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Öğe Evaluation of changes in quality of life among Turkish patients undergoing ventricular assist device implantation(2012) Ozturk C.; Ayik F.; Oguz E.; Ozturk P.; Karapolat H.; Balcioglu O.; Yagdi T.; Engin C.; Ozbaran M.Background: Ventricular assist device (VAD) application has become an increasingly common method to treatment end-stage heart failure. In this study we evaluated the effect of VAD implantation upon the quality of life among Turkish patients with end-stage heart failure. Methods: Twenty-eight VAD implantation patients included 3 (10.7%) with biventricular support using the Berlin Heart Excor; 15 (53.6%), left ventricular support with the Berlin Heart Excor; and 10 (35.7%), Heartware implantation for left ventricular support. The Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Short Form 36 (SF-36) Health Questionnaire were used to assess changes in the quality of life (QOL). Results: Of the 28 patients, 2 were females (7.1%) and 26 were males (92.9%) of overall mean age of 44.6 ± 15.3 years (range, 8-66). Preoperative mean score of MLHFQ was significantly improved at 200.4 ± 147.4 days follow-up (72.8 ± 11.5 vs 13.7 ± 10.5; P <.05). SF-36 physical scores and mental scores were improved postoperatively (physical scores, 20.0 ± 24.4 vs 70.2 ± 19.9; mental scores, 38.4 ± 18.8 vs 73.9 ± 15.7; P <.05). No significant relation was observed between the postoperative scores of questionnaires and type of surgery. More improvement in postoperative MLHFQ scores was seen in patients younger than 45 years of age (P =.027). The severity of chronic heart failure (CHF) regressed from New York Heart Association (NYHA) class IV to NYHA class II in 26 and to NYHA class III in 2 patients (P =.000). Conclusion: The QOL among patients with end-stage heart failure improved dramatically soon after VAD implantation. © 2012 Elsevier Inc. All rights reserved.Öğe Hydatid cyst confined to the papillary muscle: A very rare cause of mitral regurgitation(2009) Apaydin A.Z.; Oguz E.; Ayik F.; Nalbantgil S.; Ceylan N.Cardiac involvement of hydatid cysts is rare. Hydatidosis of the valvular apparatus can be treated successfully by the careful application of valvular surgical procedures. To the best of our knowledge, cardiac hydatidosis confined to the anterolateral papillary muscle has not been reported. Herein, we present a case involving a hydatid cyst that was located in a cardiac papillary muscle and that caused mitral regurgitation in a 37-year-old woman. The cyst was removed by papillary muscle incision, and the mitral valve was repaired. The patient experienced an uneventful recovery. © 2009 by the Texas Heart® Institute.Öğe Left ventricular assist device implantation in heart failure patients with a left ventricular thrombus(2013) Engin C.; Yagdi T.; Balcioglu O.; Erkul S.; Baysal B.; Oguz E.; Ayik F.; Ozturk P.; Ozbaran M.Background: In this report, we share our experience with left ventricular assist device (LVAD) implantation in cases with a left ventricular (LV) thrombus. Method: Over the 3 years, more than 100 end-stage heart failure cases have been treated with LVAD implantation in our center, including 6 patients with a LV thrombus. Three were detected using preoperative transthoracic echocardiography. Fifty percent of the patients had dilated cardiomyopathy and the remaining cases had an ischemic etiology. Double inotropic support with dopamine and dobutamine was used in all, with 3 drugs with the addition of adrenaline in 2 patients. In 4 cases we implanted the HeartWare Ventricular Assist System (HeartWare, Inc., Miramar, Fla, United States) and in the remaining 2 patients, the Berlin Heart EXCOR ventricular assist device (Berlin Heart AG, Berlin, Germany) for biventricular support. In 1 patient the apical ventriculotomy was extended to remove an intertrabecular thrombosis and ventricular septal surface covered with a dacron patch to minimize the thrombogenic potential. Results: Two patients died due to sepsis and multiorgan failure. None of the patients experienced a neurological event, pump thrombosis, or pump malfunction. Two subjects underwent re-explorations due to hemorrhage. Two candidates underwent successfull transplantation without any evidence of thrombosis in the explanted heart or device. Conclusion: We believe that patients with a LV thrombus and preserved right ventricular function are good candidates for implantation of a LVAD after removing the intracavitary thrombus. © 2013 Elsevier Inc.Öğe Management of vascular infection in the groin(2005) Engin C.; Posacioglu H.; Ayik F.; Apaydin A.Z.We performed this retrospective study in order to evaluate the effectiveness of different surgical methods in the treatment of inguinal vascular infections. Fourteen consecutive patients underwent surgical treatment of such infections from 1996 through 2004 in our clinic. The mean age was 52 ± 16 years. Seven of the 14 patients underwent emergency operation due to bleeding or acute ischemia. The events that caused inguinal infection were synthetic graft implantation in 8 patients, gunshot injury in 1, arterial catheterization in 2, femoropopliteal saphenous vein bypass operation in 1, and motor vehicle accident with abdominal wall laceration in 2. The most common infecting pathogen was Staphylococcus aureus (7 patients). Sixteen operations were performed in 14 patients. These operations included lateral femoral bypass (5), obturator bypass (5), revascularization with homograft (5), and femorofemoral bypass (1). All inguinal infections were completely cured after surgery. Early complications included poor wound healing (4 patients), minor amputation (1 patient), and extension of infection to the distal anastomosis of the obturator bypass and false aneurysm formation (1 patient). Late complications were acute homograft occlusion of a femorofemoral bypass and thrombosis of a below-knee lateral femoral bypass. There was no operative or late mortality. All patients were followed up for a mean of 48.1 ± 21.9 months. We did not encounter any aneurysmal degeneration, rupture, or reinfection in homograft patients during follow-up. We conclude that vascular infections of the groin can be cured by proper selection and application of one of the above techniques. © 2005 by the Texas Heart® Institute.Öğe New circulatory support system: Heartware(2012) Ozbaran M.; Yagdi T.; Engin C.; Nalbantgil S.; Ayik F.; Oguz E.; Engin Y.; Özturk P.Introduction: Through the new developments in medicine, heart failure therapy has advanced to mechanical circulatory support systems. The HeartWare Ventricular Assist System HVAD; HeartWare, Inc.; Miramar, Fla, USA) is a new device that is a centrifugal, intracorporeal, miniaturized and continuous flow pump that serves simple patient use and enhanced life quality. This article reports the midterm results of patients who underwent the heartware support system. Materials and methods: We retrospectively compiled our data from December 2010, including 10 patients of mean age 51.8 years with 90% males, 70% of the overall patient cohort had dilated cardiomyopathy and remaining ones, ischemic disease. Mean left ventricular ejection fraction was 20.1% and mean systolic pulmonary artery pressure was 49.2 mm Hg. A single patient was grade 1; seven were grade 2; and remaining ones, grade 3 according to the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) scale. All patients were operated with cardiopulmonary bypass (CPB) with moderate hypothermia. Tricuspid ring annuloplasty was performed in 3 (30%) patients. In one patient we removed a left ventricular thrombus. In a case with severe aortic regurgitation, we placed a simple coaptation stitch at the central portion of the three aortic cusps under the aortic cross clamp. The mean CPB duration was 95.5 minutes. Results: There was no operative or in-hospital mortality. Mean support time was 250.67 days. During the early postoperative period, one patient experienced a minor hemorrhagic neurological event also requiring a tracheostomy due to pneumonia. This patient has completely healed and on follow-up continues a normal life. All patients were asymptomatic regarding heart failure. One patient unfortunately died because of possible pancreatic cancer and sepsis. Two patients underwent transplantations on days 159 and 172 of support. Conclusion: The HVAD system provided effective circulatory support for patients with end-stage heart failure with low adverse event rates. Long-term results are needed particularly for destination therapy candidates. © 2012 Elsevier Inc. All rights reserved.Öğe Psychiatric evaluation of children and adolescents with left ventricular assist devices(Lippincott Williams and Wilkins, 2012) Ozbaran B.; Kose S.; Yagdi T.; Engin C.; Erermis S.; Uysal T.; Ayik F.; Karakula S.; Ulger Z.; Atay Y.; Ozbaran M.Objectives: To evaluate the psychiatric symptoms of children equipped with a ventricular assist device (VAD) and follow them up for 6 months. With the shortage of donor hearts available for the treatment of end-stage heart failure, VADs have been used to provide temporary treatment until a heart becomes available. VADs provide external sources of power for mechanical circulatory support and are capable of sustaining life over weeks and months. This study provides preliminary details about the psychiatric symptoms and disorders of the first eight children equipped with a VAD in Turkey. Methods: Eight pediatric patients who recently underwent VAD implantation, aged 1 to 16 years, were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia, Child Behavior Checklist, Children's Depression Inventory, Beck Depression Inventory, and State-Trait Anxiety Inventory for Children and followed up for 6 months. Results: In the first evaluation, five participants had a psychiatric disorder diagnosis. Two patients had adjustment disorder with depressive and anxiety symptoms; one had anxiety disorder, not otherwise specified; and two had major depressive disorder. The anxiety and depressive symptom levels in questionnaires were consistent with psychiatric diagnoses. Two patients had heart transplantation during the follow-up period. Conclusions: To determine and treat psychiatric symptoms and disorders at an earlier stage, it is important for children and adolescents with a VAD and those who have undergone heart transplantation to be evaluated by a multidisciplinary consultation liaison team including psychiatrists, psychologists, consultant nurses, and counselors. Abbreviations: VAD = ventricular assist deviceK-SADS = Kiddie Schedule for Affective Disorders and SchizophreniaCBCL = Child Behavior ChecklistBDI = Beck Depression InventoryCDI = Children's Depression InventorySTAI-C = State-Trait Anxiety Inventory for ChildrenMDD = major depressive disorderAD = adjustment disorderPE.I = initial psychiatric evaluationPE.II = second psychiatric evaluation © 2012 by the American Psychosomatic Society.Öğe Valvular procedures during ventricular assist device implantation(2012) Ozturk P.; Engin C.; Ayik F.; Yagdi T.; Nalbantgil S.; Baysal B.; Ozbaran M.Background: Increased experience and success with ventricular asist devices (VAD) has permitted more aggressive use in patients formerly believed to be inappropriate for mechanical circulatory support (MCS). There is no clearly proven policy to manage end-stage heart failure patients with valvular pathologies. The aim of this report was to analysis our experience with combined approach of VAD implantation and valvular procedures among patients with valvular heart disease and end-stage heart failure. Methods: We evaluated the clinical records of 67 patients who underwent MCS from April 2007 to September 2011. We identified 12 patients (17.9%) who received concomitant valvular procedures, four of whom had significant aortic insufficiency and received a simple coaptation stitch at the center to approximate the fibrous nodules of Arantius. The mechanical aortic valve was replaced with a stentless bioprosthesis in three patients. Mitral valve commissurotomy was performed in one patient with mitral stenosis and seven patients underwent tricuspit valve repair using an annuloplasty ring. Results: All 12 patients were males, of mean age 50.3 ± 11.5 years (range = 25-66). Eleven of them (91.6%) survived the early and late postoperative periods. Ten subjects (83.3%) continue to be supported with VAD; 1 (8.3%) was successfully bridged to transplantation. Each study participant regression of the valvular pathologies by early echocardiography demonstrated. Conclusion: Concomitant valve surgery during VAD implantation appeared to be a reasonable option in end-stage heart failure patients with valvular heart disease. © 2012 Elsevier Inc. All rights reserved.
