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Öğe Abnormal white matter integrity and impairment of cognitive abilities in adolescent inhalant abusers(Pergamon-Elsevier Science Ltd, 2015) Yuncu, Zeki; Zorlu, Nabi; Saatcioglu, Hozan; Basay, Burge; Basay, Omer; Zorlu, Pelin Kurtgoz; Kitis, Omer; Gelal, FazilInhalant abuse represents a major health problem especially among adolescents and young adults. However, less is known about white matter (WM) microstructure in adolescent inhalant abusers. In the present study, we used diffusion tensor imaging (DTI) to study WM changes in adolescent inhalant abusers compared with healthy controls. We also tested whether there was any relationship between WM integrity and neuropsychological measures in adolescent inhalant abusers. The study included 19 adolescent inhalant abusers and 19 healthy control subjects. Whole brain analysis of WM microstructure was performed using tract-based spatial statistics (TBSS) to detect abnormal WM regions between groups. Wisconsin card sorting test (WCST) and Stroop test were used to measure neuropsychological performance. We found that adolescent inhalant abuser group had significantly higher axial diffusivity (AD) values in left parietal, occipital and temporal WM than in healthy control group. Inhalant abuser and control groups did not differ significantly on fractional anisotropy (FA) and radial diffusivity (RD) values. Adolescent inhalant abusers showed worse performance when compared with control group in WCST and Stroop test. There was no significant correlation of AD values in significant clusters with neuropsychological test performances within the two groups. We only found discrete impairments in neuropsychological test performance and WM integrity in adolescent inhalant abusers compared with healthy control subjects and we were not able to demonstrate a direct correlation between WM alterations and neurocognitive performance. Future work is required to longitudinally evaluate brain abnormalities through methods assessing brain structure, function and connectivity. (C) 2014 Elsevier Inc. All rights reserved.Öğe Acute Dystonia Following a Switch in Treatment from Atomoxetine to Low-dose Aripiprazole(Korean Coll Neuropsychopharmacology, 2016) Basay, Omer; Basay, Burge Kabukcu; Ozturk, Onder; Yuncu, ZekiThe present report describes the cases of a 17 year old male patient and a 13 year old female patient who developed acute dystonia following the administration of low dose aripiprazole (5 mg/day) after the cessation of atomoxetine treatment. Although aripiprazole induced dystonia has been previously reported in the literature, it is rare, and most of these cases were associated with doses higher than 5 mg/day. Furthermore, both of the patients in the present study discontinued atomoxetine prior to the initiation of aripiprazole treatment; thus, this report also discussed the possible mechanisms underlying the manifestation of dystonia from the perspective of neurotransmitter activity.Öğe Brain-Derived Neurotrophic Factor Gene Va166Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample(Korean Neuropsychiatric Assoc, 2016) Ozturk, Onder; Basay, Burge Kabukcu; Buber, Ahmet; Basay, Omer; Alacam, Huseyin; Bacanli, Ali; Yilmaz, Senay Gorucu; Erdal, Mehmet Emin; Herken, Hasan; Ercan, Eyup SabriObjective Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that negatively affects different areas of life. We aimed to evaluate the associations between the Va166Met polymorphism of brain-derived neurotrophic factor (BDNF) and ADHD and to assess the effect of the BDNF polymorphism on the neurocognitive profile and clinical symptomatology in ADHD. Methods Two hundred one ADHD cases and 99 typically developing subjects (TD) between the ages of 8 and 15 years were involved in the study. All subjects were evaluated using a complete neuropsychological battery, Child Behavior Checklist, the Teacher's Report Form (TRF) and the DSM-IV Disruptive Behavior Disorders Rating Scale-teacher and parent forms. Results The GG genotype was significantly more frequent in the patients with ADHD than in the TD controls, and the GG genotype was also significantly more frequent in the ADHD-combined (ADHD-C) subtype patients than in the TDs. However, there were no significant associations of the BDNF polymorphism with the ADHD subtypes or neurocognitive profiles of the patients. The teacher-assessed hyperactivity and inattention symptom count and the total score were higher, and the appropriately behaving subtest score of the TRF was lower in the GG genotypes than in the GA and AA (i.e., the A-containing) genotypes. Conclusion We found a positive association between the BDNF gene Va166Met polymorphism and ADHD, and this association was observed specifically in the ADHD-C subtype and not the ADHD-predominantly inattentive subtype. Our findings support that the Va166Met polymorphism of BDNF gene might be involved in the pathogenesis of ADHD. Furthermore Va166Met polymorphism of BDNF gene may be more closely associated with hyperactivity rather than inattention.Öğe Does the quality of life in autism spectrum disorder differ from other chronic disorders and healthy children?(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Ozturk, Onder; Erermis, Serpil; Ercan, Eyup Sabri; Gulen, Figen; Kabukcu Basay, Burge; Basay, Omer; Kose, Sezen; Ozgun Ozturk, Fatma; Alacam, Huseyin; Aydin, CahideObjective: Autism spectrum disorder (ASD) is characterized by deficits in social interaction, communication, restricted interests, and repetitive patterns of behavior. This study examined quality of life (QoL) and related clinical factors in children with ASD, compared to children with Attention Deficit Hyperactivity Disorder (ADHD), children with asthma, and healthy controls (HC). Methods: QoL was assessed by the Pediatric Quality of Life Inventory 4.0 (PedsQLTM 4.0). Additionally, parents of the children provided sociodemographic information and filled out an evaluation questionnaire, child behavior check list (CBCL), and Turgay DSM-IV Disruptive Behavior Disorders Rating Scale (T-DSM-IV-S). Results: The physical health, psychosocial health, social functioning, and scale total score of the ASD group were significantly lower than those of the three comparison groups. The school functioning score domain was lower in the ASD group than in the asthma and HC groups. In contrast, the emotional functioning domain assessments did not reveal statistically significant differences between the ASD group and the comparison groups. In the ASD group, the total problem score, inattention, and hyperactivity scores were significantly higher than both the asthma and HC groups, and the internalizing scores were higher than the healthy group. Conclusion: The poor QoL is most likely due to functional losses and problem behaviors related to ASD and may negatively affect not only children with ASD but also the whole life of the family.Öğe Personality characteristics of adolescents with substance use disorders(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Basay, Omer; Yuncu, Zeki; Kabukcu Basay, Burge; Ozturk, Onder; Aydin, CahideObjective: Personality characteristics are found to be related with substance use initiation, substance abuse, substance dependence and substance use continuance. The aim of this study is to investigate the personality characteristics of adolescents with alcohol/substance use disorder (ASUD). Methods: Sixty-nine adolescents with ASUD, aged between 16 and 18 were compared with 69 adolescents with similar sociodemographic properties and without ASUD. Minnesota Multiphasic Personality Inventory (MMPI) was used to assess personality traits. Results: Adolescents with SUD had higher scores for psychopathology (F), hypochondriasis, hysteria, depression, psychopathic deviation, paranoia, psychasthenia, schizophrenia, and hypomania scales and lower score for defensiveness (K) scale when compared with the control group. Discussion: Adolescents with ASUD have insufficient defense mechanisms and negative personality characteristics. Personality characteristics of these adolescents should be considered in the treatment and follow up periods.Öğe Prevalence of non-suicidal self-injury and distinct groups of self-injurers in a community sample of adolescents(Springer Heidelberg, 2015) Somer, Oya; Bildik, Tezan; Kabukcu-Basay, Burge; Gungor, Duygu; Basay, Omer; Farmer, Richard F.Adolescence is an important developmental period for the first onset of non-suicidal self-injury (NSSI), a behavior known to be associated with elevated suicide risk. Little is currently known, however, about NSSI among adolescents. The primary objectives of this research were to establish the prevalence of non-suicidal self-injury (NSSI) in a representative sample of Turkish high school students and to identify and describe distinct subgroups of self-injurers. A total of 1656 of 1676 eligible students (98.8 % participation rate) from 18 schools were surveyed during the 2010-2011 academic year. Questionnaires were administered that assessed prior engagement in a variety of self-injurious behaviors, current psychiatric symptoms, suicide-related risk factors, and participation in health-risk behaviors. Latent class analysis (LCA) methods were used to identify distinct groups of self-injurers. Almost one-third of the sample (N = 519) endorsed some previous engagement in NSSI behaviors. In LCA analyses restricted to youth with prior histories of NSSI, four distinct classes were identified characterized by: (1) low rates of NSSI behaviors (29 %); (2) high rates of self-battery (32 %); (3) high rates of self-cutting (19 %); and (4) high rates of multiple NSSI behaviors (19 %). These classes were further distinguished by current psychiatric symptoms, suicide risk factors, and other health-risk behaviors. Findings from the present study indicate that NSSI is a common form of behavior among adolescent youth. There is, however, considerable heterogeneity among those with NSSI histories, with about 40 % at particularly high risk for ongoing distress, future acts of intentional self-harm, and suicidal behavior.Öğe Prevalence of non-suicidal self-injury and distinct groups of self-injurers in a community sample of adolescents(Springer Heidelberg, 2015) Somer, Oya; Bildik, Tezan; Kabukcu-Basay, Burge; Gungor, Duygu; Basay, Omer; Farmer, Richard F.Adolescence is an important developmental period for the first onset of non-suicidal self-injury (NSSI), a behavior known to be associated with elevated suicide risk. Little is currently known, however, about NSSI among adolescents. The primary objectives of this research were to establish the prevalence of non-suicidal self-injury (NSSI) in a representative sample of Turkish high school students and to identify and describe distinct subgroups of self-injurers. A total of 1656 of 1676 eligible students (98.8 % participation rate) from 18 schools were surveyed during the 2010-2011 academic year. Questionnaires were administered that assessed prior engagement in a variety of self-injurious behaviors, current psychiatric symptoms, suicide-related risk factors, and participation in health-risk behaviors. Latent class analysis (LCA) methods were used to identify distinct groups of self-injurers. Almost one-third of the sample (N = 519) endorsed some previous engagement in NSSI behaviors. In LCA analyses restricted to youth with prior histories of NSSI, four distinct classes were identified characterized by: (1) low rates of NSSI behaviors (29 %); (2) high rates of self-battery (32 %); (3) high rates of self-cutting (19 %); and (4) high rates of multiple NSSI behaviors (19 %). These classes were further distinguished by current psychiatric symptoms, suicide risk factors, and other health-risk behaviors. Findings from the present study indicate that NSSI is a common form of behavior among adolescent youth. There is, however, considerable heterogeneity among those with NSSI histories, with about 40 % at particularly high risk for ongoing distress, future acts of intentional self-harm, and suicidal behavior.Öğe Prevalence of non-suicidal self-injury and distinct groups of self-injurers in a community sample of adolescents(Springer Heidelberg, 2015) Somer, Oya; Bildik, Tezan; Kabukcu-Basay, Burge; Gungor, Duygu; Basay, Omer; Farmer, Richard F.Adolescence is an important developmental period for the first onset of non-suicidal self-injury (NSSI), a behavior known to be associated with elevated suicide risk. Little is currently known, however, about NSSI among adolescents. The primary objectives of this research were to establish the prevalence of non-suicidal self-injury (NSSI) in a representative sample of Turkish high school students and to identify and describe distinct subgroups of self-injurers. A total of 1656 of 1676 eligible students (98.8 % participation rate) from 18 schools were surveyed during the 2010-2011 academic year. Questionnaires were administered that assessed prior engagement in a variety of self-injurious behaviors, current psychiatric symptoms, suicide-related risk factors, and participation in health-risk behaviors. Latent class analysis (LCA) methods were used to identify distinct groups of self-injurers. Almost one-third of the sample (N = 519) endorsed some previous engagement in NSSI behaviors. In LCA analyses restricted to youth with prior histories of NSSI, four distinct classes were identified characterized by: (1) low rates of NSSI behaviors (29 %); (2) high rates of self-battery (32 %); (3) high rates of self-cutting (19 %); and (4) high rates of multiple NSSI behaviors (19 %). These classes were further distinguished by current psychiatric symptoms, suicide risk factors, and other health-risk behaviors. Findings from the present study indicate that NSSI is a common form of behavior among adolescent youth. There is, however, considerable heterogeneity among those with NSSI histories, with about 40 % at particularly high risk for ongoing distress, future acts of intentional self-harm, and suicidal behavior.Öğe The Validity and Reliability of the Turkish Version of the Inventory of Statements About Self-injury(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2013) Bildik, Tezan; Somer, Oya; Basay, Burge Kabukcu; Basay, Omer; Ozbaran, BurcuObjective: Non-suicidal self-injury (NSSI) is defined as the repetitive deliberate destruction of one's body tissue without suicidal intent and is frequently repetitive. The aim of this study was to examine the psychometric properties of the Inventory of Statements About Self-injury (ISAS), a measure designed to comprehensively assess non-suicidal self-injury (NSSI). The ISAS assesses 13 functions of NSSI, as well as the frequency of 12 NSSI behaviors. Method: The ISAS was administered to 529 high school students who had performed at least one NSSI behavior. The internal consistency and test-retest reliability of the scale were examined; for construct validity, the relationship between the Turkish form of the ISAS and various criteria scales was examined, and confirmatory factor analysis (CFA) was conducted. Results: Consistent with previous research, factor analysis of the functions scale confirmed the good-fit of the original's 2-dimension model (x(2)=243; s.d. = 59; NCI (x(2)/sd) = 4; RMSEA = 0.08 (.07.09); CFI=0.97; NFI=0.97). In order to test the scale for construct validity, the Brief Symptom Inventory and Suicide Probability Scale were administered to participants, in addition to the ISAS, and the correlations with clinical constructs (e.g., suicidality, depression, anxiety) were in the expected direction. Also the reliability analysis revealed that the ISAS subscales demonstrated high internal consistency. Conclusion: In the light of the findings, it was concluded that the Turkish version of ISAS could be used as a reliable and valid tool in assessing non-suicidal self-injury in research and treatment contexts.Öğe The Validity and Reliability of the Turkish Version of the Inventory of Statements About Self-injury(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2013) Bildik, Tezan; Somer, Oya; Basay, Burge Kabukcu; Basay, Omer; Ozbaran, BurcuObjective: Non-suicidal self-injury (NSSI) is defined as the repetitive deliberate destruction of one's body tissue without suicidal intent and is frequently repetitive. The aim of this study was to examine the psychometric properties of the Inventory of Statements About Self-injury (ISAS), a measure designed to comprehensively assess non-suicidal self-injury (NSSI). The ISAS assesses 13 functions of NSSI, as well as the frequency of 12 NSSI behaviors. Method: The ISAS was administered to 529 high school students who had performed at least one NSSI behavior. The internal consistency and test-retest reliability of the scale were examined; for construct validity, the relationship between the Turkish form of the ISAS and various criteria scales was examined, and confirmatory factor analysis (CFA) was conducted. Results: Consistent with previous research, factor analysis of the functions scale confirmed the good-fit of the original's 2-dimension model (x(2)=243; s.d. = 59; NCI (x(2)/sd) = 4; RMSEA = 0.08 (.07.09); CFI=0.97; NFI=0.97). In order to test the scale for construct validity, the Brief Symptom Inventory and Suicide Probability Scale were administered to participants, in addition to the ISAS, and the correlations with clinical constructs (e.g., suicidality, depression, anxiety) were in the expected direction. Also the reliability analysis revealed that the ISAS subscales demonstrated high internal consistency. Conclusion: In the light of the findings, it was concluded that the Turkish version of ISAS could be used as a reliable and valid tool in assessing non-suicidal self-injury in research and treatment contexts.Öğe White matter alterations related to attention-deficit hyperactivity disorder and COMT val(158)met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)(Dove Medical Press Ltd, 2016) Basay, Burge Kabukcu; Buber, Ahmet; Basay, Omer; Alacam, Huseyin; Ozturk, Onder; Suren, Serkan; Ay, Ozlem Izci; Acikel, Cengizhan; Agladioglu, Kadir; Erdal, Mehmet Emin; Ercan, Eyup Sabri; Herken, HasanIntroduction: In this article, the COMT gene val(158)met polymorphism and attention-deficit hyperactivity disorder (ADHD)-related differences in diffusion-tensor-imaging-measured white matter (WM) structure in children with ADHD and controls were investigated. Patients and methods: A total of 71 children diagnosed with ADHD and 24 controls aged 8-15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA). Results: First, an interaction between the COMT val(158)met polymorphism and ADHD in the right (R) cingulum (cingulate gyrus) (CGC) was found. According to this, valine (val) homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the R-CGC than ADHD-diagnosed methionine (met) carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L)-uncinate fasciculus and lower RD in the L-posterior corona radiata and L-posterior thalamic radiation (include optic radiation) than the val homozygotes, independent of ADHD diagnosis. Third, children with ADHD had lower FA in the L-CGC and R-retrolenticular part of the internal capsule than the controls, independent of the COMT polymorphism. Conclusion: Significant differences reported here may be evidence that the COMT gene val(158)met polymorphism variants, as well as ADHD, could affect brain development. ADHD and the COMT polymorphism might be interactively affecting WM development in the R-CGC to alter the WM connectivity in children with val homozygote ADHD.
