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    Cardiac troponin T in diagnosis of acute myocardial infarction
    (1998) Alper, Gülinnaz; Erkızan, Ömür; Can, Hasdemir; Akıllı, Azem; Onat, Taner
    Cardiac Troponin T (TnT) is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. This study was designed to evaluate the diagnostic efficiency of TnT enzyme immunoassay for the early diagnosis of AMI (Acute Myocardial Infarction) and to compare this newly developed test with the conventionally used cardiac enzyme tests in need of an alternative test of greater sensitivity and specificity. the study population consisted of 13 patients with a mean age of 52±8 years who were hospitalized for AMI. Blood samples for TnT, CPK and CK-MB measurements were drawn at the time of admission (2.9±1.7 hours after the onset of chest pain) and at the 4th, 14-16th, 32-34th and 100-130th hours thereafter. We used an enzyme immunologic assay for the quantitative determination of serum TnT and enzymatic methods for CPK and CK-MB. TnT appeared in circulation slightly earlier than CPK and CK-MB and increased to a peak value of 46 times the detection limit during the first day. Relative peak values of TnT af-ter onset of pain were 6.4 and 6.8 fold higher than CK-MB and CPK results. the sensitivity of TnT for detecting AMI was 100% from the 4th hour to the 100-130th hour after the onset of symptoms and the diagnostic sensitivity of TnT was superior to that of CPK and CK-MB (100% versus 23% and 15%). Thus the results of this study indicate that; TnT test improves the efficiency of serodiagnostic tools in detection of AMI and gives a larger diagnostic window that allows serological detection of subacute myocardial infarction.
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    The effects of vitamin E on catalase activies in various rat tissues
    (1998) Alper, Gülinnaz; Çınar, Mehtap; Can, Cenk; Menteş, Gülriz; Ersöz, Biltan; Evinç, Akgün
    Vitamin E and other antioxidants prevent or minimize oxidative damage in biological systems. the level of antioxidant defense sufficient to protect the organism from high free radical concentrations is one of the new horizons for Vitamin E research. the role of Vitamin E as a protective agent aganist oxidative stress was evaluated by measuring the antioxidant enzyme catalase (CAT) activities in different tissues of Swiss male albino rats aged two months. in this study, rats were divided to three groups; control (n=10), E1 (n=5) which received 25 mg/kg. per day of Vitamin E, IM. for 10 days and E2 (n=7) which received 50 mg/kg. per day of Vitamin E, I.M. for 25 days. Catalase activities of cortex cerebrum,cerebellum, liver, kidney, heart and lung tissues were determined by a modified method of Luck and Aebi. Comparing the Vitamin E supplemented group (El +E2) with the controls, no significant difference could be detected in tissue CAT activities. However, in group E2 both renal and cardiac CAT activities were found to be higher when compared to the controls (p<0.01) as well as to the E1 group Since beneficial effects of Vitamin E has been observed on human health, this issue is very important for basic science and for the rapeutic approaches as well.