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Öğe Benzoic acid formation and its relationship with microbial properties in traditional Turkish cheese varieties(Elsevier Ltd, 2021) Yerlikaya O.; Gucer L.; Akan E.; Meric S.; Aydin E.; Kinik O.Benzoic acid, the simplest member of the aromatic carboxylic acid family, is a weak acid that is a precursor to the synthesis of many important organic compounds. In addition to being used to prevent microbial spoilage in foods, it can also form due to different factors in foods. Hippuric acid found in the natural content of milk can be converted into benzoic acid naturally and can be found in different levels in dairy products. The present study aimed to determine the naturally-forming benzoic acid values in fresh and ripened traditional type cheese varieties and to determine the effect of some physicochemical and microbiological changes of cheeses on the amount of benzoic acid. In this research, benzoic acid levels of six different cheese types (White pickled cheese (traditional-industrial), Tulum cheese (canned or goat skin-packed), and Kashar cheese (fresh and ripened)) were determined. As a result of the analysis performed by HPLC, the amount of benzoic acid in cheese samples varied between 5.95 and 55.72 mg/kg, and it was determined that the microbiota of cheese significantly affected the formation of benzoic acid (p < 0.05). Especially, a lower benzoic acid level was observed in fresh Kashar and industrial White pickled cheeses with short shelf life, whereas a higher shelf-life was observed in cheese types such as ripened traditional White pickled and skin-packed Tulum cheese (p < 0.05). Although there is a difference according to the cheese types, especially between hippuric acid content and changes in pH, and Lactococcus and Enterococcus, a correlation was found between benzoic acid content and yeast-molds changes. © 2021 Elsevier LtdÖğe Central nervous system infections in the absence of cerebrospinal fluid pleocytosis(Elsevier B.V., 2017) Erdem H.; Ozturk-Engin D.; Cag Y.; Senbayrak S.; Inan A.; Kazak E.; Savasci U.; Elaldi N.; Vahaboglu H.; Hasbun R.; Nechifor M.; Tireli H.; Kilicoglu G.; Defres S.; Gulsun S.; Ceran N.; Crisan A.; Johansen I.S.; Namiduru M.; Dayan S.; Kayabas U.; Parlak E.; Khalifa A.; Kursun E.; Sipahi O.R.; Yemisen M.; Akbulut A.; Bitirgen M.; Popovic N.; Kandemir B.; Luca C.; Parlak M.; Stahl J.P.; Pehlivanoglu F.; Simeon S.; Ulu-Kilic A.; Yasar K.; Yilmaz G.; Yilmaz E.; Beovic B.; Catroux M.; Lakatos B.; Sunbul M.; Oncul O.; Alabay S.; Sahin-Horasan E.; Kose S.; Shehata G.; Andre K.; Dragovac G.; Gul H.C.; Karakas A.; Chadapaud S.; Hansmann Y.; Harxhi A.; Kirova V.; Masse-Chabredier I.; Oncu S.; Sener A.; Tekin R.; Deveci O.; Ozkaya H.D.; Karabay O.; Agalar C.; Gencer S.; Karahocagil M.K.; Karsen H.; Kaya S.; Pekok A.U.; Celen M.K.; Deniz S.; Ulug M.; Demirdal T.; Guven T.; Bolukcu S.; Avci M.; Nayman-Alpat S.; Yaşar K.; Pehlivano?lu F.; Ates-Guler S.; Mutlu-Yilmaz E.; Tosun S.; Sirmatel F.; Batirel A.; Öztoprak N.; Kadanali A.; Turgut H.; Baran A.I.; Karaahmetoglu G.; Sunnetcioglu M.; Haykir-Solay A.; Denk A.; Ayaz C.; Gorenek L.; Larsen L.; Poljak M.; Barsic B.; Argemi X.; Sørensen S.M.; Bohr A.L.; Tattevin P.; Gunst J.D.; Baštáková L.; Jereb M.; Johansen I.S.; Chehri M.; Beraud G.; Del Vecchio R.F.; Maresca M.; Yilmaz H.; Sharif-Yakan A.; Kanj S.S.; Korkmaz F.; Komur S.; Coskuner S.A.; Ince N.; Akkoyunlu Y.; Halac G.; Nemli S.A.; Ak O.; Kaya S.; Gunduz A.; Gozel M.G.; Hatipoglu M.; Cicek-Senturk G.; Akcam F.Z.; Inkaya A.C.; Sagmak-Tartar A.; Ersoy Y.; Tuncer-Ertem G.; Balkan I.I.; Cetin B.; Ersoz G.; Ozgunes N.; Yesilkaya A.; Erturk A.; Gundes S.; Turhan V.; Yalci A.; Aydin E.; Diktas H.; Ulcay A.; Seyman D.; Leblebicioglu H.Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. © 2017 The Author(s)Öğe Iatrogenic vascular injuries due to spinal surgeries: Endovascular perspective(Turkish Neurosurgical Society, 2018) Gok M.; Aydin E.; Guneyli S.; Akay A.; Cinar C.; Oran I.AIM: Iatrogenic vascular injuries due to spinal surgeries are rare but serious complications. Surgical management of these injuries is challenging with high morbidity rates. In this study we aim to present the results of endovascular management of iatrogenic vascular injuries due to spinal surgeries. MATERIAL and METHODS: We retrospectively reviewed 11 patients (5 male, 6 female) who had vascular injuries due to cervical and lumbar spinal surgeries. Clinical findings were bleeding (n=5), leg edema (n=6) and right heart failure with severe dyspnea (n=1). The age range of the patients were between 42-67 (mean: 57.1). Six patients were reviewed with imaging before the procedures and the rest of the patients (n=5) were directly referred to the angiography unit for diagnosis and possible endovascular treatment. RESULTS: The types of surgeries were; cervical surgery (n=5) and lumbar disc operation (n=6). The type of vascular injuries were; vertebral artery stenosis (n=1), vertebral artery pseudoaneurysm (n=3), vertebral artery occlusion (n=1) and iliac arteriovenous fistula (n=6). The type of endovascular treatments were; parent artery occlusion (PAO) (n=2), covered stent graft implantation (n=6) and intrasaccular coil embolization of pseudoaneurysm (n=1). The remaining 2 patients were managed conservatively. No major complications or mortality occured during endovascular interventions. No bleeding or ischemia occured in the follow-up period. CONCLUSION: Iatrogenic vascular injuries due to spinal surgeries are rare but serious complications. Endovascular interventions are safe and effective in the diagnosis and treatment of such vascular injuries. © 2017, Turkish Neurosurgical Society.Öğe Identification of candida species isolated from clinical samples and investigating antifungal susceptibility in Turkey(Acta Medica Mediterranea, 2014) Aydin E.; Karakas A.; Savasci U.; Akpak Y.K.; Caymaz S.O.; Aydin S.; Avci M.; Gul H.C.; Coskun O.; Coskuner S.A.; Metin D.Y.; Ozgenc O.; Eyigun C.P.Objectives: The purpose of this study is identify typology of candida species from patients' samples, and determine their invitro antifungal susceptibility. Materials and methods: In this study, Candida species isolated from patients who applied to our laboratory between 2009-2010 were included in order to identify the types of Candida and to carry out their antifungal sensitivity. The Candida species were typed using germ tube test, corn meal Tween-80 and BBL CHROMagar medium, and API ID32C yeast identification system. Antifungal drugs' susceptibility of Candida species for amphotericin B, fluconazole, itraconazole, and voriconazole were conducted through microdilution system. Results: Of the 97 Candida species, 58.76% were identified as Candida albicans, other identified types were as follows: C. parapsilosis (13.4%), C. glabrata (11.3%), C. tropicalis (5.15%) respectively. Antifungal drugs sensitivity tests results revealed 1.03% resistance to fluconazole and 4.12% to itracanazole, whereas no resistance was found to amphotericin B and voriconazole. Conclusion: Target population for Candida has gradually been expanding. Therefore, it may be suggested that determining the type of pathogen and running its susceptibility tests are significant factors that will enhance the success of the treatment before empirical treatment against Candida infections is initiated.Öğe MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson’s disease and multiple system atrophy(Taylor and Francis Ltd., 2019) Eraslan C.; Acarer A.; Guneyli S.; Akyuz E.; Aydin E.; Colakoglu Z.; Kitis O.; Calli M.C.Objectives: To evaluate the magnetic resonance imaging (MRI)-derived parameters in differentiation of patients with progressive supranuclear palsy (PSP) from patients with Parkinson’s disease (PD), multiple system atrophy (MSA), and control subjects was aimed. Methods: Thirty-three patients [mean age, 65.21 ± 4.75 years; PSP (n = 9), MSA (n = 8), PD (n = 6), and control subjects (n = 10)] who have undergone cranial MRI were included in this retrospective study. MRI-derived parameters including areas of midbrain and pons, midbrain area-to-pons area (M/P) ratio, widths of middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP), MCP/SCP ratio, magnetic resonance parkinsonism index (MRPI), cerebral interpeduncular angle, and length of midbrain tegmentum were compared in patients with PSP, PD, MSA, and control subjects through the analysis of variance and Kruskal–Wallis tests with Bonferroni correction and Mann–Whitney U test. Results: The length of midbrain tegmentum, midbrain area, SCP, and M/P ratio were found to be lower, while cerebral interpeduncular angle and MRPI were higher in patients with PSP. Pons area, MCP width, and MCP/SCP ratio were found to be lower in patients with MSA. For PSP, cerebral interpeduncular angle has a sensitivity of 100% and specifity of 90%, and MRPI had a sensitivity of 88.9% and specifity of 100% for PSP. Discussion: Several MRI-derived parameters can be used in differentiation of patients with PSP from patients with PD, MSA and control subjects. The cerebral interpeduncular angle and MRPI, which demonstrated higher values in patients with PSP, were more significant for PSP than the other parameters. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.Öğe Neuropathic pain in elderly: A multicenter study [Yaşlilarda nöropatik ağri: çok merkezli çalişma](Geriatrics Society, 2016) Gökce Kutsal Y.; Eyigör S.; Doğan A.; Zardoust S.; Durmuş B.; Evcik D.; Günaydin R.; Şahin N.; Aydeniz A.; Öztop P.; Gökkaya K.O.; Hizmetli S.; Borman P.; Paker N.; Demir G.; Kayalar G.; Aydin E.; Özyemişci Ö.Introduction: Aging brings with it an increase in the prevalence of pain. For effective pain treatment, it is important to determine pain prevalence, its nature, and the factors affecting it. However, epidemiologic information on neuropathic pain in the elderly is inadequate. In our cross-sectional multicenter study, we aimed to determining the prevalence of neuropathic pain in elderly patients and the relationship of neuropathic pain with socio-demographic and clinical factors. Materials and Method: Thirteen centers in different regions of Turkey. The study included 1163 individuals over age 65. Physicians conducted face-to-face interviews to obtain clinical and socio-demographic data and The Douleur Neuropathic 4 (DN4) and The Self-completed Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) pain scales were used to assess neuropathic pain. Patients who scored ?4 or ?12 on the DN4 and S-LANSS scales, respectively, were determined to be experiencing neuropathic pain. Results: Neuropathic pain was found in 52.5% of the patients (n=610) in this study. Approximately 67.5% of the patients with neuropathic pain were in the 65-74 age group, and 72.1% (n=440) were females. Of the patients who were experiencing neuropathic pain, 48.4% were graduates of primary school, 91.6% engaged in very little or no physical activity, and 56.7% were taking four or more medications. Conclusions: Neuropathic pain prevalence was 52.5% in the elderly over age 65 who had presented with pain complaints. Neuropathic pain was more frequently seen in women, patients with comorbidities, those with poor levels of ambulation, those using walking aids, and those using multiple drugs. Interrogating the elderly for neuropathic pain seems important for effective treatment. © 2016, Geriatrics Society. All rights reserved.Öğe [No title available](Turkiye Klinikleri Journal of Medical Sciences, 2016) Karabay O.; Hoşoğlu S.; Güçlü E.; Akalin Ş.; Altay F.A.; Aydin E.; Ceylan B.; Çelik A.; Çelik İ.; Demirdal T.; Demirli K.; Erben N.; Erkorkmaz Ü.; Erol S.; Evirgen Ö.; Gönen İ.; Güner A.E.; Güven T.; Kadanali A.; Koçoğlu M.E.; Kökoğlu Ö.F.; Küçükbayrak A.; Sargin F.; Sünnetçioğlu M.; Şenol Ş.; Taşbakan M.I.; Tekin R.; Turhan V.; Yilmaz G.; Dede B.Background/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics. Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician. Results: A total of 1906 specialists from 20 cities in Turkey participated in the study. Of those who participated, 1271 (67.5%) had ?5 years of occupational experience (junior specialists = JSs) and 942 (49.4%) of them were physicians. Specialists having >5 years of occupational experience in their branch expressed that they followed the antibiotic guidelines more strictly than the JSs (P < 0.05) and 755 of physicians (88%) and 720 of surgeons (84.6%) thought that the AR policy was necessary and useful (P < 0.05). Conclusion: This study indicated that the AR policy was supported by most of the specialists. Physicians supported this restriction policy more so than surgeons did. © TÜBITAK.Öğe Use of industrial and agricultural wastes in construction concrete(American Concrete Institute, 2018) Arel H.Ş.; Aydin E.This work investigated the effects of Class F fly ash (FA), coconut husk ash (CHA), and rice husk ash (RHA) as cement replacements at various proportions on the workability, setting time, compressive strength, and pullout strength of concrete. Concretes containing partial replacement of cement by 20 and 40% FA and 10, 15, and 20% CHA and RHA were investigated. The results revealed that FA, CHA, and RHA can be used as replacements for cement in concrete production to produce sustainable and ecological products. The mixed composition of 20% FA and 20% RHA had 15.3% greater compressive strength than that of the reference composition after 180 days, while a slight reduction in this parameter was observed in FA-CHA combinations. FA and RHA mixtures showed the highest compressive and pullout strengths for all aging times tested. © 2018, American Concrete Institute. All Rights Reserved.Öğe Visual prognosis and risk factors in patients with uveitis associated with ankylosing spondylitis [Ankilozan spondilit ile ilişkili üveit olgularinin görsel prognozu ve risk faktörleri](Gazi Eye Foundation, 2017) Balikoglu Yilmaz M.; Saritepe Imre S.; Aydin E.; Kazanci L.; Köse T.Aim: To examine factors affecting visual prognosis and recurrence in patients having uveitis associated with ankylosing spondylitis (AS). Methods: Thirty-five eyes of 26 patients with uveitis associated with ankylosing spondylitis were evaluated, retrospectively. Clinical and laboratory findings of patients at time of diagnosis possibly affecting visual outcome and recurrence were analyzed. Results: The mean follow-up period was 33.1 ± 32.7 (1-116) months, baseline best corrected visual acuity (BCVA) (logMAR) was 0.33 ± 0.45, final BCVA was 0.22 ± 0.39 (p=0.02). The final BCVA (logMAR) in eyes with baseline legal blindness and cataracts was significantly higher than those without them (p<0.05). However, final BCVA was similar in males and females, in patients with unilateral or bilateral involvement, and with or without a family history, history of unilateral variable or recurrent uveitis, baseline glaucoma, ma- cular edema or recurrence (p>0.05). The positive correlation was also detected between final and baseline BCVA (r = 0.73, p<0.001), while there was no correlation between final BCVA and age of first symptoms, time between AS and uveitis, attack duration, C-reactive protein and erythrocyte sedimentation rate, anterior chamber cell and vitreous hazy levels. When all these factors were examined in terms of recurrence; the recurrence was only affected by gender and it was higher in women than in men (70.6%vs. 33.3%, p=0.028). Conclusion: The final BCVA in patients with uveitis associated with AS was just correlated with the baseline BCVA and influenced by baseline legal blindness and cataract. The recurrence was higher in women than in men. © 2017 Gazi Eye Foundation. All rights reserved.
