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    A fluorescent biosensor based on acetylcholine sterase and 5-oxazolone derivative immobilized in polyvinylchloride (PVC) matrix
    (Elsevier Science Bv, 2007) Ozturk, G.; Alp, S.; Timur, S.
    A new 2-phenyl-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone (CPO) derivative was utilized to develop an optical acetylcholinesterase (AChE) biosensor in which the azlactone derivative was embedded in plasticized polyvinylchloride (PVC) matrix. The sensor system was calibrated for the detection of acetylcholine (ACh) and donepezil which is a competitive cholinesterase (ChE) inhibitor. Two different biosensing systems were developed by using AChE enzyme in solution and immobilized together with the fluorescent derivative (CPO) doped in transparent PVC membrane. The enzymatic hydrolysis of ACh was monitored by following changes in the pH induced fluorescence intensity. When AChE enzyme was immobilized in PVC matrix together with CPO, the sensitivity of the measuring system has increased approximately three times for ACh, in comparison to the sensing system where AChE enzyme was in solution phase. The photophysical parameters of CPO were also examined in solvents of tetrahydrofuran (THF), acetonitrile (ACN) and dichloromethane (DCM) and in solid matrix of PVC. The azlactone derivative exhibits excellent photostability in PVC matrix. (c) 2007 Elsevier B.V. All rights reserved.
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    Prediction of unfavorable outcomes in cryptococcal meningitis: results of the multicenter Infectious Diseases International Research Initiative (ID-IRI) cryptococcal meningitis study
    (Springer, 2018) Hakyemez, I. N.; Erdem, H.; Beraud, G.; Lurdes, M.; Silva-Pinto, A.; Alexandru, C.; Bishop, B.; Mangani, F.; Argemi, X.; Poinot, M.; Hasbun, R.; Sunbul, M.; Akcaer, M.; Alp, S.; Demirdal, T.; Angamuthu, K.; Amer, F.; Ragab, E.; Shehata, G. A.; Ozturk-Engin, D.; Ozgunes, N.; Larsen, L.; Zimmerli, S.; Sipahi, O. R.; Tigen, E. Tukenmez; Celebi, G.; Oztoprak, N.; Yardimci, A. C.; Cag, Y.
    Cryptococcal meningitis (CM) is mostly seen in immunocompromised patients, particularly human immunodeficiency virus (HIV)-positive patients, but CM may also occur in apparently immunocompetent individuals. Outcome analyses have been performed in such patients but, due to the high prevalence of HIV infection worldwide, CM patients today may be admitted to hospitals with unknown HIV status, particularly in underdeveloped countries. The objective of this multicenter study was to analyze all types of CM cases in an aggregate cohort to disclose unfavorable outcomes. We retrospectively reviewed the hospitalized CM patients from 2000 to 2015 in 26 medical centers from 11 countries. Demographics, clinical, microbiological, radiological, therapeutic data, and outcomes were included. Death, neurological sequelae, or relapse were unfavorable outcomes. Seventy (43.8%) out of 160 study cases were identified as unfavorable and 104 (65%) were HIV infected. On multivariate analysis, the higher Glasgow Coma Scale (GCS) scores (p = 0.021), cerebrospinal fluid (CSF) leukocyte counts > 20 (p = 0.038), and higher CSF glucose levels (p = 0.048) were associated with favorable outcomes. On the other hand, malignancy (p = 0.026) was associated with poor outcomes. Although all CM patients require prompt and rational fungal management, those with significant risks for poor outcomes need to be closely monitored.
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    Prediction of unfavorable outcomes in cryptococcal meningitis: results of the multicenter infectious Diseases International Research Initiative (ID-IRI) cryptococcal meningitis study (vol 37, pg 1231, 2018)
    (Springer, 2018) Hakyemez, I. N.; Erdem, H.; Beraud, G.; Lurdes, M.; Silva-Pinto, A.; Alexandru, C.; Bishop, B.; Mangani, F.; Argemi, X.; Poinot, M.; Hasbun, R.; Sunbul, M.; Akcaer, M.; Alp, S.; Demirdal, T.; Angamuthu, K.; Amer, F.; Ragab, E.; Shehata, G. A.; Ozturk-Engin, D.; Ozgunes, N.; Larsen, L.; Zimmerli, S.; Sipahi, O. R.; Tigen, E. Tukenmez; Celebi, G.; Oztoprak, N.; Yardimci, A. C.; Cag, Y.
    In the original version of this article, Mustafa Sunbul was not included in the list of authors for this article. The name has been added accordingly.