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Öğe Acute generalized exanthematous pustulosis caused by a probable spider bite: A case report and review of the literature(Deri Zuhrevi Hastaliklar Dernegi, 2020) Dirican, Fatmagul; Acar, Ayda; Yaman, Banu; Turk, Bengt GercekerAcute generalized exanthematous pustulosis (AGEP) is a toxic cutaneous reaction pattern that is mostly caused by drug intake and rarely associated with spider bites. We report a case of a female patient, 47 years old, with febrile pustular lesions on an erythematous base at the abdominal region. She had three violaceous erythematous and edematous plaques on the interscapular region, one of which had a necrotic crust at its center. The lesions were compatible with spider bites. By considering histopathological and clinical findings, the patient was diagnosed with AGEP. Since she had no history of drug intake, viral infection or other triggers, a spider bite was thought to have caused the AGEP.Öğe Ado-trastuzumab emtansine associated spider telangiectasia(Sage Publications Ltd, 2022) Gursoy, Pinar; Acar, Ayda; Acikalin, TanerIntroduction Breast cancer is the most common cancer in women. Human epidermal growth factor receptor 2 (HER2) positivity rate is 20% and generally has a poor prognosis. Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate consisting of HER2 target monoclonal antibody trastuzumab and microtubule inhibitor emtansine. The most common side effects are fatigue, diarrhea, anemia, and it is generally a safe and tolerable agent. Case report In our case, we reported our patient who developed mucosal and cutaneous telangiectasia after T-DM1 treatment and who had a complete response in metastases after skin lesions. Management and Outcome While no side effects were observed during the use of T-DM1 for HER2 positive disease, nose bleeding and spider telangiectasia on the skin developed in the 9th month of the treatment. In these lesions, which did not require any treatment, no regression was observed during T-DM1 treatment. Discussion We think that T-DM1, which was detected with a low incidence of skin toxicity in studies, may form telangiectatic lesions due to vascular dilatation through emtansine, and therefore care should be taken in the treatment of T-DM1.Öğe Age distribution of psoriasis clinical types: A single center study(Deri Zuhrevi Hastaliklar Dernegi, 2021) Alakbarov, Hasan; Sagduyu, Ilgen Ertam; Acar, Ayda; Turk, Bengu Gerceker; unal, IdilBackground and Design: Psoriasis is a multifactorial, chronic inflammatory skin disease. Clinical and epidemiological parameters in psoriasis may vary in different age groups. The age of the patient is significant in the choice of treatment. We therefore aimed at performing a general and comparative assessment of epidemiologic and clinical parameters of patients with psoriasis according to four age groups. Materials and Methods: We assessed the files of patients with psoriasis who applied to our clinic between 2006 and 2016. Sex, age, duration of disease, family history of psoriasis, clinical types, psoriasis area and severity index, nail and joint involvement, associated comorbidities and dermatoses, and treatments for psoriasis were obtained from the patient files. They were then evaluated comparatively in four age groups: 0-18 years, 19-40 years, 41-65 years and over 65 years. Results: We enrolled 374 patients (54.3% male, 45.7% female). Age of the patients were between 6 years and 85 years (mean: 42.17 +/- 18.54 years), with 16% of the patients between the age of 0-18, 26.7% between 19-40, 45.5% between 41-65 and 11.8% above 65. Guttate psoriasis and generalized pustular psoriasis were observed more frequently in females (p=0.001). Plaque psoriasis was the most observed clinical type in all age groups, while between the age of 0-18 years, the frequency of guttate psoriasis (31,7%) increased significant compared to that in other age groups (p<0.001). Nail involvement in 41-65 years occurred in 64.7% of patients, while it was 18.3% in the 0-18 age group (p<0.001). Frequency of joint involvement was identified in 1.7% of the 0-18 age group, 4% of 19-40 age group, 8.8% of 41-65 age group and 9.1% of the age group above 65 years (p<0.001). Frequency of comorbidities significantly increased with increase in age (p<0.001). Conclusion: In this study, age was noted as a significant factor in distribution of clinical types, nail and joint involvement, comorbidities and selection of treatment modalities.Öğe AL Amyloidosis Presenting with Yellow Discolouration of the Skin with Dermoscopic Findings(Wolters Kluwer Medknow Publications, 2023) Acar, Ayda; Baklan, Ecem; Yaman, Banu; Turk, Bengu Gerceker; Sen, Sait; Keser, Gokhan[No abstract available]Öğe A Case Report of Monkeypox: A New Pandemic with Genital Infections(Bilimsel Tip Yayinevi, 2023) Dirik, Sukru; Pullukcu, Husnu; Acar, Ayda; Tasbakan, MeltemMonkeypox is a zoonotic disease that is endemic in Central and West Africa. Until May 2022, sporadic cases associated with travel to Africa have been reported in the United States and the United Kingdom. After May 2022, many non-travel-related cases have started to be reported in European countries and the United States. Initial symptoms include fever, headache, myalgia, and lymphadenopathy. After 1-5 days from the onset of symptoms, rashes that concentrate on the face and extremities appear. The number of lesions can vary from a few to thousands. In the current pandemic, most cases have been seen in men who have sex with men (MSM) and present with vesiculopustular rash or genital lesions. These genital lesions can be mistaken for those of other sexually transmitted diseases, such as genital herpes. In this article, we present a case of monkeypox in a patient who presented with genital lesions and was initially suspected to have genital herpes.Öğe Comparison of psoriasis area and severity index and physician's global assessment in determining psoriasis severity(Kuwait Medical Assoc, 2021) Acar, Ayda; Bozkurt, Ada; Yenipazar, Gizem Kocabas; Alper, Sibel; Ceylan, CanObjective: In clinical studies, it is crucial to assess psoriasis severity accurately and with no substantial variation between different raters. The Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA) are the two most commonly used tools for the assessment of psoriasis severity. The aim of this study was to evaluate the intra-rater and inter-rater reliability of these methods and to determine whether inter-rater reliability is affected by rater experience. Design: An open uncontrolled study Setting: Dermatology Department of Ege University, Medical Faculty Subjects: Fifty-five patients with plaque psoriasis who were examined between 15 August 2012 and 15 November 2012 in the dermatology department of Ege University Interventions: Three dermatology residents with varying experience evaluated the patients individually using both the PASI and PGA for each patient (in that order). Main Outcome Measure: PASI and PGA Results: PASI and PGA scores showed high intra-rater correlation for all three residents. Inter-rater reliability for PASI was high between the most experienced and second most experienced resident and between the most experienced and least experienced resident. However, inter-rater reliability for PGA was high between the most experienced and second most experienced residents, but only moderate between the most experienced and least experienced resident. Conclusions: There were no significant interrater differences between PGA and PASI scores in our study. However, because PGA is more subjective and may be affected by rater experience, PASI is considered to be a more reliable method for assessing severity of psoriasis.Öğe Comparison of Skin Scraping and Standard Superficial Skin Biopsy in the Laboratory Diagnosis of Scabies(2020) Zorbozan, Orçun; Ünver, Ayşegül; Töz, Seray; Turgay, Nevin; Türk, Bengü Gerçeker; Acar, Ayda; Ünal, İdilObjective: Scabies is diagnosed based on the presence of burrows on the skin, Sarcoptes scabiei adult, egg, or scybala in skin scrapings. the laboratory diagnosis of scabies poses various challenges. We aimed to compare the analytical performance of skin scraping and standard superficial skin biopsy (SSSB) and to investigate the correlation with false negative results in the laboratory diagnosis of scabies.Methods: Skin scraping and SSSB were applied from July 1 to December 31, 2018 on 42 patients whose burrows were marked using dermatoscopy, as obtained from the laboratory information system.Results: the number of patients who tested positive for scabies with skin scraping was 18 (42.9%) and 24 (57.1%) with SSSB, and the difference was significant (p=0.003). Sensitivity was 42.9% for skin scraping and 57.1% for SSSB. the number of positive cases with both techniques was 15 (35.7%). the number of patients positive with only skin scraping was 3 (7.1%) and only SSSB was 9 (21.4%).Conclusion: To date, it has seemed impossible to diagnose scabies using a single clinical or laboratory test. According to our results, SSSB is an inexpensive and easy-to-apply method with high sensitivity for obtaining skin samples for scabies laboratory diagnosis.Öğe Comparison of Skin Scraping and Standard Superficial Skin Biopsy in the Laboratory Diagnosis of Scabies(2020) Zorbozan, Orçun; Ünver, Ayşegül; Töz, Seray; Turgay, Nevin; Türk, Bengü Gerçeker; Acar, Ayda; Oraloğlu, GöktürkObjective: Scabies is diagnosed based on the presence of burrows on the skin, Sarcoptes scabiei adult, egg, or scybala in skin scrapings. The laboratory diagnosis of scabies poses various challenges. We aimed to compare the analytical performance of skin scraping and standard superficial skin biopsy (SSSB) and to investigate the correlation with false negative results in the laboratory diagnosis of scabies.Methods: Skin scraping and SSSB were applied from July 1 to December 31, 2018 on 42 patients whose burrows were marked using dermatoscopy, as obtained from the laboratory information system.Results: The number of patients who tested positive for scabies with skin scraping was 18 (42.9%) and 24 (57.1%) with SSSB, and the difference was significant (p=0.003). Sensitivity was 42.9% for skin scraping and 57.1% for SSSB. The number of positive cases with both techniques was 15 (35.7%). The number of patients positive with only skin scraping was 3 (7.1%) and only SSSB was 9 (21.4%).Conclusion: To date, it has seemed impossible to diagnose scabies using a single clinical or laboratory test. According to our results, SSSB is an inexpensive and easy-to-apply method with high sensitivity for obtaining skin samples for scabies laboratory diagnosis.Öğe Cutaneous graft-versus-host disease after hematopoietic stem cell transplantation; a single institution experience(Nature Publishing Group, 2018) Atilla, Fatos Dilan; Bulbul, Hale; Soyer, Nur; Turk, Bengu Gerceker; Acar, Ayda; Tombuloglu, Murat; Vural, Filiz[No Abstract Available]Öğe Dermoscopic and reflectance confocal microscopic findings in a case of plasma-cell cheilitis(Deri Zuhrevi Hastaliklar Dernegi, 2020) Yaman, Banu; Karaarslan, Isil; Acar, Ayda; Hekimgil, Mine; Akalin, Taner; Ozdemir, Fezal[No Abstract Available]Öğe Efficacy of intense pulsed light therapy for melasma(Taylor & Francis Inc, 2019) Sagduyu, Ilgen Ertam; Dirican, Fatmagul; Acar, Ayda; Unal, IdilÖğe Ege Üniversitesi Hastanesinde görülen deri melanomlarının epidemiyolojik ve genel sağ kalım özellikleri(2020) Acar, Ayda; Yoldaş, Ayşe Hande; Yaman, Banu; Ceylan, Can; Burçak, Şaziye Karaca; Esassolak, Mustafa; Karaarslan, IşılAmaç: Bu çalışmada Ege Üniversitesi Hastanesi veri tabanındaki 1992-2017 yılları arası melanom tanısı alan hastaların epidemiyolojik ve genel sağ kalım özelliklerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezinin özel eğitimli ve sertifikalı kanser kayıt elemanları tarafından CANREG-4 programı ile kaydedilen 1992-2017 yılları arasında Ege Üniversitesinde kayıtlı 1530 melanom tanılı hastanın verileri toplanmıştır. Kategorik değişkenler arası ilişki varlığı Ki-Kare yöntemiyle değerlendirilirken, gruplar arası nümerik değişkenler Tek Yönlü Varyans Analizi ve Tukey HSD Testi ile karşılaştırıldı. Sağ kalım üzerine kategorik değişkenlerin etkileri Kaplan Meier ve LogRank (Mantel-Cox) yöntemleri ile incelenirken, nümerik değişkenler için CoxRegresyon analizi kullanıldı. Tüm Hipotez testleri 0,05 önem seviyesinde uygulandı. Bulgular: Bin beş yüz otuz melanom olgusunun %53,1’i erkek, %46,9’u kadındı. Yaş ortalaması 54,14±16,537’ydi. Yüzeyel yayılan melanom ve lentigo malign melanom en sık görülen alt tiplerdi. Hastaların takip süresi 0 ile 313 ay arasında değişmekteydi. Ortalama genel sağ kalım (GSK) süresi 147,4 ± 5,3 aydı. Yaş artışı ile GSK süresi azalmaktaydı (p<0,01). Kadınlarda erkeklere göre GSK süresi daha yüksekti (p<0,001). Sonuçlar: Çalışmamızda tanı sırasında ileri yaş, erkek cinsiyet, tümörün in situ olmaması, lenf bezi tutulumu ve metastaz varlığı sağ kalımı azaltan faktörlerdir. Beş yıllık GSK nodüler melanomda diğer histopatolojik alt tiplere göre daha kısadır. Beş yıllık GSK; lokalize hastalıkta %90, lokal yayılım durumunda %52, bölgesel yayılımda %56, ilerlemiş metastatik hastalıkta ise %15’tir. Kutanöz melanomda erken tanı prognozu önemli ölçüde etkilemektedir. Melanomun yüksek mortalite oranı dikkate alındığında; daha erken dönemde başvuruyu sağlamak açısından; toplumsal bilinç düzeyinin olabildiğince arttırılması son derece önemlidir.Öğe Ege Üniversitesi Hastanesinde görülen melanom dışı deri kanserlerinin epidemiyolojik ve demografik özellikleri(2020) Acar, Ayda; Yaman, Banu; Yanmaz, Ayris; Yoldaş, Ayşe Hande; Karaarslan, Işıl; Akalın, Taner; Ceylan, CanAmaç: Bu çalışmada Ege Üniversitesi Hastanesi veri tabanındaki 1992-2017 yılları arası melanom dışı malign deri kanseri tanısı alan hastaların epidemiyolojik ve demografik özelliklerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezinin özel eğitimli ve sertifikalı kanser kayıt elemanları tarafından CANREG 4 programı ile kaydedilen 1992-2017 yılları arasında Ege Üniversitesinde kayıtlı 8395 melanom dışı malign deri kanseri tanılı hastanın; tanı yaşı, cinsiyeti, tümörün histopatolojik tanısı, tümör yerleşim yeri, hastalık evresi ve uygulanan tedavi yöntemleri değerlendirilmiştir. Kategorik değişkenler arası ilişki varlığı Ki-Kare yöntemiyle değerlendirilirken, gruplar arası nümerik değişkenler Kruskal Wallis ve Dunn Testi ile karşılaştırıldı. Tüm Hipotez testleri 0,05 önem seviyesinde uygulandı. Bulgular: Ege Üniversitesi Kanser Araştırma Merkezinde 1992 ile 2017 yılları arasında kayıtlı melanom dışı deri kanseri olan 8395 hastanın 8386’sı dahil edildi. Hastaların %55,9’unda bazal hücreli karsinom, %30,3’ünde skuamoz hücreli karsinom, %3,6’sında malign kutanöz yumuşak doku tümörü, %3,4’ünde bazoskuamoz karsinom, %2,7’sinde kutanöz lenfoma, %1,4’ünde malign deri eki tümörü, %0,4’ünde Merkel hücreli karsinom, %2,3’ünde sınıflandırılamayan tümör mevcuttu. Hastaların %57,3’ü erkek, %42,7’si kadındı. Yaş ortalaması 63,3±14,3 idi. Sonuçlar: Olguların çoğunu epitelyal karsinomlar oluşturmakta idi. Çalışmada en sık görülen kanser tipi bazal hücreli karsinomdu ve bunu ikinci sırada skuamoz hücreli karsinom izlemekteydi. En az görülen Merkel hücreli karsinomdu. Merkel hücreli karsinom dışında erkek cinsiyet daha baskındı. Yaş ortalaması en genç olan grup kutanöz lenfomalarken, en ileri yaş gruplu tümör skuamoz hücreli karsinomdu.Öğe Evaluation of platelet-rich plasma efficacy in melasma(Taylor & Francis Inc, 2022) Acar, Ayda; Ozturk, Ayris; Sokmen, Nur; Unal, Idil; Sagduyu, Ilgen ErtamPlatelet-rich plasma (PRP), which is widely used in many dermatologic conditions, has also been used in the treatment of melasma in recent years. The objective of this study is to determine the efficacy of PRP in melasma. Fifteen female patients with melasma participated in this study. Intradermal PRP was performed every 3 weeks for three times. We photographed all participants, performed Melasma Area and Severity Index (MASI), and measured melanin and erythema index (EI) with mexameter before every session and 1 month after the last session. Patients self-assessment of pigmentation grade (0-10) were also employed at baseline and 1 month after the last procedure. Mean MASI of the patients reduced from 10 +/- 3.6 to 7.3 +/- 2.5. Melanin index (MI) and EI evaluated by mexameter reduced from 256.5 +/- 31 to 238.9 +/- 29.9 and from 329.9 +/- 53.8 to 322.7 +/- 77.6, respectively. Mean patients self-assessment score (PSS) reduced from 8.3 +/- 1.3 to 5 +/- 1.4. Mean MASI, MI, and PSS reduction after treatment was found significant (p = .001, p = .000, p = .000). Intradermal application of PRP is an effective option for treatment of melasma. It also has other benefits like improvement in skin appearance. Because recurrence is common in melasma, depigmenting agents should be used after all procedures.Öğe Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal involvement: A Multicenter Observational Study(Mattioli 1885, 2024) Polat, Asude Kara; Mulayim, Mehmet Kamil; Gur, Tugba Falay; Acar, Ayda; Bozca, Burcin Cansu; Ceylan, Can; Kilinc, FadimeIntroduction: Pemphigus vulgaris (PV) is an autoimmune disease primarily affecting the oral mucosa. Objectives: This study aimed to determine the demographic, clinical and treatment characteristics of PV patients with oral mucosal involvement and to assess the impact on their quality of life. Methods: We conducted a prospective observational study among 106 patients diagnosed with PV and presenting oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded. Results: The study included 106 patients, 55 (51.89%) were male and there was a predominance of the mucocutaneous subtype in 83 individuals (78.38%). Oral mucosa was the initial site of manifestation in 44 patients (41.51%). Bilateral buccal mucosa was the most frequently affected site. The predominant symptom reported was a burning sensation, noted in 91 patients (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. Systemic steroids were the most commonly administered treatment, and rituximab was used in 18 patients (16.98%). A positive and significant correlation was found between pemphigus severity and Oral Health Impact Profile-14, Dermatology Life Quality Index and Dermatological Quality of Life Scale scores (P < 0.05). The presence of superficial ulcers, flaccid bullae, lesion diameter >= 1 cm, and >10 lesions were factors that markedly diminished quality of life. Complete response to treatment was noted in all patients administered rituximab. Conclusions: The most common area of involvement was bilateral buccal mucosa, and the severity of PV closely correlated with a decline in quality of life measures. These results highlight the need for careful clinical oversight of PV, taking into account its effects on patients quality of life.Öğe Experience with Omalizumab for the treatment of chronic spontaneous urticaria in a tertiary center: real life experience(Taylor & Francis Ltd, 2020) Acar, Ayda; Gerceker Turk, Bengu; Ertam Sagduyu, Ilgen; Ceylan, Can; Ozturk, Gunseli; Unal, IdilPurpose Chronic spontaneous urticaria (CSU) is defined as urticaria and/or angioedema that appears spontaneously due to known or unknown causes and lasts for at least 6 weeks. Omalizumab, an anti-IgE antibody that binds circulating free IgE, has recently emerged as a promising treatment for CSU, a condition which impairs patients' quality of life. We aimed to contribute real life data by reporting our experience with omalizumab in the treatment of intractable CSU. Methods of 140 patients treated with omalizumab in our clinic between September 2013 and January 2018, 86 CSU patients with available current data were retrospectively evaluated in terms of sex, age, urticaria duration, urticaria activity score over 7 days (UAS7) before and after omalizumab, relapses and time to relapse, length of remission after omalizumab cessation, adverse events, and comorbidities. Results the mean age of the patients was 45.5 +/- 14.3 years and 73.3% were women. Mean duration of urticaria before initiation of omalizumab therapy was 54.5 +/- 67 months. All patients had used antihistamines before starting omalizumab treatment. the mean number of omalizumab doses was 11.9 +/- 9.3. the mean duration of omalizumab treatment was 13.3 +/- 10.4 months. Mean UAS7 score was 38.9 +/- 4.1 before the start of omalizumab treatment, and 7.9 +/- 10.5 after treatment. Treatment was discontinued in 10 patients (11.6%) due to nonresponse or loss of effect. Four patients (4.65%) experienced adverse events. Treatment was discontinued in 1 patient (1.16%) due to side effects. of the 55 patients whose treatment was discontinued after their symptoms resolved, 31 (56.3%) relapsed after omalizumab cessation. Twenty-four patients (43.6%) did not relapse after omalizumab cessation. Conclusions Our results show that omalizumab was an effective treatment for intractable CSU and did not cause any serious adverse effects other than asthenia, vertigo, and injection site reaction in four patients. These findings are relevant because they reflect real-life data.Öğe Extranasal extranodal NK/T cell lymphoma: A post-transplantation lymphoproliferative disease(Wiley, 2019) Acar, Ayda; Nurlu, Ertan; Sokmen, Nur; Ozsan, Nazan; Davulcu, Eren A.; Ceylan, CanExtranodal NK/T cell lymphoma (ENKTL) is a rare form of non-Hodgkin lymphoma. It mostly occurs in the upper respiratory tract. Cutaneous involvement can be seen among the extranasal ENKTLs. After solid organ and haematopoietic stem cell transplantation, post-transplantation lymphoproliferative disease because of immunosuppressive therapy is usually B cell-derived; T and NK/T cell-derived disease is rarely seen. A 43-year-old female patient who had renal transplantation 14 years ago presented with cutaneous ulceration and subcutaneous nodules located in the abdomen. The patient was diagnosed with ENKTL, nasal type. Although it is rare, ENKTL nasal type is a lymphoproliferative disease that should be considered in the differential diagnosis of ulcerated cutaneous tumoural lesions.Öğe In vivo reflectance confocal microscopy terminology in the Turkish language(Deri Zuhrevi Hastaliklar Dernegi, 2021) ozdemir, Fezal; Gurel, Mehmet Salih; Karaarslan, Isil; Erdemir, Vefa Asli Turgut; Aksu, Ayse Esra Koku; Acar, AydaIn vivo reflectance confocal microscopy (RCM) is a diagnostic method to examine a skin lesion at the cellular level in vivo without biopsy. It provides non-invasive, high resolution imaging for diagnosis and follow-up of malignant, benign skin tumors and inflammatory dermatologic diseases, and its use is spreading worldwide. Standard terminology which has been used in RCM was described earlier in the English language. This study aimed to propose a Turkish terminology for RCM to allow Turkish-speaking dermatologists to communicate in a homogeneous language and familiarize themselves with the terminology of this new diagnostic technic. Six Turkish-speaking dermatologists with RCM experience participated in the study. RCM terminology used in English was determined and translated into Turkish. Turkish terms and their definitions were reviewed by each participant and the consensus was provided in the group. Finally, philology department examined the last version of the terms and the study was finalized. The terms, definitions and the translations of the terms have been identified, and the Turkish RCM terminology has been created and shown. Turkish RCM terminology will provide Turkish-speaking dermatologists to describe their findings in a homogenous language.Öğe Is it necessary to perform eye examination for patients with cutaneous atypical nevi?(Wiley, 2020) Karaarslan, Isil; Yagci, Ayse; Acar, Ayda; Sahin, Arzu; Ozkapu, Tugce; Palamar, Melis; Ozdemir, FezalRegular dermatological examination for patients with dysplastic nevi is indicated. However, the literature on whether those patients should also be examined by ophthalmologists or not regarding a relation between suspicious lesions for ocular melanoma and cutaneous dysplastic nevi is limited. in this study, we aimed to compare the findings of a single ophthalmologic examination between the group of patients with multiple atypical nevi with at least one histopathologically proven dysplastic nevus and another group without atypical nevi. We examined the eyes of 110 patients with multiple atypical nevi with at least one histopathologically proven dysplastic nevus (47 had the diagnosis of dysplastic nevus syndrome type A, B, C, D1 or D2) for any lesion and compared the results with a control group consisted of 110 gender, age and skin-type matched patients without atypical nevi no ocular melanoma was detected in any of the groups. the frequency of the conjunctival nevi, iris nevi, choroidal nevi and conjunctival acquired melanosis were similar in both groups. Iris freckles were detected more frequently in the study group. Conjunctival racial hyperpigmentation was detected more frequently in the control group (P < .05). in this study, any significant difference in the distribution of the ocular lesions with any risk of malignancy in the study and control groups was not observed. However, considering the limitations of the study, there may still be a need of regular ophthalmic examination for the patients with atypical nevi in case of having high risk factors for developing melanoma.Öğe Melazmada trombositten zengin plazma uygulaması etkinliğinin değerlendirilmesi(Ege Üniversitesi, 2022) Acar, Ayda; Sağduyu, İlgen Ertam; Köseoğlu, İdil Ünal; Sökmen, Nur; Öztürk, AyrisBirçok dermatolojik durumda yaygın olarak kullanılan trombositten zengin plazma, son yıllarda melazma tedavisinde de kullanılmaktadır. Bu çalışmanın amacı, trombositten zengin plazmanın melazmadaki etkinliğini belirlemektir. Bu çalışmaya melazmalı 15 kadın hasta katıldı. Üç haftada bir üç kez intradermal PRP uygulandı. Tüm katılımcılar fotoğraflandı, melazma alanı şiddet indeksi (MAŞİ) uygulandı ve her seanstan önce ve son seanstan bir ay sonra meksametre ile melanin ve eritem indeksi ölçüldü. Tedavi başlangıcında ve son işlemden 1 ay sonra hastalar tarafından kendi pigmentasyon derecesi (0 ila 10) değerlendirmesi yapıldı. Tedavi sonunda hastaların ortalama MAŞİ'si 10±3, 6'dan 7, 3±2, 5'e geriledi. Meksametre ile değerlendirilen melanin indeksi ve eritem indeksi sırasıyla 256, 5±31'dan 238, 9±29, 9'e ve 329, 9±53, 8'dan 322, 7±77, 6'ya geriledi. Ortalama hasta öz değerlendirme puanı 8, 3±1, 3'den 5±1, 48'e düştü. Ortalama MAŞİ, melanin indeksi ve hastanın tedavi sonrası öz değerlendirme puanındaki azalma anlamlı bulundu (p=0, 001, p=0, 000, p=0, 000). PRP'nin intradermal uygulaması melazma tedavisi için etkili bir seçenektir. Ayrıca deri görünümünde iyileşme gibi başka faydaları da vardır. Melazmada nüks sık görüldüğü için tüm işlemlerden sonra depigmentasyon ajanları kullanılmalıdır.;Trombositten zengin plazma, melazma, melazma alan şiddet indeksi, meksametre.;Platelet-rich plasma, melasma, melasma area and severity index, mexameter.
