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Öğe Osteomyelitis caused by bacillus calmette-guérin vaccination in a healthy toddler(Oxford University Press, 2019) Avcu G.; Sahbudak Bal Z.; Cavusoglu C.; Vardar F.Bacillus Calmette-Guérin (BCG) osteomyelitis in immunocompetent children is a rare complication of BCG immunization which presents with nonspecific findings and often leads to delayed diagnosis. We report a 1-year and 10-month-old male infant with complaining of knee pain and limping for 5 months. He received surgical debridement due to suspicion of malignancy but BCG osteomyelitis of the distal femur was diagnosed with the culture of the specimens which revealed to have Mycobacterium bovis-BCG strain. He was successfully treated with antituberculous therapy lasting for 1 year. © 2019 The Author(s) [2019]. Published by Oxford University Press. All rights reserved.Öğe Prevalence of bacterial agents in children with acute gastroenteritis in the pediatric emergency department of ege university school of medicine [Ege üniversitesi tıp fakültesi çocuk acil servisine başvuran akut gastroenteritli çocuklarda bakteriyel etkenlerin prevelansı](AVES Ibrahim Kara, 2016) Avcu G.; Sahbudak Bal Z.; Ulaş Saz E.; Aydemir Ş.; Vardar F.Objective: Acute gastroenteritis is one of the main causes of morbidity and mortality in childhood. Although rotavirus is reported to be the most common agent in diarrhea, infectious gastroenteritis due to enteric pathogenic bacteria is still widely seen in developing and underdeveloped countries. In this study, we aimed to determine the incidence of bacterial agents in children with acute gastroenteritis in Pediatric Emergency Department of Ege University School of Medicine. Material and Methods: Data of patients aged 0-18 years with acute gastroenteritis, who were admitted to our hospital between September 2013 to August 2014 were analyzed retrospectively. Frequency of bacterial gastroenteritis, antimicrobial susceptibility and seasonal variations were investigated. Results: Bacterial pathogens were detected in 143 (16.3%) of 875 stool cultures. Among them, Campylobacter spp. was detected in 88 (10.1%) cases, Salmonella spp. in 43 (4.9%) cases and Shigella spp. in 12 (1.4%) cases. No cases of Vibrio spp. and E. coli were isolated. Campylobacter spp. were isolated in all months of the year with a slight increase in frequency in spring while Salmonella spp. and Shigella spp. were the most common agents in summer. Salmonella spp. were the least resistant isolates. We determined increased resistance to quinolones in Campylobacter isolates. Majority of isolated Shigella spp. were resistant to co-trimoxazole. Resistance to 3 rd generation cephalosporins was detected in three cases of S. sonnei gastroenteritis. Conclusion: The most common bacterial enteropathogen in acute gastroenteritis was C. jejuni in our region and quinolone resistance was higher than expected. In the light of these findings, azithromycin may be a good option in the empirical treatment of acute diarrhea when antibiotics are indicated. © 2016 by Pediatric Infectious Diseases Society.Öğe Quantitative Antibody Levels Against SARS-CoV-2 Spike Protein in COVID-19 and Multisystem Inflammatory Syndrome in Children(NLM (Medline), 2022) Avcu G.; Arslan S.Y.; Soylu M.; Bilen N.M.; Bal Z.S.; Cicek C.; Kurugol Z.The majority of children with coronavirus diseases 2019 (COVID-19) are asymptomatic or develop mild symptoms, and a small number of patients require hospitalization. Multisystem inflammatory syndrome in children (MIS-C) is one of the most severe clinical courses of COVID-19 and is suggested to be a hyperinflammatory condition. This study aimed to compare quantitative antibody levels against SARS-CoV-2 spike protein in children with COVID-19 and MIS-C. Blood samples from 75 patients [n?=?36 (48%) with mild/asymptomatic (group 1), n?=?22 (29.3%) with moderate-to-severe SARS-CoV-2 infection (group 2) and n?=?17 (22.6%) patients with MIS-C (group 3)] were analyzed 3 months after COVID-19. The majority of the children with asymptomatic/mild COVID-19 symptoms (80.6%), moderate/severe disease (90.9%), and MIS-C (82.4%) had detectable IgG antibodies to SARS-CoV-2 spike protein (p?=?0.567). The mean antibody value against SARS-CoV-2 spike protein was 321.9?±?411.6 in group 1, 274?±?261 in group 2, and 220?±?299 in group 3, respectively (p?>?0.05). Patients diagnosed with COVID-19 (asymptomatic/mild+moderate/severe) and those with MIS-C were also compared; the antibody positivity rates [COVID-19 group: 85.5%, MIS-C group: 82.4%, (p?=?0.833)] and mean antibody values [COVID-19 group: 303.9?±?360.3, MIS-C group: 220?±?299, (p?>?0.05)] were similar in both groups. In conclusion, the majority of children with COVID-19 and MIS-C developed a detectable antibody level against SARS-CoV-2 spike protein 3 months after COVID-19. Quantitative antibody levels were similar in both asymptomatic/mild disease, moderate/severe disease, and MIS-C group. Long-term studies evaluating antibody responses in children with COVID-19 and MIS-C are needed for more accurate vaccine schedules.Öğe Thanks to Trauma: A Delayed Diagnosis of Pott Disease(Lippincott Williams and Wilkins, 2015) Avcu G.; Sahbudak Bal Z.; Duyu M.; Akkus E.; Karapinar B.; Vardar F.[No abstract available]
