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    Antı-?2 Glycoprotein I Antibodies in Children with Rheumatologic Disorders
    (Springer, 2019) Azarsiz E.; Eman G.; Akarcan S.E.; Severcan E.U.; Karaca N.; Aksu G.; Kutukculer N.
    Anti-beta-2-glycoprotein I antibodies (anti-?2GPI) which are the main antiphospholipid antibodies that characterize the autoimmune “antiphospholipid syndrome” are pathogenic and are contributing to thrombosis. We aimed to evaluate the presence and the diagnostic importance of these antibodies in children with different rheumatologic diseases with or without thrombosis risk. A total of 100 children with different rheumatologic diseases evaluated retrospectively. The mean anti-?2GPI IgG (p = 0.108), IgA (p = 0.547), and IgM (p = 0.807) levels showed no statistically significant difference between different diagnosis groups. But anti-?2GPI IgA and IgM levels were higher in SLE patient group. The mean anti-?2GPI IgG (p = 0.375), IgA (p = 0.811), and IgM (p = 0.276) levels were not also showed difference between disease groups with/without predisposition to thrombosis even though concentrations were higher in thrombosis group. In children with rheumatological complaints, anti-?2GPI antibody measurements should not be the first diagnostic criteria if vasculitis is not thought as the primary defect underlying the clinical symptoms. © 2017, Association of Clinical Biochemists of India.
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    Cut-Off Values of Specific IgE and Skin Prick Test to Predict Oral Food Challenge Positivity in Children with Cow’s Milk Allergy
    (AVES, 2022) Günaydın N.C.; Akarcan S.E.; Gülen F.; Bal C.M.; Tanaç R.; Atasever M.; Demir E.
    Objective: The cut-off values for the skin prick test diameters and cow’s milk-specific IgE mea-surements are used to predict the result of the oral food challenge test for the diagnosis of cow’s milk allergy. This study aimed to determine the diagnostic values of skin prick test and cow’s milk-specific IgE according to age groups and compare the diagnostic powers of these 2 methods. Materials and Methods: In total, 153 children who had a preliminary diagnosis of cow’s milk allergy were evaluated. Group A (n = 90) consisted of cow’s milk allergy patients whose diagnosis was confirmed by a positive oral food challenge or a history of anaphylaxis. Group B (n = 63) was composed of patients with a negative oral food challenge. The demographic, clinical, and laboratory findings of 2 groups were compared. Results: The cut-off points for cow’s milk-specific IgE and cow’s milk-skin prick test were determined as >2.12 kUA/L and >5 mm, respectively. The area under the curve was 0.844 for cow’s milk-skin prick test (sensitivity 73%, specificity 84%) and 0.745 for cow’s milk-specific IgE (sensitivity 67%, specificity 86%). The diagnostic power of skin prick test was determined to be higher when compared to cow’s milk-specific IgE (P = .02). According to the predicted probability curves, decision points for cow’s milk-specific IgE and cow’s milk-skin prick test with 95% probability were determined as follows, respectively: for ?24 months: 22 kUA/L, 11.3 mm; for >24 months: 44.1 kUA/, 15.1 mm. The lowest cut-off value with a positive predictive value of 95% and a specificity of 96% was found in patients <1-year-old (>3.3 kUA/L) Conclusion: The use of high probability diagnostic values of communities for specific IgE anskin prick test along with a significant clinical history may provide accurate and rapid diagnosof cow’s milk allergy and facilitate patient follow-up. © 2022, AVES. All rights reserved.