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Öğe The Correlation between miRNA (miR: microribonucleic acid) Levels and Clinical Endpoints in Heart Failure(Elsevier Science Inc, 2013) Sayin, Ahmet; Zihni, Burcu; Alkan, Mustafa Beyazit; Bilgin, Murat; Yildiz, Berkir Serhat; Gul, Ilker; Cogulu, Muhsin Ozgur; Karaca, Emin; Zoghi, MehdiÖğe Evaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failure(Turkish Soc Cardiology, 2016) Bilgin, Murat; Yildiz, Bekir Serhat; Tuluce, Kamil; Gul, Ilker; Alkan, Mustafa Beyazit; Sayin, Ahmet; Islamli, Aysel; Efe, Tolga Han; Alihanoglu, Yusuf Izzettin; Zoghi, Mehdi; Akin, MustafaObjective: Atrial functions are relatively suppressed in heart failure (HF). We aimed to investigate the associations of intra-and inter-atrial electromechanical conduction delay (EMCD) with functional class and mortality over a 12-month follow-up period. Methods: The prospective study included 65 patients with systolic HF and 65 healthy subjects with normal sinus rhythm. Left ventricular (LV) systolic functions and left atrial (LA) dimensions and volumes were evaluated by transthoracic echocardiography. Tissue Doppler imaging (TDI) signals at the lateral border of the mitral annulus (lateral PA'), septal mitral annulus (septal PA'), and tricuspid annulus (tricuspid PA') were measured. Intra-and inter-atrial EMCD were calculated. Results: Mitral inflow velocities were studied using pulsed-wave Doppler after placing the sample volume at the leaflets' tips. The peak early (E wave) and late (A wave) velocities were measured. The septal annular E/E' ratio was relatively higher and lateral, septal, and right ventricular S,E', and A' waves were significantly lower in the HF group than in the control group (12.49 +/- 6.03-7.16 +/- 1.75, pE/E' <0.0001). Intra-atrial EMCD was detected as 117.5 ms and inter-atrial EMCD as 127.5 ms in patients with prolonged atrial EMCD. A significant increase was found in prolonged intra-and inter-atrial EMCD according to functional capacity increase (p=0.012 and p=0.031, respectively). The incidence of mortality was significantly higher in patients with prolonged atrial EMCD (p=0.025), and 5 patients in the HF group died during the study over the 12-month follow-up period. Conclusions: In this study, we found a relationship between prolonged atrial conduction time and increased functional class and mortality in patients with systolic HF.Öğe Evaluating Left Ventricular Functions in Primary Mitral Regurgitation by Two Dimensional Strain Echocardiography(Elsevier Science Inc, 2013) Zihni, Burcu; Alkan, Mustafa Beyazit; Bilgin, Murat; Sayin, Ahmet; Kemal, Hatice Soner; Cinar, Cahide SoydasÖğe Plasma miRNA (miR: microribonucleic acid) Levels in Patients with Decompensated Heart Failure: Can miRNA Be an Indicator of the Effectiveness of the Treatment?(Elsevier Science Inc, 2013) Sayin, Ahmet; Bilgin, Murat; Zihni, Burcu; Alkan, Mustafa Beyazit; Kemal, Hatice Soner; Gul, Ilker; Yildiz, Bekir Serhat; Tekin, Ismihan Merve; Gunduz, Cumhur; Zoghi, MehdiÖğe Serum Chitotriosidase Activity in Acute Coronary Syndrome(Japan Atherosclerosis Soc, 2013) Yildiz, Bekir Serhat; Barutcuoglu, Burcu; Alihanoglu, Yusuf Izzettin; Alkan, Mustafa Beyazit; Bilgin, Murat; Gul, Ilker; Gungor, Hasan; Esin, Fatma; Sayin, Ahmet; Zoghi, MehdiAim: Inflammation is a critical participant in mediating all stages of cardiovascular disease. Studies related with chitotriosidase that was recently found to be relevant to arterial inflammation. In this study we evaluated activity of serum chitotriosidase in acute coronary syndrome patients and its relationship with cardiovascular events, cardiac enzymes and inflammatory indicators. Methods: We prospectively analyzed consecutive 30 patients with ST-segment elevation myocardial infarction, 30 patients with non ST-segment elevation myocardial infarction, 30 patients with unstable angina pectroris who were admitted to our intensive care unit and 30 healthy people (average age 56.86 +/- 10.44 years, 81 male) between Jaunary and June 2010. Details of baseline clinical characteristics, biochemical values, receiving treatment and basal ECG findings were recorded. Data of patients with coronary angiography were evaluated. Results: Cut off value of chitotriosidase was calculated 82.00 mmol.ml-1.h-1, with 83 percent sensitivity and 72 percent spesificity. The activity of chitotriosidase in acute coronary syndrome group was 88.85 +/- 23.08 mmol.ml-1.h-1, where as the control group was 68.47 +/- 28.44 mmol.ml-1.h-1, respectively p=0.001). The highest activity of chitotriosidase (96.11 +/- 19.77 mmol.ml-1.h-1) was found in ST-segment elevation myocardial infarction group and the minimal activity of chitotriosidase was in the control group (68.47 +/- 28.44 mmol.ml-1.h-1) (p=0.001). The activity of chitotriosidase in ST-segment elevation myocardial infarction and non ST-segment elevation myocardial infarction groups were significantly higher than control group (p=0.001 and p=0.045). When acute coronary syndrome groups compared to control; a positive correlation was found between chitotriosidase activity and hs-CRP (r =0.21, p=0.046), troponin T (r=0.25, p=0.016), creatine kinase-MB (r=0.20, p=0.059). Conclusion: The activity of chitotriosidase is increased in acute coronary syndrome patients. Chitotriosidase is higher in ST-segment elevation myocardial infaction group than non ST-segment elevation myocardial infarction and unstable angina pectoris group.Öğe Serum Chitotriosidase Activity in Acute Coronary Syndrome(Japan Atherosclerosis Soc, 2013) Yildiz, Bekir Serhat; Barutcuoglu, Burcu; Alihanoglu, Yusuf Izzettin; Alkan, Mustafa Beyazit; Bilgin, Murat; Gul, Ilker; Gungor, Hasan; Esin, Fatma; Sayin, Ahmet; Zoghi, MehdiAim: Inflammation is a critical participant in mediating all stages of cardiovascular disease. Studies related with chitotriosidase that was recently found to be relevant to arterial inflammation. In this study we evaluated activity of serum chitotriosidase in acute coronary syndrome patients and its relationship with cardiovascular events, cardiac enzymes and inflammatory indicators. Methods: We prospectively analyzed consecutive 30 patients with ST-segment elevation myocardial infarction, 30 patients with non ST-segment elevation myocardial infarction, 30 patients with unstable angina pectroris who were admitted to our intensive care unit and 30 healthy people (average age 56.86 +/- 10.44 years, 81 male) between Jaunary and June 2010. Details of baseline clinical characteristics, biochemical values, receiving treatment and basal ECG findings were recorded. Data of patients with coronary angiography were evaluated. Results: Cut off value of chitotriosidase was calculated 82.00 mmol.ml-1.h-1, with 83 percent sensitivity and 72 percent spesificity. The activity of chitotriosidase in acute coronary syndrome group was 88.85 +/- 23.08 mmol.ml-1.h-1, where as the control group was 68.47 +/- 28.44 mmol.ml-1.h-1, respectively p=0.001). The highest activity of chitotriosidase (96.11 +/- 19.77 mmol.ml-1.h-1) was found in ST-segment elevation myocardial infarction group and the minimal activity of chitotriosidase was in the control group (68.47 +/- 28.44 mmol.ml-1.h-1) (p=0.001). The activity of chitotriosidase in ST-segment elevation myocardial infarction and non ST-segment elevation myocardial infarction groups were significantly higher than control group (p=0.001 and p=0.045). When acute coronary syndrome groups compared to control; a positive correlation was found between chitotriosidase activity and hs-CRP (r =0.21, p=0.046), troponin T (r=0.25, p=0.016), creatine kinase-MB (r=0.20, p=0.059). Conclusion: The activity of chitotriosidase is increased in acute coronary syndrome patients. Chitotriosidase is higher in ST-segment elevation myocardial infaction group than non ST-segment elevation myocardial infarction and unstable angina pectoris group.Öğe A survey for the evaluation of the training period of cardiology specialists in Turkey(Aves Yayincilik, 2011) Yildiz, Bekir Serhat; Alkan, Mustafa Beyazit; Gungor, Hasan; Gul, Ilker; Bilgin, Murat; Akin, Mustafa; Nalbantgil, Sanem; Zoghi, MehdiObjective: To evaluate postgraduate training period, social life and problems of cardiology residents in Turkey by using a questionnaire form and to compare with the core curriculum of European Society of Cardiology for general cardiology. Methods: Overall, 529 residents of cardiology ages in range of 24-35 years (mean age: 26.5 +/- 2.0 years, 81.4% male) participated as volunteers in this cross-sectional survey study. An 86-item questionnaire form was used to evaluate the education process, capacity of knowledge and skill and social effectiveness level of participants. The questionnaire were composed both closed- and open-ended questions. The questionnaire form was filled in with the face-to-face communication method. The data of survey were compared with the core curriculum of European Society of Cardiology for general cardiology training period. Chi-square or Fischer exact test was used for statistical analysis. Results: The participants were working in various university hospitals (70.3%) and training-research (state) hospitals in 31 different provinces in Turkey (40.8% in Marmara region). They visited 40 +/- 10 outpatients and 10 +/- 5 hospitalized pts daily in the clinics. The 3-5 residents worked at the clinic on night shifts and mostly (89%) 8 or more night shifts per month were held in their first training years. During first three-years of training 76% of residents have performed echocardiography, 40.8%-transesophageal echocardiography and 10%-intraoperative echocardiography. The 84.3% of them evaluated exercise tests, 76.4%-Holter electrocardiography and 53.3%-tilt-table tests. The rate of residents working in coronary angiography laboratories was 54.3%. The 53.7% of residents performed coronary angiography and 64%-only in the 4th year of their training. The number of coronary angiography performance was under expected when compared with European Society of Cardiology curriculum. The 18.5% of residents were participated as assistant researcher in an international multi-center study and only 10% had an article published in national journals (4.3% published in Science Citation Index). The 30.6% considered the cardiology training period in their centers to be insufficient, whereas 37.4% found it partially sufficient and 31.9% sufficient. Only 32.9% of participants could dedicate time for social activities. Conclusion: According to the referred core curriculum of ESC for general cardiology the training of cardiology residents in non-invasive applications is adequate however coronary angiography applications are slightly insufficient in Turkey. In addition, the number of publications per capita is quiet low. (Anadolu Kardiyol Derg 2011; 11: 661-5)Öğe Unusual association of multiple congenital left ventricular diverticulum and cerebrovascular events in an adult(Turkish Soc Cardiology, 2015) Alkan, Mustafa Beyazit; Bilgin, Murat; Zihni, Burcu; Nalbantgil, SanemCongenital ventricular diverticulum is a rare and usually asymptomatic cardiac malformation which can cause major complications such as systemic thromboembolism, infective endocarditis, cardiac rupture, heart failure, arrhythmia and sudden death. We present a case with multiple congenital left ventricular diverticulum admitted to hospital with sudden onset right-sided hemiplegia and dysarthria.Öğe Unusual association of multiple congenital left ventricular diverticulum and cerebrovascular events in an adult(Turkish Soc Cardiology, 2015) Alkan, Mustafa Beyazit; Bilgin, Murat; Zihni, Burcu; Nalbantgil, SanemCongenital ventricular diverticulum is a rare and usually asymptomatic cardiac malformation which can cause major complications such as systemic thromboembolism, infective endocarditis, cardiac rupture, heart failure, arrhythmia and sudden death. We present a case with multiple congenital left ventricular diverticulum admitted to hospital with sudden onset right-sided hemiplegia and dysarthria.Öğe Unusual association of multiple congenital left ventricular diverticulum and cerebrovascular events in an adult(Turkish Soc Cardiology, 2015) Alkan, Mustafa Beyazit; Bilgin, Murat; Zihni, Burcu; Nalbantgil, SanemCongenital ventricular diverticulum is a rare and usually asymptomatic cardiac malformation which can cause major complications such as systemic thromboembolism, infective endocarditis, cardiac rupture, heart failure, arrhythmia and sudden death. We present a case with multiple congenital left ventricular diverticulum admitted to hospital with sudden onset right-sided hemiplegia and dysarthria.
