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    Can Ursodeoxycholic acid be an alternative of N-acetylcystein in acute acetaminophen intoxication?
    (2016) Savran, Yusuf; Çavuşoğlu, Türker; Tumer, Mehmet Kemal; Yiğittürk, Gürkan; Cıftcı, Oznur Dılek; Acara, Ahmet Çağdaş; Uyanıkgil, Yiğit
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    Oxytocin Effect on Sepsis-induced Experimental Rat Renal Failure Model: A Histological and Biochemical study
    (2018) Çavuşoğlu, Türker; Savran, Yusuf; Uyanıkgil, Yiğit; Gülle, Kanat; Acara, Ahmet Çağdaş; Yiğittürk, Gürkan; Erbaş, Oytun
    Objective: We aimed to investigate the therapeutic role of Oxytocin (OT) in sepsis induced rats and its effects on kidneys. Sepsis was induced in 24 of them by cecal ligation-perforation (CLP) method. Material-Method: One of the groups of CLP did not recieve any treatment while either saline 1 ml/kg or OT 0.4 mg/kg was applied intraperitoneally to the other groups within the first hour of surgery. 8 rats were sham-operated and 8 rats were spared as control group. Plasma TNF-? ? (Tumor necrosis factor- ?), CRP (C reactive Protein), MDA (Malondialdehyde) levels, total antioxidant capacity (TAC), creatinine level and peripheral leukocyte (WBC) counts were measured. Results: TNF-?, CRP, MDA, TAC levels and WBC counts were significantly increased in CLP and CLP-saline groups, on the contrary they are decreased in CLP-OT group. Histopathologically loss of brush border, tubular dilatation and mononuclear cell infiltration was significantly decreased in CLP-OT group but there was no significant difference in erytrocyte extravasation and cast formation when compared to CLP and CLP-saline groups. Conclusions: Our results indicate that OT may have a therapeutic value in limiting sepsis induced inflammation and organ damage.