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Öğe Amyloid deposition in knee and ankle joints in the course of multiple myeloma{lozenge, open}{lozenge, open}Pour citer cet article, utiliser ce titre en anglais et sa référence dans le même volume de Joint Bone Spine. [Dépots amyloïdes dans les articulations du genou et de la cheville au cours d'un myelome multiple](2007) Sahin F.; Soyer N.A.; Argin M.; Ertan Y.; Saydam, G..; Vural F.; Tombuloglu M.[No abstract available]Öğe Bilateral septic arthritis complicating knee osteonecrosis in renal transplant recipient: Case report [Böbrek nakli hastasinda dizde osteonekroza eşlik eden bilateral septik artrit: Olgu sunumu](2012) Tatar E.; Güngör O.; Kirçelli F.; Arda B.; Argin M.; Töz H.; Hoşcoşkun C.Septic arthritis is rarely seen in transplant patients and differs from the general population with regards to gram negative and/or atypical agents being the prominent causes. In renal transplant patients, osteonecrosis is one of the major musculo-skeletal complications. In transplant patients, immunosupressive drugs, delayed graft function, genetics, HD duration before transplantation, cause of renal failure are among the risk factors for ostenecrosis. In this case report, we present a renal transplant patient with bilateral knee osteonecrosis and septic arthritis due to Escherichia coli.Öğe Bone tumors: MRI pitfalls(Springer International Publishing, 2017) Arkun R.; Argin M.[No abstract available]Öğe Case report: MRI findings in gout [Gut hastaliginin MRG bulgulari.](2003) Argin M.; Yilmaz T.; Arkun R.MR imaging is not routinely used for the evaluation of tophaceous gout. However, gout may have atypical clinical and radiologic findings. It should be considered in the differential diagnosis when a mass reveals heterogeneous and low signal intensity on T2 weighted images. We present MR imaging characteristics of gout tophi and arthritis in two patients.Öğe Cystic bone lesions: Histopathological spectrum and diagnostic challenges [Kemiğin Kistik Lezyonları: Histopatolojik Spektrum ve Tanısal Güçlükler](Federation of Turkish Pathology Societies, 2015) Doğanavşargil B.; Ayhan E.; Argin M.; Pehlivanoğlu B.; Keçeci B.; Sezak M.; Başdemir G.; Öztop F.Objective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n=98, 68.5%), solitary bone cysts (n=17 11.9%), pseudocyst (n=10.7%), intraosseous ganglion (n=3, 2.1%), hydatid cyst (n=2; 1.4), epidermoid cyst (n=1, 0.7%) and cysts demonstrating “mixed” aneurysmal-solitary bone cyst histology (n=12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and “mixed” cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in fat bones like the vertebra, pelvis and mandible (p=0.001, chi-square). repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p=0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n=3), femur (n=3) and maxilla (n=2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the “solid” variant. The “mixed” aneurysmal-solitary bone cyst “subgroup” requires further research with larger series to be defined more thoroughly. © 2015, Federation of Turkish Pathology Societies. All Rights Reserved.Öğe False-positive 131I uptake in a benign bone lesion on post-therapy scan(Lippincott Williams and Wilkins, 2016) Yazici B.; Oral A.; Eraslan C.; Argin M.; Ömür Ö.A 56-year-old woman underwent near-total thyroidectomy and papillary thyroid carcinoma without extrathyroidal extension was diagnosed. The serum thyroglobulin (Tg) level was 2.4 µg/L, and anti-Tg was negative when serum thyroid-stimulating hormone level was 85 µIU/mL. She received 100 mCi (3.7 GBq) of 131I. Besides the residual thyroid tissue, a focal uptake in the left clavicular bone was seen on posttherapy 131I images. Then, CT and MRI were performed to diagnosis. All imaging findings suggested that it was a benign bone cyst. At 6-month follow-up, the serum Tg level was undetectable with the thyroid-stimulating hormone level of more than 150 µIU/mL. © 2015 Wolters Kluwer Health, Inc.Öğe Feasibility and clinical utility of intraoperative consultation with frozen section in osseous lesions(2012) Sezak M.; Doganavsargil B.; Kececi B.; Argin M.; Sabah D.Intraoperative consultation (IOC) with frozen section (FS) allows the surgeon to make therapy decisions during the operation.However, there is relatively little information on the use of IOC in skeletal lesions. We performed a retrospective study to examine the indications for IOC and compare the histological findings of FS and permanent paraffin section (PS) results to determine its clinical benefits. Ninety-seven consecutive cases evaluated between 2008 and 2011 were retrieved from IOC archives of our Pathology Department. In 79 % of the cases, there was no prior core needle biopsy (CNB), and IOC was performed to confirm the clinical or radiological diagnosis. In 5 (5 %) cases, no definitive result could be obtained with FS, and diagnosis was deferred. The reasons for a deferred diagnosis (DD) included poor section quality in two lipomatous lesions and the sample heterogeneity in the others. When adjusted for DD, FS and PS results showed 100 % concordance in terms of discriminating "benign vs. malignant" and defining diagnostic categories as "benign non-tumoral," "benign tumoral/tumor-like, " "malignant primary tumor," "malignant metastatic tumor," or "hematopoietic malignancy." The presence of non-sclerotic osseous tissues does not have a significant adverse impact on the FS section quality and diagnosis made by FS. Thus, sections with diagnostic value can be obtained from bone lesions via FS. In this study, specific diagnoses were made in 88 % of the cases. We believe that IOC with FS can be safely performed in tertiary referral centers where there is a multidisciplinary team working in collaboration. © Springer-Verlag 2012.Öğe Ganglion cysts of the knee originating from tendons and ligaments [Diz tendon ve baglarindan köken alan gangliyon kistleri: klinik ve MRG bulgulari.](2004) Yilmaz T.; Genç B.; Argin M.; Memiş A.; Arkun R.PURPOSE: To investigate the clinical features and MR imaging findings of the ganglion cysts arising from the tendons and ligaments of the knee. MATERIALS AND METHODS: One thousand six hundred and twenty knee MR examinations that had been performed in a three-year period were evaluated retrospectively for the presence of ganglion cysts originating from tendons or ligaments. Clinical findings and MRI features of the lesions were noted. RESULTS: Twenty-three patients had a ganglion cyst originating from a tendon or a ganglion, with an incidence of 1.4%. Six lesions were associated with the anterior cruciate ligament, six with the posterior cruciate ligament, six with the medial collateral ligament, two with the lateral collateral ligament, two with the transverse ligament, and one with the patellar tendon. The most common clinical finding was knee pain. There were swelling at the medial side of the knee in two patients, swelling at the lateral side of the knee in one patient and swelling in the popliteal region in one patient. CONCLUSION: MR appearance of ganglion cysts arising from the tendons and ligaments of the knee is characteristic. Meniscal cysts, pigmented villonodular synovitis, and synovial hemangioma should be considered in the differential diagnosis.Öğe Intraosseous lipoma: Radiological findings(2008) Öztekin Ö.; Argin M.; Oktay A.; Arkun R.OBJECTIVE: Intraosseous lipomas may be less rare lesions than previously suggested in the literature. They have frequently been misdiagnosed as other benign bone lesions. A combination of computed tomography, magnetic resonance imaging and radiography is essential for decreasing misdiagnosis rates. MATERIALS AND METHODS: This retrospective study presents ten cases of intraosseous lipoma. The patients' ages ranged from 25 to 80 years, and six of them were female. Six patients presented with bone pain, whereas four patients were asymptomatic with incidentally discovered lesions. The involved bones were: femur (four patients), tibia (two patients), calcaneus (one patient), sacrum (one patient), iliac bone (one patient), navicular bone (one patient). All of the patients were assessed by means of conventional radiography, computed tomography and magnetic resonance imaging of the affected region. RESULTS: In all of the cases, plain films revealed well-defined lytic lesions. Both computed tomography and magnetic resonance imaging were quite useful in demonstrating fat within the femur. The histologic pattern of all tumors was that of mature adipose tissue. CONCLUSION: Intraosseous lipoma is a well-defined entity that may develop with varying presentations. Plain radiographs alone cannot establish the diagnosis of this lesion. However, both computed tomography and magnetic resonance imaging are quite useful methods in these cases. © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem.Öğe The level of quality of radiology services in Turkey: A sampling analysis(2006) Özsunar Y.; Çetin M.; Taşkin F.; Yücel A.; Can S.; Argin M.; Arkun R.Purpose: To determine the quality of radiographs, which have been referred from 40 different institutions for consultation, to discuss the causes of wasted resources; and to present possible solutions. Materials and methods: Five experienced radiology instructors determined the types of radiological examinations referred for consultation (conventional radiography, mammography, computed tomography and magnetic resonance imaging), the institutions at which they were performed (university or state hospital, private health center), and assessed the coverage area, field of vision (FOV), and dosage of x-ray. They also investigated problems in film processing, defects in sequence-printing windows, checked window levels, and checked the amount and timing of contrast material used. According to these criteria, the reviewers subjectively classified each radiograph as: 1. Poor, examination should be completely repeated, 2. Fair, examination should be partially repeated, 3. Good, accepted as adequate, no need for an additional examination, 4. Excellent, examination was as it should be. Results: We reviewed 120 radiological examinations from 40 different institutions in 4 reference centers. Frequency of problems determined for each category was as follows: coverage area 32.5% (39/120), FOV 16% (14/86), X-ray dosage 16% (15/94), film processing 31% (37/120), sequence or window 65% (53/81), window level 44% (36/81); contrast material 51% (25/49), timing of contrast material 61% (30/49). Only 22% of the examinations were classified as excellent, whereas 47% required complete or partial repetition. Conclusion: Approximately half of the radiological examinations in our sampling required partial or complete repetition. Health, ethical, and economic aspects of the problem necessitates the prompt application of measures to establish radiological quality control and standardization procedures. © Turkish Society of Radiology 2006.Öğe Ochronotic arthropathy: Disappearance of alkaptonuria after liver transplantation for hepatitis B-related cirrhosis(2005) Kobak A.C.; Oder G.; Kobak Ş.; Argin M.; Inal V.The deficiency of homogentisic acid oxidase, an enzyme that is mainly found in hepatocytes, is associated with alkaptonuria and ochronosis. We report a patient with clinical and radiologic findings of ochronotic arthropathy in whom alkaptonuria disappeared and the progressive course of the disease stopped after liver transplantation for hepatitis B-related cirrhosis. Copyright © 2005 by Lippincott Williams & Wilkins.Öğe Primary osteosarcoma arising from subcutaneous tissue: 5-year follow-up(2012) Sarsilmaz A.; Argin M.; Sezak M.; Altay C.; Erdogan N.Extraskeletal osteosarcomas are extremely rare, high-grade neoplasms. Approximately 300 cases have been reported in the literature, with a 5-year survival of around 25%-37%. Extraskeletal osteosarcomas frequently arise from lower-extremity, deep soft tissue planes, including hemorrhagic, necrotic areas. While primary osteosarcomas have been observed in the first two decades of life, osteosarcomas arising from the skeletal system are rarely observed before 40 years of age. We present radiological findings of an osteosarcoma case arising from cruris subcutaneous tissue in a young adult (31 years old) at diagnosis and at the follow-up period during a 5-year monitoring process. Additionally, we reviewed the literature regarding this case. © 2012 Elsevier Inc.Öğe Retrospective analysis of seven patients with adult-onset langerhans cell histiocytosis syndromes: A single center experience(2007) Şahin F.; Özen K.P.; Vural F.; Kamer S.; Argin M.; Anacak Y.; Hekimgil M.; Saydam, G..Langerhans cell histiocytosis syndromes have been described as encompassing a range of disorders, such as eosinophilic granuloma, Letterer-Siwe syndrome and Hand-Schüller-Christian disease. These disorders have been mainly diagnosed at early ages of life and are relatively rare entities in adult age groups. In this study, we aimed to retrospectively evaluate the patients with Langerhans cell histiocytosis followed-up in our hospital. Seven patients were treated between 1995 and 2005. Median age of patients was 27.5 (1840) years. Main complaints were classified as bone pain in multiple sites (100%), polydipsia (28%), lung infiltration (14%), oral mucosal infiltration (14%), and cranial nerve infiltration (14%). Two patients were diagnosed as Hand-Schüller-Christian disease, and the others were accepted as eosinophilic granuloma. There was no bone marrow or any other organ infiltration except lung infiltration in one patient. Bone infiltration was the prominent sign in all patients with a minimum of one to maximum of seven different sites. All patients were alive during the follow-up period. All patients were treated with radiotherapy except one patient treated with chemotherapy regimen started with vincristine plus dexamethasone and continued with cladribine. Three of seven patients were treated with combined modality, one patient with only chemotherapy and the others with only radiotherapy. There was no grade 34 hematological or systemic side effects of treatment. Relapses were detected in only two patients as new bone infiltrations which responded completely to radiotherapy. Langerhans cell histiocytosis syndromes have a relatively benign course in adult patients and can be treated with either radiotherapy or chemo-radiotherapy successfully. © Turkish Society of Hematology.Öğe Sciatalgia in a patient with a rare peripheral nerve sheath tumor: Differential diagnosis [Nadir gözlenen periferal sinir ki{dotless}li{dotless}f tümörlü hastada siyatalji](Turkiye Klinikleri, 2011) Eyigör C.; Pirim A.; Argin M.; Uyar M.; Sabah D.; Zileli M.Peripheral schwannomas may mimic lumbar discopathy, and may constitute an important cause of undefined radicular pain. A 64 year-old-woman complained of worsening intermittent, severe pain, and weakness in her feet. We have observed brightness around the sciatic nerve and a tumor was detected in the nerve sheath. Patient had severe neuropathic pain in her right leg in the postoperative period. After the failure of pharmacological treatment for neuropathic pain, nerve blocks were performed to lumbar sympathetic and dorsal root ganglia (DRG). Relief of pain lasted short after the DRG blockade, thus placement of a spinal cord stimulator (SCS) was planned. Eighty percent pain reduction was achieved with the application of SCS test electrode, therefore a SCS was implanted. The management of neuropathic pain was carried out with pain treatment according to the algorithm. In conclucion, interventional pain treatments should be kept in mind in similar cases. © 2011 by Türkiye Klinikleri.Öğe The value of magnetic resonance arthrography in the evaluation of repaired menisci(Springer-Verlag France, 2015) Kececi B.; Bicer E.K.; Arkun R.; Argin M.; Taskiran E.Aim To evaluate the diagnostic value of direct magnetic resonance (MR) arthrography in detection of re-torn or unhealed menisci which were previously repaired. Materials and methods Twenty-six menisci of 24 symptomatic patients who had undergone a meniscus repair surgery were included in this retrospective study. These patients had been evaluated with gadolinium-enhanced direct MR arthrography. A subsequent second-look arthroscopy was performed thereafter. The findings of MR arthrography were compared with the arthroscopic findings. Results Sixteen recurrent meniscal lesions were detected with MR arthrography; the remaining ten repaired menisci were evaluated as healed. At second-look arthroscopy, six out of 26 repaired menisci were evaluated as completely healed. Eight of them had incomplete healing, and 12 of them were unhealed. MR arthrography had four falsenegative results, but there were none false-positive results. It was arthroscopically shown that three of these four falsenegative results were belonged to patients who had incomplete healing. MR arthrography had a sensitivity, specificity, and overall accuracy of 80, 100, and 84.6 %, respectively. When incomplete lesions were left out of analysis, its sensitivity and accuracy reached to 94.8 and 94.4 %. Conclusion The findings of this study showed that MR arthrography was a reliable diagnostic tool in evaluating previously repaired menisci. Yet diagnosis of incomplete meniscal lesions seemed to be challenging. © Springer-Verlag France 2014.Öğe Very low dose methotrexate-induced rheumatoid nodules localized in buttocks and palmar aspects of phalanges: Case report [Kalça ve parmaklann palmar yüzlerinde lokalize ve çok düşük doz metotreksat ile ortaya çi{dotless}kan romatoid noduller](Turkiye Klinikleri, 2011) Inal V.; Kocanaogullari H.; Karabulut G.; Keser G.; Tarhan F.; Argin M.; Akalin T.; Çalişkan C.Rheumatoid nodules are the most common extra-articular lesions. They usually occur in rheumatoid factor positive patients and indicate activity and severity of the disease. These nodules characteristically occur subcutaneously on extensor surfaces over the elbows or other bony prominences. They may be overlooked if they occur in sites other than well-known areas. We present a case with rheumatoid arthritis (RA) who developed multiple subcutaneous, histologically- proven rheumatoid nodules in both buttocks as well as on palmar aspects of phalanges after 3.5 years of very low-dose weekly methotrexate (MTX) treatment. These nodules occurred abruptly while there was not active arthritis in any joint. MTX-induced large nodules may occur even with very low doses of MTX, in atypical localizations such as both buttocks. © 2011 by Türkiye Klinikleri.