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    Effects of silk sericin on incision wound healing in a dorsal skin flap wound healing rat model
    (International Scientific Literature Inc., 2016) Ersel M.; Uyanikgil Y.; Akarca F.K.; Ozcete E.; Altunci Y.A.; Karabey F.; Cavusoglu T.; Meral A.; Yigitturk G.; Cetin E.O.
    Background: The wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericincontaining gel formulation in an incision wound model in rats. Material/Methods: Twenty-eight Wistar-Albino rats were divided into 4 groups (n=7). No intervention or treatment was applied to the Intact control group. For other groups, a dorsal skin flap (9×3 cm) was drawn and pulled up with sharp dissection. The Sham operated group received no treatment. The Placebo group received placebo gel without sericin applied to the incision area once a day from day 0 to day 9. The Sericin Group 3 received 1% sericin gel applied to the incision area once a day from day 0 to day 9. Hematoxylin and eosin stain was applied for histological analysis and Mallory-Azan staining was applied for histoimmunochemical analysis of antibodies and iNOS (inducible nitric oxide synthase), and desmin was applied to paraffin sections of skin wound specimens. Parameters of oxidative stress were measured in the wound area. Results: Epidermal thickness and vascularization were increased, and hair root degeneration, edema, cellular infiltration, collagen discoloration, and necrosis were decreased in Sericin group in comparison to the Placebo group and the Sham operated group. Malonyldialdehyde (MDA) levels were decreased, but superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were increased in the sericin group. Conclusions: We found that sericin had significant positive effects on wound healing and antioxidant activity. Sericin-based formulations can improve healing of incision wounds. © Med Sci Monit.
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    Hand and wrist injuries caused by glass cuts: Accidental or due to sudden anger?
    (2011) Gökhan S.; Altunci Y.A.; Orak M.; Üstündag M.; Sögüt O.; Özhasenekler A.
    Objectives: Traumatic hand and wrist injuries are the type of injuries commonly seen in the emergency department (ED). Hand and wrist injuries related to punching windows due to sudden discomposes are frequent in Turkey. The aim of this study was to analyze clinical and demographic specifications of hand and wrist injuries related to glass cuts and their underlying causes. Methods: The patient files who presented to the Dicle University Hospital ED (Diyarbakir-Turkey) with injuries due to glass cuts have been examined. Demographic data of the patients have been recorded in the standard work form and then were analyzed. Results: One hundred and fifty four patients were included in the study. 53.8% of the patients constituted those who punched on the glass during an angry episode. Punching on the glass was more frequently observed in men (n=81, 97.6%), with cuts to the right hand being the most frequent type of resulting injury (n=65, 78.3%). Twenty four (28.9%) of the patients with injuries related to glass punching were under the influence of alcohol during the incidents and injury rates of radial artery, ulnar nerve, median nerve and ulnar artery have been found considerably higher in this group. Conclusions: A thorough artery, nerve and tendon examination of the patients presenting to the ED with hand and wrist injuries needed to be performed, and especially for those under the influence of alcohol in order to prevent functional losses of the underlying structures.