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  • Küçük Resim Yok
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    Children with breakthrough varicella infection requiring hospitalization in Turkey (VARICOMP Study 2008-2013)
    (Elsevier Ltd, 2015) Dinleyici E.C.; Kurugol Z.; Kara A.; Tezer H.; Tas M.A.; Guler E.; Yasa O.; Devrim I.; Ciftci E.; Ozdemir H.; Somer A.; Ozen M.; Sensoy G.; Dalgic N.; Alhan E.; Kuzdan C.; Bayram S.N.; Uygur-Kulcu N.; Sag C.; Nuhoglu C.; Metin O.; Kondolot M.; Tapisiz A.; Celebi S.; Hacimustafaoglu M.; Akarsu S.; Aygun D.; Akin F.; Elevli M.; Velipasalioglu S.; Oncel S.; Emiroglu M.; Karbuz A.; Turel O.; Kuyucu N.; Ceyhan M.; Yilmaz-Ciftdogan D.; Hatipoglu N.; Kilic O.; Siraneci R.; Kara A.; Apa H.; Gulhan B.; Parlakay A.; Kocabas E.; Say A.; Belet N.; Baktir A.; Karli A.; Tanir G.; Ince E.; Bal B.; Akaslan A.; Goksugur Y.; Arisoy E.S.; Hatipoglu S.; VARICOMP Study Group
    Introduction: Varicella in previously immunized individuals, known as "breakthrough varicella". While the majority of breakthrough cases are mild, some may be severe, requiring hospitalization in previously healthy children or children with an underlying condition. Methods: This report, as a part of the prospective national pediatric varicella hospitalizations study (including 29 centers, represent 50% of pediatric population) in Turkey, is aimed to evaluate breakthrough varicella infection requiring hospitalization before the routine use of single-dose live varicella vaccine in national program from 2008 to 2013 (<10% of the pediatric age group received a single-dose vaccine). Results: In the time period, 1939 children were hospitalized due to varicella infection in Turkey; 36 children (20 boys, 16 girls, mean age 68.0 + 37.6 months, all received single dose live varicella vaccine) with breakthrough varicella infection. Breakthrough varicella infection might be severe in previously healthy children (61.1%) and children with immune-compromising conditions (38.9%). The time elapsed between vaccination and hospitalization was approximately 5 years, and neurological complications, mainly encephalitis and meningitis, were the most common reason for hospitalization in previously healthy children. Conclusion: Pediatric breakthrough varicella requiring hospitalization have been seen in Turkey, is mainly observed in previously healthy children at 5 years after a single-dose varicella vaccine. The varicella vaccine has been implemented as part of the National Immunization Program in Turkey in 2013 (a single dose at age 12 months). Further surveillance in the same settings could evaluate the effectiveness of national immunization with single-dose varicella vaccine at 12 months of age and potential need for second dose of vaccine. © 2015 Elsevier Ltd.
  • Küçük Resim Yok
    Öğe
    Clinical and laboratory features of hospitalized children with pandemic influenza: Is it different from the other respiratory tract infections? [Hastaneye yati{dotless}ri{dotless}lan pandemik i·nfluenza tani{dotless}li{dotless} çocuklari{dotless}n klinik ve laboratuvar özellikleri: Diger solunum yolu enfeksiyonlari{dotless}ndan farkli{dotless} mi{dotless}?]
    (2012) Bal Z.Ş.; Bal A.; Anil M.; Bayram S.N.; Arslan N.C.; Köse E.; Can F.K.; Anil A.B.; Helvaci M.
    Objective: To evaluate the clinical and laboratory findings of children hospitalized due to H1N1 virus infection with respiratory tract infection (RTI) during the last two months of 2009 and to compare patients in two groups: H1N1(+) and H1N1(-). Material and Methods: The data of 86 children with RTI, who were hospitalized between November 1 2009 and December 31 2009 at the Izmir Tepecik Training and Research Hospital Department of Pediatrics were reviewed retrospectively. Real time polymerase chain reaction (real time-PCR) was performed for all hospitalized cases. With this method, the H1N1 (+) and (-) cases were compared in terms of clinical and laboratory characteristics. Results: Forty-eight of 86 cases with RTI were H1N1(+). Older age (p=0.047) and underlying disease (p=0.043) were more frequent in H1N1(+) cases. A higher hemoglobin level (p=0.011), lower platelet count (p<0.001) and reduced incidence of a high C-reactive protein (CRP) level (>0.8 mg/dL) (p=0.004) were determined in the H1N1(+) group. Lobar infiltration determined by chest X-ray was less frequent in the H1N1(+) group (p=0.002). One patient died the in H1N1(+) group. There were no significant differences between the two groups regarding the length of hospital stay, frequency of pediatric intensive care admission and mortality rate (p>0.005). In the logistic regression analysis, hemoglobin level (p=0.033), high CRP (>0.08 mg/dL) (p=0.005) and the incidence of lobar infiltration by X-ray (p=0.036) were found to be significant parameters distinguishing the H1N1(+) and H1N1(-) groups. Conclusion: Pandemic Influenza affected children in the older age group with chronic medical conditions. The length of hospital stay, the rate of admission in the pediatric intensive care unit and the mortality rate were not different in H1N1(+) and H1N1(-) children.
  • Küçük Resim Yok
    Öğe
    Restless legs syndrome in childhood: A case report [Çocukluk çaginda huzursuz bacak sendromu: Bir vaka takdimi]
    (2007) Bayram S.N.; Karaca N.E.; Egemen A.
    Restless legs syndrome is a neurological movement disorder characterized by a distressing desire to move legs or sometimes other extremities, associated with a marked sense of discomfort usually in the leg or other affected body part. It follows a circadian pattern and the symptoms worsen at rest, in the evening or at night and there is at least momentary relief by activity. Genetic and environmental factors cause the restless legs syndrome. Recent researches have achieved the definition of the pathophysiologic mechanisms of the disorder. It is suggested that iron deficiency is a primary factor in the development of the symptoms. Because the symptoms become much worse at night while sleeping, it causes sleep disturbance and so it may severely disrupt normal life functioning. Although it is more common in adult life, it may occur more frequently in children than previously recognized. This syndrome is a clinical diagnosis that relies entirely on the patient's symptoms, thus the interviews should involve a general medical history about the associated features. Especially in the children experiencing sleep disturbance or growing pain, restless legs syndrome must also be considered in the differential diagnosis.

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