Yazar "Aslanipour, Behnaz" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome(Taylor & Francis Ltd, 2019) Alan, Murat; Gurlek, Beril; Yilmaz, Alpay; Aksit, Murat; Aslanipour, Behnaz; Gulhan, Ibrahim; Mehmet, Calan; Taner, Cuneyt EftalAsprosin associated with insulin resistance is a newly discovered peptide hormone. The peptide promotes hepatic glucose production. Polycystic ovary syndrome (PCOS) is a metabolic disorder. Insulin resistance plays a vital role in the pathogenesis of the disease. The aim of this study was to discover the association between insulin resistance and asprosin in women with PCOS. We recruited 78 subjects with PCOS and 78 age-matched and body mass index (BMI)-matched controls into this cross-sectional study. Circulating asprosin levels were validated using ELISA method. We also determined metabolic and hormonal parameters of the involved subjects. We found that circulating asprosin levels were elevated in women with PCOS with respect to controls. Asprosin levels showed a positive correlation with insulin resistance, BMI, and free androgen index (FAI). Moreover, subjects with the highest tertile of asprosin levels represented increased odds of having PCOS as compared to those subjects with the lowest tertile asprosin levels. Increased asprosin levels resulted to high possibility of having PCOS risk associated with insulin resistance.Öğe Association of decreased C1q/tumor necrosis factor- related protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndrome(Galenos Yayincilik, 2019) Calan, Mehmet; Alan, Murat; Alarslan, Pinar; Kocabas, Gokcen Unal; Bozkaya, Giray; Acara, Ahmet Cagdas; Aslanipour, Behnaz; Fenercioglu, Ozge; Isil, Ahmet Murat; Guler, AsliObjective: C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters. Material and Methods: The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters. Results: Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90 +/- 2.64 vs 11.73 +/- 3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5. Conclusion: Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.Öğe Association of decreased C1q/tumor necrosis factor-related protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndrome(2019) Çalan, Mehmet; Alarslan, Pınar; Kocabaş, Gökçen Ünal; Alan, Murat; Bozkaya, Özlem Giray; Fenercioğlu, Özge; Aslanipour, BehnazObjective: C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. the aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters.Material and Methods: the present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters.Results: Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90±2.64 vs 11.73±3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. in both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5.Conclusion: Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS. (J Turk Ger Gynecol Assoc 2019; 20: 89-96)Öğe A COMPARATIVE ANALYSIS OF MEDICINAL AND AROMATIC PLANTS USED IN THE TRADITIONAL MEDICINE OF IGDIR (TURKEY), NAKHCHIVAN (AZERBAIJAN), AND TABRIZ (IRAN)(Pakistan Botanical Soc, 2018) Ozturk, Munir; Altundag, Ernaz; Ibadullayeva, S. Jamshid; Altay, Volkan; Aslanipour, BehnazA total of 341 naturally distributed taxa belonging to 65 families are used in the traditional medicine in Igdir (Turkey), Nakhchivan (Azerbaijan), and Tabriz (Iran). Local people in three different regions generally use herbal remedies for digestive, respiratory, urogenital systems, as well as dermal, neurological and psyschological diseases. On the basis of localities three highly prevelant usesin Igdir are colds (32 taxa), stomach disorders (28 taxa), and cough (24 taxa); in Nakhchivan rheumatism (24 taxa), gastrointestinal disorders (24 taxa), and anthelmintic (20 taxa), and in Tabriz diuretic (24 taxa), fever (22 taxa), and cough (20 taxa). Our findings reveal that in these three areas belonging to three neighbouring countries 4 taxa are widely distributed and used almost forthe same applications; Glycyrrhiza glabra (for digestive and respiratory systems), Malus sylvestris ssp. orientalis (for respiratory system), Rosa canina (for digestive and urinogenital systems), and Urtica dioica (for digestive system). The studied areas show several resemblances from cultural and other aspects.Öğe Cycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysis(Elsevier Science Bv, 2017) Aslanipour, Behnaz; Gulcemal, Derya; Nalbantsoy, Ayse; Yusufoglu, Hasan; Bedir, ErdalTwo new tridesmosidic cycloartane-type triterpene glycosides (1 and 2) were isolated from the methanolic extract of the roots of Astragalus brachycalyx FISCHER (A. brachycalyx) along with ten (3-12) known cycloartanetype triterpene glycosides. Structures of the new compounds were established as 3-O-beta-D-xylopyranosyl-6-O-beta-Dglucopyranosyl- 16-O-beta-D-glucopyranosyl-3 beta, 6a, 16 beta, 24(S)-25-pentahydroxycycloartane (1), 3-O-[a-L-arabinopyranosyl-(1. 2)-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-16-O-beta-D-glucopyranosyl-3 beta, 6 alpha, 16 beta, 24(S)-25-pentahydroxycycloartane (2), by using 1D and 2D-NMR techniques and mass spectrometry. In vitro immunomodulatory effects and hemolytic activities of the new saponins (1 and 2) and acetylated form of 1 (1a) were studied together with the BuOH and MeOH extracts of Astragalus brachycalyx. The results have proven that tridesmosidic Astragalus cycloartanes are noteworthy immunomodulatory compounds via induction of cytokine production, namely IL-2 and IFN-gamma. The test compounds also resulted slight hemolysis at very high doses substantiating a safer profile compared to the positive control QS-21.Öğe Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome(Taylor & Francis Ltd, 2020) Aslanipour, Behnaz; Alan, Murat; Demir, IsmailLiver-expressed antimicrobial peptide 2 (LEAP-2) is a newly identified peptide hormone involved in glucose metabolism. It acts as a noncompetitive antagonist of ghrelin hormone's receptor. Polycystic ovary syndrome (PCOS) is a common metabolic and reproductive disease associated with insulin resistance. We aimed to compare circulating LEAP-2 levels in subjects with PCOS and controls. We also focused to determine whether there was a relationship between LEAP-2 and metabolic parameters in women with PCOS. We enrolled 64 subjects with PCOS and 64 age and body mass index (BMI)-matched controls into the current cross-sectional study. Circulating LEAP-2 and ghrelin levels were measured via ELISA method. Metabolic and hormonal parameters of the involved subjects were analyzed. We found that circulating LEAP-2 and ghrelin levels were decreased in women with PCOS as compared with controls. LEAP-2 showed a positively independent association with ghrelin while LEAP-2 exhibited an inverse association with insulin resistance, BMI, and free-androgen index (FAI). Additionally, subjects having the lowest tertile of LEAP-2 were in positive link of developing PCOS risk with respect to those subjects having the highest tertile of LEAP-2 levels. Decreased LEAP-2 levels were associated with a high possibility of having PCOS risk associated with insulin resistance.Öğe Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome(Taylor & Francis Ltd, 2019) Aslanipour, Behnaz; Alan, Murat; Demir, IsmailLiver-expressed antimicrobial peptide 2 (LEAP-2) is a newly identified peptide hormone involved in glucose metabolism. It acts as a noncompetitive antagonist of ghrelin hormone's receptor. Polycystic ovary syndrome (PCOS) is a common metabolic and reproductive disease associated with insulin resistance. We aimed to compare circulating LEAP-2 levels in subjects with PCOS and controls. We also focused to determine whether there was a relationship between LEAP-2 and metabolic parameters in women with PCOS. We enrolled 64 subjects with PCOS and 64 age and body mass index (BMI)-matched controls into the current cross-sectional study. Circulating LEAP-2 and ghrelin levels were measured via ELISA method. Metabolic and hormonal parameters of the involved subjects were analyzed. We found that circulating LEAP-2 and ghrelin levels were decreased in women with PCOS as compared with controls. LEAP-2 showed a positively independent association with ghrelin while LEAP-2 exhibited an inverse association with insulin resistance, BMI, and free-androgen index (FAI). Additionally, subjects having the lowest tertile of LEAP-2 were in positive link of developing PCOS risk with respect to those subjects having the highest tertile of LEAP-2 levels. Decreased LEAP-2 levels were associated with a high possibility of having PCOS risk associated with insulin resistance.Öğe Determination and Comparison of in Vitro Radical Scavenging Activity of Both Garlic Oil and Aqueous Garlic Extracts and Their in Vivo Antioxidant Effect on Schistosomiasis Disease in Mice(2018) Sadrefozalayi, Somayyeh; Aslanipour, Behnaz; Alan, Murat; Çalan, MehmetGarlic has long been utilizing as a folk remedy for various diseases. in this study, the effect of aqueous garlic extract (AGE) (125 mg kg-1), garlic oil extract (GOE) (125 mg kg-1), and the combination of both extracts (AGE+GOE) (62.5 from each) was studied over a parasitic disease namely schistosomiasis. Determination of some radical scavenging activities including Ferric Reducing Ability Power, Hydrogen peroxide, DPPH and nitric oxide radical scavenging activities were studied. the antioxidant properties of the mentioned extracts on both normal and Schistosoma mansoni-infected mice was also studied. the liver tissues were analyzed for the level of Malondialdehyde (MDA) and glutathione (GSH) known as biomarkers for oxidative and reducing status, respectively. the results showed that almost all tested extracts showed high effect of radical scavenging activity. Furthermore, remarkable decrease in worms and tissue eggs were analyzed in all tested extracts as AGE+ GOE (1015 ± 1.41) represented higher level of prohibition in total number of worms and eggs compared to infected untreated mice (1502 ± 2.13). the garlic extracts were potent antioxidants with slight differences.Öğe Fractalkine: an inflammatory chemokine elevated in subjects with polycystic ovary syndrome(Springer, 2019) Demir, Ismail; Guler, Asli; Alarslan, Pinar; Isil, Ahmet Murat; Ucman, Ozge; Aslanipour, Behnaz; Calan, MehmetPurpose Fractalkine (FKN) is an inflammatory chemokine related to reproductive system and glucose metabolism. There is a link between FKN and steroidogenesis as FKN induces progesterone synthesis. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with low progesterone production and insulin resistance. We aimed to explore whether women with PCOS have any difference in FKN levels compared to women without PCOS. We also focused on determination of any association between FKN levels and hormonal-metabolic parameters in women with PCOS. MethodsThe current research was designed as a case-control study. Eighty subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle were taken into the study. We measured circulating FKN levels via ELISA methods. ResultsCirculating FKN levels were higher in women with PCOS than controls (1.930.61 vs. 1.22 +/- 0.33ng/ml, P<0.001). FKN levels showed a positive correlation with body mass index (BMI), insulin resistance, inflammatory marker hs-CRP, total testosterone, and free-androgen index (FAI), whereas it showed a negative correlation with sex hormone-binding protein in women with PCOS. Linear regression analyses revealed that the link of FKN with BMI, insulin resistance, hs-CRP, and FAI was independent. Binary logistic regression analysis showed that the risk of having PCOS was associated with high levels of FKN. Conclusions Increased FKN levels related to insulin resistance, inflammation and androgens in women with PCOS. FKN may have an inter-related role in different pathophysiologic pathways of PCOS.Öğe Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus(Wiley, 2020) Alarslan, Pinar; Kocabas, Gokcen Unal; Demir, Ismail; Guler, Asli; Bozkaya, Giray; Aslanipour, Behnaz; Calan, MehmetBackground Urocortin 3 (UCN3) is a peptide hormone playing a pivotal role in glucose and lipid metabolisms. However, its clinical implications remain unclear. Our aims were to investigate the altered levels of UCN3 in newly diagnosed type 2 diabetes mellitus (nT2DM) patients in comparison to subjects with normal glucose tolerance (NGT) and to determine the presence of any possible link between UCN3 levels and metabolic parameters. Methods Eighty nT2DM and 80 age-, body mass index (BMI)-, and gender-matched NGT subjects were enrolled into this case-control study. the circulating UCN3 levels were measured using the enzyme-linked immunoabsorbent assay (ELISA). Metabolic parameters of enrolled subjects were also determined. A standard 75-g 2-hour oral glucose tolerance test was used for diagnosis of type 2 diabetes mellitus (T2DM). Results UCN3 levels were higher in subjects with nT2DM than in controls (115.64 +/- 39.26 vs 86.16 +/- 22.81 pg/mL, P < .001). UCN3 levels were increased in subjects with metabolic syndrome compared to subjects without metabolic syndrome in both nT2DM and NGT groups. UCN3 levels showed a positive correlation with BMI in both groups. Moreover, UCN3 levels were positively and independently associated with insulin, fasting blood glucose, insulin resistance, 2-hour plasma glucose, glycosylated hemoglobin, and triglycerides, whereas UCN3 levels were negatively and independently associated with high-density lipoprotein cholesterol. According to logistic regression analysis, increased risk of T2DM and metabolic syndrome were parallel with the highest elevated levels of UCN3. Conclusions Increased levels of UCN3 are associated with unfavorable metabolic profiles in T2DM, indicating a potential role of UCN3 in glucose and lipid metabolisms in T2DM. Highlights Urocortin 3 (UCN3) may play a crucial role in glucose and lipid metabolisms. Circulating levels of UCN3 were investigated in subjects with newly diagnosed type 2 diabetes mellitus (nT2DM). Circulating UCN3 levels were significantly elevated in nT2DM subjects. Increased UCN3 levels are associated with having the risk of type 2 diabetes mellitus and metabolic syndrome.Öğe Neudesin: a neuropeptide hormone decreased in subjects with polycystic ovary syndrome(Taylor & Francis Ltd, 2020) Bozkaya, Giray; Fenercioglu, Ozge; Demir, Ismail; Guler, Asli; Aslanipour, Behnaz; Calan, MehmetNeudesin is a neuropeptide hormone involves in female reproduction system via promoting effects of progesterone. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated with hypothalamic-pituitary-ovarian axis abnormalities and impaired negative feedback mechanism of progesterone upon gonadotropin-releasing hormone secretion. Our aims were to discover whether neudesin levels were altered in PCOS women comparing to controls and to determine the link of neudesin with hormonal-metabolic parameters in PCOS women. the current research was designed as a case-control study. Sixty-eight subjects with PCOS and 67 age- and body mass index (BMI)-matched subjects as controls were enrolled into the study. Circulating neudesin levels were measured by ELISA. Neudesin levels were significantly lower in PCOS subjects compared to controls (4.07 +/- 1.22 vs. 6.02 +/- 2.07 ng/ml, p < .001). Neudesin exhibited an inversely independent link with luteinizing hormone, free-androgen index, and BMI whereas it showed a positively independent link with progesterone in women with PCOS. Logistic regression analysis revealed that decreased neudesin levels were parallel with increased risk of having PCOS. Decreased neudesin levels were associated with hormonal disturbances in PCOS women, suggesting that neudesin may play a role in pathophysiology of PCOS.Öğe Relation of Decreased Circulating Sortilin Levels With Unfavorable Metabolic Profiles in Subjects With Newly Diagnosed Type 2 Diabetes Mellitus(Elsevier Science Inc, 2020) Demir, Ismail; Akan, Ozden Yildirim; Guler, Asli; Bozkaya, Giray; Aslanipour, Behnaz; Calan, MehmetBackground: Sortilin, a pluripotent peptide hormone, plays a role in glucose and lipid metabolism. A link between sortilin and insulin sensitivity has been implicated. However, the clinical implications of this link remain elusive. Our aims were to investigate whether sortilin levels were altered in subjects with newly diagnosed type 2 diabetes mellitus (nT2DM) compared with subjects with normal glucose tolerance (NGT) and to determine whether a link exist between sortilin levels and metabolic parameters. Materials and Methods: A total of 150 subjects including 75 nT2DM patients and 75 subjects with NGT who were matched in age, body mass index, and sex were enrolled into this case-control study. the circulating levels of sortilin were measured using enzyme-linked immunosorbent assay. A 2-hour 75-g oral glucose tolerance test was used for diagnosis of T2DM. Metabolic parameters of enrolled subjects were also determined. Results: the circulating levels of sortilin were found to be significantly lower in subjects with nT2DM than in controls (138.44 +/- 38.39 vs. 184.93 +/- 49.67 pg/mL, P < 0.001). Sortilin levels showed a negative correlation with insulin resistance and unfavorable lipid profiles, while they were positively correlated with high-density lipoprotein cholesterol in subjects with nT2DM. Linear regression analysis showed an independent and inverse link between sortilin and insulin resistance and unfavorable lipid profiles. Moreover, logistic regression analysis revealed that the subjects with the lowest sortilin levels had an increased risk of nT2DM compared with those subjects with the highest sortilin levels. Conclusions: Decreased circulating levels of sortilin were associated with unfavorable metabolic profiles in subjects with nT2DM.Öğe Relationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance, High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetes(Elsevier Science Inc, 2018) Bilgir, Oktay; Gokcen, Belma; Bilgir, Ferda; Guler, Asli; Calan, Mehmet; Yuksel, Arif; Aslanipour, Behnaz; Aksit, Murat; Bozkaya, GirayBackground: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass. Material and Methods: This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance. Circulating MIF levels were measured using enzyme-linked immunosorbent assay. Metabolic parameters of recruited subjects were evaluated. Visceral fat mass was measured using bioelectrical impedance method. Results: Circulating MIF levels were found to be elevated in subjects with prediabetes compared to controls (26.46 +/- 16.98 versus 17.44 +/- 11.80 ng/mL, P = 0.007). MIF positively correlated with BMI, visceral fat mass and indirect indices of homeostasis model assessment of insulin resistance. In linear regression model, an independent association was found between MIF levels and metabolic parameters, including BMI, visceral fat mass and homeostasis model assessment of insulin resistance. Multivariate logistic regression analyses revealed that the odds ratio for prediabetes was higher in subjects in the highest quartile of MIF compared to those in the lowest quartile, after adjusting for potential confounders. Conclusions: Increased MIF levels are associated with the elevation of prediabetic risk.Öğe Secondary metabolites from Astragalus karjaginii BORISS and the evaluation of their effects on cytokine release and hemolysis(Elsevier Science Bv, 2017) Aslanipour, Behnaz; Gulcemal, Derya; Nalbantsoy, Ayse; Yusufoglu, Hasan; Bedir, ErdalA new cycloartane sapogenol and a new cycloartane xyloside were isolated from Astragalus karjaginii BORISS along with thirteen known compounds. The structures of the new compounds were established as 3-oxo-6 alpha,16 beta,24(S),25-tetrahydroxycycloartane (1) and 6-O-beta-D-xylopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxycycloartane (2) by 1D- and 2D-NMR experiments as well as ESIMS and HRMS analyses. The presence of the keto function at position 3 was reported for the first time for cyclocanthogenol sapogenin of Astragalus genus. In vitro immtmomodulatory effects of the new compounds (1 and 2) along with the n-BuOH and MeOH extracts of A. karjaginii at two different doses (3 and 6 mu g) were tested on human whole blood for in vitro cytokine release (IL-2, IL-17A and IFN-gamma) and hemolytic activities. The results confirmed that compound 2, a monodesmosidic saponin, had the strongest effect on the induction of both IL-2 (6 mu g, 6345.41 +/- 0.12 pg/mL ( x 5), P < 0.001) and a slight effect upon IL-17A (3 mu g, 5217.85 +/- 0.72 pg/mL, P < 0.05) cytokines compared to the other test compounds and positive controls (AST VII: Astragaloside VII; and QS-21: Quillaja saponin 21). All tested extracts and molecules also induced release of IFN-gamma remarkably ranging between 5031.95 +/- 0.05 pg/mL, P < 0.001 for MeOH extract (6 pg) and 5877.08 +/- 0.06 pg/mL, P < 0.001 for compound 1 (6 pg) compared to QS-21 (6 mu g, 5924.87 +/- 0.1 pg/mL, P < 0.001). Administration of AST VII and other test compounds did not cause any hemolytic activity, whereas QS-21 resulted a noteworthy hemolysis.
