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    Meningitis caused by neisseria meningitidis, hemophilus influenzae type b and streptococcus pneumoniae during 2005-2012 in Turkey: A multicenter prospective surveillance study
    (Landes Bioscience, 2014) Ceyhan M.; Gürler N.G.; Ozsurekci Y.; Keser M.; Aycan A.E.; Gurbuz V.; Salman N.; Camcioglu Y.; Dinleyici E.C.; Ozkan S.; Sensoy G.; Belet N.; Alhan E.; Hacimustafaoglu M.; Celebi S.; Uzun H.; Oner A.F.; Kurugol Z.; Ali M.; Aygun D.; Oncel E.K.; Celik M.; Yasa O.; Akin F.; Coşkun Y.
    Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to ? 18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis ), Streptococcus pneumoniae ( S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey. © 2014 Taylor & Francis Group, LLC