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    Comparison of epidural and IV fentanyl induced patient controlled analgesia for postoperative pain [Postoperatif analjezide epidural ve intravenoz fentanil ile hasta kontrollu analjezi]
    (1998) Agrali S.; Uyar M.; Gokpinar B.; Ugur G.
    Fentanyl was administered by patient controlled analgesia (PCA) via epidural or intravenous route for postoperative pain relief 40 patients who undergowent total hysterectomy. Pain and sedation scores, hourly average and cumulative doses of fentanyl, incidence of side effects and vital functions were followed for 24 hours. VAS scores were lower at 2nd and 12th hours and VRS scores at 12th hours in epidural group. No difference was found between groups with respect to sedation and no patient had oversedation. Hourly average and cumulative doses of fentanyl after the 4th hour were higher in IV group. No patient had respiratory depression and significant hemodynamic alterations. Patients in both groups declared that they were satisfied with the applied technique. Although total opioid consumption was less in epidural group, we conclude that epidural and intravenous fentanyl administered by PCA provided a comparable, safe and efficient analgesia.
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    The effect of dehydrobenzperidol on nausea and vomiting in patient controlled analgesia [Hasta kontrollu analjezide dehydrobenzperidol postoperatif bulanti ve kusmaya etkisi]
    (2000) Ongun B.; Agrali S.; Sakarya M.; Gokpinar B.; Ugur G.
    This study aims to reveal the efficacy of droperidol, a neuroleptic drug with anti-emetic properties, in preventing postoperative nausea and vomiting (PONV) due to IV morphine administered during patient controlled analgesia (PCA). Thirty patients of ASA I-II to whom abdominal hysterectomy was applied were randomly allocated into two groups to receive PCA by morphine alone (Group I) or in combination with dehydrobenzperidol (DHBP) (Group II). Group I received a loading dose of 5 mg IV morphine followed by 1 mg IV boluses with a 10 min lockout period while Group II received morphine plus dehydrobenzperidol (0.05 mg/mL) infusion following loading dose. Otherwise the protocol were the same. Pain and sedation scores, mean and cumulative morphine requirements, incidence of side effects, and vital functions were recorded hourly for 24 hours. Morphine requirement did not show difference between groups. Initial and first hour VAS value was higher in Group I. PONV incidence was significantly lower in Group II (p<0.05), 6.7% vs. 28.6%. None of the patients showed side effects such as respiratory depression, significant haemodynamic changes, and extrapyramidal effects. It is concluded that the addition of DHBP to morphine in intravenous PCA lowered the incidence of PONV safely.