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    Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome
    (Taylor & Francis Ltd, 2019) Alan, Murat; Gurlek, Beril; Yilmaz, Alpay; Aksit, Murat; Aslanipour, Behnaz; Gulhan, Ibrahim; Mehmet, Calan; Taner, Cuneyt Eftal
    Asprosin associated with insulin resistance is a newly discovered peptide hormone. The peptide promotes hepatic glucose production. Polycystic ovary syndrome (PCOS) is a metabolic disorder. Insulin resistance plays a vital role in the pathogenesis of the disease. The aim of this study was to discover the association between insulin resistance and asprosin in women with PCOS. We recruited 78 subjects with PCOS and 78 age-matched and body mass index (BMI)-matched controls into this cross-sectional study. Circulating asprosin levels were validated using ELISA method. We also determined metabolic and hormonal parameters of the involved subjects. We found that circulating asprosin levels were elevated in women with PCOS with respect to controls. Asprosin levels showed a positive correlation with insulin resistance, BMI, and free androgen index (FAI). Moreover, subjects with the highest tertile of asprosin levels represented increased odds of having PCOS as compared to those subjects with the lowest tertile asprosin levels. Increased asprosin levels resulted to high possibility of having PCOS risk associated with insulin resistance.
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    The low levels of bone morphogenic protein-4 and its antagonist noggin in type 2 diabetes
    (Springer International Publishing Ag, 2018) Yurekli, Banu Sarer; Kocabas, Gokcen Unal; Aksit, Murat; Kutbay, Nilufer Ozdemir; Suner, Asli; Yurekli, Ismail; Cakir, Habib; Bozkaya, Giray; Cetinkalp, Sevki
    Objective Bone morphogenic protein-4 (BMP-4) is a proinflammatory cytokine which is controlled by BMP-4 antagonists. Our aim was to investigate the levels of BMP-4 and its antagonists, noggin and matrix Gla protein (MGP), in prediabetes and diabetes. Design One hundred and forty-two type 2 diabetic, 32 prediabetic, and 58 control subjects participated in this cross-sectional study. BMP-4, noggin, and MGP were measured with the ELISA method. Results There was a significant difference between the three groups in relation to sex, hypertension, fasting plasma glucose, HbA1c, lipid profiles, and diastolic blood pressure (p < 0.05). BMP-4 levels were significantly lower in the diabetic group compared to the control group (108.5 and 127.5 ng/mL, respectively, p < 0.001 diabetes vs. control). Noggin levels were significantly lower in the diabetic group compared to the prediabetic and control groups (10.5, 11.5, and 12.0 ng/mL, as median, respectively, p < 0.001; diabetes vs. control, p = 0.002; diabetes vs. prediabetes). BMP-4 was associated significantly with noggin in the entire study population (beta coefficient = 0.796, p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve was 0.708 (95% CI 0.551-0.864, p = 0.011) for BMP-4 levels. The optimal cutoff value of BMP-4 for detecting albuminuria was 118.5 ng/mL for which sensitivity was 71.4% and specificity was 66.4%. Conclusions BMP-4 and noggin levels were lower in the diabetic group. High BMP-4 levels were significantly associated with albuminuria. Further studies are warranted to determine the role of BMP-4 in the pathogenic processes underlying albuminuria and hyperglycemia in patients with type 2 diabetes.
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    Osteoprotegerin Levels in Acromegaly
    (Endocrine Soc, 2014) Kocabas, Gokcen; Simsir, Ilgin; Yurekli, Banu Pinar; Kutbay, Nilufer; Baykan, Emine Kartal; Altun, Ilker; Aksit, Murat; Bozkaya, Giray; Saygili, Fusun
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    Relationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance, High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetes
    (Elsevier Science Inc, 2018) Bilgir, Oktay; Gokcen, Belma; Bilgir, Ferda; Guler, Asli; Calan, Mehmet; Yuksel, Arif; Aslanipour, Behnaz; Aksit, Murat; Bozkaya, Giray
    Background: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass. Material and Methods: This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance. Circulating MIF levels were measured using enzyme-linked immunosorbent assay. Metabolic parameters of recruited subjects were evaluated. Visceral fat mass was measured using bioelectrical impedance method. Results: Circulating MIF levels were found to be elevated in subjects with prediabetes compared to controls (26.46 +/- 16.98 versus 17.44 +/- 11.80 ng/mL, P = 0.007). MIF positively correlated with BMI, visceral fat mass and indirect indices of homeostasis model assessment of insulin resistance. In linear regression model, an independent association was found between MIF levels and metabolic parameters, including BMI, visceral fat mass and homeostasis model assessment of insulin resistance. Multivariate logistic regression analyses revealed that the odds ratio for prediabetes was higher in subjects in the highest quartile of MIF compared to those in the lowest quartile, after adjusting for potential confounders. Conclusions: Increased MIF levels are associated with the elevation of prediabetic risk.