Yazar "Akkol, Esra Kupeli" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Fatty acid composition and preclinical resarches on Anthemis wiedemanniana Fisch Mey.: Discovery of a new anti-inflammatory agent
    (Medknow Publications & Media Pvt Ltd, 2014) Gonenc, Tuba Mert; Akkol, Esra Kupeli; Suntar, Ipek; Erdogan, Tugce Fafal; Kivcak, Bijen
    Background: Anthemis species have been used for the treatment of gastrointestinal disorders, hemorrhoid, stomachache and inflammatory diseases in Turkish folk medicine. Anthemis wiedemanniana Fisch. And Mey. is an endemic plant used as painkiller, antispasmodic, sedative and for the treatment of urinary inflammations. Objective: The objective of the present study is to evaluate the anti-inflamatory activity of the extracts of A. wiedemanniana by using in vivo methods. Materials and Methods: Carrageenan-, PGE 2 - and serotonin-induced hind paw edema, 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema and acetic acid-induced increase in capillary permeability models were used for the anti-inflammatory activity assessment. Moreover, the fatty acid composition of A. wiedemanniana was investigated by gas chromatography (GC). Results: n-Hexane, diethyl ether and total sesquiterpene lactone extracts exhibited significant inhibition in carrageenan-induced hind paw edema and acetic acid-induced increase in capillary permeability model. n-Hexane and total sesquiterperne lactone extracts showed anti-inflammatory activity in PGE 2 - and serotonin-induced hind paw edema model. However none of the extracts displayed significant activity in TPA-induced ear edema model in mice. C 4:0 (Buthyric acid), C 20:0 (Arachidic acid) and C 16:1 (Palmitoleik acid) were found to be the major fatty acids in these species. Saturated fatty acids (SFA) were found in higher amounts than monounsaturated fatty acids and polyunsaturated fatty acids. SFAs were determined as 63.17%, UFAs as 20.89% and PuFAs as 15.95%. Conclusion: This study confirms the traditional usage of A. wiedemanniana for inflammatory diseases.
  • Küçük Resim Yok
    Öğe
    Fatty Acid Compositions and Anti-inflammatory Activities of Tripleurospermum parviflorum (Wind.) Pobed. and Tripleurospermum tenuifolium (Kit.)
    (Acg Publications, 2015) Erdogan, Tugce Fafal; Akkol, Esra Kupeli; Suntar, Ipek; Gonenc, Tuba Mert; Kivcak, Bijen
    In Turkish traditional medicine, Tripleurospermum species have been used for the treatment of inflammatory diseases. The present study was designed to investigate the anti-inflammatory potential and fatty acid composition of the extracts prepared from Tripleurospermum parviflorum (Willd.) Pobed. and T. tenuifolium (Kit.). Anti-inflammatory activity was assessed by using carrageenan-, and serotonin- induced hind paw edema and acetic acid-induced increase in capillary permeability models. The fatty acid compositions of the plants were investigated by gas chromatography (GC). EtOAc extracts of T. tenuifolium and T. parviflorum exerted notable inhibitory effect in the all in vivo anti-inflammatory activity models tested. Generally, C 16:0 palmitic acid and C 18:2 linoleic acid were found to be the major fatty acids in two species. Saturated fatty acids (SFAs) were found in higher amounts than monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) in two species. SFAs were determinated at 63.15% and 58.68% in T. tenuifolium and T. parviflorum, respectively. The high content of linoleic acid and palmitic acid may be primarily responsible for significant anti-inflammatory activity. The present study confirms the anti-inflammatory activity of T. parviflorum and T. tenuifolium. Further phytochemical and biological activity studies are needed for the determination of the active principle/s and anti-inflammatory activity mechanism.
  • Küçük Resim Yok
    Öğe
    Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus: A comparative study
    (Elsevier Ireland Ltd, 2012) Akkol, Esra Kupeli; Suntar, Ipek; Erdogan, Tugce Fafal; Keles, Hikmet; Gonenc, Tuba Mert; Kivcak, Bijen
    Ethnopharmacological relevance: In Turkish folk medicine Ranunculus species are used for wound healing and for the treatment of rheumatism. The present study was conducted to evaluate in vivo wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus. Material and methods: In vivo wound healing activity of the extracts prepared from Ranunculus pedatus and Ranunculus constantinapolitanus was evaluated by linear incision and circular excision wound models. Hydroxyproline content of the treated tissues was also assessed. We also studied the anti-inflammatory activity using Whittle method with some modifications. Results: Methanolic extract of Ranunculus pedatus showed significant wound healing effect both in incision (31.4%) and excision (55.74%) wound models. Methanolic extract of both Ranunculus pedatus and Ranunculus constantinapolitanus demonstrated anti-inflammatory activity with the inhibition value of 26.2% and 23.3% respectively, at the dose of 100 mg/kg. Hydroxyproline content of the tissues treated with the methanolic and aqueous extracts of Ranunculus pedatus and methanolic extract of Ranunculus constantinapolitanus were found to be significantly higher than that of the other extracts. Conclusion: The experimental data revealed that Ranunculus pedatus showed significant wound healing and anti-inflammatory effect. (C) 2011 Elsevier Ireland Ltd. All rights reserved.