Yazar "Aydin, Ozgur" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Association between vitamin D receptor gene FokI polymorphism and mortality in patients with sepsis
    (Springer, 2024) Bozgul, Sukriye Miray Kilincer; Emecen, Durdugul Ayyildiz; Akarca, Funda Karbek; Bozkurt, Devrim; Aydin, Ozgur; Koca, Didem; Can, Ozge
    Background Sepsis is life-threatening organ dysfunction as a result of the host's dysregulated immune response to infection. The vitamin D receptor (VDR) gene FokI polymorphism influences immune cell behavior. In the present study, we aimed to investigate the association between VDR FokI polymorphism and mortality in sepsis and non-sepsis patients in the intensive care unit (ICU).Methods and results This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).Methods and results This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).Conclusion The VDR FokI polymorphism, particularly the CC genotype, appears to be associated with lower mortality in ICU patients.
  • Küçük Resim Yok
    Öğe
    The Association of Macrophage Activation-Like Syndrome with Mortality in Elderly Patients with Sepsis
    (Bilimsel Tip Yayinevi, 2023) Bozgul, Sukriye Miray Kilincer; Acar, Caner; Kurtulmus, Ilkce Akgun; Aydin, Ozgur; Koca, Didem; Ak, Gunes; Cilli, Fatma Feriha
    Introduction: Among the geriatric population, when compared to younger individuals, mortality is high. Macrophage activation-like syndrome (MALS) has been reported to be an independent immunological entity associated with mortality among sepsis patients in adults which represents the increased inflammation state. This study aimed to investigate the frequency of MALS in elderly sepsis patients and its association with intensive care unit (ICU) mortality. Materials and Methods: This retrospective study included patients aged 65 years or older with sepsis between January 2013 and January 2022 in the ICU of the Internal Medicine Department of Ege University Hospital. MALS was diagnosed with a hemophagocytic syndrome score (H-score) of =151 and/or co-presence of hepatobiliary dysfunction (HBD) and disseminated intravascular coagulation (DIC). Clinical, demographic, and laboratory results were retrieved from the medical records. Factors affecting ICU mortality were investigated with binary logistic regression analysis. Results: In our study of 194 patients, mortality was 46.4% and MALS frequency was 23.7%. Among non-survivors, MALS frequency was significantly higher than survivors; 32.2% and 16.3%, p= 0.010. The median H-score was 117 in non-survivors and 78.5 in survivors, p= 0.002. ICU mortality of elderly sepsis patients increased by approximately 25 times when MALS was present. Age was not identified as a risk factor for ICU mortality. Conclusion: Among elderly sepsis patients, the frequency of MALS was found to be remarkably high in our single-center study. MALS may be one of the reasons for increased mortality in elderly sepsis patients.
  • Küçük Resim Yok
    Öğe
    How Do Exercise, Sleep and Depression Affect Disease Scores and Quality of Life in Primary Sjögren's Syndrome Patients?
    (Dove Medical Press Ltd, 2024) Tastekin, Fatih; Karatas, Ezgi; Aydin, Ozgur; Zihni, Figen Yargucu; Kabasakal, Yasemin; Barutcuoglu, Burcu; Karabulut, Gonca
    Purpose: Primary Sj & ouml;gren's syndrome (PSS) has many effects such as fatigue, pain, physical activity limitation and sleep disturbance, which limit patient's daily and social lives. The aim of our study was to assess fatigue, depression, physical activity status and quality of life in patients with PSS, and to determine the relationship between these data and disease-related parameters. Patients and Methods: This study was conducted with 117 primary Sj & ouml;gren's syndrome patients. Demographic and anthropometric characteristics, disease activity (ESSDAI), quality of life scale (SF36), depression (Beck Depression Scale), physical activity status (International Physical Activity Questionnaire Short Form (IPAQ) score) and sleep status (Pittsburgh Sleep Quality Scale) of PSS patients were evaluated and relationships have been examined. Results: According to the results of our study, we found that sleep disorders are common in PSS patients (74.4%). Overweight patients, particularly higher lean mass sleep better (r:-0.201, p:0.043). Poor sleep causes fatigue (p=0.062) and depression (p=0.030). Sleep disturbance could not be explained by depressive state alone. However, after controlling for depression, the effect of sleep on fatigue seriously decreases (p=0.311). Exercise did not improve sleep quality (p=0.35) and the rate of poor sleep was higher among who exercised (p=0.192). Conclusion: Based on the results of our study, we believe that, treating depression in PSS patients is crucial for reducing fatigue. Patients need education on performing the correct exercises and weight gain should done in a professional manner. Gaining a deeper understanding of the multisystem involvement of the disease and the impact of exercise on the disease, will have positive effects on patient care and treatment decisions.