumors.