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    Diagnostic Dilemma in a Patient with Central Precocious Puberty: Ovarian Steroid Cell Tumor
    (Karger, 2021) Balki, Hanife Gul; Ata, Aysun; Karayazili, Ayse Merve; Serin, Gurdeniz; Koc, Gonca; Ozdemir, Necmettin; Celik, Ahmet
    [No Abstract Available]
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    Does minimed 780G™ insulin pump system affect energy and nutrient intake?: long-term follow-up study
    (Springernature, 2024) Atik-Altinok, Yasemin; Mansuroglu, Yelda; Demir, Gunay; Balki, Hanife Gul; Ozen, Samim; Darcan, Sukran; Goksen, Damla
    Objective: We evaluate the energy and nutrient intake of children, adolescents, and young adults with type 1 diabetes (T1D) who started to use automated insulin delivery (AID) systems before the transition and during follow-up for 6 months in a real-world setting. Research design and methods: Twenty-nine people with T1D (PwD) who started to use MiniMed 780G (TM) participated in the study. Participants' 3-day food diaries and glycemic outcomes were analyzed at baseline and after (the 3(rd) and 6(th) month) switching to an advanced hybrid closed-loop system (a-HCL). Results: Mean carbohydrate, protein, and fat intake (energy %) at baseline were 49.1 +/- 4.5, 17.8 +/- 2.3, and 33.0 +/- 3.9, respectively, and there were no statistically significant differences during the follow-up period. However, low fiber (<14 g/1000 kcal) and high saturated fat (>10 energy %) intake in PwD, both baseline and follow-up period. The median auto-correction bolus ratio was 14.0 (9.5)% at auto mode after 14 days, 18.0 (11.0)% at the 3(rd) month, and 19.0 (7.5)% at the 6(th) month (p < 0.05). A negative correlation was present between auto-correction boluses with TIR in both the 3(rd) (r:-0.747, p < 0.01) and 6(th) month (r:-0.395, p < 0.05). A negative correlation was present between auto-correction boluses with TIR in both the 3(rd) (r:-0.747, p < 0.01) and 6(th) month (r:-0.395, p < 0.05). Conclusions: a-HCLS systems offer better glycemic control. Using the Minimed 780 G (TM) insulin pump system didn't change the energy and nutrient intake of PwD. This real-world follow-up study suggests that children, adolescents, and young adults with T1D consume saturated fat above and fiber intake lower than recommendations independent of the use of a-HCLS. Clinical trials registration number: NCT05666596.
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    Evaluation of Clinical and Genetic Characteristics of Non-Syndromic Monogenic Obese Patients
    (Karger, 2023) Özalp Kızılay, Deniz; Durmaz, Asude; Arslan, Emrullah; Jalilova, Arzu; Balki, Hanife Gul; Aykut, Ayça; Gökşen, Damla
    [No abstract available]
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    Evaluation of the Frequency of Multiple Hormone Deficiency and Long-Term Data in Patients with Craniopharyngioma
    (Karger, 2022) Balki, Hanife Gul; Evin, Ferda; Eraslan, Cenk; Barutcuoglu, Burcu; Bolat, Elif; Ozen, Samim; Goksen, Damla
    [No Abstract Available]
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    Prediction of Transient or Permanent Congenital Hypothyroidism
    (Galenos Yayincilik, 2022) Evin, Ferda; Balki, Hanife Gul; Ata, Aysun; Er, Eren; Vatansever, Zeynep; Ozen, Samim; Goksen, Damla
    Aim: Congenital hypothyroidism (CH) is one of the most common endocrinological problems in the neonatal period. CH, which occurs in 1:3,000-4,000 births, is a preventable cause of mental retardation. In the literature, the most common cause of CH is dysgenesis of the thyroid gland, followed by thyroid dyshormonogenesis. We aimed to determine the prevalence of permanent (P-CH) and transient (T-CH) CH in cases followed up with a diagnosis of CH and to identify a prediction method for persistency. Materials and Methods: We retrospectively analyzed the medical records of 105 children with CH. TSH levels in a screening program, TSH and fT4 levels of the first venous sample, 10-15th day of treatment, monthly in the first 6 months, 2-3 monthly until 18th months, and 6-monthly until 3 years of age were recorded. L-T4 doses (per microgram per body weight) in each visit were also recorded. Results: From the 105 children (58 males, 47 females) enrolled in this study, 38 (36.2 %) were referred from the National Newborn Screening Program. Treatment was discontinued during the 3rd year follow-up period in 44 (41.9 %) of the cases with normal thyroid gland morphology. L-thyroxine (L-T4) therapy was discontinued at a median age of 1.9+-1.08 years. TSH levels at the time of diagnosis were higher in the P-CH group, but this difference was not statistically significant (p=0.165). At the sixth month, first and second years of follow-up, L-T4 doses were significantly higher in the P-CH than in the T-CH group (p<0.001, p<0.001, p<0.001 respectively). TSH levels were also higher in the P-CH group than in the T-CH group (p=0.123, p=0.038, p=0.049 respectively). Consistent with these results, measured fT4 levels were found to be lower in the P-CH group compared to the T-CH group (p=0.431, p=0.361, p=0.028 respectively). Conclusion: L-T4 doses at 6, 12 and 24 months may predict transient hypothyroidism in patients with normal thyroid gland morphology before 36 months.
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    The psychosocial outcomes of advanced hybrid closed-loop system in children and adolescents with type 1 diabetes
    (Springer, 2024) Jalilova, Arzu; Pilan, Birsen Senturk; Demir, Gunay; Ozbaran, Burcu; Balki, Hanife Gul; Arslan, Emrullah; Kose, Sezen Gokcen
    The study was carried out to determine the psychosocial outcomes of advanced hybrid closed-loop (AHCL) systems in children and adolescents with type 1 diabetes (T1D). Single-center and cohort study with a duration 6 months consisted of 60 children and adolescents with T1D. Standard clinical procedures, including both glycemic indicators, e.g., sensor-measured time within the 70-180 mg/dL range and glycated hemoglobin (HbA1c) levels, and psychosocial metrics were used for data collection. The psychosocial metrics included the Pediatric Quality of Life Inventory (PedsQL) 3.0 Diabetes Module for both children (8-12 years) and parents; the Quality of Life for Youth scale for adolescents (13-18 years); the Strengths and Difficulties Questionnaire (SDQ); the Hypoglycemia Fear Survey for Children (HFS-C); the Revised Child Anxiety and Depression Scale (R-CADS); and AHCLS-specific DTSEQ satisfaction and expectation survey. These metrics were evaluated at the baseline and after 6 months of AHCL use. Of the 60 children and adolescents with T1D for whom the AHCL system was utilized, 41 of them, 23 female and 18 male, completed the surveys. The mean age of the 41 children and adolescents was 12.5 +/- 3.2 (min. 6.7, max. 18) years. The time spent within the target glycemic range, i.e., time-in-range (TIR), improved from 76.9 +/- 9% at the baseline to 80.4 +/- 5% after 6 months of AHCL system use (p = 0.03). Additionally, HbA1c levels reduced from 7.1% +/- 0.7% at the baseline to 6.8% +/- 0.8% after 6 months of AHCL system use (p = 0.03). The most notable decline in HbA1c was observed in participants with higher baseline HbA1c levels. All patients' HFS-C and AHCL system-specific DTSEQ satisfaction and expectation survey scores were within the normal range at the baseline and remained unchanged during the follow-up period. No significant difference was found in the R-CADS scores of children and adolescents between baseline and after 6 months of AHCL system use. However, there was a significant decrease in the R-CADS scores of the parents. Patients' PedsQL scores were high both at the baseline and after 6 months. The SDQ scores were high at baseline, and there was no significant improvement at the end of 6 months. Conclusion: This is the first study to investigate in detail the psychosocial outcomes of AHCL system use in T1D patients and their parents. Although state-of-the-art technologies such as AHCL provide patients with more flexibility in their daily lives and information about glucose fluctuations, the AHCL resulted in a TIR above the recommended target range without a change in QOL, HFS-C, SDQ, and R-CADS scores. The scores obtained from the R-CADS conducted by the parents of the children indicated that the use of pumps caused a psychological improvement in the long term, with a significant decrease in the R-CADS scores of the children and adolescents with T1D. What is Known: center dot Previous studies focused on clinical outcomes of AHCL systems in pediatric T1D patients, showing glycemic control improvements. center dot Limited attention given to psychosocial outcomes of AHCL systems in children and adolescents with T1D. center dot Crucial psychosocial factors like quality of life, emotional well-being, and fear of hypoglycemia underexplored in AHCL system context. What is New: center dot First study to comprehensively examine psychosocial outcomes of AHCL systems in pediatric T1D patients. center dot Study's robust methodology sets new standard for diabetes technology research and its impact on qualiy of life.