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    Cyclosporine A Plus Low-Dose Steroid Treatment in Children with Idiopathic Nephrotic Syndrome
    (Springer, 2010) Bal, A.; Anil, M.; Kara, O. D.; Yavascan, O.; Sen, S.; Aksu, N.
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    Effects of air pollution on airway hyperresponsiveness in children (a multi-center study)
    (Wiley-Blackwell Publishing, Inc, 2009) Demir, E.; Midyat, L.; Can, D.; Kanyk, A.; Uzuner, N.; Avcu, G.; Tanryverdi, S.; Guelen, F.; Aksu, N.; Olmez, D.; Asilsoy, S.; Karaman, O.; Babayigit, A.; Tuncel, T.; Celik, G.; Saz, E.; Tanac, R.
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    Henoch-Schonlein Nephritis: A Nationwide Study
    (Karger, 2009) Soylemezoglu, O.; Ozkaya, O.; Ozen, S.; Bakkaloglu, A.; Dusunsel, R.; Peru, H.; Cetinyurek, A.; Yildiz, N.; Donmez, O.; Buyan, N.; Mir, S.; Arisoy, N.; Gur-Guven, A.; Alpay, H.; Ekim, M.; Aksu, N.; Soylu, A.; Gok, F.; Poyrazoglu, H.; Sonmez, F.
    Background/Aim: The aim of this retrospective study was to evaluate the presentation, clinical and pathological manifestations and outcome of the Henoch-Schonlein purpura (HSP) nephritis in children. Methods: Clinical and laboratory data of 443 children with HSP nephritis aged between 3 and 16 years from 16 pediatric nephrology reference centers were analyzed retrospectively. The biopsy findings were graded according to the classification developed by the International Study of Kidney Disease in Children (ISKDC). Results: Renal biopsy was performed in 179 of the patients with HSP nephritis. The most common presenting clinical finding in patients who were biopsied was nephrotic range proteinuria (25%) which was followed by nephritic-nephrotic syndrome (23.5%). The biopsy findings according to the ISKDC were as follows: class I: 8.3%; II: 44.1%; III: 36.3%; IV: 6.7%; V: 3.3%; VI: 1.1%. All of the patients who developed end-stage renal disease had nephritic-nephrotic syndrome at presentation. Of 443 patients, 87.2% had a favorable outcome and 12.8% had an unfavorable outcome. The overall percentage of children who developed end-stage renal disease at follow-up was 1.1%. Logistic regression analysis did not show any association of initial symptoms and histology with outcome. Conclusion: In the presented cohort, the presence of crescents in the first biopsy or presenting clinical findings did not seem to predict the outcome of HSP nephritis in children. We conclude that children with HSP nephritis even with isolated microscopic hematuria and/or mild proteinuria should be followed closely. Copyright (C) 2009 S. Karger AG, Basel
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    Value of Ultrasonographic Measurement of Peritoneal Membrane Thickness in Children on Chronic Peritoneal Dialysis Treatment
    (Springer, 2010) Yavascan, O.; Bal, A.; Anil, M.; Anil, A. B.; Kamit, F.; Aksu, N.; Mir, S.
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    Worldwide variation of dialysis-associated peritonitis in children
    (Elsevier Science Inc, 2007) Schaefer, F.; Feneberg, R.; Aksu, N.; Donmez, O.; Sadikoglu, B.; Alexander, S. R.; Mir, S.; Ha, I. S.; Fischbach, M.; Simkova, E.; Watson, A. R.; Moeller, K.; von Baum, H.; Warady, B. A.
    Peritonitis is the most common cause of dialysis failure in children on chronic peritoneal dialysis. We performed a prospective study of 501 peritonitis episodes in 44 pediatric dialysis centers located in 14 countries that examined peritonitis etiology, efficiency of opinion-based management guidelines, and final outcomes. Culture-negative incidence varied significantly from 11% in North America to 67% in Mexico. Argentina and North America had the highest rate of Gram-negative episodes. Pseudomonas-based peritonitis was eightfold more common in the United States than in Europe, and correlated with the frequency of exit site cleansing and topical mupirocin administration. Significant regional variation in antibiotic susceptibility was noted for the first generation cephalosporins and aminoglycosides. Initial response rates to standardized empiric antibiotic treatment did not differ between regions; however, final outcomes were significantly less favorable in Eastern Europe. The wide regional variation in culture-negative peritonitis, and the distribution and antibiotic susceptibilities of causative bacteria needs to be taken into consideration when the guidelines for empiric therapy of pediatric dialysis-associated peritonitis are revised.