Yazar "Aksu, K." seçeneğine göre listele

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    AGREEMENT OF PATIENT AND PHYSICIAN GLOBAL ASSESSMENT OF DISEASE ACTIVITY IN ADULT ONSET STILL'S DISEASE
    (Bmj Publishing Group, 2016) Kalyoncu, U.; Kasifoglu, T.; Kisacik, B.; Oksuz, M. F.; Omma, A.; Bes, C.; Cinar, M.; Pamuk, O. N.; Kucuksahin, O.; Akar, S.; Aksu, K.; Yildiz, F.; Onat, A. M.; Kanitez, N. A.; Erden, A.; Dalkilic, E.; Ermurat, S.; Hayran, M.
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    ANTI-TUMOR NECROSIS FACTOR-ALPHA THERAPY IN REFRACTORY BEHCET UVEITIS: A SINGLE CENTER EXPERIENCE
    (Bmj Publishing Group, 2013) Yilmaz, S. G.; Aksu, K.; Keser, G.; Yilmaz, Z.; Sozeri, B.; Ates, H.
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    BUDD-CHIARI SYNDROME IN BEHCET'S DISEASE: A RETROSPECTIVE MULTICENTER STUDY
    (Bmj Publishing Group, 2017) Akyol, L.; Toz, B.; Bayindir, O.; Zengin, O.; Cansu, D. Uskudar; Yigit, M.; Cetin, G. Yildirim; Omma, A.; Erden, A.; Kucuksahin, O.; Altuner, M. S.; Corba, B. S.; Unal, A. U.; Kucuk, H.; Kucuk, A.; Balkarli, A.; Gonullu, E.; Tufan, A. N.; Ureyen, S. Bakirci; Oner, S. Yilmaz; Kobak, S.; Yazici, A.; Ozgen, M.; Sahin, A.; Koca, S. S.; Erer, B.; Gul, A.; Aksu, K.; Keser, G.; Onat, A. M.; Kisacik, B.; Kasifoglu, T.; Cefle, A.; Kalyoncu, U.; Sayarlioglu, M.
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    Clinical history for inflammatory back pain in diagnosing ankylosing spondylitis: The sensitivity, specificity and consistency of clinical features
    (B M J Publishing Group, 2007) Akar, S.; Birlik, M.; Aksu, K.; Kabasakal, Y.; Senocak, O.; Ergor, G.; Akkoc, N.; Onen, F.
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    Comments on the development of aortic structural damage (aneurysm or dilatation) in patients with giant cell arteritis
    (Clinical & Exper Rheumatology, 2016) Keser, G.; Tekeoglu, S.; Zihni, F. Yargucu; Aksu, K.
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    Comparison of 18F-FDG PET/CT findings with current clinical disease status in patients with Takayasu's arteritis
    (Clinical & Exper Rheumatology, 2013) Karapolat, I.; Kalfa, M.; Keser, G.; Yalcin, M.; Inal, V.; Kumanlioglu, K.; Pirildar, T.; Aksu, K.
    Objective. 18F-fluorodeoxyglucosepositron emission tomography/computed tomography (18F-FDG PET/CT) scanning has been proposed as a new tool to assess disease activity in Takayasu arteritis (TA). We investigated whether 18F-FDG PET/CT findings were consistent with current clinical disease status in patients with TA. Methods. In this cross sectional study, 22 patients with TA were enrolled. Clinical disease activity was assessed by the combination of National Institutes of Health (NIH) criteria, Disease Extent Index-Takayasu (DEI-Tak) score, physician global assessment and 18F-FDG PET/CT scans. Results. At the time 18F-FDG PET/CT scans were taken, the majority of the patients (17122) were using immunosuppressive (IS) drugs, and only four patients had clinically active disease. 18F-FDG PET/CT scans confirmed the presence of active vasculitic lesions in those four patients. In 16 out of 18 patients who were accepted to be in clinical remission, 18F-FDG PET/CT scans were also normal. There were only two patients with discordant results, i.e. active 18F-FDG PET/CT findings despite the lack of clinical activity. Interestingly, clinical exacerbation occurred four weeks later in one of them. Overall sensitivity and specificity of 18F-FDG PET/CT findings for clinical activity were 100% and 88.9%, respectively. Conclusion. We found that 18F-FDG PET/CT findings were generally consistent with clinical disease status in TA. Although use of IS drugs certainly impairs diagnostic accuracy of 18F-FDG PET/CT in TA, this imaging method may still have a potential for confirming remission or detecting disease activity in patients with TA receiving treatment.
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    Comparison of 18F-FDG PET/CT findings with current clinical disease status in patients with Takayasu's arteritis
    (Clinical & Exper Rheumatology, 2013) Karapolat, I.; Kalfa, M.; Keser, G.; Yalcin, M.; Inal, V.; Kumanlioglu, K.; Pirildar, T.; Aksu, K.
    Objective. 18F-fluorodeoxyglucosepositron emission tomography/computed tomography (18F-FDG PET/CT) scanning has been proposed as a new tool to assess disease activity in Takayasu arteritis (TA). We investigated whether 18F-FDG PET/CT findings were consistent with current clinical disease status in patients with TA. Methods. In this cross sectional study, 22 patients with TA were enrolled. Clinical disease activity was assessed by the combination of National Institutes of Health (NIH) criteria, Disease Extent Index-Takayasu (DEI-Tak) score, physician global assessment and 18F-FDG PET/CT scans. Results. At the time 18F-FDG PET/CT scans were taken, the majority of the patients (17122) were using immunosuppressive (IS) drugs, and only four patients had clinically active disease. 18F-FDG PET/CT scans confirmed the presence of active vasculitic lesions in those four patients. In 16 out of 18 patients who were accepted to be in clinical remission, 18F-FDG PET/CT scans were also normal. There were only two patients with discordant results, i.e. active 18F-FDG PET/CT findings despite the lack of clinical activity. Interestingly, clinical exacerbation occurred four weeks later in one of them. Overall sensitivity and specificity of 18F-FDG PET/CT findings for clinical activity were 100% and 88.9%, respectively. Conclusion. We found that 18F-FDG PET/CT findings were generally consistent with clinical disease status in TA. Although use of IS drugs certainly impairs diagnostic accuracy of 18F-FDG PET/CT in TA, this imaging method may still have a potential for confirming remission or detecting disease activity in patients with TA receiving treatment.
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    COMPARISON OF CHARACTERISTICS OF ANKYLOSING SPONDYLITIS IN ASSOCIATION WITH FAMILIAL MEDITERRANEAN FEVER WITH THOSE OF TYPICAL ANKYLOSING SPONDYLITIS
    (Bmj Publishing Group, 2014) Solmaz, D.; Akar, S.; Kisacik, B.; Apras, S.; Senel, S.; Onat, A. M.; Kasifoglu, T.; Aksu, K.; Sari, I.; Ozturk, M. A.; Sayarlioglu, M.; Akdogan, A.; Cetin, P.; Akkoc, N.
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    CYCLOPHOSPHAMIDE INDUCED BLADDER TOXICITY AND PROTECTIVE EFFECT OF 2-MERCAPTOETHANE SULFONATE (MESNA) IN SYSTEMIC AUTOIMMUNE DISORDERS
    (Bmj Publishing Group, 2013) Yilmaz, N.; Emmungil, H.; Ozen, G.; Yildiz, F.; Dogan, I.; Balkarli, A.; Yasar, S.; Pamuk, O. N.; Cagatay, Y.; Cetin, G.; Aksu, K.; Direskeneli, H.; Erken, E.; Karadag, O.; Cobankara, V.; Kasifoglu, T.; Sayarlioglu, M.; Yavuz, S.
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    DNA damage and its relationship with other oxidative stress parameters in Behcet's disease
    (Springer Heidelberg, 2012) Sezer, E. D.; Aksu, K.; Caglayan, O.; Keser, G.; Karabulut, G.; Ercan, G.
    Beh double dagger et's disease (BD) is a multisystemic, chronic inflammatory, relapsing disorder that is characterized by oral/genital ulcerations, ocular, arthritic, vascular, and neurologic involvements. Recent findings suggest the role of increased oxidative stress and insufficient antioxidant defence system in BD pathogenesis. It has been proposed that the increase in phagocytic cell activity by triggering oxidative reactions in various targets such as lipids, proteins, and DNA leads to severe inflammatory and degenerative pathologies seen in BD In this study, oxidant/antioxidant status of patients with BD was evaluated in comparison with controls and in respect to disease activity by measuring serum nitrite/nitrate, vitamin A, malondialdehyde (MDA), 8-hydroxy deoxyguanosine (8-OHdG), and total sulfhydryl levels (T-SH). The increase in serum MDA and 8-OHdG levels (respectively 30.04 vs. 17.93 nmol/ml, P = 0.0004 and 1.60 vs. 1.03 ng/ml, P = 0.0019) and the decrease in T-SH levels of patients with BD in comparison with controls (0.69 vs. 0.76 mmol/l, P = 0.0085) all indicate the impaired oxidant/antioxidant status in BD. The positive correlation found between MDA/8-OHdG levels (P = 0.02), and the negative correlations both between T-SH/8-OHdG levels (P = 0.031) and T-SH/MDA levels (P = 0.009) show the concordance between the parameters evaluating oxidant-antioxidant status. Among the parameters used for evaluating oxidant/antioxidant status, serum 8-OHdG was the only one showing significantly higher levels in patients with clinically active disease in comparison (P = 0.004) to patients in inactive period. Therefore, 8-OHdG that is assessed for the fist time in BD with this study can be proposed as a more reliable indicator of oxidant stress in evaluating disease activity.
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    Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with Behcet's disease
    (Clinical & Exper Rheumatology, 2006) Oksel, F.; Keser, G.; Ozmen, M.; Aksu, K.; Kitapcioglu, G.; Berdeli, A.; Doganavsargil, E.
    Objective. The 894 G -> T (Glu298Asp) polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene was previously reported to be associated with Behcet's Disease (BD) susceptibility in Italian origin and Korean patients, but not in a group of unrelated Turkish patients. We analyzed whether this polymorphism is associated with BD, in another group of Turkish patients. Methods. We studied 132 consecutive Turkish BD patients being followed up by Ege University Rheumatology Department and 91 healthy controls. All individuals were genotyped by PCR-RFLP for 894 G -> T in exon 7 (Glu298Asp). Results. The frequency of the T allele in BD group (1011264) was significantly higher than in healthy controls (OR 1.88, %95 CI 1.27-2.49, p < 0.001). The frequency of the homozygote (TT) Glu298Asp polymorphism in BD (27/132) was also significantly higher than in healthy controls (5/91) (OR 3.72, %95 CI 3.44-4.0, p < 0.001). However, no association was found between the Glu298Asp polymorphism and clinical parameters in BD. Conclusions. In this study, we found that Glu298Asp polymorphism of the eNOS gene was associated with BD in Turkish patients.
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    Epidemiology of Takayasu's arteritis in Turkey
    (Clinical & Exper Rheumatology, 2016) Birlik, M.; Kucukyavas, Y.; Aksu, K.; Solmaz, D.; Can, G.; Taylan, A.; Akar, S.; Sari, I.; Keser, G.; Onen, F.; Akkoc, N.
    Objective. To estimate the prevalence and incidence of Takayasu arteritis (TA) among the residents of the city of Izmir, the third largest metropolis in Turkey. Methods. Five tertiary care teaching hospitals, which were the only ones that provided rheumatology specialty care during the study period in the city of Izmir from 2006 through 2010, were invited to take part in the present study. A case search was performed electronically in the information systems of these hospitals using The International Classification of Diseases Tenth Revision (ICD-10) code for Takayasu arteritis (M31.4). The diagnosis was confirmed through chart review by a rheumatologist according to the 1990 American College of Rheumatology (ACR) criteria. Annual prevalence was calculated based on the number of patients that were alive at the end of 2010. Age-and sex-adjusted prevalence rates were standardised according to the 2010 Turkish population, based on 2010 Turkish Census. Results. A total of 41 patients were confirmed to have TA and also to live within the targeted area. The annual prevalence was estimated as 12.8 (95% CI 12.0-13.6) per million; 23.5/million (95% CI 21.9-25.0) in females and 1.9/million (95% CI 1.5-2.4) in males. The prevalence was higher 8.8/million (95% CI 7.7-10.0) in the population >40 years of age. During the study period, the mean annual incidence of TA was estimated as 1.11/million (95% CI 0.54-1.67). Conclusion. The first epidemiologic study of TA in a Turkish population suggests that TA is a relatively common vasculitis in Turkey.
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    EVALUATION OF PLASMA PENTRAXIN-3 LEVEL IN PATIENTS WITH TAKAYASU'S ARTERITIS
    (Bmj Publishing Group, 2015) Alibaz-Oner, F.; Aksu, K.; Yentur, S. P.; Keser, G.; Saruhan-Direskeneli, G.; Direskeneli, H.
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    EVALUATION OF PLASMA PENTRAXIN-3 LEVEL IN PATIENTS WITH TAKAYASU'S ARTERITIS
    (Bmj Publishing Group, 2015) Alibaz-Oner, F.; Aksu, K.; Yentur, S. P.; Keser, G.; Saruhan-Direskeneli, G.; Direskeneli, H.
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    EVALUATION OF PLASMA PENTRAXIN-3 LEVEL IN PATIENTS WITH TAKAYASU'S ARTERITIS
    (Bmj Publishing Group, 2015) Alibaz-Oner, F.; Aksu, K.; Yentur, S. P.; Keser, G.; Saruhan-Direskeneli, G.; Direskeneli, H.
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    Evaluation of telomerase activity in 53 cases with connective tissue disorders
    (B M J Publishing Group, 2006) Tarhan, F.; Kosova, B.; Vural, F.; Aksu, K.; Cogulu, O.; Keser, G.; Gunduz, C.; Tombuloglu, M.; Oder, G.; Karaca, E.; Doganavsargil, E.
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    Extracellular peroxiredoxin II in rheumatoid arthritis and other autoimmune conditions
    (Oxford Univ Press, 2008) Szabo, K.; Tarr, J.; Eggleton, P.; Line, K.; Ryan, B.; Aksu, K.; Akcay, Y.; Haigh, R.; Littlechild, J.; Winyard, P.
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    Influence of methylenetetrahydrofolate reductase gene polymorphisms on methotrexate toxicity in patients with rheumatoid arthritis
    (B M J Publishing Group, 2007) Tetik, A.; Keser, G.; Inal, V.; Aksu, K.; Eroglu, Z.
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    Interleukin (IL)-12, IL-2, and IL-6 gene polymorphisms in Takayasu's arteritis from Turkey
    (Elsevier Science Inc, 2006) Saruhan-Direskeneli, G.; Bicakcigil, M.; Yilmaz, V.; Kamali, S.; Aksu, K.; Fresko, I.; Akkoc, N.; Kiraz, S.; Ozer, H. T. E.; Tunc, E.; Yucel, E.; Karaarslan, Y.; Uyar, F. A.; Doganavsargil, E.; Inanc, M.; Direskeneli, H.
    Takayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Genetic polymorphisms of cytokines are screened as susceptibility factors for TA in Turkey. A total of 94 patients with TA were investigated for the genetic polymorphisms of the interleukin genes IL12, IL2,and IL6 and were compared with 108 healthy control subjects using polymerase chain reaction-sequence-specific primer method. The frequencies of IL12B 1188 C allele (p = 0.03, OR = 1.7) and CC genotype (p = 0.007, OR = 3.7) were both higher in TA patients than in control subjects. TT genotype at IL2-330 (p = 0.006, OR = 2.4) and GG genotype at IL6-174 (p = 0.04, OR = 1.9) were more frequent in TA patients. Lower prevalence of GT genotype at IL2-330 (P = 0,005, OR = 0.4), CG genotype at IL6-174 (p = 0.001, OR = 0.4), and AG genotypes at IL6-598 (p = 0.01, OR = 0.4) were also detected. The polymorphism of IL-12 as well as IL-6 and IL-2 genes may contribute to susceptibility and pathogenesis of TA by altering cytokine production and inducing inflammation. (c) American Society for Histocompatibility and Immunogenetics, 2006. Published by Elsevier Inc.
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    IS RELAPSE RATE OF GIANT CELL ARTERITIS IN REAL-LIFE EXPERIENCE LOWER THAN IN THE CONTROLLED TRIALS? RESULTS OF A RETROSPECTIVE, MULTI-CENTRE COHORT STUDY
    (Bmj Publishing Group, 2018) Alibaz-Oner, F.; Balci, M. A.; Pamuk, O. N.; Zengin, O.; Tasci, M.; Dogru, A.; Bayindir, O.; Yavuz, S.; Cefle, A.; Tezcan, M. E.; Oksuz, M. F.; Kucuksahin, O.; Omma, A.; Bilge, S. Yasar; Kasifoglu, T.; Erturk, Z.; Bes, C.; Unal, A. U.; Armagan, B.; Gonullu, E.; Yazici, A.; Karadag, O.; Dalkilic, E.; Aksu, K.; Keser, G.; Direskeneli, H.