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Öğe Autopsy Findings of a Case with Oxalosis(Alliance Communications Group Division Allen Press, 2009) Doganavsargil, Basak; Akil, Ipek; Sen, Sait; Mir, Sevg; Basdemir, GulcinOxalosis, deposition of calcium oxalate in tissues, is the final stage of hyperoxaluric syndromes. Being a rare entity, it is often missed, or the diagnosis is delayed, since the definitive diagnosis requires special laboratory tests. Kidneys, the walls of blood vessels, and bones are the major sites for crystal deposition. We report the autopsy findings of a 4-year-old girl who presented with end-stage renal disease in which the clinical presentation was consistent with primary hyperoxaluria Type 1. The case is unusual, as there was extensive crystal deposition throughout the body, including in tissues that are rarely involved, such as ovaries, fallopian tubes, uterus, thymus, salivary glands, pancreas, and bladder.Öğe Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients(Elsevier Science Inc, 2014) Yalcinkaya, Ulviye; Doganavsargil, Basak; Sezak, Murat; Kececi, Burcin; Argin, Mehmet; Basdemir, Gulcin; Oztop, FikriOsteoid osteoma and osteoblastoma are histologically similar, benign bone-forming tumors. In this retrospective study, we aimed to evaluate the natural history; clinical, pathologic, and radiologic findings; and treatment results in 204 patients between 1959 and 2006 in a single institution. According to the World Health Organization's definition, tumors <= 1 cm in diameter were classified as osteoid osteoma, and those >= 2 cm, as osteoblastoma. For tumors between 1 cm and 2 cm, other criteria, such as the bone involved, the site, the presence of a nidus, and presence of peripheral sclerosis, were used for diagnosis. There were 131 patients with osteoid osteoma (93 male, 38 female) and 73 patients with osteoblastoma (40 male, 33 female). The mean age in the osteoid osteoma and osteoblastoma groups was 16.4 +/- 7 and 19.6 +/- 9.9 years, respectively. The osteoid osteoma cases were mostly localized in the extremities, whereas the osteoblastoma cases involved the vertebral column and sacrum. The nidus size varied between 0.2 and 1.5 cm in osteoid osteoma cases, and the tumor size range was 1.3-10 cm in the osteoblastoma cases. The pain was encountered in 89% of osteoid osteoma and 45% of osteoblastoma patients. Histopathology was similar in both cases. The treatment of choice was conservative surgery for both diagnoses. In conclusion, osteoblastoma is clinically and radiologically more aggressive than osteoid osteoma. (C) 2014 Elsevier Inc. All rights reserved.Öğe Comparison of epoprostenol and Viscum album efficiencies in the treatment of avascular necrosis of the femoral head: An experimental animal study(F. Hernandez, 2024) Kumbaraci, Mert; Kumbaraci, Banu Sarsik; Yakut, Basak Doganavsargil; Can, Cenk; Basdemir, Gulcin; Aydogdu, SemihBackground. The aim of our study is to compare the efficacy of epoprostenol and Viscum album in the treatment of femoral head avascular necrosis with an experimental study. Our hypothesis is that Viscum album, which has similar properties to epoprostenol on the vascular system, is as effective as epoprostenol in the treatment of avascular necrosis. Methods. Avascular necrosis was created on the femoral heads of 45 New Zealand type rabbits by surgical vascular deprivation method. The rabbits were divided into 3 groups. Group 1 was designed as a control group, in group 2 Ilomedin (epoprostenol analogue) was administrated to subjects and in group 3, Helixor ( Viscum album extract) was administrated. At the end of the study, there were nine subjects in each group. Osteocyte necrosis, bone marrow necrosis, new bone formation and cartilage degeneration were evaluated microscopically. The extent of bone necrosis and repair and involvement of epiphysis, the bone marrow cellularity ratio and trabecular bone volume were investigated. Results. Subchondral necrosis was seen in more animals in the control group (p=0.03). Osteoblastic and osteoclastic activity were more prominent in the Ilomedin group (p=0.25 and 0.07, respectively). It was seen that the cartilages of the subjects in the Helixor and Ilomedin groups were less damaged. In the Ilomedin group, more animals were seen in the chronic phase of the repair process than in the other groups (p=0.07). Bone marrow cellularity was higher in treatment groups (22% and 20,6% for Ilomedin and Helixor, respectively, p=0,04). Trabecular volume was found to be increased in damaged femoral heads in the treatment groups, the highest increased observed in the Helixor group (p=0.01). Conclusion. Viscum album seems to be effective in decreasing the extention of necrosis and protecting the articular cartilage, and epoprostenol in increasing repair and regeneration.Öğe Cystic Bone Lesions: Histopathological Spectrum and Diagnostic Challenges(De Gruyter Poland Sp Zoo, 2015) Doganavsargil, Basak; Ayhan, Ezgi; Argin, Mehmet; Pehlivanoglu, Burcin; Kececi, Burcin; Sezak, Murat; Basdemir, Gulcin; Oztop, FikriObjective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n= 98, 68.5%), solitary bone cysts (n= 17 11.9%), pseudocyst (n= 10.7%), intraosseous ganglion (n= 3, 2.1%), hydatid cyst (n= 2; 1.4), epidermoid cyst (n= 1, 0.7%) and cysts demonstrating "mixed" aneurysmal-solitary bone cyst histology (n= 12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and "mixed" cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in flat bones like the vertebra, pelvis and mandible (p= 0.001, chi-square). Repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p= 0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n= 3), femur (n= 3) and maxilla (n= 2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the "solid" variant. The "mixed" aneurysmal-solitary bone cyst "subgroup" requires further research with larger series to be defined more thoroughly.Öğe Cystic Bone Lesions: Histopathological Spectrum and Diagnostic Challenges(De Gruyter Poland Sp Zoo, 2015) Doganavsargil, Basak; Ayhan, Ezgi; Argin, Mehmet; Pehlivanoglu, Burcin; Kececi, Burcin; Sezak, Murat; Basdemir, Gulcin; Oztop, FikriObjective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n= 98, 68.5%), solitary bone cysts (n= 17 11.9%), pseudocyst (n= 10.7%), intraosseous ganglion (n= 3, 2.1%), hydatid cyst (n= 2; 1.4), epidermoid cyst (n= 1, 0.7%) and cysts demonstrating "mixed" aneurysmal-solitary bone cyst histology (n= 12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and "mixed" cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in flat bones like the vertebra, pelvis and mandible (p= 0.001, chi-square). Repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p= 0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n= 3), femur (n= 3) and maxilla (n= 2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the "solid" variant. The "mixed" aneurysmal-solitary bone cyst "subgroup" requires further research with larger series to be defined more thoroughly.Öğe Cystic Bone Lesions: Histopathological Spectrum and Diagnostic Challenges(De Gruyter Poland Sp Zoo, 2015) Doganavsargil, Basak; Ayhan, Ezgi; Argin, Mehmet; Pehlivanoglu, Burcin; Kececi, Burcin; Sezak, Murat; Basdemir, Gulcin; Oztop, FikriObjective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n= 98, 68.5%), solitary bone cysts (n= 17 11.9%), pseudocyst (n= 10.7%), intraosseous ganglion (n= 3, 2.1%), hydatid cyst (n= 2; 1.4), epidermoid cyst (n= 1, 0.7%) and cysts demonstrating "mixed" aneurysmal-solitary bone cyst histology (n= 12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and "mixed" cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in flat bones like the vertebra, pelvis and mandible (p= 0.001, chi-square). Repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p= 0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n= 3), femur (n= 3) and maxilla (n= 2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the "solid" variant. The "mixed" aneurysmal-solitary bone cyst "subgroup" requires further research with larger series to be defined more thoroughly.Öğe Evaluation of chondrogenesis and osteogenesis via Wnt/?-Catenin, S100 immunoexpression and histomorphometry in fetal rats following maternal uterine artery ligation(2020) Uslu, Serap; Öktem, Gülperi; Oltulu, Fati?H; Demir, Kenan; İrban, Arzu; Basdemir, Gulcin; Uysal, AyşegülAim: The aim of this study is to investigate the effects of intrauterine growth retardation depending on maternal uterine artery ligation model, Wnt/?-catenin and S100 expression immunohistochemistry and histomorphometrically on growth plate and bone tissue of fetal rats. Materials and Methods: Maternal rats were randomly divided into 3 groups (n=5). No surgery or anesthesia were applied in control group. Bilaterally the maternal uterine arteries were ligated on gestational day 18 in experimental group. Although all surgical procedures were performed in sham group, the uterine artery ligation were not made. Fetuses were taken on gestational day 20, thicknesses of growth plate and zones, trabecular number and thickness and cortical thickness were evaluated with the histomorphometrically in samples from left proximal tibia. The expressions of ?catenin and S100 immunohistochemically were evaluated in the growth plate. Results: Thicknesses of growth plate (p<0.01), proliferation zone (p<0.05) and degeneration zone (p<0.01) were measured significantly thinner in experimental group than the others and thicknesses of hypertrophic zones were lesser than the control and sham group, but the results were not statistically significant (p>0.05). Also trabecular numbers were lower (p<0.01) and trabecular thickness were also thinner (p<0.05) in experimental group. Expression of ?-catenin was declined and S100 expression was increased in experimental group. Conclusion: We conclude that maternal uterine artery ligation, leads to shortness of growth plate and degenerated bone architecture because of Wnt/?-catenin signaling pathway.Öğe Evaluation of chondrogenesis and osteogenesis via Wnt/ß-Catenin, S100 immunoexpression and histomorphometry in fetal rats following maternal uterine artery ligation(2020) Uysal, Ayşegül; Uslu, Serap; İnce, Ümit; Basdemir, Gulcin; İrban, Arzu; Oltulu, Fatih; Öktem, GülperiAim: The aim of this study is to investigate the effects of intrauterine growth retardation depending onmaternal uterine artery ligation model, Wnt/?-catenin and S100 expression immunohistochemistry andhistomorphometrically on growth plate and bone tissue of fetal rats.Materials and Methods: Maternal rats were randomly divided into 3 groups (n=5). No surgery oranesthesia were applied in control group. Bilaterally the maternal uterine arteries were ligated ongestational day 18 in experimental group. Although all surgical procedures were performed in shamgroup, the uterine artery ligation were not made. Fetuses were taken on gestational day 20,thicknesses of growth plate and zones, trabecular number and thickness and cortical thickness wereevaluated with the histomorphometrically in samples from left proximal tibia. The expressions of ?catenin and S100 immunohistochemically were evaluated in the growth plate.Results: Thicknesses of growth plate (p<0.01), proliferation zone (p<0.05) and degeneration zone(p<0.01) were measured significantly thinner in experimental group than the others and thicknesses ofhypertrophic zones were lesser than the control and sham group, but the results were not statisticallysignificant (p>0.05). Also trabecular numbers were lower (p<0.01) and trabecular thickness were alsothinner (p<0.05) in experimental group. Expression of ?-catenin was declined and S100 expressionwas increased in experimental group.Conclusion: We conclude that maternal uterine artery ligation, leads to shortness of growth plate anddegenerated bone architecture because of Wnt/?-catenin signaling pathway.
