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Öğe Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population(Mattioli 1885, 2018) Buyukozturk, S.; Kekik, C.; Gokyigit, A. Z.; Filik, F. I. Tezer; Karakaya, G.; Saygi, S.; Dursun, A. B.; Kirbas, S.; Tufekci, A.; Sin, A. Z.; Aydogdu, I.; Sorgun, M. H.; Aydin, N.; Gelincik, A.; Colakoglu, B.; Celik, G.; Oguz, F.Background and objective. Many studies have shown associations between HLAB*15: 02, HLA-A*31: 01 and carbamazepine (CBZ)-induced delayed cutaneous hypersensitivity reactions. The aim of this study is to evaluate a possible association between delayed cutaneous reactions to antiepileptic drugs (AEDs) and certain HLA-A and HLA-B alleles in the Turkish population. Methods. The study consisted of 3 groups: Group I (reactive group) included the patients who had documented delayed cutaneous reactions to any antiepileptic drug. Group II (non-reactive group) included the patients who have been on antiepileptic treatment at least for three months without any adverse reactions. Group III consisted of healthy subjects. The HLA-A and B alleles were analyzed in all groups. Results. Forty patients (29 female) had experienced different hypersensitivity reactions due to AEDs: maculopapular exanthema (26 patients), Stevens-Johnson syndrome (6 patients), drug rash with eosinophilia and systemic symptoms (7 patients), toxic epidermal necrolysis (1 patient). Lamotrigine (11) and CBZ (10) were the most common culprit drugs involved in the reactions. The HLA-B*15: 02 was not present in any of the study groups. However, HLA-B* 35: 02 was found in 4 patients from the reactive group, while it was not observed in non-reactive patients and was detected in only one healthy subject (p = 0.021). Conclusion. Although our preliminary results did not indicate a strong allele association with AED hypersensitivity, HLA-B* 35: 02 appears to be a candidate allele for MPE /DRESS /DIHSS induced by AED's in Turkish population. Further studies with a larger sample size may result in more comprehensive data about the genetic tendency for AED hypersensitivity in the Turkish population.Öğe EFFICACY AND SAFETY OF RUXOLITINIB IN TURKISH PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS: A MULTICENTER AND RETROSPECTIVE ANALYSIS(Pergamon-Elsevier Science Ltd, 2017) Soyer, N.; Turgut, M.; Haznedaroglu, I.; Yilmaz, F.; Aydogdu, I.; Pir, A.; Karakus, V.; Ozgur, G.; Kis, C.; Ceran, F.; Ilhan, G.; Ozkan, M.; Arslaner, M.; Ince, I.; Yavasoglu, I.Öğe ELECTRO-CLINICAL ANALYSIS OF ICTAL KISSING AUTOMATISM(Wiley-Blackwell, 2015) Taskiran, E.; Carpraz, I.; Bilir, E.; Bican, A.; Bora, I.; Chassoux, F.; Aydogdu, I.; Ozkara, C.Öğe EVALUATION OF FEBRILE NEUTROPENIC EPISODES IN ACUTE MYELOID LEUKEMIA PATIENTS(Ferrata Storti Foundation, 2013) Comert, M.; Aydogdu, I.; Kaya, E.; Yetkin, F.; Erkurt, M.; Kuku, I.Öğe Facial motor cortex plasticity in patients with unilateral peripheral facial paralysis(Ios Press, 2007) Yildiz, S.; Bademkiran, F.; Yildiz, N.; Aydogdu, I.; Uludag, B.; Ertekin, C.Hand motor representation area expands towards the area of the perioral facial motor cortex in patients with peripheral facial paralysis (PFP) and in hemifacial spasm cases treated with botulinum toxin. In this current study, we aimed to investigate the changes both in the ipsilateral and contralateral facial motor cortex areas in patients with PFP with transcranial magnetic stimulation (TMS). Thirty healthy individuals and 41 patients with unilateral PFP with partial or total axonal degeneration participated in this study. Motor evoked potentials (MEPs) of perioral muscles elicited by TMS of the intracranial portion of the facial nerve and motor cortex, were recorded. TMS was delivered through a figure-of-eight coil. Mapping of the cortical representation of perioral muscles were also studied in 13 of 41 patients and in 10 of control subjects. Mean amplitude of the intact perioral MEPs elicited by the ipsilateral hemisphere TMS, was significantly higher in patients than the control subjects. There was also a mild enlargement of the mean cortical representation area of intact perioral muscles on both hemispheres though it was not significant. We have concluded that there was a cortical reorganization in the hemisphere contralateral to the paralytic side resulting in an increase at corticofugal output related to intact perioral muscles.Öğe FRONTAL INTERMITTANT RHYTHMIC DELTA ACTIVITY (FIRDA): CLINICAL AND LABORATORY CORRELATES IN 20 PATIENTS(Wiley-Blackwell, 2015) Ciftci, S.; Ekinci, A.; Tabakoglu, A.; Guler, A.; Aydogdu, I.; Bademkiran, F.; Uludag, B.; Arac, N.Öğe PARTIAL AND SECONDARY GENERALIZED SEIZURES INDUCED BY DECISION MAKING: A CASE REPORT(Wiley-Blackwell, 2015) Kilic, I. H.; Uludag, B.; Aydogdu, I.Öğe Relapsing encephalopathy in a multiple sclerosis patient with unfavourable outcome (another aspect of Hashimoto encephalopathy?)(Sage Publications Ltd, 2006) Yuceyar, N.; Aydogdu, I.; Akgun, A.; Kocaman, A.Öğe Reply to Josef Finsterer about the article ‘What does epileptic nystagmus show us in cases presenting acute neurological symptoms?’(W.B. Saunders Ltd, 2023) Aykac, S.C.; Ekinci, A.S.; Tabakoglu, A.Y.; Gulluoglu, H.; Aydogdu, I.; Bademkıran, F.; Uludag, B.[No abstract available]Öğe Reply to P. Gelisse, P. Genton, A. Crespela ‘Failure to recognize muscular artifacts on the EEG may cause a wrong diagnosis of myoclonic status epilepticus’. Epilepsy Behav Rep. 5 April 2020, 100362. https://doi.org/10.1016/j.ebr.2020.100362(Elsevier Inc., 2020) Baysal-Kirac, L.; Aydogdu, I.[No abstract available]Öğe Retrospective and multicenter analysis of efficacy and safety of ruxolitinib in 176 Turkish patients with myelofibrosis: updated data(Pergamon-Elsevier Science Ltd, 2018) Soyer, N.; Ali, R.; Turgut, M.; Haznedaroglu, I.; Yilmaz, F.; Aydogdu, I.; Ceran, F.[No Abstract Available]Öğe Retrospective and multicenter analysis of efficacy and safety of ruxolitinib in 176 Turkish patients with myelofibrosis: updated data(Pergamon-Elsevier Science Ltd, 2018) Soyer, N.; Ali, R.; Turgut, M.; Haznedaroglu, I.; Yilmaz, F.; Aydogdu, I.; Pir, A.; Karakus, V.; Ozgur, G.; Kis, C.; Ceran, F.; Ilhan, G.; Ozkan, M.; Arslaner, M.; Ince, I.Öğe A SERIES OF 30 PATIENTS WITH EPILEPSIA PARTIALIS CONTINUA(Wiley-Blackwell, 2015) Ekinci, A. Suzen; Ciftci, S.; Guler, A.; Tabakoglu, A. Yildiz; Aydogdu, I.; Arac, N.; Bademkiran, F.; Uludag, B.
