Yazar "Akdeniz, F" seçeneğine göre listele
Listeleniyor 1 - 20 / 26
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Bipolar disorder treatment guidelines of Psychiatric Association of Turkey: Main differences as reflections of countrywide applications and their rationale(Elsevier Science Bv, 2004) Vahip, S; Yazici, O; Akdeniz, F; Gonul, AS; Karadag, F; Kocadere, M; Kora, K; Oral, ET; Ozerdem, A; Ozpoyraz, N; Tamam, L; Tunca, Z; Ucok, A; Va, IÖğe Characteristics of bipolar depressive patients treated in natural design in 1990s(Blackwell Publishing, 2004) Kandemir, I; Vahip, S; Gonul, AS; Vahip, I; Akdeniz, FÖğe Characteristics of bipolar depressive patients: comparison of BP-I vs. BP-II(Blackwell Publishing, 2004) Kandemir, I; Vahip, S; Gonul, AS; Vahip, I; Akdeniz, FÖğe A comparison of different filters for white cell reduction(Turkish J Pediatrics, 1998) Yaprak, I; Yercen, N; Aksit, S; Akdeniz, F; Turker, M; Caglayan, SRemoval of white blood cells (WBCs) from blood components before transfusion by filters with at least 3 log(10) depletion may prevent or delay leukocyte-associated transfusion reactions such as HLA alloimmunization, non-hemolytic febrile reactions, transmitted infections (e.g., CMV, HTLV-1), and immunomodulation. The aim of this study was to compare the leukocyte removal efficiency (LRE) of six commercial bedside filters that are said to achieve 3 log(10) (Bio R-01, Leucostop 4LT-1, Pall RC 50) and 4 log(10) (Bio R-01 Plus, Pall RC 400, Pall RC XL-1) WBC depletion. A total of 430 units of whole blood ranging from 32 to 92 for each filter type were analyzed by an automated counter before and after filtration. Postfiltration blood samples were also evaluated for WBCs by Nageotte chamber. All the filters demonstrated leukocyte removal about 1 log(10) less than the manufacturer's claim. The fourth generation filters showed a better performance than the third generation filters. Of them, Pall RC XL-1 showed the best efficacy with 99.93 percent leukocyte removal and a median residual WBCs of 1.6 x 10(6) per unit. These results indicate that the fourth generation filters, which are designed for the filtration of packed red cells, in particular Pall RC XL-1, are also able to reduce WBCs from whole blood below the critical antigenic leukocyte load (5 x 10(6)), and can be efficiently used for polytransfused patients to prevent alloimmunization.Öğe The effect of antidepressant treatment on N-acetyl aspartate levels of medial frontal cortex in drug-free depressed patients(Pergamon-Elsevier Science Ltd, 2006) Gonul, AS; Kitis, O; Ozan, E; Akdeniz, F; Eker, C; Eker, OD; Vahip, SThe medial frontal cortex has been shown to modulate emotional behavior and stress responses, suggesting that the dysfunction of this region may be involved in the pathogenesis of depressive symptoms. The present study was performed to determine whether there was any effect of antidepressant treatment on the metabolite levels in the left medial frontal cortex as measured by proton magnetic resonance spectroscopy in depressed patients. Twenty patients diagnosed as having major depressive disorder according to DSM-IV and 18 healthy volunteer subjects were included in the study. Twelve of patients had their first episode and were drug-naive. Other depressed patients were drug-free for at least 4 weeks. 3 The severity of depression was assessed by HAM-D and Clinical Global Impression Scale-Severity (CGI-S). Single voxel, 8 cm(3), 1H MR spectra of left medial frontal cortex was acquired both before and following antidepressant treatment. The concentrations and ratios of N-acetyl aspartate (NAA), Creatine+Phosphocreatine (Cr+PCr) and Choline (Cho) were measured. Pretreatment NAA/Cr values of patients were lower than those of healthy controls, but this difference did not reach to statistically significant levels (t=1.83, df=36, p=0.07). However, antidepressant treatment had significant effect on NAA/Cr ratios (group x treatment interaction: F=9.93 df=1,36, p=0.03). After the treatment, NAA/Cr values of patients increased significantly compared to pretreatment values (t =3.32, df=19, p=0.004). No significant difference was observed between the post-treatment NAA/Cr values of patients and those of controls (t=1.64, df=36, p=0.19). Correlation analysis detected negative correlation between pretreatment CGI-S scores and NAA/Cr ratios (r=-0.51, p=0.02). This preliminary result suggests that there might be a possible defect in the neuronal integrity in the left medial frontal cortex (mainly left anterior cingulate cortex) of depressed patients. Antidepressant treatment with its neurotrophic effects might play a positive role in restoring the neuronal integrity. Further studies are needed to support these initial findings. (c) 2005 Elsevier Inc. All rights reserved.Öğe Effect of antipsychotics on low serum brain derived neurotrophic factor levels in schizophrenia(Elsevier Science Bv, 2005) Pirildar, S; Gonul, AS; Taneli, F; Akdeniz, FÖğe Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients(Springer Heidelberg, 2005) Gonul, AS; Akdeniz, F; Taneli, F; Donat, O; Eker, C; Vahip, SResearchers have reported that serum brain-derived neurotrophic factor (sBDNF) of drug-free depressed patients are lower than those of healthy controls and proposed that low sBDNF levels might reflect failure of neuronal plasticity in depression. In this study, we compared sBDNF levels of depressed patients (n = 28) before and after 8 weeks of antidepressant treatment, with those of healthy controls (n = 18) to test the hypothesis that initially low sBDNF levels of drug-free depressed patients will increase parallel with their clinical response to antidepressant treatment. The severity of depression and response to treatment were assessed with Hamilton Rating Scale for Depression (HAM-D). sBDNF was assayed with the sandwich ELISA method. Baseline sBDNF levels of patients (mean, 20.8 ng/ml; [S.D., 6.7]) were significantly lower than those of controls (mean, 26.8 ng/ml; [S.D., 9.3]; p = 0.015), and were negatively correlated with HAM-D scores (r = -0.49, p = 0.007). After 8 weeks of treatment, sBDNF levels of patients had increased significantly (mean, 33.3 ng/ml; [S.D., 9.9]; p < 0.001) and no longer differed from those of controls. These results support the hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients.Öğe The effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients(Elsevier Science Bv, 2003) Gonul, AS; Akdeniz, F; Taneli, F; Donat, O; Eker, C; Vahip, SÖğe The effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients(Elsevier Science Bv, 2003) Gonul, AS; Akdeniz, F; Taneli, F; Donat, O; Eker, C; Vahip, SÖğe Evidence for theory of mind deficits in euthymic patients with bipolar disorder(Blackwell Publishing, 2005) Bora, E; Vahip, S; Gonul, AS; Akdeniz, F; Alkan, M; Ogut, M; Eryavuz, Ai) To investigate the subtle ToM (theory of mind) deficits in euthymic patients with bipolar disorder. ii) To investigate the impact of non-ToM cognitive deficits on ToM abilities. Forty-three euthymic patients with bipolar disorder and 30 healthy control subjects were involved in this study. ToM was assessed by the Eyes test and the Hinting task. Both groups were also evaluated with a comprehensive neuropsychological battery including tasks for basic emotion and face recognition. The patient group was impaired on both of the ToM tasks. The patient group also showed impairment in many cognitive tasks including tasks related to sustained attention. Even euthymic patients with bipolar disorder may be impaired in advanced ToM tasks. Executive dysfunction and some other cognitives deficits such as basic emotion recognition may be at least partly responsible for this result.Öğe Is obesity a risk factor for psychopathology among adolescents?(Blackwell Publishing Asia, 2004) Erermis, S; Cetin, N; Tamar, M; Bukusoglu, N; Akdeniz, F; Goksen, DBackground: Although several studies have documented the existence of psychopathology in obese adolescents, disagreement remains regarding the extent and nature of this psychopathology. The aim of the present study was to explore the type and frequency of psychopathology in a clinical as well as a non-clinical sample of obese adolescents, and in a normal weight control group. Methods: The study sample consisted of a clinical study group of 30 obese adolescents, a non-clinical obese group of 30 obese adolescents, and a control group of 30 normal weight adolescents. Psychological assessment was performed using a non-structured psychiatric interview, the Child Behavior Checklist (CBCL), Children Depression Inventory (CDI), Rosenberg Self-esteem scale (SES) and the Eating Attitude Test (EAT). Results: More than half of the clinical obese adolescents (16/30) had a DSM-IV diagnosis, often involving major depressive disorder (n = 10). The mean scores of anxiety-depression, social problems, social withdrawal and total problem in the CBCL scale of the clinical obese group were significantly higher than the non-clinical obese group and the normal weight control group. The mean total scores of the SES and the CDI of the clinical obese group were higher than the normal weight control group. The mean total score of EAT of the clinical obese group was significantly higher than the normal weight control group, and the mean score of EAT of the non-clinical obese group was significantly higher than the normal weight control group. Conclusions: The results support previously published reports which show a higher ratio of psychopathology (depression, behavioral problems, low-esteem) among clinical obese adolescents than among non-clinical obese adolescents. Findings provided evidence for a psychosocial at-risk population in a subgroup of obese adolescents.Öğe Is there a relationship between mood disorders and affective temperaments?(Blackwell Publishing, 2004) Akdeniz, F; Kesebir, S; Vahip, S; Gonul, ASÖğe Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatment(Pergamon-Elsevier Science Ltd, 2004) Pirildar, S; Gonul, AS; Taneli, F; Akdeniz, FBrain-derived neurotrophic factor (BDNF) has been suggested to be involved in the etiology of schizophrenia. There is a line of evidence that disruption of neurotrophins could play a role in the etiology of schizophrenia, and antipsychotics show their effect by altering levels of neurotrophins. The aim of this study was to evaluate the effect of antipsychotics on serum BDNF levels and their relationship with the symptoms in patients with schizophrenia. Twenty-two schizophrenia patients were enrolled in the study. The control group consisted of 22 age- and sex-matched physically and mentally healthy volunteers (7 male, 15 female). Serum BDNF levels and the positive and negative syndrome scale (PANSS) scores were recorded at baseline and after 6 weeks of treatment. Serum BDNF levels were also recorded in the control group. Schizophrenia patients who failed to meet 30% improvement in PANSS score were excluded from the study. The baseline serum BDNF levels of schizophrenia patients were lower than those of controls (t=4.56; df=21; p<0.001). There was no correlation between serum BDNF levels and PANSS scores inpatients with schizophrenia (p>0.05). Although PANSS (for positive symptoms p<0.001, for negative symptoms p<0.001) and general psychopathology (t=20.9; df=22;p<0.001) scores improved significantly after 6 weeks of antipsychotic treatment; there was no change in BDNF levels in patients' serum (p>0.05). Our results support the view that BDNF would be associated with schizophrenia. However, we could not conclude that treatment with antipsychotics alters serum BDNF levels in patients with schizophrenia. (C) 2004 Elsevier Inc. All rights reserved.Öğe Manic switch rates and possible risk factors: 5-year retrospective evaluation from a university clinic(Blackwell Munksgaard, 2004) Vahip, S; Kandemir, I; Akdeniz, F; Gonul, AS; Vahip, IÖğe Menstrually related symptom changes in women with treatment-responsive bipolar disorder(Blackwell Munksgaard, 2004) Karadag, F; Akdeniz, F; Erten, E; Pirildar, S; Yucel, B; Polat, A; Atmaca, MObjective: In the present study, we aimed to evaluate menstrually related symptom changes in euthymic women with treatment-responsive bipolar disorder (BD) compared with healthy control subjects and investigate the presence of premenstrual dysphoric disorder (PMDD). Methods: Thirty-four euthymic women with treatment-responsive BD on mood-stabilizers (lithium and/or valproate) for at least 6 months and 35 control Subjects with no history of medical/mental disorder between ages of 18 and 35 years with regular menstrual cycles were prospectively followed up for at least two consecutive menstrual cycles using the Daily Record of Severity of Problems-Short Form (DRSP). Each subject was administered the retrospective self-report questionnaire, Premenstrual Assessment Form (PAF) in the first postmenstrual phase of the menstrual cycle. venous blood samples were collected between 19 and 22 days of menstrual cycle to evaluate ovulation by measuring the serum progesterone levels. Results: The differences in mean age, age of onset of menses, cycle length and bleeding length did not appear to be significantly meaningful between groups. In the retrospective assessment of premenstrual symptom changes, controls complained more than women with BD. More controls showed a 30% change in DRSP and in depressive and physical sub-groups than the women with BD. Controls demonstrated a significant increase compared with treatment-responsive BD patients in total, depressive, anxiety and attention sub-group scores of DRSP from the postmenstrual to the premenstrual phase, whereas the scores of vegetative symptoms of controls and women with BD did not differ significantly during one cycle or both. Significant menstrual cycle effect was observed in both groups. Conclusion: Within the limitations of the study, the results suggest that ongoing mood-stabilizing treatment may have a prophylactic effect against premenstrual symptom changes in women with treatment-responsive BD.Öğe Neuroleptic malignant-like syndrome induced with low-dose quetiapine treated with electroconvulsive therapy(Editions Scientifiques Medicales Elsevier, 2003) Bora, E; Gonul, AS; Akdeniz, F; Vahip, SÖğe Neuroleptic malignant-like syndrome induced with low-dose quetiapine treated with electroconvulsive therapy(Editions Scientifiques Medicales Elsevier, 2003) Bora, E; Gonul, AS; Akdeniz, F; Vahip, SÖğe Premenstrual symptom changes among women with mood disorders(Elsevier Science Bv, 2002) Akdeniz, F; Karadag, F; Korkmaz, S; Yucel, BÖğe The relationship of affective temperament and clinical features in bipolar disorder(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2005) Kesebir, S; Vahip, S; Akdeniz, F; Yuncu, ZObjective: The aim of the present study was to investigate the relationship between affective temperaments and clinical features in bipolar disorder. Testing the relationships between phenomenological features, course, severity of episodes, overall severity of illness and comorbid conditions would clarify the reliability and validity of affective temperamental descriptions. Methods: One hundred patients with bipolar I disorder were recruited from consecutive admissions and evaluated when euthymic. Affective temperaments were assessed with TEMPS-A Turkish version. Information about the characteristics of each patient's illness was obtained from three main sources; interview with patient (SCID-1), interview with at least one close relative and patient records. We compared the clinical features of patients with and without a specific affective temperament. Results: Similar rates of cyclothymic, hyperthymic and irritable temperaments were observed in bipolar patients. Five important findings of the present study were (1) hyperthymic temperament was more frequent in males than females; (2) manic switches were more frequent among bipolar patients with hyperthymic temperament; (3) psychotic features were more common in the irritable temperament group; (4) comorbid conditions, (mostly alcohol use disorders) were more common among bipolar patients with cyclothymic temperament; and (5) bipolar patients with irritable temperament were more likely to have a manic episode at the onset of illness. Conclusion: These findings suggest that affective temperaments have significant clinical implications in bipolar disorder, beyond the genetic basis and predisposing factors. There were significant differences between patients with different affective temperaments in terms of gender, type of first episode, psychotic symptoms, switch and comorbidity.Öğe Risk factors associated with childbearing-related episodes in women with bipolar disorder(Karger, 2003) Akdeniz, F; Vahip, S; Pirildar, S; Vahip, I; Doganer, I; Bulut, IObjective: For the onset of illness and possible recurrence during the childbearing period, women with bipolar disorder (BD) are at a higher risk. The aim of this study was to evaluate the impact of clinical and psychosocial factors associated with pregnancy and the postpartum period on the course of BD. Methods: The childbearing and illness history of 72 women with BD were assessed to determine mood episodes related to the childbearing period. Data was analyzed to evaluate the risk factors (clinical, obstetric and psychosocial factors) related with mood episodes during pregnancy and the postpartum period. Results: Data of 252 pregnancies and childbirths of 72 women with BD were included in the analysis. Twenty-three (32%) women with BD reported at least one mood episode during pregnancy or within 1 month after childbirth (childbearing-related episode, CBRE). Subjects with CBREs mean age at onset of illness and mean age at the time of assessment were significantly younger than subjects with N-CBRE. A lower number of women who experienced a postpartum episode after the birth of the first child chose to have the second one. Psychosocial factors during pregnancy and the postpartum period and method of delivery did not predict the first postpartum episode. Onset of illness at an early age, experiencing episode during the first pregnancy and experiencing physical problems during pregnancy predicted a mood episode during the first postpartum period. Conclusions: Interpretation of the results of the study is limited with the retrospective nature of data collection. Within the limitations, we may suggest that psychosocial factors do not play a significant role in the genesis of CBREs in women with BD. Copyright (C) 2003 S. Karger AG, Basel.
